1.1.1.417: 3beta-hydroxysteroid-4beta-carboxylate 3-dehydrogenase (decarboxylating)
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For detailed information about 3beta-hydroxysteroid-4beta-carboxylate 3-dehydrogenase (decarboxylating), go to the full flat file.
Reaction
Synonyms
sdmB
ECTree
1.1.1.417 3beta-hydroxysteroid-4beta-carboxylate 3-dehydrogenase (decarboxylating)Advanced search results
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| 2 | General Information |
| 4 | Natural Substrates/ Products (Substrates) |
| 2 | Organism |
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| 1 | Reaction |
| 2 | Reference |
| 4 | Substrates and Products (Substrate) |
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| 1 | Systematic Name |
Systematic Name
Systematic Name on EC 1.1.1.417 - 3beta-hydroxysteroid-4beta-carboxylate 3-dehydrogenase (decarboxylating)
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SYSTEMATIC NAME 
IUBMB Comments
3beta-hydroxysteroid-4beta-carboxylate:NAD(P)+ 3-oxidoreductase (decarboxylating)
This bacterial enzyme participates in the biosynthesis of bacterial sterols. Together with EC 1.14.13.246, 4beta-methylsterol monooxygenase (SdmA) it forms an enzyme system that removes one methyl group from the C-4 position of 4,4-dimethylated steroid molecules. SdmA catalyses three successive oxidations of the C-4beta methyl group, turning it into a carboxylate group; SdmB is a bifunctional enzyme that catalyses two different activities. As EC 1.1.1.417 it catalyses an oxidative decarboxylation that results in reduction of the 3beta-hydroxy group at the C-3 carbon to an oxo group. As EC 1.1.1.270, 3beta-hydroxysteroid 3-dehydrogenase, it reduces the 3-oxo group back to a 3beta-hydroxyl. Since the remaining methyl group at C-4 is in an alpha orientation, it cannot serve as a substrate for a second round of demethylation by this system.
