EC Number |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
---|
2.3.2.26 | Abortion, Spontaneous |
27901130 |
HUWE1 plays important role in mouse preimplantation embryo development and the dysregulation is associated with poor embryo development in humans. |
causal interaction therapeutic application unassigned |
3 2 0 |
2.3.2.26 | Acquired Immunodeficiency Syndrome |
30854719 |
Distinguishing the optimal binding mechanism of an E3 ubiquitin ligase: Covalent versus noncovalent inhibition. |
unassigned |
0 |
2.3.2.26 | Acute Kidney Injury |
34061176 |
cMet agonistic antibody prevents acute kidney injury to chronic kidney disease transition by suppressing Smurf1 and activating Smad7. |
ongoing research therapeutic application unassigned |
1 1 0 |
2.3.2.26 | Adenocarcinoma |
25395181 |
Nedd4-1 is an exceptional prognostic biomarker for gastric cardia adenocarcinoma and functionally associated with metastasis. |
causal interaction diagnostic usage unassigned |
3 1 0 |
2.3.2.26 | Adenocarcinoma |
28423617 |
The E3 ubiquitin ligase NEDD4 is translationally upregulated and facilitates pancreatic cancer. |
causal interaction diagnostic usage ongoing research unassigned |
4 3 4 0 |
2.3.2.26 | Adenocarcinoma of Lung |
21750651 |
Regulation of EGFR protein stability by the HECT-type ubiquitin ligase SMURF2. |
causal interaction diagnostic usage ongoing research therapeutic application |
4 3 4 3 |
2.3.2.26 | Adenocarcinoma of Lung |
21967197 |
Ubiquitination of heat shock protein 27 is mediated by its interaction with Smad ubiquitination regulatory factor 2 in A549 cells. |
causal interaction ongoing research unassigned |
1 2 0 |
2.3.2.26 | Adenocarcinoma of Lung |
29271375 |
Upregulation of Neural Precursor Cell Expressed Developmentally Downregulated 4-1 is Associated with Poor Prognosis and Chemoresistance in Lung Adenocarcinoma. |
causal interaction diagnostic usage ongoing research unassigned |
3 1 4 0 |
2.3.2.26 | Adenocarcinoma of Lung |
29455656 |
The E3 ubiquitin ligase NEDD4 mediates cell migration signaling of EGFR in lung cancer cells. |
causal interaction diagnostic usage ongoing research therapeutic application |
4 3 4 4 |
2.3.2.26 | Adenocarcinoma of Lung |
30026863 |
HUWE1 controls the development of non-small cell lung cancer through down-regulation of p53. |
causal interaction diagnostic usage ongoing research therapeutic application |
4 4 4 4 |