EC Number   |
Expression |
Reference |
|---|
   3.4.24.56 | down |
all-trans retinoic acid treatment down-regulates enzyme expression in neuroblastoma cells |
734222 |
| 3.4.24.56 | down |
IDE levels are decreased in type 2 diabetes mellitus. IDE levels are significantly inversely correlated with plasma insulin, fasting blood glucose, triglyceride, total cholesterol, low-density lipoprotein, but not high-density lipoprotein |
707363 |
| 3.4.24.56 | down |
palmitic acid suppresses the expression of IDE and induces Alzheimer's disease |
710227 |
| 3.4.24.56 | down |
reduced neuronal expression of insulin-degrading enzyme in the dorsolateral prefrontal cortex of patients with haloperidol-treated, chronic schizophrenia |
709705 |
| 3.4.24.56 | down |
reduced neuronal expression of insulin-degrading enzyme in the left and right dorsolateral prefrontal cortex, but not in other brain areas investigated, of haloperidol-treated rats |
709705 |
| 3.4.24.56 | down |
tissue necrosis factor-alpha (10 ng/ml) decreases protein expression |
735142 |
| 3.4.24.56 | more |
insulin does not regulate enzyme expression in hepatocytes |
735142 |
| 3.4.24.56 | up |
amyloid beta-induced oxidation of IDE by 4-hydroxy-nonenal does not affect IDE activity in human neuroblastoma SH-SY5Y cells, but rapidly induces IDE expression |
708863 |
| 3.4.24.56 | up |
docosahexaenoic acid induces the expression of IDE in primary hippocampal neurons and prevents Alzheimer's disease |
710227 |
| 3.4.24.56 | up |
enzyme activity and protein level are increased in the liver of diet-induced obese mice. Pioglitazone (10 mg/kg/day) administration for 2 months significantly enhances the enzyme activity (75%), protein (180%) and mRNA expression (100%). Free fatty acid (palmitate, 0.3 mM) induces protein expression, but reduces the mRNA. Glucagon and forskolin (100 ng/ml) also induce protein expression |
735142 |
