Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
118000 | - |
x * 118000, SDS-PAGE | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
insulin + H2O | Mus musculus | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q9JHR7 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hepa-1c1c7 cell | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid beta-peptide + H2O | - |
Mus musculus | ? | - |
? | |
insulin + H2O | - |
Mus musculus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 118000, SDS-PAGE | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
IDE | - |
Mus musculus |
Insulin-degrading enzyme | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | tissue necrosis factor-alpha (10 ng/ml) decreases protein expression | down |
Mus musculus | insulin does not regulate enzyme expression in hepatocytes | additional information |
Mus musculus | enzyme activity and protein level are increased in the liver of diet-induced obese mice. Pioglitazone (10 mg/kg/day) administration for 2 months significantly enhances the enzyme activity (75%), protein (180%) and mRNA expression (100%). Free fatty acid (palmitate, 0.3 mM) induces protein expression, but reduces the mRNA. Glucagon and forskolin (100 ng/ml) also induce protein expression | up |