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Literature summary for 3.4.24.56 extracted from

  • Wei, X.; Ke, B.; Zhao, Z.; Ye, X.; Gao, Z.; Ye, J.
    Regulation of insulin degrading enzyme activity by obesity-associated factors and pioglitazone in liver of diet-induced obese mice (2014), PLoS ONE, 9, e95399.
    View publication on PubMedView publication on EuropePMC

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
118000
-
x * 118000, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
insulin + H2O Mus musculus
-
?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9JHR7
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hepa-1c1c7 cell
-
Mus musculus
-
liver
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid beta-peptide + H2O
-
Mus musculus ?
-
?
insulin + H2O
-
Mus musculus ?
-
?

Subunits

Subunits Comment Organism
? x * 118000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
IDE
-
Mus musculus
Insulin-degrading enzyme
-
Mus musculus

Expression

Organism Comment Expression
Mus musculus tissue necrosis factor-alpha (10 ng/ml) decreases protein expression down
Mus musculus insulin does not regulate enzyme expression in hepatocytes additional information
Mus musculus enzyme activity and protein level are increased in the liver of diet-induced obese mice. Pioglitazone (10 mg/kg/day) administration for 2 months significantly enhances the enzyme activity (75%), protein (180%) and mRNA expression (100%). Free fatty acid (palmitate, 0.3 mM) induces protein expression, but reduces the mRNA. Glucagon and forskolin (100 ng/ml) also induce protein expression up