EC Number   |
Application |
Reference |
|---|
    1.4.3.2 | analysis |
in-gel detection of L-amino acid oxidase activity. L-amino acid concentrations in the range of 2-5 mM lead to activity bands of similar intensities, while higher concentrations results in partial substrate inhibition. Complete supplement mixture containing adenine, uracil, and L-amino acids (Arg, Asp, His, Ile, Leu, Lys, Met, Phe, Thr, Trp, Tyr, Val, each at different concentrations) is optimized at concentrations of 0.1-0.5% in combination with 1 and 2 mM o-phenylendiamine and horseradish peroxidase concentrations of 0.1-0.8 U/ml |
762526 |
| 1.4.3.2 | drug development |
ACTX-6 demonstrates cytotoxicity in vitro and can inhibit tumor growth in vivo. It can markedly increase accumulation of sub-G1 phase, which suggests that this enzyme can induce apoptosis. ACTX-6 is a potential substance to develop into an antitumor drug |
694317 |
| 1.4.3.2 | drug development |
purified LAAO-I exhibits antiprotozoal activities which are demonstrated to be hydrogen-peroxide mediated. Exposure of promastigotes of Leishmania sp. results in dose-dependent parasite killing. LAAOs are interesting multifunctional enzymes, not only for a better understanding of the ophidian envenomation mechanism, but also due to their biotechnological potential as model for therapeutic agents |
690693 |
| 1.4.3.2 | medicine |
a high level of enzyme expression seems associated with absence of bone marrow involvement and better outcome in follicular lymphoma cases, enzyme levels could serve as prognosis factor |
699933 |
| 1.4.3.2 | medicine |
after infection with Cryptocaryon irritans, the LAAO mRNA is upregulated early post infection (from 6 to 24 h) in both gill and spleen, but then returns to normal levels |
763047 |
| 1.4.3.2 | medicine |
antiviral (Dengue virus) and antiprotozoal (trypanocidal and leishmanicide) activities |
690856 |
| 1.4.3.2 | medicine |
apotxin can selectively kill tumor cells, with less cytotoxicity to the normal cells. Its anti-tumor activity is mainly due to the hydrogen peroxide produced from LAAO oxidation, but catalase does not reverse its anti-tumor effect completely. Deglycosylation can significantly reduce the LAAO activity and anti-tumor activity of apotxin |
763323 |
| 1.4.3.2 | medicine |
coadministering adipose-derived mesenchymal stromal cells and Ophiophagus hannah L-amino acid oxidase in a mouse model of methicillin-resistant Staphylococcus aureus-infected wounds results in reduction of MRSA load by one order of magnitude to the approximate range of 6 log10 colony-forming units compared to untreated controls (7.3 log10 CFU). Similar wound healing and improvements in histological parameters are observed between the two groups. Coadministration of adipose-derived mesenchymal stromal cells and L-amino acid oxidase reduces bacterial burden by approximately two orders of magnitude to 5.1 log10 CFU and leads to a significant enhancement in the wound healing process |
763748 |
| 1.4.3.2 | medicine |
enzyme displays dosedependent inhibition on HIV-1 infection and replication |
654441 |
| 1.4.3.2 | medicine |
enzyme displays fibrinogen polymerizing procoagulation and PMSF-associated anticoagulation. The LAAO must be polymerizing fibrinogen independent of endogenous thrombin generation and FXIII crosslinking. The direct deaminating action of LAAO, not the coincident generation of H2O2, is responsible for the coagulation procoagulant profile |
763155 |
