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Literature summary for 1.4.3.2 extracted from

  • Zhang, L.; Wu, W.T.
    Isolation and characterization of ACTX-6: a cytotoxic L-amino acid oxidase from Agkistrodon acutus snake venom (2008), Nat. Prod. Res., 22, 554-563.
    View publication on PubMed

Application

Application Comment Organism
drug development ACTX-6 demonstrates cytotoxicity in vitro and can inhibit tumor growth in vivo. It can markedly increase accumulation of sub-G1 phase, which suggests that this enzyme can induce apoptosis. ACTX-6 is a potential substance to develop into an antitumor drug Deinagkistrodon acutus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
96000
-
gel filtration, mass spectrometry Deinagkistrodon acutus

Organism

Organism UniProt Comment Textmining
Deinagkistrodon acutus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
by gel filtration Deinagkistrodon acutus

Source Tissue

Source Tissue Comment Organism Textmining
venom
-
Deinagkistrodon acutus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-leucine + H2O + O2 one of the best substrates Deinagkistrodon acutus 4-methyl-2-oxopentanoic acid + NH3 + H2O2
-
?
L-methionine + H2O + O2 one of the best substrates Deinagkistrodon acutus 4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
-
?
L-phenylalanine + H2O + O2 one of the best substrates Deinagkistrodon acutus phenylpyruvate + NH3 + H2O2
-
?
L-tryptophan + H2O + O2 one of the best substrates Deinagkistrodon acutus 3-indole-2-oxopropanoate + NH3 + H2O2
-
?

Subunits

Subunits Comment Organism
homodimer SDS-PAGE Deinagkistrodon acutus

Synonyms

Synonyms Comment Organism
ACTX-6
-
Deinagkistrodon acutus
LAAO
-
Deinagkistrodon acutus