EC Number   |
Natural Substrates |
|---|
   3.4.22.B67 | more |
Ulp2 is required for cell division following termination of the DNA damage checkpoint in Sacharomyces cerevisiae. The DNA damage checkpoint is a crucial defense mechanism used by cells to withstand DNA damage. Activation of the checkpoint halts the cell cycle at metaphase and allows time for DNA repair prior to cell division |
| 3.4.22.B67 | more |
Ulp2 SUMO protease is required for proper spindle dynamics during cell cycle resumption following a DNA damage-induced cell cycle arrest. It is proposed that one or more proteins is sumoylated following DNA damage-induced checkpoint activation, and this substrate(s) must be desumoylated by Ulp2 for proper cell cycle resumption |
| 3.4.22.B67 | polySUMO-protein conjugate + H2O |
- |
| 3.4.22.B67 | polySUMO-protein conjugate + H2O |
Ulp2 can cleave the SUMO-SUMO linkage in poly-SUMO chains |
| 3.4.22.B67 | Smt3-modified protein conjugate + H2O |
Ulp2 is able to cleave isopeptide-linked Smt3 molecules from natural substrates. Smt3-protein deconjugation by Ulp2 is important for normal meiotic development |
| 3.4.22.B67 | Smt3-precursor + H2O |
Ulp2 is able to process the Smt3 precursor in vivo, albeit inefficiently relative to Ulp1 |
