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Information on EC 3.4.22.B67 - Ulp2 peptidase

for references in articles please use BRENDA:EC3.4.22.B67
preliminary BRENDA-supplied EC number
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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.B67 Ulp2 peptidase
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Word Map
  • 3.4.22.B67
  • sumoylation
  • checkpoint
  • deconjugation
  • sumo-1
  • sumo-protein
  • helicase
  • sumo-specific
  • hydroxyurea
  • restart
  • nuclear-localization
  • poly-sumo
  • dna-damaging
  • nucleolar
  • ubiquitin-related
  • spindle
  • euploidy
  • polysumoylation
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Ulp2 hydrolyses the SUMO-SUMO linkage in poly-SUMO chains. It catalyzes desumoylation of SUMO-modified-Ndc10 kinetochore protein, SUMO-modified-Bir1 kinetochore protein or SUMO-modified-Cep3 kinetochore protein.
Synonyms
ulp2p, smt3-specific protease, ulp2 sumo protease, sumo de-conjugating/chain-editing enzyme ulp2p, ulp2 sumo isopeptidase, sumo isopeptidase ulp2, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
Ulp2 hydrolyses the SUMO-SUMO linkage in poly-SUMO chains. It catalyzes desumoylation of SUMO-modified-Ndc10 kinetochore protein, SUMO-modified-Bir1 kinetochore protein or SUMO-modified-Cep3 kinetochore protein.
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