Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + (R)-ibuprofen + CoA | Rattus norvegicus | (R)-ibuprofenoyl-CoA synthetase and long-chain acyl-CoA synthetase are identical enzymes that are involved in the metabolism of various xenobiotics | AMP + diphosphate + (R)-ibuprofenoyl-CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
heart | - |
Rattus norvegicus | - |
ileum | - |
Rattus norvegicus | - |
kidney | - |
Rattus norvegicus | - |
liver | high expression | Rattus norvegicus | - |
lung | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.017 | - |
formation of (R)-ibuprofenoyl-CoA | Rattus norvegicus |
0.28 | - |
formation of palmitoyl-CoA | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + (R)-ibuprofen + CoA | 9% of the activity with palmitate | Rattus norvegicus | AMP + diphosphate + (R)-ibuprofenoyl-CoA | - |
? | |
ATP + (R)-ibuprofen + CoA | (R)-ibuprofenoyl-CoA synthetase and long-chain acyl-CoA synthetase are identical enzymes that are involved in the metabolism of various xenobiotics | Rattus norvegicus | AMP + diphosphate + (R)-ibuprofenoyl-CoA | - |
? | |
ATP + arachidonate + CoA | 85% of the activity with palmitate | Rattus norvegicus | AMP + diphosphate + arachidonoyl-CoA | - |
? | |
ATP + hexanoate + CoA | 4% of the activity with palmitate | Rattus norvegicus | AMP + diphosphate + hexanoyl-CoA | - |
? | |
ATP + octanoate + CoA | 20% of the activity with palmitate | Rattus norvegicus | AMP + diphosphate + octanoyl-CoA | - |
? | |
ATP + palmitate + CoA | - |
Rattus norvegicus | AMP + diphosphate + palmitoyl-CoA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LACS | - |
Rattus norvegicus |
R-ibuprofenoyl-CoA synthetase | - |
Rattus norvegicus |