Application | Comment | Organism |
---|---|---|
medicine | the enzyme is a potential target for antibacterial compounds | Escherichia coli |
Cloned (Comment) | Organism |
---|---|
- |
Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
mureidomycin B | IC50: 0.000038 mM | Escherichia coli | |
RU66950 | IC50: 0.07 mM | Escherichia coli | |
RU70157 | IC50: 0.0054 mM | Escherichia coli | |
RU72143 | IC50: 0.0015 mM | Escherichia coli | |
RU72839 | IC50: 0.0003 mM | Escherichia coli | |
RU74709 | IC50: 0.000096 mM | Escherichia coli | |
RU74854 | IC50: 0.000022 mM | Escherichia coli | |
RU75413 | IC50: 0.000033 mM | Escherichia coli | |
RU76491 | IC50: 0.000084 mM | Escherichia coli | |
RU76492 | IC50: 0.0001 mM | Escherichia coli | |
RU77254 | IC50: 0.000027 mM | Escherichia coli | |
RU78695 | IC50: 0.000034 mM | Escherichia coli | |
RU80303 | IC50: 0.0005 mM | Escherichia coli | |
RU88108 | IC50: 0.000051 mM | Escherichia coli | |
RU88110 | IC50: 0.000016 mM | Escherichia coli | |
RU88114 | IC50: 0.000084 mM | Escherichia coli | |
RU88155 | IC50: 0.0015 mM | Escherichia coli | |
tunicamycin | IC50: 0.0019 mM | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate | Escherichia coli | catalyzes the first membrane step in biosynthesis of bacterial cell wall peptidoglycan | UMP + Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
assay for MraY by using UDP-MurNAc-Nepsilon-dansylpentapeptide, a fluorescent derivative of the MraY nucleotide substrate. Two assay versions are developed, one consisting of the high-pressure liquid chromatography separation of the substrate and product and the other, without separation and adapted to the high-throughput format, taking advantage of the different fluorescent properties of the nucleotide and lipid I in the reaction medium | Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate | catalyzes the first membrane step in biosynthesis of bacterial cell wall peptidoglycan | Escherichia coli | UMP + Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MraY | - |
Escherichia coli |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000016 | - |
IC50: 0.000016 mM | Escherichia coli | RU88110 | |
0.000022 | - |
IC50: 0.000022 mM | Escherichia coli | RU74854 | |
0.000027 | - |
IC50: 0.000027 mM | Escherichia coli | RU77254 | |
0.000033 | - |
IC50: 0.000033 mM | Escherichia coli | RU75413 | |
0.000034 | - |
IC50: 0.000034 mM | Escherichia coli | RU78695 | |
0.000038 | - |
IC50: 0.000038 mM | Escherichia coli | mureidomycin B | |
0.000051 | - |
IC50: 0.000051 mM | Escherichia coli | RU88108 | |
0.000084 | - |
IC50: 0.000084 mM | Escherichia coli | RU76491 | |
0.000084 | - |
IC50: 0.000084 mM | Escherichia coli | RU88114 | |
0.000096 | - |
IC50: 0.000096 mM | Escherichia coli | RU74709 | |
0.0001 | - |
IC50: 0.0001 mM | Escherichia coli | RU76492 | |
0.0003 | - |
IC50: 0.0003 mM | Escherichia coli | RU72839 | |
0.0005 | - |
IC50: 0.0005 mM | Escherichia coli | RU80303 | |
0.0015 | - |
IC50: 0.0015 mM | Escherichia coli | RU88155 | |
0.0015 | - |
IC50: 0.0015 mM | Escherichia coli | RU72143 | |
0.0019 | - |
IC50: 0.0019 mM | Escherichia coli | tunicamycin | |
0.0054 | - |
IC50: 0.0054 mM | Escherichia coli | RU70157 | |
0.07 | - |
IC50: 0.07 mM | Escherichia coli | RU66950 |