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dansyl-UDP-NAc-muramoyl-pentapeptide + undecaprenyl phosphate
UMP + dansyl-UDP-NAc-muramoyl-pentapeptide-diphosphoundecaprenol
-
-
-
-
?
N-dansyl-UDP-NAc-muramoyl-L-Ala-gamma-D-Glu-meso-diaminopimelic acid-D-Ala-D-Ala + undecaprenyl phosphate
UMP + ?
N-fluorescamine-UDP-NAc-muramoyl-L-Ala-gamma-D-Glu-meso-diaminopimelic acid-D-Ala-D-Ala + undecaprenyl phosphate
UMP + ?
N-o-phthalaldehyde-UDP-NAc-muramoyl-L-Ala-gamma-D-Glu-meso-diaminopimelic acid-D-Ala-D-Ala + undecaprenyl phosphate
UMP + ?
UDP-Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
UDP-MurNAc + undecaprenyl phosphate
UMP + MurNAc-diphosphoundecaprenol
UDP-MurNAc(oyl-L-Ala-gamma-D-Glu-meso-2,6-diaminopimelyl-(N-dansyl)-D-Ala-D-Ala) + dodecaprenyl phosphate
UMP + MurNAc(oyl-L-Ala-gamma-D-Glu-meso-2,6-diaminopimelyl-(N-dansyl)-D-Ala-D-Ala)-diphosphododecaprenol
UDP-MurNAc-(oyl-L-Ala) + undecaprenyl phosphate
UMP + MurNAc(oyl-L-Ala)-diphosphoundecaprenol
UDP-MurNAc-(oyl-L-Ala-gamma-D-Glu) + undecaprenyl phosphate
UMP + MurNAc(oyl-L-Ala-gamma-D-Glu)-diphosphoundecaprenol
36% activity compared to UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)
-
-
r
UDP-MurNAc-(oyl-L-Ala-gamma-D-Glu-meso-diaminopimelate) + undecaprenyl phosphate
UMP + MurNAc(oyl-L-Ala-gamma-D-Glu-meso-diaminopimelate)-diphosphoundecaprenol
51% activity compared to UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)
-
-
r
UDP-MurNAc-Ala-D-Glu-Lys + undecaprenyl phosphate
UMP + MurNAc-Ala-D-Glu-Lys-diphosphoundecaprenol
UDP-MurNAc-Ala-D-Glu-Lys-D-Ala + undecaprenyl phosphate
UMP + MurNAc-Ala-D-Glu-Lys-D-Ala-diphosphoundecaprenol
UDP-MurNAc-Ala-D-Glu-Lys-D-Ala-Gly + undecaprenyl phosphate
UMP + MurNAc-Ala-D-Glu-Lys-D-Ala-Gly-diphosphoundecaprenol
-
-
-
-
?
UDP-MurNAc-Ala-D-Glu-Lys-Gly-D-Ala + undecaprenyl phosphate
UMP + MurNAc-Ala-D-Glu-Lys-Gly-D-Ala-diphosphoundecaprenol
-
-
-
-
?
UDP-MurNAc-Ala-D-Glu-Orn-D-Ala-D-Ala + undecaprenyl phosphate
UMP + MurNAc-Ala-D-Glu-Orn-D-Ala-D-Ala-diphosphoundecaprenol
-
-
-
-
?
UDP-MurNAc-Ala-Glu-Lys + undecaprenyl phosphate
UMP + MurNAc-Ala-Glu-Lys-diphosphoundecaprenol
-
-
-
-
?
UDP-MurNAc-Gly-D-Glu-Lys-D-Ala-D-Ala + undecaprenyl phosphate
UMP + MurNAc-Gly-D-Glu-Lys-D-Ala-D-Ala-diphosphoundecaprenol
-
-
-
-
?
UDP-MurNAc-L-Ala-gamma-D-Glu-m-DAP-[Nepsilon-dansyl]-D-Ala-D-Ala + undecaprenyl phosphate
UMP + MurNAc-L-Ala-gamma-D-Glu-m-DAP-[Nepsilon-dansyl]-D-Ala-D-Ala-diphosphoundecaprenol
UDP-MurNAc-pentapeptide + C55-isoprenyl phosphate
C55-isoprenyl-diphosphate-MurNAc-pentapeptide
UDP-MurNAc-pentapeptide + undecaprenoid-1-ol-phosphate
lipid-P-P-MurNAc-pentapeptide + UMP
UDP-MurNAc-pentapeptide + undecaprenyl phosphate
UMP + MurNAc-pentapeptide-diphosphoundecaprenol
UDP-MurNAc-pentapeptide + undecaprenyl phosphate
UMP + undecaprenol diphosphate N-acetylmuramyl pentapeptide
-
30 min, 35°C, pH 7.5
-
-
?
UDP-MurNAc-pentapeptide + undecaprenyl-phosphate
UMP + MurNAc-pentapeptide diphosphoryl undecaprenol
UDP-N-acetyl-alpha-D-glucosamine + ditrans,octacis-undecaprenyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
UDP-N-acetylmuramoyl-pentapeptide + undecaprenyl phosphate
?
-
a homogeneous fluorescence resonance energy transfer (FRET)-based assay for the translocase activity of MraY in which the donor fluorophore is attached to UNAM-pp and the acceptor is embedded in detergent micelles containing MraY and undecaprenyl phosphate is described
-
-
?
UDP-N-acetylmuramoyl-pentapeptide + undecaprenyl phosphate
UMP + N-acetylmuramoyl-pentapeptide-diphosphoundecaprenol
25°C, pH 7.2
lipid I synthesis, peptidoglycan biosynthesis
-
?
UDP-N-acetylmuramoyl-pentapeptide + [2H]UMP
UMP + [2H]UDP-NAc-muramoyl-pentapeptide
UDP-NAc-muramoyl-L-Ala-gamma-D-Glu-meso-diaminopimelic acid-D-Ala-D-Ala + undecaprenyl phosphate
UMP + ?
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
UDP-NAc-muramoyl-pentapeptide + dodecaprenyl-phosphate
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
UDP-NAc-muramoyl-pentapeptide + heptaprenyl-phosphate
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + undecaprenyl phosphate
UMP + undecaprenyl-phospho-NAc-muramoyl-pentapeptide
UDPMur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
additional information
?
-
N-dansyl-UDP-NAc-muramoyl-L-Ala-gamma-D-Glu-meso-diaminopimelic acid-D-Ala-D-Ala + undecaprenyl phosphate
UMP + ?
-
-
-
-
?
N-dansyl-UDP-NAc-muramoyl-L-Ala-gamma-D-Glu-meso-diaminopimelic acid-D-Ala-D-Ala + undecaprenyl phosphate
UMP + ?
-
-
-
-
?
N-fluorescamine-UDP-NAc-muramoyl-L-Ala-gamma-D-Glu-meso-diaminopimelic acid-D-Ala-D-Ala + undecaprenyl phosphate
UMP + ?
-
-
-
-
?
N-fluorescamine-UDP-NAc-muramoyl-L-Ala-gamma-D-Glu-meso-diaminopimelic acid-D-Ala-D-Ala + undecaprenyl phosphate
UMP + ?
-
-
-
-
?
N-o-phthalaldehyde-UDP-NAc-muramoyl-L-Ala-gamma-D-Glu-meso-diaminopimelic acid-D-Ala-D-Ala + undecaprenyl phosphate
UMP + ?
-
-
-
-
?
N-o-phthalaldehyde-UDP-NAc-muramoyl-L-Ala-gamma-D-Glu-meso-diaminopimelic acid-D-Ala-D-Ala + undecaprenyl phosphate
UMP + ?
-
-
-
-
?
UDP-Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
-
-
-
r
UDP-Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
catalyzes the first membrane step of bacterial cell wall peptidyglycan synthesis
-
-
r
UDP-Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
-
-
-
r
UDP-Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
catalyzes the first membrane step in biosynthesis of bacterial cell wall peptidoglycan
-
-
?
UDP-Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
catalyzes the first membrane step of bacterial cell wall peptidyglycan synthesis
-
-
r
UDP-Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
catalyzes the first of a sequence of lipid-linked steps that ultimately assemble the peptidoglycan layer of the bacterial cell wall
-
-
?
UDP-Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
-
-
-
r
UDP-Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
catalyzes the first membrane step of bacterial cell wall peptidyglycan synthesis
-
-
r
UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
-
-
?
UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
-
-
r
UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
the forward and reverse exchange reactions require the presence of the second substrate, undecaprenyl phosphate and UMP, respectively. No activity is detected with isopentenyl phosphate, but the enzyme is highly active with neryl phosphate, heptaprenyl phosphate, dodecaprenyl phosphate, and pentadecaprenyl phosphate
-
-
r
UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
-
-
?
UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
-
-
r
UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
the forward and reverse exchange reactions require the presence of the second substrate, undecaprenyl phosphate and UMP, respectively. No activity is detected with isopentenyl phosphate, but the enzyme is highly active with neryl phosphate, heptaprenyl phosphate, dodecaprenyl phosphate, and pentadecaprenyl phosphate
-
-
r
UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
-
-
-
?
UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
-
-
-
?
UDP-MurNAc + undecaprenyl phosphate
UMP + MurNAc-diphosphoundecaprenol
24% activity compared to UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)
-
-
r
UDP-MurNAc + undecaprenyl phosphate
UMP + MurNAc-diphosphoundecaprenol
24% activity compared to UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)
-
-
r
UDP-MurNAc(oyl-L-Ala-gamma-D-Glu-meso-2,6-diaminopimelyl-(N-dansyl)-D-Ala-D-Ala) + dodecaprenyl phosphate
UMP + MurNAc(oyl-L-Ala-gamma-D-Glu-meso-2,6-diaminopimelyl-(N-dansyl)-D-Ala-D-Ala)-diphosphododecaprenol
-
dPP
-
r
UDP-MurNAc(oyl-L-Ala-gamma-D-Glu-meso-2,6-diaminopimelyl-(N-dansyl)-D-Ala-D-Ala) + dodecaprenyl phosphate
UMP + MurNAc(oyl-L-Ala-gamma-D-Glu-meso-2,6-diaminopimelyl-(N-dansyl)-D-Ala-D-Ala)-diphosphododecaprenol
-
dPP
-
r
UDP-MurNAc-(oyl-L-Ala) + undecaprenyl phosphate
UMP + MurNAc(oyl-L-Ala)-diphosphoundecaprenol
9% activity compared to UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)
-
-
r
UDP-MurNAc-(oyl-L-Ala) + undecaprenyl phosphate
UMP + MurNAc(oyl-L-Ala)-diphosphoundecaprenol
9% activity compared to UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)
-
-
r
UDP-MurNAc-Ala-D-Glu-Lys + undecaprenyl phosphate
UMP + MurNAc-Ala-D-Glu-Lys-diphosphoundecaprenol
-
-
-
-
?
UDP-MurNAc-Ala-D-Glu-Lys + undecaprenyl phosphate
UMP + MurNAc-Ala-D-Glu-Lys-diphosphoundecaprenol
-
-
-
-
?
UDP-MurNAc-Ala-D-Glu-Lys-D-Ala + undecaprenyl phosphate
UMP + MurNAc-Ala-D-Glu-Lys-D-Ala-diphosphoundecaprenol
-
-
-
-
?
UDP-MurNAc-Ala-D-Glu-Lys-D-Ala + undecaprenyl phosphate
UMP + MurNAc-Ala-D-Glu-Lys-D-Ala-diphosphoundecaprenol
-
-
-
-
?
UDP-MurNAc-L-Ala-gamma-D-Glu-m-DAP-[Nepsilon-dansyl]-D-Ala-D-Ala + undecaprenyl phosphate
UMP + MurNAc-L-Ala-gamma-D-Glu-m-DAP-[Nepsilon-dansyl]-D-Ala-D-Ala-diphosphoundecaprenol
-
inhibitory assay
-
-
?
UDP-MurNAc-L-Ala-gamma-D-Glu-m-DAP-[Nepsilon-dansyl]-D-Ala-D-Ala + undecaprenyl phosphate
UMP + MurNAc-L-Ala-gamma-D-Glu-m-DAP-[Nepsilon-dansyl]-D-Ala-D-Ala-diphosphoundecaprenol
-
inhibitory assay
-
-
?
UDP-MurNAc-pentapeptide + C55-isoprenyl phosphate
C55-isoprenyl-diphosphate-MurNAc-pentapeptide
-
-
-
r
UDP-MurNAc-pentapeptide + C55-isoprenyl phosphate
C55-isoprenyl-diphosphate-MurNAc-pentapeptide
-
-
-
r
UDP-MurNAc-pentapeptide + undecaprenoid-1-ol-phosphate
lipid-P-P-MurNAc-pentapeptide + UMP
-
-
-
-
r
UDP-MurNAc-pentapeptide + undecaprenoid-1-ol-phosphate
lipid-P-P-MurNAc-pentapeptide + UMP
-
-
-
-
r
UDP-MurNAc-pentapeptide + undecaprenoid-1-ol-phosphate
lipid-P-P-MurNAc-pentapeptide + UMP
-
-
-
-
r
UDP-MurNAc-pentapeptide + undecaprenoid-1-ol-phosphate
lipid-P-P-MurNAc-pentapeptide + UMP
-
UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala + lipid phosphate, specificity profile towards peptide subunit
-
-
r
UDP-MurNAc-pentapeptide + undecaprenoid-1-ol-phosphate
lipid-P-P-MurNAc-pentapeptide + UMP
-
-
-
-
r
UDP-MurNAc-pentapeptide + undecaprenoid-1-ol-phosphate
lipid-P-P-MurNAc-pentapeptide + UMP
-
UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala + lipid phosphate, specificity profile towards peptide subunit
-
-
r
UDP-MurNAc-pentapeptide + undecaprenyl phosphate
UMP + MurNAc-pentapeptide-diphosphoundecaprenol
Lipid I precursor synthesis, murein biosynthesis
-
-
?
UDP-MurNAc-pentapeptide + undecaprenyl phosphate
UMP + MurNAc-pentapeptide-diphosphoundecaprenol
efficient complementation of enzymatic activity in bacterial strain lacking endogenous MraY
-
-
?
UDP-MurNAc-pentapeptide + undecaprenyl phosphate
UMP + MurNAc-pentapeptide-diphosphoundecaprenol
-
Lipid I precursor synthesis, murein biosynthesis
-
-
?
UDP-MurNAc-pentapeptide + undecaprenyl-phosphate
UMP + MurNAc-pentapeptide diphosphoryl undecaprenol
-
-
-
-
r
UDP-MurNAc-pentapeptide + undecaprenyl-phosphate
UMP + MurNAc-pentapeptide diphosphoryl undecaprenol
-
natural acceptor
-
-
r
UDP-N-acetyl-alpha-D-glucosamine + ditrans,octacis-undecaprenyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + ditrans,octacis-undecaprenyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
-
-
-
?
UDP-N-acetylmuramoyl-pentapeptide + [2H]UMP
UMP + [2H]UDP-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-N-acetylmuramoyl-pentapeptide + [2H]UMP
UMP + [2H]UDP-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-N-acetylmuramoyl-pentapeptide + [2H]UMP
UMP + [2H]UDP-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-N-acetylmuramoyl-pentapeptide + [2H]UMP
UMP + [2H]UDP-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-N-acetylmuramoyl-pentapeptide + [2H]UMP
UMP + [2H]UDP-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-N-acetylmuramoyl-pentapeptide + [2H]UMP
UMP + [2H]UDP-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-N-acetylmuramoyl-pentapeptide + [2H]UMP
UMP + [2H]UDP-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-N-acetylmuramoyl-pentapeptide + [2H]UMP
UMP + [2H]UDP-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-N-acetylmuramoyl-pentapeptide + [2H]UMP
UMP + [2H]UDP-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-N-acetylmuramoyl-pentapeptide + [2H]UMP
UMP + [2H]UDP-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-L-Ala-gamma-D-Glu-meso-diaminopimelic acid-D-Ala-D-Ala + undecaprenyl phosphate
UMP + ?
-
-
-
-
?
UDP-NAc-muramoyl-L-Ala-gamma-D-Glu-meso-diaminopimelic acid-D-Ala-D-Ala + undecaprenyl phosphate
UMP + ?
-
-
-
-
?
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
-
?
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
first step in lipid cycle reactions in biosynthesis of bacterial cell wall peptidoglycans
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
biosynthesis of peptidoglycan, first lipid intermediate
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
biosynthesis of peptidoglycan, first lipid intermediate
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
-
?
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
biosynthesis of peptidoglycan, first lipid intermediate
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
first step in lipid cycle reactions in biosynthesis of bacterial cell wall peptidoglycans
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
equilibrium constant 0.25
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
first step in lipid cycle reactions in biosynthesis of bacterial cell wall peptidoglycans
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
initial stage in peptidoglycan synthesis, key role in selecting analogs of UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla, membrane associated reaction of cell wall biosynthesis
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
initial stage in peptidoglycan synthesis, key role in selecting analogs of UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla, membrane associated reaction of cell wall biosynthesis
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
initial stage in peptidoglycan synthesis, key role in selecting analogs of UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla, membrane associated reaction of cell wall biosynthesis
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
biosynthesis of peptidoglycan, first lipid intermediate
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
biosynthesis of peptidoglycan, first lipid intermediate
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
biosynthesis of peptidoglycan, first lipid intermediate
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
equilibrium constant 0.25
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
biosynthesis of peptidoglycan, first lipid intermediate
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
initial stage in peptidoglycan synthesis, key role in selecting analogs of UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla, membrane associated reaction of cell wall biosynthesis
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
biosynthesis of peptidoglycan, first lipid intermediate
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
initial stage in peptidoglycan synthesis, key role in selecting analogs of UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla, membrane associated reaction of cell wall biosynthesis
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
initial stage in peptidoglycan synthesis, key role in selecting analogs of UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla, membrane associated reaction of cell wall biosynthesis
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
first step in lipid cycle reactions in biosynthesis of bacterial cell wall peptidoglycans
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
biosynthesis of peptidoglycan, first lipid intermediate
-
r
UDP-NAc-muramoyl-pentapeptide + dodecaprenyl-phosphate
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
dodecaprenyl phosphate is a more efficient substrate than heptaprenyl-phosphate, enzyme is selective for larger substrate which is closer in chain length to the natural substrate, undecaprenyl-phosphate
-
r
UDP-NAc-muramoyl-pentapeptide + dodecaprenyl-phosphate
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
dodecaprenyl phosphate is a more efficient substrate than heptaprenyl-phosphate, enzyme is selective for larger substrate which is closer in chain length to the natural substrate, undecaprenyl-phosphate
-
r
UDP-NAc-muramoyl-pentapeptide + undecaprenyl phosphate
UMP + undecaprenyl-phospho-NAc-muramoyl-pentapeptide
-
-
-
-
?
UDP-NAc-muramoyl-pentapeptide + undecaprenyl phosphate
UMP + undecaprenyl-phospho-NAc-muramoyl-pentapeptide
-
-
-
-
?
UDPMur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
-
-
-
r
UDPMur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
catalyzes the first membrane step of bacterial cell wall peptidyglycan synthesis
-
-
r
additional information
?
-
all five cytoplasmic segments contribute to catalytic site with at least 14 invariant polar and/or charged, non-clustered residues, conserved residue D98 supposedly involved in deprotonation of lipid substrate during catalysis at physiological pH 7.4 (pKa for undecaprenyl phosphate: 6.6 and 9.2)
-
-
?
additional information
?
-
-
all five cytoplasmic segments contribute to catalytic site with at least 14 invariant polar and/or charged, non-clustered residues, conserved residue D98 supposedly involved in deprotonation of lipid substrate during catalysis at physiological pH 7.4 (pKa for undecaprenyl phosphate: 6.6 and 9.2)
-
-
?
additional information
?
-
functional complementation in a MraY-lacking, thermosensitive Escherichia coli mutant strain (2fold increased UDP-N-acetylmuramoyl-pentapeptide level compared to wild-type cells when grown 30 min at 42°C, depletion of lipid I) by overexpression of wild-type or mutants E299Q, D177N, N168A, H45R, K48Q, H291R
-
-
?
additional information
?
-
-
functional complementation in a MraY-lacking, thermosensitive Escherichia coli mutant strain (2fold increased UDP-N-acetylmuramoyl-pentapeptide level compared to wild-type cells when grown 30 min at 42°C, depletion of lipid I) by overexpression of wild-type or mutants E299Q, D177N, N168A, H45R, K48Q, H291R
-
-
?
additional information
?
-
assay method development for high-throughput screening assays and metadata annotation, overview
-
-
?
additional information
?
-
the enzyme does not display any diphosphatase activity on the nucleotide substrate. No activity with UDP-GlcNAc and 1-diphospho-MurNAc-pentapeptide. Enzyme catalytic mechanism and substrate specificity, overview. The essential aspartate residue, that is invariant in the superfamily, is Asp98 in Bacillus subtilis MraY, the residue is involved in the deprotonation of the lipid substrate during the catalytic process. UDPMurNAc, UDP-MurNAc-L-Ala, UDP-MurNAc-L-Ala-D-Glu and UDPMurNAc-L-Ala-gamma-D-Glu-meso-diaminopimelate precursors of the peptidoglycan biosynthesis pathway are all substrates of the enzyme, no activity with 1-diphospho-MurNAc-pentapeptide. No activity with isopentenyl phosphate as lipid substrate, the enzyme is highly active when tested with neryl phosphate, heptaprenyl phosphate, dodecaprenyl phosphate, and pentadecaprenyl phosphate
-
-
?
additional information
?
-
-
the enzyme does not display any diphosphatase activity on the nucleotide substrate. No activity with UDP-GlcNAc and 1-diphospho-MurNAc-pentapeptide. Enzyme catalytic mechanism and substrate specificity, overview. The essential aspartate residue, that is invariant in the superfamily, is Asp98 in Bacillus subtilis MraY, the residue is involved in the deprotonation of the lipid substrate during the catalytic process. UDPMurNAc, UDP-MurNAc-L-Ala, UDP-MurNAc-L-Ala-D-Glu and UDPMurNAc-L-Ala-gamma-D-Glu-meso-diaminopimelate precursors of the peptidoglycan biosynthesis pathway are all substrates of the enzyme, no activity with 1-diphospho-MurNAc-pentapeptide. No activity with isopentenyl phosphate as lipid substrate, the enzyme is highly active when tested with neryl phosphate, heptaprenyl phosphate, dodecaprenyl phosphate, and pentadecaprenyl phosphate
-
-
?
additional information
?
-
assay method development for high-throughput screening assays and metadata annotation, overview
-
-
?
additional information
?
-
the enzyme does not display any diphosphatase activity on the nucleotide substrate. No activity with UDP-GlcNAc and 1-diphospho-MurNAc-pentapeptide. Enzyme catalytic mechanism and substrate specificity, overview. The essential aspartate residue, that is invariant in the superfamily, is Asp98 in Bacillus subtilis MraY, the residue is involved in the deprotonation of the lipid substrate during the catalytic process. UDPMurNAc, UDP-MurNAc-L-Ala, UDP-MurNAc-L-Ala-D-Glu and UDPMurNAc-L-Ala-gamma-D-Glu-meso-diaminopimelate precursors of the peptidoglycan biosynthesis pathway are all substrates of the enzyme, no activity with 1-diphospho-MurNAc-pentapeptide. No activity with isopentenyl phosphate as lipid substrate, the enzyme is highly active when tested with neryl phosphate, heptaprenyl phosphate, dodecaprenyl phosphate, and pentadecaprenyl phosphate
-
-
?
additional information
?
-
-
UDP-N-acetylmuramyl-L-alanyl-gamma-D-glutamyl-meso-diaminopimelyl-D-alanyl-D-alanine: Parks nucleotide, UDP-MurNAc-pentapeptide
-
-
?
additional information
?
-
-
catalyzes an exchange reaction between UMP and UDP-MurNAc-pentapeptide in the absence of undecaprenyl phosphate
-
-
?
additional information
?
-
-
catalyzes an exchange reaction between UMP and UDP-MurNAc-pentapeptide in the absence of undecaprenyl phosphate
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
UDP-Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
UDP-MurNAc-pentapeptide + undecaprenyl phosphate
UMP + MurNAc-pentapeptide-diphosphoundecaprenol
UDP-MurNAc-pentapeptide + undecaprenyl-phosphate
UMP + MurNAc-pentapeptide diphosphoryl undecaprenol
UDP-N-acetyl-alpha-D-glucosamine + ditrans,octacis-undecaprenyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
UDPMur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
catalyzes the first membrane step of bacterial cell wall peptidyglycan synthesis
-
-
r
UDP-Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
catalyzes the first membrane step of bacterial cell wall peptidyglycan synthesis
-
-
r
UDP-Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
catalyzes the first membrane step in biosynthesis of bacterial cell wall peptidoglycan
-
-
?
UDP-Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
catalyzes the first membrane step of bacterial cell wall peptidyglycan synthesis
-
-
r
UDP-Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
catalyzes the first of a sequence of lipid-linked steps that ultimately assemble the peptidoglycan layer of the bacterial cell wall
-
-
?
UDP-Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
catalyzes the first membrane step of bacterial cell wall peptidyglycan synthesis
-
-
r
UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
-
-
r
UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
-
-
r
UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
-
-
-
?
UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
-
-
-
?
UDP-MurNAc-pentapeptide + undecaprenyl phosphate
UMP + MurNAc-pentapeptide-diphosphoundecaprenol
Lipid I precursor synthesis, murein biosynthesis
-
-
?
UDP-MurNAc-pentapeptide + undecaprenyl phosphate
UMP + MurNAc-pentapeptide-diphosphoundecaprenol
-
Lipid I precursor synthesis, murein biosynthesis
-
-
?
UDP-MurNAc-pentapeptide + undecaprenyl-phosphate
UMP + MurNAc-pentapeptide diphosphoryl undecaprenol
-
-
-
-
r
UDP-MurNAc-pentapeptide + undecaprenyl-phosphate
UMP + MurNAc-pentapeptide diphosphoryl undecaprenol
-
natural acceptor
-
-
r
UDP-N-acetyl-alpha-D-glucosamine + ditrans,octacis-undecaprenyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + ditrans,octacis-undecaprenyl phosphate
UMP + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol
-
-
-
?
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
first step in lipid cycle reactions in biosynthesis of bacterial cell wall peptidoglycans
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
biosynthesis of peptidoglycan, first lipid intermediate
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
biosynthesis of peptidoglycan, first lipid intermediate
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
biosynthesis of peptidoglycan, first lipid intermediate
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
first step in lipid cycle reactions in biosynthesis of bacterial cell wall peptidoglycans
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
-
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
first step in lipid cycle reactions in biosynthesis of bacterial cell wall peptidoglycans
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
initial stage in peptidoglycan synthesis, key role in selecting analogs of UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla, membrane associated reaction of cell wall biosynthesis
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
initial stage in peptidoglycan synthesis, key role in selecting analogs of UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla, membrane associated reaction of cell wall biosynthesis
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
initial stage in peptidoglycan synthesis, key role in selecting analogs of UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla, membrane associated reaction of cell wall biosynthesis
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
biosynthesis of peptidoglycan, first lipid intermediate
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
biosynthesis of peptidoglycan, first lipid intermediate
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
biosynthesis of peptidoglycan, first lipid intermediate
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
biosynthesis of peptidoglycan, first lipid intermediate
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
initial stage in peptidoglycan synthesis, key role in selecting analogs of UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla, membrane associated reaction of cell wall biosynthesis
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
biosynthesis of peptidoglycan, first lipid intermediate
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
initial stage in peptidoglycan synthesis, key role in selecting analogs of UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla, membrane associated reaction of cell wall biosynthesis
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
initial stage in peptidoglycan synthesis, key role in selecting analogs of UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla, membrane associated reaction of cell wall biosynthesis
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
first step in lipid cycle reactions in biosynthesis of bacterial cell wall peptidoglycans
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
biosynthesis of peptidoglycan, first lipid intermediate
-
r
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Struve, W.G.; Sinha, R.K.; Neuhaus, F.C.
On the initial stage in peptidoglycan synthesis. Phospho-N-acetylmuramyl-pentapeptide translocase (uridine monophosphate)
Biochemistry
5
82-93
1966
Staphylococcus aureus, Staphylococcus aureus Copenhagen
brenda
Heydanek, M.G.; Neuhaus, F.C.
The initial stage in peptidoglycan synthesis. IV. Solubilization of phospho-N-acetylmuramyl-pentapeptide translocase
Biochemistry
8
1474-1481
1969
Staphylococcus aureus, Staphylococcus aureus Copenhagen
brenda
Umbreit, J.N.; Strominger, J.L.
Complex lipid requirements for detergent-solubilized phosphoacetylmuramyl-pentapeptide translocase from Micrococcus luteus
Proc. Natl. Acad. Sci. USA
69
1972-1974
1972
Micrococcus luteus
brenda
Pless, D.D.; Neuhaus, F.C.
Initial membrane reaction in peptidoglycan synthesis. Lipid dependence of phospho-n-acetylmuramyl-pentapeptide translocase (exchange reaction)
J. Biol. Chem.
248
1568-1576
1973
Staphylococcus aureus, Staphylococcus aureus Copenhagen
brenda
Hammes, W.P.; Neuhaus, F.C.
On the specificity of phospho-N-acetylmuramyl-pentapeptide translocase. The peptide subunit of uridine diphosphate-N-actylmuramyl-pentapeptide
J. Biol. Chem.
249
3140-3150
1974
Staphylococcus aureus, Staphylococcus aureus Copenhagen
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Geis, A.; Plapp, R.
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