Application | Comment | Organism |
---|---|---|
medicine | target for antimicrobial therapeutic intervention, novel antibiotic chemotypes must be developed to deter the alarming rate of antibiotic resistance growth | Escherichia coli |
Cloned (Comment) | Organism |
---|---|
mraY gene cloned into pASK-IBA3 vector and overexpressed | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | MraY natural product inhibitors are not broad in spectrum nor practical for general antibiotic use | Escherichia coli | |
mureidomycin A | inhibitor isolated from Streptomyces flavidovirens WD31235, also antibacterial activity against Pseudomonas aeruginosa A27853 | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-MurNAc-pentapeptide + undecaprenyl-phosphate | Escherichia coli | - |
UMP + MurNAc-pentapeptide diphosphoryl undecaprenol | - |
r | |
UDP-NAc-muramoyl-pentapeptide + acceptor | Escherichia coli | - |
UMP + acceptor-phospho-NAc-muramoyl-pentapeptide | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-MurNAc-pentapeptide + undecaprenoid-1-ol-phosphate | - |
Escherichia coli | lipid-P-P-MurNAc-pentapeptide + UMP | - |
r | |
UDP-MurNAc-pentapeptide + undecaprenyl-phosphate | - |
Escherichia coli | UMP + MurNAc-pentapeptide diphosphoryl undecaprenol | - |
r | |
UDP-NAc-muramoyl-pentapeptide + acceptor | - |
Escherichia coli | UMP + acceptor-phospho-NAc-muramoyl-pentapeptide | - |
r |
Synonyms | Comment | Organism |
---|---|---|
MraY protein | - |
Escherichia coli |