Inhibitors | Comment | Organism | Structure |
---|---|---|---|
EDTA | - |
Saccharomyces cerevisiae |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.31 | - |
ADP | pH 5.9, 37°C | Saccharomyces cerevisiae | |
5.7 | - |
ATP | pH 5.9, 37°C | Saccharomyces cerevisiae |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | as good as Mn2+ | Saccharomyces cerevisiae | |
Co2+ | slight activation of P1,P4-bis(5'-adenosyl) tetraphosphate-synthesis | Saccharomyces cerevisiae | |
Mg2+ | less effective than Mn2+ or Ca2+ | Saccharomyces cerevisiae | |
Mg2+ | activation, P1,P4-bis(5'-adenosyl) tetraphosphate-synthesis | Saccharomyces cerevisiae | |
Mn2+ | requirement, Ap4A-synthesis | Saccharomyces cerevisiae | |
additional information | no activation by Ni2+ | Saccharomyces cerevisiae | |
additional information | Cu2+ | Saccharomyces cerevisiae | |
Zn2+ | slight activation of P1,P4-bis(5'-adenosyl) tetraphosphate-synthesis | Saccharomyces cerevisiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate | Saccharomyces cerevisiae | involved in catabolism of dinucleoside polyphosphates | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADP + ATP | - |
Saccharomyces cerevisiae | P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate | - |
r | |
NTP + N'DP | asymmetric catalytic site: synthesis of Ap4G or Ap4C is much faster from ATP plus CDP or GDP than from CTP or GTP plus ADP | Saccharomyces cerevisiae | P1,P4-bis(5'-nucleosyl) tetraphosphate' + phosphate | N is A or G, N' is A, C, G, U or dA | ? | |
NTP + N'DP | N is A or G, not C, U or dA, and N' is A, C, G, U or dA | Saccharomyces cerevisiae | P1,P4-bis(5'-nucleosyl) tetraphosphate' + phosphate | N is A or G, N' is A, C, G, U or dA | ? | |
P1(5'-adenosyl)-P4(5'-cytosyl) tetraphosphate + phosphate | - |
Saccharomyces cerevisiae | CDP + ATP | not CTP + ADP | ? | |
P1(5'-adenosyl)-P4(5'-guanosyl) tetraphosphate + phosphate | - |
Saccharomyces cerevisiae | GDP + ATP | - |
r | |
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate | - |
Saccharomyces cerevisiae | ADP + ATP | - |
? | |
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate | involved in catabolism of dinucleoside polyphosphates | Saccharomyces cerevisiae | ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Saccharomyces cerevisiae |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.9 | - |
P1,P4-bis(5'-adenosyl) tetraphosphate-synthesis | Saccharomyces cerevisiae |
8 | - |
P1,P4-bis(5'-adenosyl) tetraphosphate-phosphorolysis | Saccharomyces cerevisiae |