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Literature summary for 2.7.4.24 extracted from

  • Safrany, S.T.
    Protocols for regulation and study of diphosphoinositol polyphosphates (2004), Mol. Pharmacol., 66, 1585-1591.
    View publication on PubMed
Search for more literature for 2.7.4.24

Activating Compound

Activating Compound Comment Organism Structure
monoperoxo(picolinato)oxovanadate(V) 15fold activation Mesocricetus auratus
sorbitol rapid activation in vivo Mesocricetus auratus
sucrose rapid activation in vivo Mesocricetus auratus

Inhibitors

Inhibitors Comment Organism Structure
chlorpromazine inhibition in vivo Mesocricetus auratus
genistein rapid inhibition in vivo Mesocricetus auratus
additional information no in vivo inhibition by wortmannin, SB203580, i.e. 4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole, PD98059, i.e. 2'-amino-3'-methoxyflavone, rapamycin, dephostatin, okadaic acid, herbimycin, K-252a, i.e. methyl-(9S,12R)-epoxy-1H-diinodolo[1,2,3-fg:3',2',1'-kI]pyrrolo[3,4-i][1,6]benzodiazocine-2,3,9,10,11,12-hexahydro-(10R)-hydroxy-9-methyl-1-oxo-10-carboxylate, and KN-93, i.e. 2-[N-(4-chlorocinnamoyl)-N-methylbenzylamine] Mesocricetus auratus
N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide i.e. W-7, rapid inhibition in vivo Mesocricetus auratus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 5-diphospho-1D-myo-inositol pentakisphosphate Mesocricetus auratus bis(diphospho)-1D-myo-inositol tetrakisphosphate specifically impedes protein trafficking, no regulation by extracellular signal-regulated kinase or phopholipase D ADP + bis(diphospho)-1D-myo-inositol tetrakisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mesocricetus auratus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
cell culture
-
 Mesocricetus auratus
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DDT1-MF-2 cell smooth muscle cell line Mesocricetus auratus
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smooth muscle
-
 Mesocricetus auratus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 5-diphospho-1D-myo-inositol pentakisphosphate
-
 Mesocricetus auratus ADP + bis(diphospho)-1D-myo-inositol tetrakisphosphate
-
 ?
ATP + 5-diphospho-1D-myo-inositol pentakisphosphate bis(diphospho)-1D-myo-inositol tetrakisphosphate specifically impedes protein trafficking, no regulation by extracellular signal-regulated kinase or phopholipase D Mesocricetus auratus ADP + bis(diphospho)-1D-myo-inositol tetrakisphosphate
-
 ?

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mesocricetus auratus