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Literature summary for 2.7.4.14 extracted from

  • Zhang, X.; Zhang, K.; Zhang, Y.
    Pigment epithelium-derived factor facilitates NLRP3 inflammasome activation through downregulating cytidine monophosphate kinase 2 A potential treatment strategy for missed abortion (2020), Int. J. Mol. Med., 45, 1436-1446 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine lipopolysaccharide-induced human chorionic trophoblast HTR8/SVneo cell model to mimic missed abortion in vitro. CMPK2 expression and NLRP3 inflammasome activation, downstream pro-IL-18 and pro-IL-1beta expression, and IL-18 and IL-1beta release, are all significantly increased in missed abortion tissues or LPS-induced HTR8/SVneo cells. Pigment epithelium-derived factor reverses the increase in CMPK2 expression and activation of the NLRP3 inflammasome axis and downregulates the production of mitochondrial reactive oxygen species and mitochondrial DNA release Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q5EBM0
-
-

Source Tissue

Source Tissue Comment Organism Textmining
chorion
-
 Homo sapiens
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decidua
-
 Homo sapiens
-

Expression

Organism Comment Expression
Homo sapiens CMPK2 expression and NLRP3 inflammasome activation, downstream pro-IL-18 and pro-IL-1beta expression, and IL-18 and IL-1beta release, are all significantly increased in missed abortion tissues or LPS-induced HTR8/SVneo cells. Pigment epithelium-derived factor reverses the increase in CMPK2 expression up