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Literature summary for 2.6.1.99 extracted from

  • Zheng, Z.; Guo, Y.; Novak, O.; Dai, X.; Zhao, Y.; Ljung, K.; Noel, J.; Chory, J.
    Coordination of auxin and ethylene biosynthesis by the aminotransferase VAS1 (2013), Nat. Chem. Biol., 9, 244-246.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.6.1.99

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Arabidopsis thaliana 5737
-

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q9C969
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-isoleucine + indole-3-pyruvic acid 1% of the activity with L-methionine Arabidopsis thaliana 3-methyl-2-oxopentanoate + L-tryptophan
-
 ?
L-leucine + indole-3-pyruvic acid 1% of the activity with L-methionine Arabidopsis thaliana 2-oxo-4-methylpentanoate + L-tryptophan
-
 ?
L-methionine + indole-3-pyruvic acid most catalytically preferred amino donor. No reverse VAS1 activity detected Arabidopsis thaliana 2-oxo-4-methylthiobutanoate + L-tryptophan
-
 ir
L-phenylalanine + indole-3-pyruvic acid 21% of the activity with L-methionine Arabidopsis thaliana phenylpyruvate + L-tryptophan
-
 ?
L-tyrosine + indole-3-pyruvic acid 1% of the activity with L-methionine Arabidopsis thaliana 3-(4-hydroxyphenyl)-2-oxopropanoate + L-tryptophan
-
 ?
L-valine + indole-3-pyruvic acid 1% of the activity with L-methionine Arabidopsis thaliana 3-methyl-2-oxobutanoate + L-tryptophan
-
 ?

Synonyms

Synonyms Comment Organism
At1g80360
-
 Arabidopsis thaliana
F5I6.11
-
 Arabidopsis thaliana
Vas1
-
 Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
physiological function in a loss-of-function mutant, levels of the phytohormone auxin and the ethylene precursor 1-aminocyclopropane-1-carboxylate are simultaneously increased. VAS1 overexpression reduces plant stature and seed set, and these plants accumulate less auxin than wild-type under shade. VAS1 serves key roles in coordinating the levels of these two vital hormones. VAS1 and tryptophan aminotransferases Sav3 catalyze opposing reactions with respect to 3-IPA formation. In response to shade, Vas1/Sav3 double mutant plants have longer hypocotyls and petioles than sav3 single mutants. When grown in continuous white light, Vas1 or Vas1/Sav3 mutant seedlings display elongated hypocotyls and petioles, with increased leaf hyponasty, decreased leaf area Arabidopsis thaliana