Crystallization (Comment) | Organism |
---|---|
vapor diffusion in sitting drops. In order to examine the actual binding interactions between the new PNP-BPs and hFPPS, co-crystal structures with the key inhibitors YS05035, JDS05119, and JDS05120 are determined | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
JDS05119 | - |
Homo sapiens | |
JDS05120 | - |
Homo sapiens | |
risedronate | - |
Homo sapiens | |
YS04070 | - |
Homo sapiens | |
YS05035 | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
geranyl diphosphate + isopentenyl diphosphate | Homo sapiens | - |
diphosphate + (2E,6E)-farnesyl diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P14324 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
geranyl diphosphate + isopentenyl diphosphate | - |
Homo sapiens | diphosphate + (2E,6E)-farnesyl diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
farnesyl pyrophosphate synthase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme is a key regulator of the mevalonate pathway | Homo sapiens |