KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.008 | - |
dimethylallyl diphosphate | pH 7.2, 20°C | Haematococcus lacustris | |
0.012 | - |
geranyl diphosphate | pH 7.2, 20°C | Haematococcus lacustris | |
0.019 | - |
(2E,6E)-farnesyl diphosphate | pH 7.2, 20°C | Haematococcus lacustris | |
0.039 | - |
isopentenyl diphosphate | pH 7.2, 20°C | Haematococcus lacustris |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate | Haematococcus lacustris | reaction of EC 2.5.1.29, the enzyme catalyze the sequential head-to-tail addition of three C5 molecules of isopentenyl diphosphate to dimethylallyl diphosphate with the concomitant release of pyrophosphate. Under environmental stresses, Haematococcus pluvialis accumulates large amounts of carotenoids. Scale of carotenoid biosynthesis depends on availability of geranylgeranyl pyrophosphate precursor, which is supplied by GGPP synthase through sequential 1'-4 condensation of three isopentenyl pyrophosphates into dimethylallyl pyrophosphate | diphosphate + geranylgeranyl diphosphate | - |
? | |
dimethylallyl diphosphate + isopentenyl diphosphate | Haematococcus lacustris | the enzyme catalyze the sequential head-to-tail addition of three C5 molecules of isopentenyl diphosphate to dimethylallyl diphosphate with the concomitant release of pyrophosphate. Under environmental stresses, Haematococcus pluvialis accumulates large amounts of carotenoids. Scale of carotenoid biosynthesis depends on availability of geranylgeranyl pyrophosphate precursor, which is supplied by GGPP synthase through sequential 1'-4 condensation of three isopentenyl pyrophosphates into dimethylallyl pyrophosphate | diphosphate + geranyl diphosphate | - |
? | |
geranyl diphosphate + isopentenyl diphosphate | Haematococcus lacustris | the enzyme catalyze the sequential head-to-tail addition of three C5 molecules of isopentenyl diphosphate to dimethylallyl diphosphate with the concomitant release of pyrophosphate. Under environmental stresses, Haematococcus pluvialis accumulates large amounts of carotenoids. Scale of carotenoid biosynthesis depends on availability of geranylgeranyl pyrophosphate precursor, which is supplied by GGPP synthase through sequential 1'-4 condensation of three isopentenyl pyrophosphates into dimethylallyl pyrophosphate | diphosphate + (2E,6E)-farnesyl diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Haematococcus lacustris | A0A0K0TQ44 | i..e. Haematococcus pluvialis | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate | reaction of EC 2.5.1.29, the enzyme catalyze the sequential head-to-tail addition of three C5 molecules of isopentenyl diphosphate to dimethylallyl diphosphate with the concomitant release of pyrophosphate. Under environmental stresses, Haematococcus pluvialis accumulates large amounts of carotenoids. Scale of carotenoid biosynthesis depends on availability of geranylgeranyl pyrophosphate precursor, which is supplied by GGPP synthase through sequential 1'-4 condensation of three isopentenyl pyrophosphates into dimethylallyl pyrophosphate | Haematococcus lacustris | diphosphate + geranylgeranyl diphosphate | - |
? | |
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate | reaction of EC 2.5.1.29, the enzyme catalyze the sequential head-to-tail addition of three C5 molecules of isopentenyl diphosphate to dimethylallyl diphosphate with the concomitant release of pyrophosphate | Haematococcus lacustris | diphosphate + geranylgeranyl diphosphate | - |
? | |
dimethylallyl diphosphate + isopentenyl diphosphate | the enzyme catalyze the sequential head-to-tail addition of three C5 molecules of isopentenyl diphosphate to dimethylallyl diphosphate with the concomitant release of pyrophosphate. Under environmental stresses, Haematococcus pluvialis accumulates large amounts of carotenoids. Scale of carotenoid biosynthesis depends on availability of geranylgeranyl pyrophosphate precursor, which is supplied by GGPP synthase through sequential 1'-4 condensation of three isopentenyl pyrophosphates into dimethylallyl pyrophosphate | Haematococcus lacustris | diphosphate + geranyl diphosphate | - |
? | |
dimethylallyl diphosphate + isopentenyl diphosphate | reaction of EC 2.5.1.1, the enzyme catalyze the sequential head-to-tail addition of three C5 molecules of isopentenyl diphosphate to dimethylallyl diphosphate with the concomitant release of pyrophosphate | Haematococcus lacustris | diphosphate + geranyl diphosphate | - |
? | |
geranyl diphosphate + isopentenyl diphosphate | the enzyme catalyze the sequential head-to-tail addition of three C5 molecules of isopentenyl diphosphate to dimethylallyl diphosphate with the concomitant release of pyrophosphate. Under environmental stresses, Haematococcus pluvialis accumulates large amounts of carotenoids. Scale of carotenoid biosynthesis depends on availability of geranylgeranyl pyrophosphate precursor, which is supplied by GGPP synthase through sequential 1'-4 condensation of three isopentenyl pyrophosphates into dimethylallyl pyrophosphate | Haematococcus lacustris | diphosphate + (2E,6E)-farnesyl diphosphate | - |
? | |
geranyl diphosphate + isopentenyl diphosphate | the enzyme catalyze the sequential head-to-tail addition of three C5 molecules of isopentenyl diphosphate to dimethylallyl diphosphate with the concomitant release of pyrophosphate | Haematococcus lacustris | diphosphate + (2E,6E)-farnesyl diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HpGGPPS | - |
Haematococcus lacustris |
General Information | Comment | Organism |
---|---|---|
metabolism | under environmental stresses, Haematococcus pluvialis accumulates large amounts of carotenoids. Scale of carotenoid biosynthesis depends on availability of geranylgeranyl pyrophosphate precursor, which is supplied by geranylgeranyl pyrophosphate synthase through sequential 1'-4 condensation of three isopentenyl pyrophosphates into dimethylallyl pyrophosphate. Transcription of geranylgeranyl pyrophosphate synthase genes, morphological transformation, and carotenoid biosynthesis are differentially induced by environmental stresses, while the products of the enzyme are low in vivo, implying that most of prenyl pyrophosphate flux is shunted into carotenoid biosynthesis | Haematococcus lacustris |
physiological function | under environmental stresses, Haematococcus pluvialis accumulates large amounts of carotenoids. Scale of carotenoid biosynthesis depends on availability of geranylgeranyl pyrophosphate precursor, which is supplied by geranylgeranyl pyrophosphate synthase through sequential 1'-4 condensation of three isopentenyl pyrophosphates into dimethylallyl pyrophosphate. Transcription of geranylgeranyl pyrophosphate synthase genes, morphological transformation, and carotenoid biosynthesis are differentially induced by environmental stresses, while the products of the enzyme are low in vivo, implying that most of prenyl pyrophosphate flux is shunted into carotenoid biosynthesis | Haematococcus lacustris |