Cloned (Comment) | Organism |
---|---|
the enzyme with an N-terminal His6 tag is transformed into Escherichia coli BL21 (DE3) cells | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
vapour diffusion in a sitting drop at 22°C. Crystalized in the presence of farnesyl diphosphate, and its X-ray structure is determined at 1.9 A resolution | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
farnesyl diphosphate | allosteric product inhibition. the product can trap the enzyme in an unreactive state by binding to its allosteric pocket | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
dimethylallyl diphosphate + isopentenyl diphosphate | Homo sapiens | reaction of EC 2.5.1.1, the enzyme catalyses the sequential condensation of dimethylallyl diphosphate with isopentenyl diphosphate (IPP) and the resulting geranyl diphosphate (GPP) with another unit of IPP, eventually producing the 15-carbon isoprenoid farnesyl diphosphate | diphosphate + geranyl diphosphate | - |
? | |
geranyl diphosphate + isopentenyl diphosphate | Homo sapiens | the enzyme catalyses the sequential condensation of dimethylallyl diphosphate with isopentenyl diphosphate (IPP) and the resulting geranyl diphosphate (GPP) with another unit of IPP, eventually producing the 15-carbon isoprenoid farnesyl diphosphate | diphosphate + (2E,6E)-farnesyl diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P14324 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dimethylallyl diphosphate + isopentenyl diphosphate | reaction of EC 2.5.1.1, the enzyme catalyses the sequential condensation of dimethylallyl diphosphate with isopentenyl diphosphate (IPP) and the resulting geranyl diphosphate (GPP) with another unit of IPP, eventually producing the 15-carbon isoprenoid farnesyl diphosphate | Homo sapiens | diphosphate + geranyl diphosphate | - |
? | |
geranyl diphosphate + isopentenyl diphosphate | the enzyme catalyses the sequential condensation of dimethylallyl diphosphate with isopentenyl diphosphate (IPP) and the resulting geranyl diphosphate (GPP) with another unit of IPP, eventually producing the 15-carbon isoprenoid farnesyl diphosphate | Homo sapiens | diphosphate + (2E,6E)-farnesyl diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FPPS | - |
Homo sapiens |