Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.2.28 extracted from

  • Kadariya, Y.; Yin, B.; Tang, B.; Shinton, S.A.; Quinlivan, E.P.; Hua, X.; Klein-Szanto, A.; Al-Saleem, T.I.; Bassing, C.H.; Hardy, R.R.; Kruger, W.D.
    Mice heterozygous for germ-line mutations in methylthioadenosine phosphorylase (MTAP) die prematurely of T-cell lymphoma (2009), Cancer Res., 69, 5961-5969.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.2.28

Cloned(Commentary)

Cloned (Comment) Organism
RRK081 embryonic stem cells, containing a gene-trap vector inserted between exon 3 and exon 4 of the mouse Mtap locus (MtaplacZ) injected into mouse blastocysts derived from C57BL/6 animals, embryos implanted in pseudopregnant females Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
 Mus musculus
-
lymphoma cell
-
 Mus musculus
-
additional information RRK081 cells, heterozygous for the MtaplacZ allele Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5'-methylthioadenosine + phosphate
-
 Mus musculus adenine + 5-methylthio-D-ribose 1-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
methylthioadenosine phosphorylase
-
 Mus musculus
MTAP
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus lymphoma-infiltrated tissues tend to have reduced levels of Mtap mRNA and MTAP protein in addition to unaltered levels of methyldeoxycytidine. Loss of MTAP expression is independent from loss of CDKN2A expression down

General Information

General Information Comment Organism
malfunction mice homozygous for a MTAP null allele (MtaplacZ) have an embryonic lethal phenotype dying around day 8 postconception. Mtap/MtaplacZ heterozygotes are born at Mendelian frequencies and appear indistinguishable from wild-type mice during the first year of life, but tend to die prematurely with a median survival of 585 days. These animals have greatly enlarged spleens, altered thymic histology, and lymphocytic infiltration of their livers, consistent with lymphoma Mus musculus
physiological function Mtap is essential during embryogenesis. Mtap is a tumor suppressor gene independent of CDKN2A and ARF Mus musculus