Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.1.65 extracted from

  • Wang, H.; Morales-Levy, M.; Rose, J.; Mackey, L.C.; Bodary, P.; Eitzman, D.; Homeister, J.W.
    alpha(1,3)-Fucosyltransferases FUT4 and FUT7 control murine susceptibility to thrombosis (2013), Am. J. Pathol., 182, 2082-2093.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.65

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
alpha(1,3/4)-FUT
-
 Mus musculus
alpha-1,3-fucosyltransferase
-
 Mus musculus
FUT4 isoform Mus musculus
FUT7 isoform Mus musculus

General Information

General Information Comment Organism
malfunction mice lacking both isoforms FUT4 and FUT7 have a shorter time to occlusive thrombus formation in the injured carotid artery and a higher mortality due to collagen/epinephrine-induced pulmonary thromboemboli. FUT4-, but not FUT7, -deficient mice have increased pulmonary thromboembolism-induced mortality and decreased thromboemboli dissolution in vivo Mus musculus
metabolism isoforms FUT4 and FUT7 are required for the synthesis of functional selectin-type leukocyte adhesion molecule ligands Mus musculus
physiological function isoform FUT4 and FUT7 activity regulates thrombosis in a P-selectine and P-selectin glycoprotein ligand-1-independent manner. Isoform FUT4 activity is important for thrombolysis Mus musculus