Crystallization (Comment) | Organism |
---|---|
structure of AAC(6')-Ig in complex with tobramycin reveals a large substrate-binding cleft remaining partially unoccupied by the substrate | Acinetobacter haemolyticus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0029 | - |
tobramicin | S 0.5 value, Hill coefficient 2.12, pH 8.0, 37°C | Acinetobacter baumannii | |
0.0059 | - |
arbekacin | S 0.5 value, Hill coefficient 2.5, pH 8.0, 37°C | Acinetobacter baumannii | |
0.0062 | - |
ribostamycin | S 0.5 value, Hill coefficient 1.92, pH 8.0, 37°C | Acinetobacter baumannii | |
0.0074 | - |
neomycin C | S 0.5 value, Hill coefficient 1.43, pH 8.0, 37°C | Acinetobacter haemolyticus | |
0.0079 | - |
neomycin C | S 0.5 value, Hill coefficient 2.05, pH 8.0, 37°C | Acinetobacter baumannii | |
0.0087 | - |
gentamicin | S 0.5 value, Hill coefficient 1.84, pH 8.0, 37°C | Acinetobacter baumannii | |
0.0098 | - |
dibekacin | S 0.5 value, Hill coefficient 1.42, pH 8.0, 37°C | Acinetobacter baumannii | |
0.0105 | - |
sisomicin | S 0.5 value, Hill coefficient 1.93, pH 8.0, 37°C | Acinetobacter baumannii | |
0.0118 | - |
ribostamycin | S 0.5 value, Hill coefficient 1.96, pH 8.0, 37°C | Acinetobacter haemolyticus | |
0.012 | - |
kanamycin B | S 0.5 value, Hill coefficient 2.30, pH 8.0, 37°C | Acinetobacter baumannii | |
0.0139 | - |
arbekacin | S 0.5 value, Hill coefficient 2.19, pH 8.0, 37°C | Acinetobacter haemolyticus | |
0.0168 | - |
sisomicin | S 0.5 value, Hill coefficient 2.04, pH 8.0, 37°C | Acinetobacter haemolyticus | |
0.0173 | - |
butirosin A | S 0.5 value, Hill coefficient 1.77, pH 8.0, 37°C | Acinetobacter haemolyticus | |
0.0176 | - |
gentamicin | S 0.5 value, Hill coefficient 2.05, pH 8.0, 37°C | Acinetobacter haemolyticus | |
0.0183 | - |
2'-N-ethylnetilmicin | S 0.5 value, Hill coefficient 2.28, pH 8.0, 37°C | Acinetobacter haemolyticus | |
0.0216 | - |
butirosin A | S 0.5 value, Hill coefficient 2.03, pH 8.0, 37°C | Acinetobacter baumannii | |
0.022 | - |
tobramicin | S 0.5 value, Hill coefficient 1.21, pH 8.0, 37°C | Acinetobacter haemolyticus | |
0.0259 | - |
dibekacin | S 0.5 value, Hill coefficient 1.26, pH 8.0, 37°C | Acinetobacter haemolyticus | |
0.029 | - |
kanamycin B | S 0.5 value, Hill coefficient 1.93, pH 8.0, 37°C | Acinetobacter haemolyticus | |
0.0441 | - |
amikacin | S 0.5 value, Hill coefficient 1.55, pH 8.0, 37°C | Acinetobacter haemolyticus | |
0.049 | - |
2'-N-ethyl netilmicin | S 0.5 value, Hill coefficient 1.39, pH 8.0, 37°C | Acinetobacter baumannii | |
0.0996 | - |
amikacin | S 0.5 value, Hill coefficient 1.26, pH 8.0, 37°C | Acinetobacter baumannii | |
0.104 | - |
isepamicin | S 0.5 value, Hill coefficient 1.45, pH 8.0, 37°C | Acinetobacter haemolyticus | |
0.111 | - |
isepamicin | S 0.5 value, Hill coefficient 1.48, pH 8.0, 37°C | Acinetobacter baumannii |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Acinetobacter baumannii | Q43899 | - |
- |
Acinetobacter haemolyticus | Q44057 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + 2'-N-ethyl netilmicin | - |
Acinetobacter baumannii | CoA + N6'-acetyl-2'-N-ethylnetilmicin | - |
? | |
acetyl-CoA + 2'-N-ethylnetilmicin | - |
Acinetobacter haemolyticus | CoA + N6'-acetyl-2'-N-ethylnetilmicin | - |
? | |
acetyl-CoA + amikacin | - |
Acinetobacter haemolyticus | CoA + 6'-N-acetylamikacin | - |
? | |
acetyl-CoA + amikacin | - |
Acinetobacter baumannii | CoA + 6'-N-acetylamikacin | - |
? | |
acetyl-CoA + arbekacin | - |
Acinetobacter haemolyticus | CoA + N6'-acetylarbekacin | - |
? | |
acetyl-CoA + arbekacin | - |
Acinetobacter baumannii | CoA + N6'-acetylarbekacin | - |
? | |
acetyl-CoA + butirosin A | - |
Acinetobacter haemolyticus | CoA + 6'-N-acetyl-butirosin A | - |
? | |
acetyl-CoA + butirosin A | - |
Acinetobacter baumannii | CoA + 6'-N-acetyl-butirosin A | - |
? | |
acetyl-CoA + dibekacin | - |
Acinetobacter haemolyticus | CoA + 6'-N-acetyldibekacin | - |
? | |
acetyl-CoA + dibekacin | - |
Acinetobacter baumannii | CoA + 6'-N-acetyldibekacin | - |
? | |
acetyl-CoA + gentamicin | - |
Acinetobacter haemolyticus | CoA + 6'-N-acetylgentamicin | - |
? | |
acetyl-CoA + gentamicin | - |
Acinetobacter baumannii | CoA + 6'-N-acetylgentamicin | - |
? | |
acetyl-CoA + isepamicin | - |
Acinetobacter haemolyticus | CoA + 6'-N-acetylisepamicin | - |
? | |
acetyl-CoA + isepamicin | - |
Acinetobacter baumannii | CoA + 6'-N-acetylisepamicin | - |
? | |
acetyl-CoA + kanamycin B | - |
Acinetobacter haemolyticus | CoA + N6'-acetylkanamycin B | - |
? | |
acetyl-CoA + kanamycin B | - |
Acinetobacter baumannii | CoA + N6'-acetylkanamycin B | - |
? | |
acetyl-CoA + neomycin C | - |
Acinetobacter haemolyticus | CoA + 6'-N-acetylneomycin C | - |
? | |
acetyl-CoA + neomycin C | - |
Acinetobacter baumannii | CoA + 6'-N-acetylneomycin C | - |
? | |
acetyl-CoA + ribostamycin | - |
Acinetobacter haemolyticus | CoA + 6'-N-acetylribostamycin | - |
? | |
acetyl-CoA + ribostamycin | - |
Acinetobacter baumannii | CoA + 6'-N-acetylribostamycin | - |
? | |
acetyl-CoA + sisomicin | - |
Acinetobacter haemolyticus | CoA + 6'-N-acetylsisomicin | - |
? | |
acetyl-CoA + sisomicin | - |
Acinetobacter baumannii | CoA + 6'-N-acetylsisomicin | - |
? | |
acetyl-CoA + tobramicin | - |
Acinetobacter haemolyticus | CoA + 6'-N-acetyltobramicin | - |
? | |
acetyl-CoA + tobramicin | - |
Acinetobacter baumannii | CoA + 6'-N-acetyltobramicin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AAC(6')-Ig | - |
Acinetobacter haemolyticus |
AAC(6')-Ih | - |
Acinetobacter baumannii |
aminoglycoside N(6')-acetyltransferase type 1 | - |
Acinetobacter haemolyticus |
aminoglycoside N(6')-acetyltransferase type 1 | - |
Acinetobacter baumannii |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.016 | - |
gentamicin | pH 8.0, 37°C | Acinetobacter baumannii | |
0.021 | - |
arbekacin | pH 8.0, 37°C | Acinetobacter baumannii | |
0.022 | - |
tobramicin | pH 8.0, 37°C | Acinetobacter baumannii | |
0.04 | - |
ribostamycin | pH 8.0, 37°C | Acinetobacter baumannii | |
0.04 | - |
dibekacin | pH 8.0, 37°C | Acinetobacter baumannii | |
0.051 | - |
sisomicin | pH 8.0, 37°C | Acinetobacter baumannii | |
0.055 | - |
gentamicin | pH 8.0, 37°C | Acinetobacter haemolyticus | |
0.057 | - |
neomycin C | pH 8.0, 37°C | Acinetobacter haemolyticus | |
0.06 | - |
kanamycin B | pH 8.0, 37°C | Acinetobacter baumannii | |
0.06 | - |
neomycin C | pH 8.0, 37°C | Acinetobacter baumannii | |
0.072 | - |
ribostamycin | pH 8.0, 37°C | Acinetobacter haemolyticus | |
0.077 | - |
arbekacin | pH 8.0, 37°C | Acinetobacter haemolyticus | |
0.085 | - |
tobramicin | pH 8.0, 37°C | Acinetobacter haemolyticus | |
0.097 | - |
2'-N-ethylnetilmicin | pH 8.0, 37°C | Acinetobacter haemolyticus | |
0.098 | - |
2'-N-ethyl netilmicin | pH 8.0, 37°C | Acinetobacter baumannii | |
0.107 | - |
butirosin A | pH 8.0, 37°C | Acinetobacter haemolyticus | |
0.113 | - |
butirosin A | pH 8.0, 37°C | Acinetobacter baumannii | |
0.127 | - |
dibekacin | pH 8.0, 37°C | Acinetobacter haemolyticus | |
0.13 | - |
sisomicin | pH 8.0, 37°C | Acinetobacter haemolyticus | |
0.181 | - |
kanamycin B | pH 8.0, 37°C | Acinetobacter haemolyticus | |
0.328 | - |
amikacin | pH 8.0, 37°C | Acinetobacter haemolyticus | |
0.496 | - |
amikacin | pH 8.0, 37°C | Acinetobacter baumannii | |
0.62 | - |
isepamicin | pH 8.0, 37°C | Acinetobacter baumannii | |
0.779 | - |
isepamicin | pH 8.0, 37°C | Acinetobacter haemolyticus |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.84 | - |
gentamicin | kcat/S 0.5 value, Hill coefficient 1.84, pH 8.0, 37°C | Acinetobacter baumannii | |
2 | - |
2'-N-ethyl netilmicin | kcat/S 0.5 value, Hill coefficient 1.39, pH 8.0, 37°C | Acinetobacter baumannii | |
3.13 | - |
gentamicin | kcat/S 0.5 valuevalue, Hill coefficient 2.05, pH 8.0, 37°C | Acinetobacter haemolyticus | |
3.56 | - |
arbekacin | kcat/S 0.5 value, Hill coefficient 2.5, pH 8.0, 37°C | Acinetobacter baumannii | |
3.86 | - |
tobramicin | kcat/S 0.5 valuevalue, Hill coefficient 1.21, pH 8.0, 37°C | Acinetobacter haemolyticus | |
4.08 | - |
dibekacin | kcat/S 0.5 value, Hill coefficient 1.42, pH 8.0, 37°C | Acinetobacter baumannii | |
4.86 | - |
sisomicin | kcat/S 0.5 value, Hill coefficient 1.93, pH 8.0, 37°C | Acinetobacter baumannii | |
4.9 | - |
dibekacin | kcat/S 0.5 valuevalue, Hill coefficient 1.26, pH 8.0, 37°C | Acinetobacter haemolyticus | |
4.98 | - |
amikacin | kcat/S 0.5 value, Hill coefficient 1.26, pH 8.0, 37°C | Acinetobacter baumannii | |
5 | - |
kanamycin B | kcat/S 0.5 value, Hill coefficient 2.30, pH 8.0, 37°C | Acinetobacter baumannii | |
5.23 | - |
butirosin A | kcat/S 0.5 value, Hill coefficient 2.03, pH 8.0, 37°C | Acinetobacter baumannii | |
5.3 | - |
2'-N-ethylnetilmicin | kcat/S 0.5 valuevalue, Hill coefficient 2.28, pH 8.0, 37°C | Acinetobacter haemolyticus | |
5.54 | - |
arbekacin | kcat/S 0.5 valuevalue, Hill coefficient 2.19, pH 8.0, 37°C | Acinetobacter haemolyticus | |
5.59 | - |
isepamicin | kcat/S 0.5 value, Hill coefficient 1.48, pH 8.0, 37°C | Acinetobacter baumannii | |
6.1 | - |
ribostamycin | kcat/S 0.5 value, Hill coefficient 1.96, pH 8.0, 37°C | Acinetobacter haemolyticus | |
6.18 | - |
butirosin A | kcat/S 0.5 valuevalue, Hill coefficient 1.77, pH 8.0, 37°C | Acinetobacter haemolyticus | |
6.24 | - |
kanamycin B | kcat/S 0.5 valuevalue, Hill coefficient 1.93, pH 8.0, 37°C | Acinetobacter haemolyticus | |
7.1 | - |
ribostamycin | kcat/S 0.5 value, Hill coefficient 1.92, pH 8.0, 37°C | Acinetobacter baumannii | |
7.44 | - |
amikacin | kcat/S 0.5 value, Hill coefficient 1.55, pH 8.0, 37°C | Acinetobacter haemolyticus | |
7.49 | - |
isepamicin | kcat/S 0.5 valuevalue, Hill coefficient 1.45, pH 8.0, 37°C | Acinetobacter haemolyticus | |
7.59 | - |
neomycin C | kcat/S 0.5 value, Hill coefficient 2.05, pH 8.0, 37°C | Acinetobacter baumannii | |
7.59 | - |
tobramicin | kcat/S 0.5 value, Hill coefficient 2.12, pH 8.0, 37°C | Acinetobacter baumannii | |
7.7 | - |
neomycin C | kcat/S 0.5 value, Hill coefficient 1.43, pH 8.0, 37°C | Acinetobacter haemolyticus | |
7.74 | - |
sisomicin | kcat/S 0.5 valuevalue, Hill coefficient 2.04, pH 8.0, 37°C | Acinetobacter haemolyticus |