Cloned (Comment) | Organism |
---|---|
gene nat3, DNA and amino acid sequence determination and analysis, functional expression of genes nat1, nat2, and nat3 in Escherichia coli strain JM105 | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0058 | - |
4-aminobiphenyl | recombinant isozyme Nat1 | Rattus norvegicus | |
0.018 | - |
4-aminobiphenyl | recombinant isozyme Nat3 | Rattus norvegicus | |
0.033 | - |
2-Aminofluorene | recombinant isozyme Nat3 | Rattus norvegicus | |
0.037 | - |
2-Aminofluorene | recombinant isozyme Nat1 | Rattus norvegicus | |
0.058 | - |
N-Hydroxy-4-aminobiphenyl | recombinant isozyme Nat1 | Rattus norvegicus | |
0.062 | - |
N-Hydroxy-4-aminobiphenyl | recombinant isozyme Nat3 | Rattus norvegicus | |
0.568 | - |
2-Aminofluorene | recombinant isozyme Nat2 | Rattus norvegicus | |
1.57 | - |
4-aminobiphenyl | recombinant isozyme Nat2 | Rattus norvegicus | |
3.3 | - |
N-Hydroxy-4-aminobiphenyl | recombinant isozyme Nat2 | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
33500 | - |
x * 33500, recombinant isozyme Nat3, SDS-PAGE | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + an arylamine | Rattus norvegicus | - |
CoA + an N-acetylarylamine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | Q80SX3 | isozyme Nat3; inbred strains F344, WKY, and SPRD, isozymes Nat1, Nat2, and Nat3 | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
substrate specificities of isozymes Nat1-Nat3 | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + 2-aminofluorene | - |
Rattus norvegicus | CoA + 2-acetylaminofluorene | - |
? | |
acetyl-CoA + 3,5-dimethylaniline | - |
Rattus norvegicus | CoA + N-acetyl-3,5-dimethylaniline | - |
? | |
acetyl-CoA + 3-ethylaniline | - |
Rattus norvegicus | CoA + N-acetyl-3-ethylaniline | - |
? | |
acetyl-CoA + 4,4'-methylenebis(2-chloroaniline) | - |
Rattus norvegicus | CoA + N-acetyl-4,4'-methylenebis(2-chloroaniline) | - |
? | |
acetyl-CoA + 4,4'-methylenedianiline | - |
Rattus norvegicus | CoA + N-acetyl-4,4'-methylenedianiline | - |
? | |
acetyl-CoA + 4-aminobiphenyl | - |
Rattus norvegicus | CoA + 4-acetylaminobiphenyl | - |
? | |
acetyl-CoA + 5-aminosalicylic acid | - |
Rattus norvegicus | CoA + 5-acetylaminosalicylic acid | - |
? | |
acetyl-CoA + an arylamine | - |
Rattus norvegicus | CoA + an N-acetylarylamine | - |
? | |
acetyl-CoA + N-hydroxy-4-aminobiphenyl | O-acetylation activity | Rattus norvegicus | N-hydroxy-O-acetyl-4-aminobiphenyl + CoA | - |
? | |
additional information | substrate specificities of isozymes Nat1-Nat3, overview | Rattus norvegicus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 33500, recombinant isozyme Nat3, SDS-PAGE | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
NAT | - |
Rattus norvegicus |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
50 | - |
recombinant isozyme Nat1 is completely stable for 120 min, recombinant isozyme Nat3 loses most activity within 80 min, recombinant isozyme Nat2 is almost inactivated within 5 min | Rattus norvegicus |