Cloned (Comment) | Organism |
---|---|
expression analysis in subcellular fractions of melanocytes, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-methionine-(R)-S-oxide + thioredoxin | Homo sapiens | MsrB is involved in regulation of protein function and in elimination of reactive oxygen species via reversible methionine formation besides protein repair in human skin | L-methionine + thioredoxin disulfide + H2O | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
several splicing variants resulting in three isozymes MsrB1-3 | - |
Purification (Comment) | Organism |
---|---|
partially by subcellular fractionation | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epidermis | - |
Homo sapiens | - |
melanocyte | epidermal | Homo sapiens | - |
additional information | expression analysis of MsrB isozymes | Homo sapiens | - |
skin | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-methionine-(R)-S-oxide + thioredoxin | MsrB is involved in regulation of protein function and in elimination of reactive oxygen species via reversible methionine formation besides protein repair in human skin | Homo sapiens | L-methionine + thioredoxin disulfide + H2O | - |
r | |
L-methionine-(R)-S-oxide + thioredoxin | stereospecific reduction, MsrB accepts free and protein-bound substrates | Homo sapiens | L-methionine + thioredoxin disulfide + H2O | - |
r |
Synonyms | Comment | Organism |
---|---|---|
methionine sulfoxide reductase B | - |
Homo sapiens |
MsrB | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
thioredoxin | - |
Homo sapiens |