KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.13 | - |
(S)-3-hydroxyisobutyrate | at pH 9.5 and 22°C | Candida albicans | |
0.58 | - |
(R)-3-hydroxyisobutyrate | at pH 9.5 and 22°C | Candida albicans | |
5.37 | - |
3-hydroxypropanoate | at pH 9.5 and 22°C | Candida albicans | |
46.7 | - |
L-serine | at pH 9.5 and 22°C | Candida albicans |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Candida albicans | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
39200 | - |
x * 39200, calculated from amino acid sequence | Candida albicans |
40000 | - |
x * 40000, SDS-PAGE | Candida albicans |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-hydroxypropanoate + NAD+ | Candida albicans | preferred substrate | 3-oxopropanoate + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Candida albicans | A0A1D8PQ07 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(R)-3-hydroxyisobutyrate + NAD+ | - |
Candida albicans | 3-oxoisobutyrate + NADH + H+ | - |
? | |
(S)-3-hydroxyisobutyrate + NAD+ | - |
Candida albicans | 3-oxoisobutyrate + NADH + H+ | - |
? | |
3-hydroxypropanoate + NAD+ | preferred substrate | Candida albicans | 3-oxopropanoate + NADH + H+ | - |
? | |
L-serine + NAD+ | - |
Candida albicans | 3-oxo-L-alanine + NADH + H+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 40000, SDS-PAGE | Candida albicans |
? | x * 39200, calculated from amino acid sequence | Candida albicans |
Synonyms | Comment | Organism |
---|---|---|
Hpd1p | - |
Candida albicans |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.31 | - |
(R)-3-hydroxyisobutyrate | at pH 9.5 and 22°C | Candida albicans | |
2.48 | - |
(S)-3-hydroxyisobutyrate | at pH 9.5 and 22°C | Candida albicans | |
9.41 | - |
L-serine | at pH 9.5 and 22°C | Candida albicans | |
30.97 | - |
3-hydroxypropanoate | at pH 9.5 and 22°C | Candida albicans |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
9.5 | - |
- |
Candida albicans |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Candida albicans |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.202 | - |
L-serine | at pH 9.5 and 22°C | Candida albicans | |
2.26 | - |
(R)-3-hydroxyisobutyrate | at pH 9.5 and 22°C | Candida albicans | |
5.77 | - |
3-hydroxypropanoate | at pH 9.5 and 22°C | Candida albicans | |
19.1 | - |
(S)-3-hydroxyisobutyrate | at pH 9.5 and 22°C | Candida albicans |