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ATP + 2,5-anhydro-D-glucitol
?
ATP + 2,5-anhydro-D-lyxitol
?
ATP + 2,5-anhydro-D-mannitol
?
ATP + 2,5-anhydro-D-mannose
?
ATP + 5-keto-D-fructose
?
-
-
-
-
?
ATP + D-fructose
ADP + D-fructose 1-phosphate
ATP + D-psicose
?
-
-
-
-
r
ATP + D-ribono-gamma-lactone
?
-
-
-
-
r
ATP + D-ribulose
?
-
-
-
-
?
ATP + D-sedoheptulose
?
-
-
-
-
r
ATP + D-xylose
ADP + D-xylose 1-phosphate
ATP + L-galactoheptulose
?
-
-
-
-
r
ATP + L-ribulose
?
-
-
-
-
r
ATP + mannoheptulose
?
-
-
-
-
r
GTP + D-fructose
?
-
-
-
-
?
additional information
?
-
ATP + 2,5-anhydro-D-glucitol
?
-
-
-
-
?
ATP + 2,5-anhydro-D-glucitol
?
-
-
-
-
r
ATP + 2,5-anhydro-D-glucitol
?
-
-
-
-
?
ATP + 2,5-anhydro-D-lyxitol
?
-
-
-
-
?
ATP + 2,5-anhydro-D-lyxitol
?
-
-
-
-
r
ATP + 2,5-anhydro-D-mannitol
?
-
-
-
-
?
ATP + 2,5-anhydro-D-mannitol
?
-
-
-
-
r
ATP + 2,5-anhydro-D-mannitol
?
-
-
-
-
?
ATP + 2,5-anhydro-D-mannose
?
-
-
-
-
?
ATP + 2,5-anhydro-D-mannose
?
-
-
-
-
r
ATP + 2,5-anhydro-D-mannose
?
-
-
-
-
?
ATP + D-fructose
ADP + D-fructose 1-phosphate
-
-
-
?
ATP + D-fructose
ADP + D-fructose 1-phosphate
-
-
-
-
?
ATP + D-fructose
ADP + D-fructose 1-phosphate
-
-
-
?
ATP + D-fructose
ADP + D-fructose 1-phosphate
-
-
-
-
r
ATP + D-fructose
ADP + D-fructose 1-phosphate
-
specific for beta-furanose anomer
-
-
?
ATP + D-fructose
ADP + D-fructose 1-phosphate
-
D-fructose metabolism
-
?
ATP + D-fructose
ADP + D-fructose 1-phosphate
-
-
-
-
?
ATP + D-fructose
ADP + D-fructose 1-phosphate
-
except for ATP, other nucleotides such as UTP, CTP, GTP, or ITP can not act as phosphoryl donors
-
-
?
ATP + D-fructose
ADP + D-fructose 1-phosphate
-
-
-
-
?
ATP + D-fructose
ADP + D-fructose 1-phosphate
-
except for ATP, other nucleotides such as UTP, CTP, GTP, or ITP can not act as phosphoryl donors
-
-
?
ATP + D-fructose
ADP + D-fructose 1-phosphate
-
-
-
-
?
ATP + D-fructose
ADP + D-fructose 1-phosphate
-
fructose enters glycolytic metabolism after phosphorylation by ketohexokinase and is converted to fructose-1-phosphate. Fructose-driven glycolytic respiration in Heterocephalus glaber tissues avoids feedback inhibition of glycolysis via phosphofructokinase, allowing continued glycolytic flux independent of cellular energy status and supporting viability
-
-
?
ATP + D-fructose
ADP + D-fructose 1-phosphate
-
-
-
-
?
ATP + D-fructose
ADP + D-fructose 1-phosphate
-
-
-
-
r
ATP + D-fructose
ADP + D-fructose 1-phosphate
-
-
-
?
ATP + D-fructose
ADP + D-fructose 1-phosphate
-
-
-
-
?
ATP + D-fructose
ADP + D-fructose 1-phosphate
-
role in formation of glycoaldehyde
-
-
?
ATP + D-fructose
ADP + D-fructose 1-phosphate
-
-
-
?
ATP + D-fructose
ADP + D-fructose 1-phosphate
-
-
-
-
?
ATP + D-fructose
ADP + D-fructose 1-phosphate
-
-
-
-
ir
ATP + D-fructose
ADP + D-fructose 1-phosphate
-
-
-
?
ATP + D-fructose
ADP + D-fructose 1-phosphate
-
conversion of fructose to glucose in liver homogenates involves the intermediary formation of D-fructose 1-phosphate
-
?
ATP + D-fructose
ADP + D-fructose 1-phosphate
-
-
-
-
?
ATP + D-fructose
ADP + D-fructose 1-phosphate
-
-
-
-
?
ATP + D-ribose
?
-
-
-
-
r
ATP + D-ribose
?
-
-
-
-
?
ATP + D-sorbose
?
-
-
-
-
?
ATP + D-sorbose
?
-
-
-
-
?
ATP + D-tagatose
?
-
-
-
-
?
ATP + D-tagatose
?
-
-
-
-
r
ATP + D-xylose
ADP + D-xylose 1-phosphate
-
-
-
-
?
ATP + D-xylose
ADP + D-xylose 1-phosphate
-
-
-
-
?
ATP + D-xylulose
?
-
-
-
-
r
ATP + D-xylulose
?
-
-
-
-
?
ATP + L-sorbose
?
-
-
-
-
r
ATP + L-sorbose
?
-
specific for alpha anomer
-
-
?
ATP + L-sorbose
?
-
-
-
-
?
additional information
?
-
-
not: UTP
-
-
?
additional information
?
-
-
not: ITP
-
-
?
additional information
?
-
-
the minimum molecule for substrate activity seems to be (2R)-2-hydroxymethyl-3,4-dihydroxytetrahydrofuran
-
-
?
additional information
?
-
-
not: 2,6-anhydro-D-glucitol
-
-
?
additional information
?
-
-
specificity of fructokinase is for a tetrahydrofuran ring with beta-D-(or alpha-L-)configuration at position 2, L-configuration at position 3 and either D- or L-configuration at position 4 and 5
-
-
?
additional information
?
-
-
not: 2,6-anhydro-D-mannitol
-
-
?
additional information
?
-
-
not: 5-thio-D-fructose
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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1-deoxy-D-fructose
-
dead-end inhibitor
2,5-anhydro-D-glucitol
-
-
2,5-anhydro-D-lyxitol
-
-
2,5-anhydro-D-mannitol
-
-
2,5-anhydro-D-mannose
-
-
2,5-Anhydro-D-xylitol
-
-
2-(4-aminopiperidin-1-yl)-N8-(cyclopropylmethyl)-N4-(2-methylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
2-ethyl-7-(3-hydroxy-3-methylpyrrolidin-1-yl)-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile
-
2-[(3R)-3-aminopiperidin-1-yl]-N8-(cyclopropylmethyl)-N4-[2-(methylsulfanyl)phenyl]pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
2-[(3S)-3-aminopiperidin-1-yl]-N8-(cyclopropylmethyl)-N4-[2-(methylsulfanyl)phenyl]pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
2-[3-(aminomethyl)azetidin-1-yl]-N8-(cyclopropylmethyl)-N4-[2-(methylsulfanyl)phenyl]pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
2-[4-(aminomethyl)piperidin-1-yl]-N8-(cyclopropylmethyl)-N4-(2-methylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
2-[4-(aminomethyl)piperidin-1-yl]-N8-(cyclopropylmethyl)-N4-[2-(methylsulfanyl)phenyl]pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
3-(trifluoromethyl)quinoxalin-2(1H)-one
-
4,6-dimethyl-2-(morpholin-4-yl)pyridine-3-carbonitrile
-
4-chloromercuribenzoate
-
-
5-Thio-D-fructose
-
competitive to D-fructose
6-[(3S,4S)-3,4-dihydroxypyrrolidin-1-yl]-2-[(3S)-3-hydroxy-3-methylpyrrolidin-1-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile
6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-[(3S)-3-hydroxy-3-methylpyrrolidin-1-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile
-
6-[4-(2-hydroxyethyl)piperazin-1-yl]-4-[3-(hydroxymethyl)piperidin-1-yl]-2-(trifluoromethyl)pyridine-3-carbonitrile
-
7-[(3R)-3-hydroxy-3-methylpyrrolidin-1-yl]-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile
-
7-[(3S)-3-hydroxy-3-methylpyrrolidin-1-yl]-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile
alpha-/gamma-mangostin
-
-
CrADP
-
dead-end inhibitor
CrATP
-
dead-end inhibitor
D-Fructose 1-phosphate
-
competitive against D-fructose, noncompetitive to MgATP2-
D-ribono-gamma-lactone
-
-
methoxy-isobavachalcone
-
-
MgADP-
-
competitive to MgATP2-
N,N'-dicyclopropyl-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
N4-(2-bromophenyl)-N8-cyclopropyl-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
N4-(2-chlorophenyl)-N8-cyclopropyl-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
N4-(2-methylphenyl)-2-(piperazin-1-yl)-N8-(1,3-thiazol-2-ylmethyl)pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
N4-(2-methylphenyl)-2-(piperazin-1-yl)-N8-(prop-2-yn-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
N4-(2-methylphenyl)-2-(piperazin-1-yl)-N8-(tetrahydrothiophen-2-ylmethyl)pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
N4-(2-methylphenyl)-2-(piperazin-1-yl)-N8-propylpyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
N4-cyclohexyl-N8-cyclopropyl-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
N4-[2-(methylsulfanyl)phenyl]-2-(piperazin-1-yl)-N8-(1,3-thiazol-2-ylmethyl)pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
N4-[2-(methylsulfanyl)phenyl]-2-(piperazin-1-yl)-N8-(pyridin-2-ylmethyl)pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
N4-[2-(methylsulfanyl)phenyl]-2-(piperazin-1-yl)-N8-(thiophen-2-ylmethyl)pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
N4-[2-(methylsulfanyl)phenyl]-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
N8-(2-cyclopropylethyl)-N4-[2-(methylsulfanyl)phenyl]-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
N8-(2-methoxyethyl)-N4-[2-(methylsulfanyl)phenyl]-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
N8-(cyclobutylmethyl)-N4-[2-(methylsulfanyl)phenyl]-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
N8-(cyclopropylmethyl)-2-(1,4-diazepan-1-yl)-N4-(2-methylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
N8-(cyclopropylmethyl)-2-(4-iminopiperidin-1-yl)-N4-(2-methylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
N8-(cyclopropylmethyl)-2-(4-methylpiperazin-1-yl)-N4-[2-(methylsulfanyl)phenyl]pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
N8-(cyclopropylmethyl)-2-[4-[(dimethylamino)methyl]piperidin-1-yl]-N4-[2-(methylsulfanyl)phenyl]pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
N8-(cyclopropylmethyl)-N2-methyl-N2-[2-(methylamino)ethyl]-N4-[2-(methylsulfanyl)phenyl]pyrimido[5,4-d]pyrimidine-2,4,8-triamine
-
-
N8-(cyclopropylmethyl)-N4-(2-methylphenyl)-2-(4-methylpiperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
N8-(cyclopropylmethyl)-N4-(2-methylphenyl)-2-(morpholin-4-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
N8-benzyl-N4-(2-methylphenyl)-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
N8-cyclohexyl-N4-(2-methylphenyl)-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
N8-cyclopropyl-2-(piperazin-1-yl)-N4-[2-(propan-2-yl)phenyl]pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
N8-cyclopropyl-2-(piperazin-1-yl)-N4-[2-[(trifluoromethyl)sulfanyl]phenyl]pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
N8-cyclopropyl-N4-(2-cyclopropylphenyl)-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
N8-cyclopropyl-N4-(2-ethoxyphenyl)-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
N8-cyclopropyl-N4-(2-ethylphenyl)-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
N8-cyclopropyl-N4-(2-fluorophenyl)-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
N8-cyclopropyl-N4-(2-methoxyphenyl)-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
N8-cyclopropyl-N4-(2-methylphenyl)-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
N8-cyclopropyl-N4-(3-methylphenyl)-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
N8-cyclopropyl-N4-phenyl-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
N8-cyclopropyl-N4-[2-(ethylsulfanyl)phenyl]-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
N8-cyclopropyl-N4-[2-(methylsulfanyl)phenyl]-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
N8-cyclopropyl-N4-[2-(methylsulfonyl)phenyl]-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
N8-cyclopropyl-N4-[3-(methylsulfanyl)phenyl]-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
N8-cyclopropyl-N4-[4-(methylsulfanyl)phenyl]-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
N8-ethyl-N4-(2-methylphenyl)-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
N8-hexyl-N4-(2-methylphenyl)-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
N8-methyl-N4-(2-methylphenyl)-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
-
-
phloretin
-
Malus domestica extract, IC50 value 8.99.2 microg/mL
[(3R)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl]methanol
-
6-[(3S,4S)-3,4-dihydroxypyrrolidin-1-yl]-2-[(3S)-3-hydroxy-3-methylpyrrolidin-1-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile
nonbasic moderately potent and highly selective ketohexokinase inhibitor
6-[(3S,4S)-3,4-dihydroxypyrrolidin-1-yl]-2-[(3S)-3-hydroxy-3-methylpyrrolidin-1-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile
nonbasic moderately potent and highly selective ketohexokinase inhibitor with favorable ADME and safety profiles and good exposure in rats
7-[(3S)-3-hydroxy-3-methylpyrrolidin-1-yl]-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile
-
7-[(3S)-3-hydroxy-3-methylpyrrolidin-1-yl]-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile
-
ADP
-
strong, noncompetitive
additional information
-
extracts of Angelica archangelica, Garcinia mangostana, Petroselinum crispum, and Scutellaria baicalensis exhibit ketohexokinase inhibitory activity and block fructose-induced ATP depletion and fructose-induced elevation in triglyerides and uric acid
-
additional information
-
not: glucose
-
additional information
-
the phosphorylation of D-fructose by ketohexokinase is resistant to inhibition by D-mannoheptulose
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Carcinogenesis
Prognostic Impact of Metabolism Reprogramming Markers Acetyl-CoA Synthetase 2 Phosphorylation and Ketohexokinase-A Expression in Non-Small-Cell Lung Carcinoma.
Carcinoma
KHK-A promotes the proliferation of oesophageal squamous cell carcinoma through the up-regulation of PRPS1.
Carcinoma
The expression of ketohexokinase is diminished in human clear cell type of renal cell carcinoma.
Carcinoma, Hepatocellular
A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation.
Carcinoma, Renal Cell
The expression of ketohexokinase is diminished in human clear cell type of renal cell carcinoma.
Cardiomegaly
HIF-driven SF3B1 induces KHK-C to enforce fructolysis and heart disease.
Diabetes Mellitus
Endogenous fructose is correlated with urinary albumin creatinine ratios and uric acid in type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Endogenous fructose is correlated with urinary albumin creatinine ratios and uric acid in type 2 diabetes mellitus.
Esophageal Squamous Cell Carcinoma
KHK-A promotes the proliferation of oesophageal squamous cell carcinoma through the up-regulation of PRPS1.
Fatty Liver
Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling.
Fatty Liver
Ketohexokinase inhibition improves NASH by reducing fructose-induced steatosis and fibrogenesis.
Fructose Intolerance
Expression of rat liver ketohexokinase in yeast results in fructose intolerance.
Glioma
Ketohexokinase is involved in fructose utilization and promotes tumor progression in glioma.
Heart Diseases
HIF-driven SF3B1 induces KHK-C to enforce fructolysis and heart disease.
Hepatitis
Science letters: Proteomic analysis of differentially expressed proteins in mice with concanavalin A-induced hepatitis.
Hyperoxaluria
Calciuria, oxaluria and phosphaturia after ingestion of glucose, xylitol and sorbitol in two population groups with different stone-risk profiles.
Hypoglycemia
Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sensitive mice.
Insulin Resistance
Fructose and hepatic insulin resistance.
ketohexokinase deficiency
Properties of normal and mutant recombinant human ketohexokinases and implications for the pathogenesis of essential fructosuria.
ketohexokinase deficiency
Tissue-Specific Fructose Metabolism in Obesity and Diabetes.
Liver Diseases
Fructose and fructose kinase in cancer and other pathologies.
Liver Diseases
Ketohexokinase inhibition improves NASH by reducing fructose-induced steatosis and fibrogenesis.
Metabolic Syndrome
Short-term fructose ingestion affects the brain independently from establishment of metabolic syndrome.
Neoplasms
Dietary fructose improves intestinal cell survival and nutrient absorption.
Neoplasms
Fructose and fructose kinase in cancer and other pathologies.
Neoplasms
Ketohexokinase is involved in fructose utilization and promotes tumor progression in glioma.
Neoplasms
KHK-A promotes the proliferation of oesophageal squamous cell carcinoma through the up-regulation of PRPS1.
Neoplasms
Prognostic Impact of Metabolism Reprogramming Markers Acetyl-CoA Synthetase 2 Phosphorylation and Ketohexokinase-A Expression in Non-Small-Cell Lung Carcinoma.
Neoplasms
The expression of ketohexokinase is diminished in human clear cell type of renal cell carcinoma.
Non-alcoholic Fatty Liver Disease
Ketohexokinase inhibition improves NASH by reducing fructose-induced steatosis and fibrogenesis.
Obesity
Inhibitors of Ketohexokinase: Discovery of Pyrimidinopyrimidines with Specific Substitution that Complements the ATP-Binding Site.
Obesity
Pyrimidinopyrimidine inhibitors of ketohexokinase: Exploring the ring C2 group that interacts with Asp-27B in the ligand binding pocket.
Proteinuria
IL-6/STAT3 signaling activation exacerbates high fructose-induced podocyte hypertrophy by ketohexokinase-A-mediated tristetraprolin down-regulation.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
2.9 - 47
2,5-anhydro-D-glucitol
10 - 67
2,5-anhydro-D-lyxitol
1.6 - 6.3
2,5-anhydro-D-mannitol
0.31 - 1.5
2,5-anhydro-D-mannose
1.2
5-keto-D-fructose
-
25°C, pH 7
120
D-mannoheptulose
-
25°C, pH 7
11
D-psicose
-
25°C, pH 7
58
D-ribono-gamma-lactone
-
25°C, pH 7
2.2
D-sedoheptulose
-
25°C, pH 7
6
D-xylulose
-
37°C, pH 7.5
1.8
L-galacto-2-heptulose
-
25°C, pH 7, D-fructose 1-phosphate
0.37
L-ribulose
-
25°C, pH 7
2.9
2,5-anhydro-D-glucitol
-
25°C, pH 7
5.9
2,5-anhydro-D-glucitol
-
25°C, pH 7.5, MgATP2-2-: 4mM
47
2,5-anhydro-D-glucitol
-
25°C, pH 7.5, MgATP2-2-: 2mM
10
2,5-anhydro-D-lyxitol
-
25°C, pH 7
67
2,5-anhydro-D-lyxitol
-
25°C, pH 7.5, MgATP2-2-: 4mM
1.6
2,5-anhydro-D-mannitol
-
25°C, pH 7
1.7
2,5-anhydro-D-mannitol
-
25°C, pH 7.5, MgATP2-2-: 4mM
6.3
2,5-anhydro-D-mannitol
-
25°C, pH 7.5, MgATP2-2-: 2mM
0.31
2,5-anhydro-D-mannose
-
25°C, pH 7.5, MgATP2-: 2mM
1
2,5-anhydro-D-mannose
-
25°C, pH 7
1.5
2,5-anhydro-D-mannose
-
25°C, pH 7.5, MgATP2-: 4mM
0.15
ATP
-
25°C, pH 7, ketohexokinase-C wild type
0.15
ATP
-
ATP in form of MgATP2-
0.32
ATP
-
25°C, pH 7, ketohexokinase-C A43T
0.32
ATP
-
ATP in form of MgATP2-
0.36
ATP
-
25°C, pH 7, ketohexokinase-A wild type
0.36
ATP
-
ATP in form of MgATP2-
0.41
ATP
-
25°C, pH 7, ketohexokinase-A A43T
0.41
ATP
-
ATP in form of MgATP2-
0.1
D-fructose
-
25°C, pH 7
0.5
D-fructose
-
25°C, pH 7.5, MgATP2-: 4mM
0.56
D-fructose
-
pH 7.4, cosubstrate GTP
0.8
D-fructose
-
25°C, pH 7, ketohexokinase-C wild type
0.83
D-fructose
-
pH 7.4, + ATP
0.84
D-fructose
-
25°C, pH 7, ketohexokinase-C A43T
0.86
D-fructose
-
37°C, pH 7.5
5
D-fructose
-
pH 9.0, 37°C
7
D-fructose
-
25°C, pH 7, ketohexokinase-A wild type
8.2
D-fructose
-
25°C, pH 7, ketohexokinase-A A43T
142
D-ribose
-
25°C, pH 7
201
D-ribose
-
25°C, pH 7, ketohexokinase-A wild type
434
D-ribose
-
25°C, pH 7, ketohexokinase-C wild type
1.8
D-ribulose
-
25°C, pH 7, ketohexokinase-C wild type
32.7
D-ribulose
-
25°C, pH 7, ketohexokinase-A wild type
0.9
D-tagatose
-
25°C, pH 7
0.9
D-tagatose
-
25°C, pH 7.5, MgATP2-: 4mM
0.44
D-xylose
-
25°C, pH 7, ketohexokinase-C wild type
1
D-xylose
-
25°C, pH 7, ketohexokinase-A wild type
1.4
D-xylose
-
25°C, pH 7
0.4
L-sorbose
-
25°C, pH 7.5, MgATP2-: 4mM
0.43
L-sorbose
-
25°C, pH 7
5.8
L-sorbose
-
25°C, pH 7, ketohexokinase-C wild type
19.3
L-sorbose
-
25°C, pH 7, ketohexokinase-A wild type
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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0.0002
2-(4-aminopiperidin-1-yl)-N8-(cyclopropylmethyl)-N4-(2-methylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.00148
2-ethyl-7-(3-hydroxy-3-methylpyrrolidin-1-yl)-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile
Homo sapiens
23°C, pH 7.4
0.000018
2-[(3R)-3-aminopiperidin-1-yl]-N8-(cyclopropylmethyl)-N4-[2-(methylsulfanyl)phenyl]pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000023
2-[(3S)-3-aminopiperidin-1-yl]-N8-(cyclopropylmethyl)-N4-[2-(methylsulfanyl)phenyl]pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.00003
2-[3-(aminomethyl)azetidin-1-yl]-N8-(cyclopropylmethyl)-N4-[2-(methylsulfanyl)phenyl]pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.00007
2-[4-(aminomethyl)piperidin-1-yl]-N8-(cyclopropylmethyl)-N4-(2-methylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.00001
2-[4-(aminomethyl)piperidin-1-yl]-N8-(cyclopropylmethyl)-N4-[2-(methylsulfanyl)phenyl]pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.1
3-(trifluoromethyl)quinoxalin-2(1H)-one
Homo sapiens
23°C, pH 7.4
0.319
4,6-dimethyl-2-(morpholin-4-yl)pyridine-3-carbonitrile
Homo sapiens
23°C, pH 7.4
0.00039 - 0.00045
6-[(3S,4S)-3,4-dihydroxypyrrolidin-1-yl]-2-[(3S)-3-hydroxy-3-methylpyrrolidin-1-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile
0.00103
6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-[(3S)-3-hydroxy-3-methylpyrrolidin-1-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile
Homo sapiens
23°C, pH 7.4
0.01679
6-[4-(2-hydroxyethyl)piperazin-1-yl]-4-[3-(hydroxymethyl)piperidin-1-yl]-2-(trifluoromethyl)pyridine-3-carbonitrile
Homo sapiens
23°C, pH 7.4
0.02421
7-[(3R)-3-hydroxy-3-methylpyrrolidin-1-yl]-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile
Homo sapiens
23°C, pH 7.4
0.00064 - 0.00067
7-[(3S)-3-hydroxy-3-methylpyrrolidin-1-yl]-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile
0.0015
alpha-/gamma-mangostin
Homo sapiens
-
37°C, pH 7.2
0.001
cratoxyarborenone E
Homo sapiens
-
37°C, pH 7.2
0.0002
methoxy-isobavachalcone
Homo sapiens
-
37°C, pH 7.2
0.009
N,N'-dicyclopropyl-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.00017
N4-(2-bromophenyl)-N8-cyclopropyl-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.00054
N4-(2-chlorophenyl)-N8-cyclopropyl-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.00006
N4-(2-methylphenyl)-2-(piperazin-1-yl)-N8-(1,3-thiazol-2-ylmethyl)pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.0017
N4-(2-methylphenyl)-2-(piperazin-1-yl)-N8-(prop-2-yn-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.0003
N4-(2-methylphenyl)-2-(piperazin-1-yl)-N8-(tetrahydrothiophen-2-ylmethyl)pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.0004
N4-(2-methylphenyl)-2-(piperazin-1-yl)-N8-propylpyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.009
N4-cyclohexyl-N8-cyclopropyl-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000016
N4-[2-(methylsulfanyl)phenyl]-2-(piperazin-1-yl)-N8-(1,3-thiazol-2-ylmethyl)pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.0000098
N4-[2-(methylsulfanyl)phenyl]-2-(piperazin-1-yl)-N8-(pyridin-2-ylmethyl)pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.00003
N4-[2-(methylsulfanyl)phenyl]-2-(piperazin-1-yl)-N8-(thiophen-2-ylmethyl)pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.0000071
N4-[2-(methylsulfanyl)phenyl]-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.00005
N8-(2-cyclopropylethyl)-N4-[2-(methylsulfanyl)phenyl]-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000007
N8-(2-methoxyethyl)-N4-[2-(methylsulfanyl)phenyl]-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000018
N8-(cyclobutylmethyl)-N4-[2-(methylsulfanyl)phenyl]-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.0003
N8-(cyclopropylmethyl)-2-(1,4-diazepan-1-yl)-N4-(2-methylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.00071
N8-(cyclopropylmethyl)-2-(4-iminopiperidin-1-yl)-N4-(2-methylphenyl)pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.00011
N8-(cyclopropylmethyl)-2-(4-methylpiperazin-1-yl)-N4-[2-(methylsulfanyl)phenyl]pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.00014
N8-(cyclopropylmethyl)-2-[4-[(dimethylamino)methyl]piperidin-1-yl]-N4-[2-(methylsulfanyl)phenyl]pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.00013
N8-(cyclopropylmethyl)-N2-methyl-N2-[2-(methylamino)ethyl]-N4-[2-(methylsulfanyl)phenyl]pyrimido[5,4-d]pyrimidine-2,4,8-triamine
Homo sapiens
-
pH and temperature not specified in the publication
0.0015
N8-(cyclopropylmethyl)-N4-(2-methylphenyl)-2-(4-methylpiperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.007
N8-(cyclopropylmethyl)-N4-(2-methylphenyl)-2-(morpholin-4-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.0003
N8-benzyl-N4-(2-methylphenyl)-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.0016
N8-cyclohexyl-N4-(2-methylphenyl)-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.005
N8-cyclopropyl-2-(piperazin-1-yl)-N4-[2-(propan-2-yl)phenyl]pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.003
N8-cyclopropyl-2-(piperazin-1-yl)-N4-[2-[(trifluoromethyl)sulfanyl]phenyl]pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.00038
N8-cyclopropyl-N4-(2-cyclopropylphenyl)-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.0002
N8-cyclopropyl-N4-(2-ethoxyphenyl)-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.00013
N8-cyclopropyl-N4-(2-ethylphenyl)-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.0015
N8-cyclopropyl-N4-(2-fluorophenyl)-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.0001
N8-cyclopropyl-N4-(2-methoxyphenyl)-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.00021
N8-cyclopropyl-N4-(2-methylphenyl)-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.0028
N8-cyclopropyl-N4-(3-methylphenyl)-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.0032
N8-cyclopropyl-N4-phenyl-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.009
N8-cyclopropyl-N4-[2-(ethylsulfanyl)phenyl]-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.000012
N8-cyclopropyl-N4-[2-(methylsulfanyl)phenyl]-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.009
N8-cyclopropyl-N4-[2-(methylsulfonyl)phenyl]-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.002
N8-cyclopropyl-N4-[3-(methylsulfanyl)phenyl]-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.009
N8-cyclopropyl-N4-[4-(methylsulfanyl)phenyl]-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.0023
N8-ethyl-N4-(2-methylphenyl)-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.0004
N8-hexyl-N4-(2-methylphenyl)-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.0004
N8-methyl-N4-(2-methylphenyl)-2-(piperazin-1-yl)pyrimido[5,4-d]pyrimidine-4,8-diamine
Homo sapiens
-
pH and temperature not specified in the publication
0.0007
osthole
Homo sapiens
-
37°C, pH 7.2
0.118
[(3R)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl]methanol
Homo sapiens
23°C, pH 7.4
0.00039
6-[(3S,4S)-3,4-dihydroxypyrrolidin-1-yl]-2-[(3S)-3-hydroxy-3-methylpyrrolidin-1-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile
Homo sapiens
23°C, pH 7.4, splice variant KHK-A
0.00045
6-[(3S,4S)-3,4-dihydroxypyrrolidin-1-yl]-2-[(3S)-3-hydroxy-3-methylpyrrolidin-1-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile
Homo sapiens
23°C, pH 7.4, splice variant KHK-C
0.00064
7-[(3S)-3-hydroxy-3-methylpyrrolidin-1-yl]-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile
Rattus norvegicus
23°C, pH 7.4
0.00067
7-[(3S)-3-hydroxy-3-methylpyrrolidin-1-yl]-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile
Homo sapiens
23°C, pH 7.4
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-
relatively low expression of ketohexokinase.The expression profile for ketohexokinase in human is derived from from Unigene by adding the number of EST clones obtained from normal tissues
brenda
-
relatively low expression of ketohexokinase.The expression profile for ketohexokinase in human is derived from from Unigene by adding the number of EST clones obtained from normal tissues
brenda
-
ketohexokinase protein is detected in the trophectoderm at day 11 of pregnancy
brenda
expressed at significantly higher level in glioma tissues than in non-tumor brain
brenda
-
-
brenda
-
-
brenda
-
hepatocellular carcinoma cell
brenda
-
12.4% of the phosphorylation of D-fructose by ileum homogenates is attributable to ketohexokinase
brenda
-
relatively high expression of ketohexokinase.The expression profile for ketohexokinase in human is derived from from Unigene by adding the number of EST clones obtained from normal tissues
brenda
-
-
brenda
represent the most prevalent cancer of the kidney. The mean ketohexokinase activity in the renal cell carcinoma tissue samples is approximately 1.4fold lower than that in their normal kidney tissue. Ketohexokinase activity is approximately 1.5fold lower in pT3 renal cell carcinoma tissue than that in pT1 renal cell carcinoma tissue. The enzyme activity of tumor in histological grade 3 is 1.8fold lower than for grade 1 tumor(reaction mixture activity assay: acid-treated supernatant (100 microl) containing 10 mM MgCl2, 50 mM TrisHCl, pH 7.4, 10 mM ATP, 50 mM N-acetyl-D-glucosamine, 10 mM D[UL-14C]fructose and water, at 37°C). The expression level of ketohexokinase mRNA is reduced two- to eightfold in nearly all the clear cell renal cell carcinoma tissue samples compared with normal kidney, except for one renal cell carcinoma sample.
brenda
-
-
brenda
-
relatively low expression of ketohexokinase.The expression profile for ketohexokinase in human is derived from from Unigene by adding the number of EST clones obtained from normal tissues
brenda
-
-
brenda
-
ketohexokinase protein is detected at all stages of gestation studied through day 85
brenda
-
expression of ketohexokinase mRNA is greater from day 9 through 17 of pregnancy compared to the corresponding days of the estrous cycle. There is an increase in expression of KHK mRNA through day 85, with peaks at days 30 and 85. Ketohexokinase protein is only detectable in GE of the endometrium at day 30 of pregnancy
brenda
-
-
brenda
-
-
brenda
-
relatively high expression of ketohexokinase.The expression profile for ketohexokinase in human is derived from from Unigene by adding the number of EST clones obtained from normal tissues
brenda
expressed at significantly higher level in glioma tissues than in non-tumor brain
brenda
-
the expression of ketohexokinase is investigated in coronal sections of the hindbrain containing the cerebellum. There is a lack of general DIG-labeled cells in the molecular layer of the cerebellum, but the Purkinje cell layer, which separates the molecular layer from the granular layer, demonstrated the strongest DIG labeling. DIG-labeled RNA in situ hybridization identifies specific cellular location of ketohexokinase mRNA expression.
brenda
-
-
brenda
-
-
brenda
-
relatively low expression of ketohexokinase.The expression profile for ketohexokinase in human is derived from from Unigene by adding the number of EST clones obtained from normal tissues
brenda
-
-
brenda
-
-
brenda
-
high expression of ketohexokinase.The expression profile for ketohexokinase in human is derived from from Unigene by adding the number of EST clones obtained from normal tissues
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
brenda
-
high expression of ketohexokinase.The expression profile for ketohexokinase in human is derived from from Unigene by adding the number of EST clones obtained from normal tissues
brenda
-
-
brenda
-
-
brenda
-
the phosphorylation of D-fructose by liver homogenates is attributable to ketohexokinase
brenda
-
-
brenda
-
relatively low expression of ketohexokinase.The expression profile for ketohexokinase in human is derived from from Unigene by adding the number of EST clones obtained from normal tissues
brenda
-
of the intestine
brenda
-
-
brenda
-
-
brenda
-
relatively low expression of ketohexokinase.The expression profile for ketohexokinase in human is derived from from Unigene by adding the number of EST clones obtained from normal tissues
brenda
-
activity of ketohexokinase in pancreas homogenates. In pancreatic islets ketohexokinase activity is present.
brenda
-
relatively low expression of ketohexokinase.The expression profile for ketohexokinase in human is derived from from Unigene by adding the number of EST clones obtained from normal tissues
brenda
-
expression of ketohexokinase mRNA increases from day 30 to 40 of pregnancy
brenda
-
-
brenda
ketohexokinase-dependent induction by fructose of lipogenic gene expression
brenda
additional information
-
not expressed in lung
brenda
additional information
peripheral isoform (isoform C is a hepatic isoform)
brenda
additional information
-
peripheral isoform (isoform C is a hepatic isoform)
brenda
additional information
-
semi-purified B and non-B islet cells are investigated. The major fraction of D-fructose phosphorylation by islet cell homogenates (B and non-B) is not attributable to ketohexokinase.
brenda
additional information
-
there is no biologically significant amount of ketohexokinase in the parotid gland
brenda
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Bais, R.; James, H.M.; Rofe, A.M.; Conyers, A.J.
The purification and properties of human liver ketohexokinase. A role for ketohexokinase and fructose-bisphosphate aldolase in the metabolic production of oxalate from xylitol
Biochem. J.
230
53-60
1985
Homo sapiens
brenda
Cori, G.T.; Ochoa, S.; Slein, M.W.; Cori, C.F.
The metabolism of fructose in liver. Isolation of fructose-I-phosphate and inorganic pyrophosphate
Biochim. Biophys. Acta
7
304-317
1951
Rattus norvegicus
brenda
Hers, H.G.
La fructokinase du foie
Biochim. Biophys. Acta
8
416-423
1952
Bos taurus
-
brenda
Parks, R.E.; Ben-Gershom, E.; Lardy, H.E.
Liver fructokinase
J. Biol. Chem.
227
231-242
1957
Bos taurus
brenda
Weiser, M.M.; Quill, H.
Estimation of fructokinase (ketohexokinase) in crude tissue preparations
Methods Enzymol.
41B
61-63
1975
Mammalia
-
brenda
Raushel, F.M.; Cleland, W.W.
Bovine liver fructokinase: purification and kinetic properties
Biochemistry
16
2169-2175
1977
Bos taurus
brenda
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