Literature summary for 2.7.1.3 extracted from

Le, M.; Lanaspa, M.; Cicerchi, C.; Rana, J.; Scholten, J.; Hunter, B.; Rivard, C.; Randolph, R.; Johnson, R.
Bioactivity-guided identification of botanical inhibitors of ketohexokinase (2016), PLoS ONE, 11, e0157458.

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Inhibitors

Inhibitors	Comment	Organism	Structure
alpha-/gamma-mangostin	-	Homo sapiens
cratoxyarborenone E	-	Homo sapiens
methoxy-isobavachalcone	-	Homo sapiens
additional information	extracts of Angelica archangelica, Garcinia mangostana, Petroselinum crispum, and Scutellaria baicalensis exhibit ketohexokinase inhibitory activity and block fructose-induced ATP depletion and fructose-induced elevation in triglyerides and uric acid	Homo sapiens
osthole	-	Homo sapiens
phloretin	Malus domestica extract, IC50 value 8.99.2 microg/mL	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Hep-G2 cell	-	Homo sapiens	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0002	-	37°C, pH 7.2	Homo sapiens	methoxy-isobavachalcone
0.0007	-	37°C, pH 7.2	Homo sapiens	osthole
0.001	-	37°C, pH 7.2	Homo sapiens	cratoxyarborenone E
0.0015	-	37°C, pH 7.2	Homo sapiens	alpha-/gamma-mangostin

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Release 2023.1 (January 2023)