Disease on EC 2.4.99.8 - alpha-N-acetylneuraminate alpha-2,8-sialyltransferase
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Acquired Immunodeficiency Syndrome
Differential effect of disease-associated ST8SIA2 haplotype on cerebral white matter diffusion properties in schizophrenia and healthy controls.
Adenocarcinoma
Effects of intronic single nucleotide polymorphisms (iSNPs) of a polysialyltransferase, ST8SIA2 gene found in psychiatric disorders on its gene products.
Adenocarcinoma of Lung
Curcumin Downregulates Human GM3 Synthase (hST3Gal V) Gene Expression with Autophagy Induction in Human Colon Carcinoma HCT116 Cells.
Adenocarcinoma, Follicular
miR-146a and miR-146b promote proliferation, migration and invasion of follicular thyroid carcinoma via inhibition of ST8SIA4.
alpha-n-acetylneuraminate alpha-2,8-sialyltransferase deficiency
Altered developmental neuroplasticity due to polysialyltransferase ST8SiaII deficiency in mice leads to schizophrenia-like phenotype.
alpha-n-acetylneuraminate alpha-2,8-sialyltransferase deficiency
Amygdala GluN2B-NMDAR dysfunction is critical in abnormal aggression of neurodevelopmental origin induced by St8sia2 deficiency.
alpha-n-acetylneuraminate alpha-2,8-sialyltransferase deficiency
Effect of expression alteration in flanking genes on phenotypes of St8sia2-deficient mice.
alpha-n-acetylneuraminate alpha-2,8-sialyltransferase deficiency
Impact of the polysialyltransferases ST8SiaII and ST8SiaIV on polysialic acid synthesis during postnatal mouse brain development.
alpha-n-acetylneuraminate alpha-2,8-sialyltransferase deficiency
Level and localization of polysialic acid is critical for early peripheral nerve regeneration.
alpha-n-acetylneuraminate alpha-2,8-sialyltransferase deficiency
Polysialic acid affects pathophysiological consequences of status epilepticus.
alpha-n-acetylneuraminate alpha-2,8-sialyltransferase deficiency
Schizophrenia-like phenotype of polysialyltransferase ST8SIA2-deficient mice.
alpha-n-acetylneuraminate alpha-2,8-sialyltransferase deficiency
St8sia2 deficiency plus juvenile cannabis exposure in mice synergistically affect higher cognition in adulthood.
alpha-n-acetylneuraminate alpha-2,8-sialyltransferase deficiency
ST8SIA2 promotes oligodendrocyte differentiation and the integrity of myelin and axons.
Alzheimer Disease
Brain gangliosides of a transgenic mouse model of Alzheimer's disease with deficiency in GD3-synthase: expression of elevated levels of a cholinergic-specific ganglioside, GT1a?.
Astrocytoma
Expression profiling of glycosyltransferases and related enzymes using in situ hybridization.
Astrocytoma
Sialyltransferase levels and ganglioside expression in melanoma and other cultured human cancer cells.
Ataxia
Campylobacter sialyltransferase gene polymorphism directs clinical features of Guillain-Barré syndrome.
Ataxia
[Campylobacter genes responsible for the development and determinant of clinical features of Guillain-Barré syndrome]
Atherosclerosis
Disialoganglioside (GD3) synthase gene expression suppresses vascular smooth muscle cell responses via the inhibition of ERK1/2 phosphorylation, cell cycle progression, and matrix metalloproteinase-9 expression.
Atherosclerosis
Reactive oxygen species mediates disialoganglioside GD3-induced inhibition of ERK1/2 and matrix metalloproteinase-9 expression in vascular smooth muscle cells.
Autoimmune Diseases
Cutting Edge: ST8Sia6-Generated ?-2,8-Disialic Acids Mitigate Hyperglycemia in Multiple Low-Dose Streptozotocin-Induced Diabetes.
Basal Ganglia Diseases
Functional roles of ST8SIA3-mediated sialylation of striatal dopamine D2 and adenosine A2A receptors.
Brain Ischemia
Ganglioside GD3 is up-regulated in microglia and regulates phagocytosis following global cerebral ischemia.
Breast Neoplasms
Accumulation of Unusual Gangliosides GQ3 and GP3 in Breast Cancer Cells Expressing the GD3 Synthase.
Breast Neoplasms
Comprehensive Transcriptomic Analysis Identifies ST8SIA1 as a Survival-Related Sialyltransferase Gene in Breast Cancer.
Breast Neoplasms
Disialyl GD2 ganglioside suppresses ICAM-1-mediated invasiveness in human breast cancer MDA-MB231 cells.
Breast Neoplasms
Estradiol represses the G(D3) synthase gene ST8SIA1 expression in human breast cancer cells by preventing NF?B binding to ST8SIA1 promoter.
Breast Neoplasms
Functional roles of sialylation in breast cancer progression through miR-26a/26b targeting ST8SIA4.
Breast Neoplasms
GD3 Synthase Expression Enhances Proliferation and Tumor Growth of MDA-MB-231 Breast Cancer Cells through c-Met Activation.
Breast Neoplasms
GD3 synthase regulates epithelial-mesenchymal transition and metastasis in breast cancer.
Breast Neoplasms
Gene expression of ceramide kinase, galactosyl ceramide synthase and ganglioside GD3 synthase is associated with prognosis in breast cancer.
Breast Neoplasms
IKK inhibition by BMS-345541 suppresses breast tumorigenesis and metastases by targeting GD2+ cancer stem cells.
Breast Neoplasms
Interaction of glycosphingolipids GD3 and GD2 with growth factor receptors maintains breast cancer stem cell phenotype.
Breast Neoplasms
lncRNA MALAT1/miR?26a/26b/ST8SIA4 axis mediates cell invasion and migration in breast cancer cell lines.
Breast Neoplasms
ST8SIA1 inhibition sensitizes triple negative breast cancer to chemotherapy via suppressing Wnt/?-catenin and FAK/Akt/mTOR.
Breast Neoplasms
The ganglioside GD2 induces the constitutive activation of c-Met in MDA-MB-231 breast cancer cells expressing the GD3 synthase.
Breast Neoplasms
TNF differentially regulates ganglioside biosynthesis and expression in breast cancer cell lines.
Brucellosis
Comparison of a Brucella Enzyme Immunoassay and the Standard Agglutination with 2-Mercaptoethanol Test in the Diagnosis and Monitoring of Brucellosis in Mexican Patients.
Campylobacter Infections
Epidemiological association of Campylobacter jejuni groups with pathogenicity-associated genetic markers.
Carcinogenesis
IKK inhibition by BMS-345541 suppresses breast tumorigenesis and metastases by targeting GD2+ cancer stem cells.
Carcinogenesis
Long noncoding RNA HOTAIR promotes renal cell carcinoma malignancy through alpha-2, 8-sialyltransferase 4 by sponging microRNA-124.
Carcinogenesis
ST8SIA1 Regulates Tumor Growth and Metastasis in TNBC by Activating the FAK-AKT-mTOR Signaling Pathway.
Carcinoma
Apoptosis of human breast carcinoma cells in the presence of cis-platin and L-/D-PPMP: IV. Modulation of replication complexes and glycolipid: Glycosyltransferases.
Carcinoma
Characterization of Distinct Populations of Carcinoma-Associated Fibroblasts from Non-Small Cell Lung Carcinoma Reveals a Role for ST8SIA2 in Cancer Cell Invasion.
Carcinoma
Glycolipid sialyltransferases are enhanced during neural differentiation of mouse embryonic carcinoma cells, P19.
Carcinoma
Transcriptional Activation of Human GD3 Synthase (hST8Sia I) Gene in Curcumin-Induced Autophagy in A549 Human Lung Carcinoma Cells.
Carcinoma
Upregulation of miR-181c inhibits chemoresistance by targeting ST8SIA4 in chronic myelocytic leukemia.
Carcinoma, Non-Small-Cell Lung
Characterization of Distinct Populations of Carcinoma-Associated Fibroblasts from Non-Small Cell Lung Carcinoma Reveals a Role for ST8SIA2 in Cancer Cell Invasion.
Carcinoma, Non-Small-Cell Lung
Expression of polysialic acid and STX, a human polysialyltransferase, is correlated with tumor progression in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Prognostic significance of polysialic acid expression in resected non-small cell lung cancer.
Cholangiocarcinoma
miR-144-5p and miR-451a Inhibit the Growth of Cholangiocarcinoma Cells Through Decreasing the Expression of ST8SIA4.
Colonic Neoplasms
Evaluation of SAT-1, SAT-2 and GalNAcT-1 mRNA in colon cancer by real-time PCR.
Colonic Neoplasms
The ceramide moiety of disialoganglioside (GD3) is essential for GD3 recognition by the sialic acid-binding lectin SIGLEC7 on the cell surface.
Colorectal Neoplasms
Decreased expression of alpha2,8 sialyltransferase and increased expression of beta1,4 N-acetylgalactosaminyltransferase in gastrointestinal cancers.
Colorectal Neoplasms
MicroRNA-33a and let-7e inhibit human colorectal cancer progression by targeting ST8SIA1.
Demyelinating Diseases
Polysialylation at Early Stages of Oligodendrocyte Differentiation Promotes Myelin Repair.
Demyelinating Diseases
Remyelination after cuprizone induced demyelination is accelerated in mice deficient in the polysialic acid synthesizing enzyme St8siaIV.
Demyelinating Diseases
ST8SIA2 promotes oligodendrocyte differentiation and the integrity of myelin and axons.
Encephalitis
Bickerstaff's brainstem encephalitis after an outbreak of Campylobacter jejuni enteritis.
Enteritis
Prevalence of potentially neuropathic Campylobacter jejuni strains on commercial broiler chicken products.
Epilepsy
Characterization of a 520?kb deletion on chromosome 15q26.1 including ST8SIA2 in a patient with behavioral disturbance, autism spectrum disorder, and epilepsy.
Epilepsy
Characterization of a 520?kb deletion on chromosome 15q26.1 including ST8SIA2 in a patient with behavioral disturbance, autism spectrum disorder, and epilepsy: additional information.
Foot-and-Mouth Disease
A first molecular epidemiological study of SAT-2 type foot-and-mouth disease viruses in West Africa.
Foot-and-Mouth Disease
An investigation into the source and spread of foot and mouth disease virus from a wildlife conservancy in Zimbabwe.
Foot-and-Mouth Disease
Characterization of Foot and Mouth Disease Virus Serotype SAT-2 in Swamp Water Buffaloes (Bubalus bubalis) under the Egyptian Smallholder Production System.
Foot-and-Mouth Disease
Experimental infection of giraffe (Giraffa camelopardalis) with SAT-1 and SAT-2 foot-and-mouth disease virus.
Foot-and-Mouth Disease
Genetic relationships between southern African SAT-2 isolates of foot-and-mouth-disease virus.
Foot-and-Mouth Disease
Molecular characterization of SAT-2 foot-and-mouth disease virus isolates obtained from cattle during a four-month period in 2001 in Limpopo Province, South Africa.
Foot-and-Mouth Disease
Natural transmission of foot-and-mouth disease virus between African buffalo (Syncerus caffer) and impala (Aepyceros melampus) in the Kruger National Park, South Africa.
Foot-and-Mouth Disease
Persistent infection of African buffalo (Syncerus caffer) with SAT-type foot-and-mouth disease viruses: rate of fixation of mutations, antigenic change and interspecies transmission.
Foot-and-Mouth Disease
Study of the genetic heterogeneity of SAT-2 foot-and-mouth disease virus in sub-Saharan Africa with specific focus on East Africa.
Gastrointestinal Neoplasms
Decreased expression of alpha2,8 sialyltransferase and increased expression of beta1,4 N-acetylgalactosaminyltransferase in gastrointestinal cancers.
Glioblastoma
Accumulation of Unusual Gangliosides GQ3 and GP3 in Breast Cancer Cells Expressing the GD3 Synthase.
Glioblastoma
Glycolipid GD3 and GD3 synthase are key drivers for glioblastoma stem cells and tumorigenicity.
Glioblastoma
Isolation and functional analysis of the human glioblastoma-specific promoter region of the human GD3 synthase (hST8Sia I) gene.
Glioblastoma
Molecular mechanisms involved in transcriptional activation of the human Sia-alpha2,3-Gal-beta1,4-GlcNAc-R:alpha2,8-sialyltransferase (hST8Sia III) gene induced by KCl in human glioblastoma cells.
Glioblastoma
Transcriptional regulation of the human Sia-alpha2,3-Gal-beta1,4-GlcNAc-R:alpha2,8-sialyltransferase (hST8Sia III) by retinoic acid in human glioblastoma tumor cell line.
Glioma
Increased tumorigenicity and invasiveness of C6 rat glioma cells transfected with the human alpha-2,8 sialyltransferase cDNA.
Glioma
Lack of GD3 synthase (St8sia1) attenuates malignant properties of gliomas in genetically engineered mouse model.
Graves Ophthalmopathy
Identification and Functional Characterization of ST3GAL5 and ST8SIA1 Variants in Patients with Thyroid-Associated Ophthalmopathy.
Guillain-Barre Syndrome
Campylobacter jejuni cst-II polymorphisms and association with development of Guillain-Barré syndrome.
Heart Failure
Characterization of Foot and Mouth Disease Virus Serotype SAT-2 in Swamp Water Buffaloes (Bubalus bubalis) under the Egyptian Smallholder Production System.
Hyperalgesia
GD3 synthase gene knockout mice exhibit thermal hyperalgesia and mechanical allodynia but decreased response to formalin-induced prolonged noxious stimulation.
Hyperalgesia
Glycosphingolipid Biosynthesis Pathway in the Spinal Cord and Dorsal Root Ganglia During Inflammatory Pain: Early and Late Changes in Expression Patterns of Glycosyltransferase Genes.
Hyperglycemia
Cutting Edge: ST8Sia6-Generated ?-2,8-Disialic Acids Mitigate Hyperglycemia in Multiple Low-Dose Streptozotocin-Induced Diabetes.
Infections
Experimental infection of giraffe (Giraffa camelopardalis) with SAT-1 and SAT-2 foot-and-mouth disease virus.
Infections
Prevalence of heat-stable II enterotoxigenic Escherichia coli in pigs, water, and people at farms in Thailand as determined by DNA hybridization.
Infections
The possible role that buffalo played in the recent outbreaks of foot-and-mouth disease in South Africa.
Influenza, Human
Influence of N-glycosylation and N-glycan trimming on the activity and intracellular traffic of GD3 synthase.
Intestinal Neoplasms
Evaluation of SAT-1, SAT-2 and GalNAcT-1 mRNA in colon cancer by real-time PCR.
Leukemia
Disialoganglioside GD3 synthase expression recruits membrane transglutaminase 2 during erythroid differentiation of the human chronic myelogenous leukemia K562 cells.
Leukemia
High expression of ganglioside alpha-2,8-sialyltransferase (GD3 synthase) gene in adult T-cell leukemia cells unrelated to the gene expression of human T-lymphotropic virus type I.
Leukemia
Regulation of glycolipid synthesis in HL-60 cells by antisense oligodeoxynucleotides to glycosyltransferase sequences: effect on cellular differentiation.
Leukemia
Upregulation of miR-181c inhibits chemoresistance by targeting ST8SIA4 in chronic myelocytic leukemia.
Leukemia, Erythroblastic, Acute
Purification and partial characterization of an alpha-2,8-sialyltransferase from human erythroleukemia K562 cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Disialoganglioside GD3 synthase expression recruits membrane transglutaminase 2 during erythroid differentiation of the human chronic myelogenous leukemia K562 cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Upregulation of miR-181c inhibits chemoresistance by targeting ST8SIA4 in chronic myelocytic leukemia.
Leukemia-Lymphoma, Adult T-Cell
High expression of ganglioside alpha-2,8-sialyltransferase (GD3 synthase) gene in adult T-cell leukemia cells unrelated to the gene expression of human T-lymphotropic virus type I.
Lumpy Skin Disease
High selectivity detection of FMDV- SAT-2 using a newly-developed electrochemical nanosensors.
Lung Neoplasms
Effects of the regulation of polysialyltransferase ST8SiaII on the invasiveness and metastasis of small cell lung cancer cells.
Lung Neoplasms
Expression of polysialic acid and STX, a human polysialyltransferase, is correlated with tumor progression in non-small cell lung cancer.
Lung Neoplasms
Fundamental study of small interfering RNAs for ganglioside GD3 synthase gene as a therapeutic target of lung cancers.
Lung Neoplasms
Modification of ?2,6-sialylation mediates the invasiveness and tumorigenicity of non-small cell lung cancer cells in vitro and in vivo via Notch1/Hes1/MMPs pathway.
Lung Neoplasms
Prognostic significance of polysialic acid expression in resected non-small cell lung cancer.
Melanoma
A cancer-unique glycan: de-N-acetyl polysialic acid (dPSA) linked to cell surface nucleolin depends on re-expression of the fetal polysialyltransferase ST8SIA2 gene.
Melanoma
Acceptor substrate specificity of a cloned GD3 synthase that catalyzes the biosynthesis of both GD3 and GD1c/GT1a/GQ1b.
Melanoma
Accumulation of Unusual Gangliosides GQ3 and GP3 in Breast Cancer Cells Expressing the GD3 Synthase.
Melanoma
Down-regulation of GD3 ganglioside and its O-acetylated derivative by stable transfection with antisense vector against GD3-synthase gene expression in hamster melanoma cells: effects on cellular growth, melanogenesis, and dendricity.
Melanoma
Expression of the human CMP-NeuAc:GM3 alpha2,8-sialyltransferase (GD3 synthase) gene through the NF-kappaB activation in human melanoma SK-MEL-2 cells.
Melanoma
Isolation and functional analysis of the melanoma specific promoter region of human GD3 synthase gene.
Melanoma
Sialyltransferase levels and ganglioside expression in melanoma and other cultured human cancer cells.
Melanoma
TNF?-signal and cAMP-mediated signals oppositely regulate melanoma- associated ganglioside GD3 synthase gene in human melanocytes.
Melanoma
Triptolide downregulates human GD3 synthase (hST8Sia I) gene expression in SK-MEL-2 human melanoma cells.
Melanoma
Upregulation of cell surface GD3 ganglioside phenotype is associated with human melanoma brain metastasis.
Melanoma
UVB-irradiated keratinocytes induce melanoma-associated ganglioside GD3 synthase gene in melanocytes via secretion of tumor necrosis factor ? and interleukin 6.
Meningococcal Infections
Capsule phase variation in Neisseria meningitidis serogroup B by slipped-strand mispairing in the polysialyltransferase gene (siaD): correlation with bacterial invasion and the outbreak of meningococcal disease.
Mouth Diseases
An investigation into the source and spread of foot and mouth disease virus from a wildlife conservancy in Zimbabwe.
Mouth Diseases
Characterization of Foot and Mouth Disease Virus Serotype SAT-2 in Swamp Water Buffaloes (Bubalus bubalis) under the Egyptian Smallholder Production System.
Multiple Sclerosis
Variants in ST8SIA1 do not play a major role in susceptibility to multiple sclerosis in Canadian families.
Multiple Sclerosis
Variants of ST8SIA1 are associated with risk of developing multiple sclerosis.
Neoplasm Metastasis
Effects of the regulation of polysialyltransferase ST8SiaII on the invasiveness and metastasis of small cell lung cancer cells.
Neoplasm Metastasis
GD3 synthase regulates epithelial-mesenchymal transition and metastasis in breast cancer.
Neoplasm Metastasis
Long noncoding RNA HOTAIR promotes renal cell carcinoma malignancy through alpha-2, 8-sialyltransferase 4 by sponging microRNA-124.
Neoplasm Metastasis
Reduced cell migration, tumor growth and experimental metastasis of rat F-11 cells whose expression of GD3-synthase is suppressed.
Neoplasm Metastasis
ST8SIA1 Regulates Tumor Growth and Metastasis in TNBC by Activating the FAK-AKT-mTOR Signaling Pathway.
Neoplasm Metastasis
The Cooperative Effect between Polybasic Region (PBR) and Polysialyltransferase Domain (PSTD) within Tumor-Target Polysialyltranseferase ST8Sia II.
Neoplasm Metastasis
Upregulation of cell surface GD3 ganglioside phenotype is associated with human melanoma brain metastasis.
Neoplasm Metastasis
Variations in gene expression patterns correlated with phenotype of F-11 tumor cells whose expression of GD3-synthase is suppressed.
Neoplasms
A cancer-unique glycan: de-N-acetyl polysialic acid (dPSA) linked to cell surface nucleolin depends on re-expression of the fetal polysialyltransferase ST8SIA2 gene.
Neoplasms
Accumulation of Unusual Gangliosides GQ3 and GP3 in Breast Cancer Cells Expressing the GD3 Synthase.
Neoplasms
Alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 can support immune responses toward tumors overexpressing ganglioside D3 in mice.
Neoplasms
An efficient assay for identification and quantitative evaluation of potential polysialyltransferase inhibitors.
Neoplasms
Characterization of Distinct Populations of Carcinoma-Associated Fibroblasts from Non-Small Cell Lung Carcinoma Reveals a Role for ST8SIA2 in Cancer Cell Invasion.
Neoplasms
Combining gene expression signature with clinical features for survival stratification of gastric cancer.
Neoplasms
Control of NCAM polysialylation by the differential expression of polysialyltransferases ST8SiaII and ST8SiaIV.
Neoplasms
Decreased expression of alpha2,8 sialyltransferase and increased expression of beta1,4 N-acetylgalactosaminyltransferase in gastrointestinal cancers.
Neoplasms
Differential enhancing effects of alpha2,8-sialyltransferase on the cell proliferation and mobility.
Neoplasms
Exploring and Exploiting Acceptor Preferences of the Human Polysialyltransferases as a Basis for an Inhibitor Screen.
Neoplasms
Expression of polysialic acid and STX, a human polysialyltransferase, is correlated with tumor progression in non-small cell lung cancer.
Neoplasms
Expression of the mouse WNK1 gene in correlation with ganglioside GD3 and functional analysis of the mouse WNK1 promoter.
Neoplasms
Functional activation of SRC family kinase yes is essential for the enhanced malignant properties of human melanoma cells expressing ganglioside GD3.
Neoplasms
Functional roles of sialylation in breast cancer progression through miR-26a/26b targeting ST8SIA4.
Neoplasms
GD3 Synthase Expression Enhances Proliferation and Tumor Growth of MDA-MB-231 Breast Cancer Cells through c-Met Activation.
Neoplasms
GD3 synthase overexpression sensitizes hepatocarcinoma cells to hypoxia and reduces tumor growth by suppressing the cSrc/NF-kappaB survival pathway.
Neoplasms
GD3 synthase regulates epithelial-mesenchymal transition and metastasis in breast cancer.
Neoplasms
Gene expression of ceramide kinase, galactosyl ceramide synthase and ganglioside GD3 synthase is associated with prognosis in breast cancer.
Neoplasms
Genome-scale detection of hypermethylated CpG islands in circulating cell-free DNA of hepatocellular carcinoma patients.
Neoplasms
Glycolipid composition in bladder tumor: a crucial role of GM3 ganglioside in tumor invasion.
Neoplasms
Glycolipids Recognized by A2B5 Antibody Promote Proliferation, Migration, and Clonogenicity in Glioblastoma Cells.
Neoplasms
Intrabodies against the Polysialyltransferases ST8SiaII and ST8SiaIV inhibit Polysialylation of NCAM in rhabdomyosarcoma tumor cells.
Neoplasms
Knockdown of lncRNA MIR4435?2HG and ST8SIA1 expression inhibits the proliferation, invasion and migration of prostate cancer cells in vitro and in vivo by blocking the activation of the FAK/AKT/??catenin signaling pathway.
Neoplasms
Long noncoding RNA HOTAIR promotes renal cell carcinoma malignancy through alpha-2, 8-sialyltransferase 4 by sponging microRNA-124.
Neoplasms
Loss of Forkhead Box O3 Facilitates Inflammatory Colon Cancer: Transcriptome Profiling of the Immune Landscape and Novel Targets.
Neoplasms
Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer.
Neoplasms
MicroRNA-33a and let-7e inhibit human colorectal cancer progression by targeting ST8SIA1.
Neoplasms
miR-144-5p and miR-451a Inhibit the Growth of Cholangiocarcinoma Cells Through Decreasing the Expression of ST8SIA4.
Neoplasms
miR-146a and miR-146b promote proliferation, migration and invasion of follicular thyroid carcinoma via inhibition of ST8SIA4.
Neoplasms
Novel Nine-Exon AR Transcripts (Exon 1/Exon 1b/Exons 2-8) in Normal and Cancerous Breast and Prostate Cells.
Neoplasms
Pharmacological Inhibition of polysialyltransferase ST8SiaII Modulates Tumour Cell Migration.
Neoplasms
Polysialic acid sustains cancer cell survival and migratory capacity in a hypoxic environment.
Neoplasms
Polysialylation of the neural cell adhesion molecule: interfering with polysialylation and migration in neuroblastoma cells.
Neoplasms
Prognostic significance of polysialic acid expression in resected non-small cell lung cancer.
Neoplasms
Reduced cell migration, tumor growth and experimental metastasis of rat F-11 cells whose expression of GD3-synthase is suppressed.
Neoplasms
ST8SIA1 inhibits the proliferation, migration and invasion of bladder cancer cells by blocking the JAK/STAT signaling pathway.
Neoplasms
ST8SIA1 Regulates Tumor Growth and Metastasis in TNBC by Activating the FAK-AKT-mTOR Signaling Pathway.
Neoplasms
Suppression of ganglioside GD3 expression in a rat F-11 tumor cell line reduces tumor growth, angiogenesis, and vascular endothelial growth factor production.
Neoplasms
The Cooperative Effect between Polybasic Region (PBR) and Polysialyltransferase Domain (PSTD) within Tumor-Target Polysialyltranseferase ST8Sia II.
Neoplasms
TNF differentially regulates ganglioside biosynthesis and expression in breast cancer cell lines.
Neoplasms
Transcriptional regulation of the human Sia-alpha2,3-Gal-beta1,4-GlcNAc-R:alpha2,8-sialyltransferase (hST8Sia III) by retinoic acid in human glioblastoma tumor cell line.
Neoplasms
UVB-irradiated keratinocytes induce melanoma-associated ganglioside GD3 synthase gene in melanocytes via secretion of tumor necrosis factor ? and interleukin 6.
Neoplasms
Valproic acid modulates NCAM polysialylation and polysialyltransferase mRNA expression in human tumor cells.
Neoplasms
Variations in gene expression patterns correlated with phenotype of F-11 tumor cells whose expression of GD3-synthase is suppressed.
Neuroblastoma
A cancer-unique glycan: de-N-acetyl polysialic acid (dPSA) linked to cell surface nucleolin depends on re-expression of the fetal polysialyltransferase ST8SIA2 gene.
Neuroblastoma
Accumulation of Unusual Gangliosides GQ3 and GP3 in Breast Cancer Cells Expressing the GD3 Synthase.
Neuroblastoma
Changes in the ganglioside composition of human neuroblastoma cells under different growth conditions.
Neuroblastoma
Cordycepin-mediated transcriptional regulation of human GD3 synthase (hST8Sia I) in human neuroblastoma SK-N-BE(2)-C cells.
Neuroblastoma
Differential regulation of polysialyltransferase expression during hippocampus development: Implications for neuronal survival.
Neuroblastoma
Effect of N-glycosylation on turnover and subcellular distribution of N-acetylgalactosaminyltransferase I and sialyltransferase II in neuroblastoma cells.
Neuroblastoma
Effects of intronic single nucleotide polymorphisms (iSNPs) of a polysialyltransferase, ST8SIA2 gene found in psychiatric disorders on its gene products.
Neuroblastoma
Expression of the neural cell adhesion molecule and polysialic acid in human neuroblastoma cell lines.
Neuroblastoma
Gangliosides link the acidic sphingomyelinase-mediated induction of ceramide to 12-lipoxygenase-dependent apoptosis of neuroblastoma in response to fenretinide.
Neuroblastoma
Genes modulated by expression of GD3 synthase in Chinese hamster ovary cells. Evidence that the Tis21 gene is involved in the induction of GD3 9-O-acetylation.
Neuroblastoma
Glycosylation pathways in the biosynthesis of gangliosides in melanoma and neuroblastoma cells: relative glycosyltransferase levels determine ganglioside patterns.
Neuroblastoma
Isolation of 10 differentially expressed cDNAs in differentiated Neuro2a cells induced through controlled expression of the GD3 synthase gene.
Neuroblastoma
Polysialic acid engineering: synthesis of polysialylated neoglycosphingolipids by using the polysialyltransferase from neuroinvasive Escherichia coli K1.
Neuroblastoma
Purification of an alpha-2,8-sialyltransferase, a potential initiating enzyme for the biosynthesis of polysialic acid in human neuroblastoma cells.
Neuroblastoma
Regulated expression system for GD3 synthase cDNA and induction of differentiation in Neuro2a cells.
Neuroblastoma
Relationship of glycosyltransferases and mRNA levels to ganglioside expression in neuroblastoma and melanoma cells.
Neuroblastoma
Retinoic acid-induced changes in polysialyltransferase mRNA expression and NCAM polysialylation in human neuroblastoma cells.
Neuroblastoma
Sialidase NEU4 hydrolyzes polysialic acids of neural cell adhesion molecules and negatively regulates neurite formation by hippocampal neurons.
Neuroblastoma
Sialyltransferase levels and ganglioside expression in melanoma and other cultured human cancer cells.
Neuroblastoma
Two polysialic acid synthases, mouse ST8Sia II and IV, synthesize different degrees of polysialic acids on different substrate glycoproteins in mouse neuroblastoma Neuro2a cells.
Neuroblastoma
Unique genomic structure and expression of the mouse alpha 2,8-sialyltransferase (ST8Sia III) gene.
Neuroblastoma
Upregulation of Human ST8Sia VI (?2,8-Sialyltransferase) Gene Expression by Physcion in SK-N-BE(2)-C Human Neuroblastoma Cells.
Neuroblastoma
Valproic Acid Induces Transcriptional Activation of Human GD3 Synthase (hST8Sia I) by in SK-N-BE(2)-C Human Neuroblastoma Cells.
Neuroblastoma
Valproic acid induces transcriptional activation of human GD3 synthase (hST8Sia I) in SK-N-BE(2)-C human neuroblastoma cells.
Neurologic Manifestations
Campylobacter gene polymorphism as a determinant of clinical features of Guillain-Barré syndrome.
Ophthalmoplegia
Campylobacter sialyltransferase gene polymorphism directs clinical features of Guillain-Barré syndrome.
Ophthalmoplegia
[Campylobacter genes responsible for the development and determinant of clinical features of Guillain-Barré syndrome]
Osteosarcoma
Enhancement of malignant properties of human osteosarcoma cells with disialyl gangliosides GD2/GD3.
Pancreatic Neoplasms
Disialoganglioside GD3-synthase over expression inhibits survival and angiogenesis of pancreatic cancer cells through cell cycle arrest at S-phase and disruption of integrin-?1-mediated anchorage.
Paralysis
Relationship of bacterial strains to clinical syndromes of Campylobacter-associated neuropathies.
Pheochromocytoma
GD3 synthase gene expression in PC12 cells results in the continuous activation of TrkA and ERK1/2 and enhanced proliferation.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
High expression of ganglioside alpha-2,8-sialyltransferase (GD3 synthase) gene in adult T-cell leukemia cells unrelated to the gene expression of human T-lymphotropic virus type I.
Prion Diseases
Ganglioside Synthase Knockout Reduces Prion Disease Incubation Time in Mouse Models.
Prostatic Neoplasms
Knockdown of lncRNA MIR4435?2HG and ST8SIA1 expression inhibits the proliferation, invasion and migration of prostate cancer cells in vitro and in vivo by blocking the activation of the FAK/AKT/??catenin signaling pathway.
Prostatic Neoplasms
Novel Nine-Exon AR Transcripts (Exon 1/Exon 1b/Exons 2-8) in Normal and Cancerous Breast and Prostate Cells.
Rhabdomyosarcoma
Intrabodies against the Polysialyltransferases ST8SiaII and ST8SiaIV inhibit Polysialylation of NCAM in rhabdomyosarcoma tumor cells.
Scrapie
Ganglioside Synthase Knockout Reduces Prion Disease Incubation Time in Mouse Models.
Seizures
Differential expression of mRNAs for sialyltransferase isoenzymes induced in the hippocampus of mouse following kindled seizures.
Small Cell Lung Carcinoma
Effects of the regulation of polysialyltransferase ST8SiaII on the invasiveness and metastasis of small cell lung cancer cells.
Spinal Cord Injuries
Engineering polysialic acid on Schwann cells using polysialyltransferase gene transfer or purified enzyme exposure for spinal cord injury transplantation.
Squamous Cell Carcinoma of Head and Neck
Expression of polysialic acid in primary laryngeal squamous cell carcinoma.
Status Epilepticus
Polysialic acid affects pathophysiological consequences of status epilepticus.
Stomach Neoplasms
Decreased expression of alpha2,8 sialyltransferase and increased expression of beta1,4 N-acetylgalactosaminyltransferase in gastrointestinal cancers.
Thyroid Neoplasms
miR-146a and miR-146b promote proliferation, migration and invasion of follicular thyroid carcinoma via inhibition of ST8SIA4.
Triple Negative Breast Neoplasms
Comprehensive Transcriptomic Analysis Identifies ST8SIA1 as a Survival-Related Sialyltransferase Gene in Breast Cancer.
Triple Negative Breast Neoplasms
ST8SIA1 inhibition sensitizes triple negative breast cancer to chemotherapy via suppressing Wnt/?-catenin and FAK/Akt/mTOR.
Tuberculosis
Brucella melitensis and Mycobacterium tuberculosis depict overlapping gene expression patterns induced in infected THP-1 macrophages.
Urinary Bladder Neoplasms
ST8SIA1 inhibits the proliferation, migration and invasion of bladder cancer cells by blocking the JAK/STAT signaling pathway.
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