Information on EC 2.1.1.26 - iodophenol O-methyltransferase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.1.1.26
-
RECOMMENDED NAME
GeneOntology No.
iodophenol O-methyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + 2-iodophenol = S-adenosyl-L-homocysteine + 2-iodophenol methyl ether
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
methyl group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:2-iodophenol O-methyltransferase
-
CAS REGISTRY NUMBER
COMMENTARY hide
37256-95-4
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
no activity in Cavia porcellus
liver
-
-
Manually annotated by BRENDA team
Pigeon
-
-
-
Manually annotated by BRENDA team
Sprague-Dawley rat
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3,5,3',5'-tetraiodothyroacetic acid + S-adenosyl-L-methionine
[4-(4-methoxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-acetic acid + S-adenosyl-L-homocysteine
show the reaction diagram
-
-
-
-
?
3,5,3'-triiodo-L-thyronine + S-adenosyl-L-methionine
3,5,3'-triiodo-O-methyl-L-thyronine + S-adenosyl-L-homocysteine
show the reaction diagram
-
poor substrate
-
-
?
3,5,3'-triiodothyroacetic acid + S-adenosyl-L-methionine
[3,5-diiodo-4-(3-iodo-4-methoxyphenoxy)phenyl]-acetic acid + S-adenosyl-L-homocysteine
show the reaction diagram
-
poor substrate
-
-
?
3,5-diiodo-4-hydroxybenzoic acid + S-adenosyl-L-methionine
3,5-diiodo-4-methoxybenzoic acid + S-adenosyl-L-homocysteine
show the reaction diagram
L-thyroxine + S-adenosyl-L-methionine
3,5,3'5'-tetraiodo-O'-methyl-L-thyronine + S-adenosyl-L-homocysteine
show the reaction diagram
-
poor substrate
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
-
required
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3,5-Diiodo-4-hydroxybenzoic acid
-
substrate inhibition above 0.2 mM
additional information
-
activity is suppressed by extract from microsomal fraction
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ATP
-
required
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0034
3,5-Diiodo-4-hydroxybenzoic acid
-
-
0.0015
S-adenosyl-L-methionine
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0002
-
purified enzyme with 3,5-diiodo-4-hydroxybenzoic acid as substrate
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE