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Literature summary for 2.1.1.26 extracted from
- Enzymic O-methylation of iodinated phenols and thyroide hormones (1964), J. Biol. Chem., 239, 1202-1207.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| ATP | required | Rattus norvegicus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3,5-Diiodo-4-hydroxybenzoic acid | substrate inhibition above 0.2 mM | Rattus norvegicus | |
| additional information | activity is suppressed by extract from microsomal fraction | Rattus norvegicus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0015 | - |
S-adenosyl-L-methionine | - |
Rattus norvegicus | |
| 0.0034 | - |
3,5-Diiodo-4-hydroxybenzoic acid | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| soluble | - |
Rattus norvegicus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| no activity in Cavia porcellus | - |
liver | - |
| Oryctolagus cuniculus | - |
- |
- |
| Pigeon | - |
- |
- |
| Rattus norvegicus | - |
Sprague-Dawley rat | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Rattus norvegicus | - |
| kidney | - |
Oryctolagus cuniculus | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Oryctolagus cuniculus | - |
| liver | - |
Pigeon | - |
| additional information | no activity found in muscle | Oryctolagus cuniculus | - |
| additional information | no activity found in muscle | Pigeon | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0002 | - |
purified enzyme with 3,5-diiodo-4-hydroxybenzoic acid as substrate | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3,5,3',5'-tetraiodothyroacetic acid + S-adenosyl-L-methionine | - |
Rattus norvegicus | [4-(4-methoxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-acetic acid + S-adenosyl-L-homocysteine | - |
? | |
| 3,5,3'-triiodo-L-thyronine + S-adenosyl-L-methionine | poor substrate | Rattus norvegicus | 3,5,3'-triiodo-O-methyl-L-thyronine + S-adenosyl-L-homocysteine | - |
? | |
| 3,5,3'-triiodothyroacetic acid + S-adenosyl-L-methionine | poor substrate | Rattus norvegicus | [3,5-diiodo-4-(3-iodo-4-methoxyphenoxy)phenyl]-acetic acid + S-adenosyl-L-homocysteine | - |
? | |
| 3,5-diiodo-4-hydroxybenzoic acid + S-adenosyl-L-methionine | DIB is the most effective substrate | Rattus norvegicus | 3,5-diiodo-4-methoxybenzoic acid + S-adenosyl-L-homocysteine | - |
? | |
| 3,5-diiodo-4-hydroxybenzoic acid + S-adenosyl-L-methionine | DIB is the most effective substrate | Oryctolagus cuniculus | 3,5-diiodo-4-methoxybenzoic acid + S-adenosyl-L-homocysteine | - |
? | |
| 3,5-diiodo-4-hydroxybenzoic acid + S-adenosyl-L-methionine | DIB is the most effective substrate | Pigeon | 3,5-diiodo-4-methoxybenzoic acid + S-adenosyl-L-homocysteine | - |
? | |
| L-thyroxine + S-adenosyl-L-methionine | poor substrate | Rattus norvegicus | 3,5,3'5'-tetraiodo-O'-methyl-L-thyronine + S-adenosyl-L-homocysteine | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6 | - |
- |
Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5.2 | 8 | - |
Rattus norvegicus |
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