Information on EC 1.8.4.B3 - thioredoxin-independent methionine sulfoxide reductases B

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.8.4.B3
preliminary BRENDA-supplied EC number
RECOMMENDED NAME
GeneOntology No.
thioredoxin-independent methionine sulfoxide reductases B
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
peptide-L-methionine-(R)-S-sulfoxide + thionein = peptide-L-methionine + thionein disulfide + H2O
show the reaction diagram
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-
-
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
precursor, fragment
SwissProt
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
dabsyl-L-methionine (R)-S-sulfoxide + bovine liver thionein
dabsyl-L-methionine + bovine liver thionein + H2O
show the reaction diagram
NtMsrB1
-
-
?
dabsyl-L-methionine (R)-S-sulfoxide + dithiothreitol
dabsyl-L-methionine + dithiothreitol disulfide + H2O
show the reaction diagram
NtMsrB1
-
-
?
dabsyl-L-methionine (R)-S-sulfoxide + plant Trx-like protein CDSP32
dabsyl-L-methionine + ?
show the reaction diagram
NtMsrB1
-
-
?
dabsyl-L-methionine (R)-S-sulfoxide + selenocysteamine
dabsyl-L-methionine + 2,2'-disulfanediyldiethanamine + H2O
show the reaction diagram
NtMsrB1
-
-
?
L-methionine (R)-S-sulfoxide + dithiothreitol
L-methionine + dithiothreitol disulfide + H2O
show the reaction diagram
-
-
-
?
L-methionine (R)-S-sulfoxide + thionein
L-methionine + thionein disulfide + H2O
show the reaction diagram
-
-
-
?
L-methionine (R)-S-sulfoxide + thioredoxin
L-methionine + thioredoxin disulfide
show the reaction diagram
reduced thioredoxin is not an efficient reducing agent for hMsrB3. Less than 5% of the activity with dithiothreitol
-
-
?
L-methionine (R)-S-sulfoxide + thioredoxin
L-methionine + thioredoxin disulfide + H2O
show the reaction diagram
reduced thioredoxin is not an efficient reducing agent for hMsrB2. Less than 5% of the activity with dithiothreitol
-
-
?
L-methionine (R)-sulfoxide + dithiothreitol
L-methionine + dithiothreitol disulfide
show the reaction diagram
-
-
-
?
peptide-L-methionine-(R)-S-sulfoxide + thionein
peptide-L-methionine + thionein disulfide + H2O
show the reaction diagram
-
-
-
?
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
peptide-L-methionine-(R)-S-sulfoxide + thionein
peptide-L-methionine + thionein disulfide + H2O
show the reaction diagram
A7U630
-
-
-
?
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
15200
x * 15200, calculated from sequence
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 15200, calculated from sequence
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli BL21