Disease on EC 1.5.1.20 - methylenetetrahydrofolate reductase [NAD(P)H]
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Abruptio Placentae
Placenta-mediated pregnancy complications are not associated with fetal or paternal factor V Leiden mutation.
Alzheimer Disease
High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased K(m)): relevance to genetic disease and polymorphisms.
Antiphospholipid Syndrome
[Mutations of genes associated with thromboses in ischemic stroke in patients with primary antiphospholipid syndrome]
Arthritis, Rheumatoid
Associations between the genetic polymorphisms of MTHFR and outcomes of methotrexate treatment in rheumatoid arthritis.
Atherosclerosis
Expression of the C677T Polymorphism of the 5, 10-Methylenetetrahydrofolate Reductase (MTHFR) Gene in Patients with Carotid Artery Atherosclerosis.
Atherosclerosis
The effects of diet, genetics and chemicals on toxicity and aberrant DNA methylation: an introduction.
Cardiovascular Diseases
High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased K(m)): relevance to genetic disease and polymorphisms.
Cardiovascular Diseases
Thermolabile methylenetetrahydrofolate reductase, homocysteine, and cardiovascular disease risk: the European Concerted Action Project.
Cerebral Infarction
Association of plasma homocysteine level and N5,N10-methylenetetrahydrofolate reductase gene polymorphism with cerebral infarction.
Cerebrovascular Disorders
[Mutations of genes associated with thromboses in ischemic stroke in patients with primary antiphospholipid syndrome]
Congenital Abnormalities
The effects of diet, genetics and chemicals on toxicity and aberrant DNA methylation: an introduction.
Coronary Artery Disease
Genetic polymorphism of MTHFR C677T and premature coronary artery disease susceptibility: A meta-analysis.
Coronary Artery Disease
The TT genotype of the methylenetetrahydrofolate reductase C677T gene polymorphism is associated with the extent of coronary atherosclerosis in patients at high risk for coronary artery disease.
Coronary Artery Disease
[Gene Polymorphism of 5, 10-methylenetetrahydrofolate reductase as a coronary risk factor]
Coronary Disease
The TT genotype of the methylenetetrahydrofolate reductase C677T gene polymorphism is associated with the extent of coronary atherosclerosis in patients at high risk for coronary artery disease.
COVID-19
Life-threatening course in coronavirus disease 2019 (COVID-19): Is there a link to methylenetetrahydrofolic acid reductase (MTHFR) polymorphism and hyperhomocysteinemia?
Craniosynostoses
Methylenetetrahydrofolate reductase C677T variant in Indian children with craniosynostosis: Its role in the pathogenesis, risk of craniosynostosis.
Dementia
Association of the transcobalamin II gene 776C?G polymorphism with Alzheimer's type dementia: dependence on the 5, 10-methylenetetrahydrofolate reductase 1298A?C polymorphism genotype.
Epilepsy
Haplotype analysis of the folate-related genes MTHFR, MTRR, and MTR and migraine with aura.
Favism
High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased K(m)): relevance to genetic disease and polymorphisms.
Fetal Growth Retardation
Placenta-mediated pregnancy complications are not associated with fetal or paternal factor V Leiden mutation.
Heart Defects, Congenital
Association between 5, 10-methylenetetrahydrofolate reductase (MTHFR) polymorphisms and congenital heart disease: A meta-analysis.
Hematologic Neoplasms
[A new method for 5, 10-methylenetetrahydrofolate reductase single nucleotide polymorphisms genotyping used to study susceptibility of hematological malignancy]
Homocystinuria
Infantile type of homocystinuria with N5,10-methylenetetrahydrofolate reductase defect.
Homocystinuria
Morphologic studies in a patient with homocystinuria due to 5, 10-methylenetetrahydrofolate reductase deficiency.
Hyperhomocysteinemia
A common mutation in methylenetetrahydrofolate reductase gene among the Japanese population.
Hyperhomocysteinemia
A common mutation in the 5,10-methylenetetrahydrofolate reductase gene as a new risk factor for placental vasculopathy.
Infertility, Male
A Association of MTHFR C677T and MTRR A66G Gene Polymorphisms with Iranian Male Infertility and Its Effect on Seminal Folate and Vitamin B12.
Ischemic Stroke
Genetic analysis of the thermolabile variant of 5, 10-methylenetetrahydrofolate reductase as a risk factor for ischemic stroke.
Meningomyelocele
Folate metabolism gene 5,10-methylenetetrahydrofolate reductase (MTHFR) is associated with ADHD in myelomeningocele patients.
methylenetetrahydrofolate reductase [nad(p)h] deficiency
Morphologic studies in a patient with homocystinuria due to 5, 10-methylenetetrahydrofolate reductase deficiency.
Migraine Disorders
Haplotype analysis of the folate-related genes MTHFR, MTRR, and MTR and migraine with aura.
Migraine Disorders
High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased K(m)): relevance to genetic disease and polymorphisms.
Migraine with Aura
Haplotype analysis of the folate-related genes MTHFR, MTRR, and MTR and migraine with aura.
Myocardial Infarction
The TT genotype of the methylenetetrahydrofolate reductase C677T gene polymorphism is associated with the extent of coronary atherosclerosis in patients at high risk for coronary artery disease.
Neoplasms
Loss of heterozygosity at the 5,10-methylenetetrahydrofolate reductase locus in human ovarian carcinomas.
Nervous System Diseases
The effects of diet, genetics and chemicals on toxicity and aberrant DNA methylation: an introduction.
Neural Tube Defects
Association of the 677C-->T mutation on the methylenetetrahydrofolate reductase gene in Turkish patients with neural tube defects.
Osteonecrosis
Lack of association of MTHFR gene polymorphisms with the risk of osteonecrosis of the femoral head in a Korean population.
Pre-Eclampsia
Candidate gene study of genetic thrombophilic polymorphisms in pre-eclampsia and recurrent pregnancy loss in Sinhalese women.
Pre-Eclampsia
Placenta-mediated pregnancy complications are not associated with fetal or paternal factor V Leiden mutation.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Association between MTHFR C677T Polymorphism and Risk of Acute Lymphoblastic Leukemia: A Meta-Analysis Based on 51 Case-Control Studies.
Riboflavin Deficiency
The effect of riboflavin deficiency on methylenetetrahydrofolate reductase (NADPH) (EC 1.5.1.20) and folate metabolism in the rat.
Spinal Dysraphism
[Frequency of C677T polymorphism of 5, 10-methylenetetrahydrofolate reductase (MTHFR) in Chilean mothers of spina bifida cases and controls ]
Starvation
Genetic diversity and population structure of food-borne Staphylococcus carnosus strains.
Stillbirth
Placenta-mediated pregnancy complications are not associated with fetal or paternal factor V Leiden mutation.
Thrombophilia
MTHFR (C677T, A1298C), FV Leiden polymorphisms, and the prothrombin G20210A mutation in arterial ischemic stroke among young tunisian adults.
Thrombophilia
Placenta-mediated pregnancy complications are not associated with fetal or paternal factor V Leiden mutation.
Thrombosis
Methylenetetrahydrofolate reductase gene C677T mutation and plasma homocysteine level in Behçet's disease.
Thrombosis
Prevalence of the C677T methylenetetra- hydrofolate reductase mutation in Thai patients with deep vein thrombosis.
Tuberculosis
bis-Molybdopterin guanine dinucleotide is required for persistence of Mycobacterium tuberculosis in guinea pigs.
Uterine Cervical Neoplasms
Allelic variations in 5, 10-methylenetetrahydrofolate reductase gene and susceptibility to cervical cancer in Indian women.
Venous Thromboembolism
Lack of association of MTHFR gene polymorphisms with the risk of osteonecrosis of the femoral head in a Korean population.
Venous Thrombosis
Methylenetetrahydrofolate reductase gene C677T mutation and plasma homocysteine level in Behçet's disease.
Venous Thrombosis
Prevalence of the C677T methylenetetra- hydrofolate reductase mutation in Thai patients with deep vein thrombosis.
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