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Disease on EC 1.14.18.1 - tyrosinase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acquired Immunodeficiency Syndrome
Carbohydrates act as sorting determinants in ER-associated degradation of tyrosinase.
Adenocarcinoma
The role of the detection of hematogenous micrometastasis in prostate adenocarcinoma and malignant melanoma by RT-PCR.
Adrenal Hyperplasia, Congenital
Steroid 21-hydroxylase deficiency: three additional mutated alleles and establishment of phenotype-genotype relationships of common mutations.
Albinism
A form of albinism in cattle is caused by a tyrosinase frameshift mutation.
A nonsense mutation in the tyrosinase gene causes albinism in water buffalo.
A novel nonsense mutation in the tyrosinase gene is related to the albinism in a capuchin monkey (Sapajus apella).
A novel P gene missense mutation in a Japanese patient with oculocutaneous albinism type II (OCA2).
A point mutation in the tyrosinase gene of BALB/c albino mouse causing the cysteine----serine substitution at position 85.
A study of murine albinism using tyrosinase cDNA.
A transgenic mouse model with inducible Tyrosinase gene expression using the tetracycline (Tet-on) system allows regulated rescue of abnormal chiasmatic projections found in albinism.
A trinucleotide deletion together with a base duplication event at codon 439 in the human tyrosinase gene identifies a mutational hotspot.
A Tyrosinase missense mutation causes albinism in the Wistar rat.
AAV-mediated Tyrosinase Gene Transfer Restores Melanogenesis and Retinal Function in a Model of Oculo-cutaneous Albinism Type I (OCA1).
Advances in fluorescent probes for detection and imaging of endogenous tyrosinase activity.
Albinism and amelanotic melanoma: occurrence in a child with positive test results for tyrosinase.
Albinism and its implications with vision.
Albinism in a Suffolk sheep.
Albinism in Africa: stigma, slaughter and awareness campaigns.
Albinism in the American mink (Neovison vison) is associated with a tyrosinase nonsense mutation.
Albinism in the domestic cat (Felis catus) is associated with a tyrosinase (TYR) mutation.
Aminoluciferin 4-hydroxyphenyl amide enables bioluminescence detection of endogenous tyrosinase.
Analysis of tyrosinase gene mutations using direct automated infrared fluorescence DNA sequencing of amplified exons.
Assessment of tyrosinase variants and skin cancer risk in a large cohort of French subjects.
Base substitution at different alternative splice donor sites of the tyrosinase gene in murine albinism.
Boundary sequences flanking the mouse tyrosinase locus ensure faithful pattern of gene expression.
Cas9 ribonucleoprotein complex allows direct and rapid analysis of coding and noncoding regions of target genes in Pleurodeles waltl development and regeneration.
Catalysis-based specific detection and inhibition of tyrosinase and their application.
Characterization of human hairbulb tyrosinase: properties of normal and albino enzyme.
Classification of albinism in man.
Comparative genetics of albinism.
Comparative metabolism of copper.
Computational analysis of histidine mutations on the structural stability of human tyrosinases leading to albinism insurgence.
Conversations with ray Guillery on albinism: linking Siamese cat visual pathway connectivity to mouse retinal development.
Correction of abnormal retinal pathways found with albinism by introduction of a functional tyrosinase gene in transgenic mice.
Correction of retinal abnormalities found in albinism by introduction of a functional tyrosinase gene in transgenic mice and rabbits.
CRISPR/Cas9 engineering of albino cystinuria Type A mice.
CRISPR/Cas9-mediated mutation of tyrosinase (Tyr) 3' UTR induce graying in rabbit.
Detection of 53 novel DNA variations within the tyrosinase gene and accumulation of mutations in 17 patients with albinism.
Determination of tyrosinase substrate-binding modes reveals mechanistic differences between type-3 copper proteins.
Distinguishing between the catalytic potential and apparent expression of tyrosinase activities.
Do pigmented naevi in albinism provide evidence of tyrosinase positivity?
Ectopic expression of tyrosine hydroxylase in the pigmented epithelium rescues the retinal abnormalities and visual function common in albinos in the absence of melanin.
Efficient generation of transgenic mice with intact yeast artificial chromosomes by intracytoplasmic sperm injection.
Expression of tyrosinase gene in amelanotic mutant mice.
Free radical reduction in the human epidermis.
Functional analysis of alternatively spliced tyrosinase gene transcripts.
Functional assessment of tyrosinase variants identified in individuals with albinism is essential for unequivocal determination of genotype to phenotype correlation.
FVB.129P2-Pde6b(+) Tyr(c-ch)/Ant, a sighted variant of the FVB/N mouse strain suitable for behavioral analysis.
Genetic diseases of copper metabolism.
Highly efficient bi-allelic mutation rates using TALENs in Xenopus tropicalis.
Identification of a functionally significant tri-allelic genotype in the Tyrosinase gene (TYR) causing hypomorphic oculocutaneous albinism (OCA1B).
Identification of a tyrosinase (TYR) exon 4 deletion in albino ferrets (Mustela putorius furo).
Identification of TYR mutations in patients with oculocutaneous albinism.
Initiation codon mutation of the tyrosinase gene as a cause of human albinism.
Insertional mutagenesis by a hybrid piggyBac and sleeping beauty transposon in the rat.
Investigation of a case of oculocutaneous albinism.
Investigation of albinism genes in congenital esotropia.
l-tyrosine induces melanocyte differentiation in novel pink-eyed dilution castaneus mouse mutant showing age-related pigmentation.
Molecular cloning and expression analysis of tyr and tyrp1 genes in normal and albino yellow catfish Tachysurus fulvidraco.
Molecular cloning, gene expression in albino mutants and gene knockdown studies of tyrosinase mRNA in rainbow trout.
Murine and human b locus pigmentation genes encode a glycoprotein (gp75) with catalase activity.
Mutational spectrum of the TYR and SLC45A2 genes in Pakistani families with oculocutaneous albinism, and potential founder effect of missense substitution (p.Arg77Gln) of tyrosinase.
New animal models to study the role of tyrosinase in normal retinal development.
Oculocutaneous albinism type 1: link between mutations, tyrosinase conformational stability, and enzymatic activity.
Oculocutaneous albinism type 1: the last 100 years.
One-year pilot study on the effects of nitisinone on melanin in patients with OCA-1B.
Phenotypic rescue of the albino mutation in the medakafish (Oryzias latipes) by a mouse tyrosinase transgene.
Prenatal diagnosis of oculocutaneous albinism by analysis of the fetal tyrosinase gene.
Simple and efficient CRISPR/Cas9-mediated targeted mutagenesis in Xenopus tropicalis.
Structural insight with mutational impact on tyrosinase and PKC-? interaction from Homo sapiens: Molecular modeling and docking studies for melanogenesis, albinism and increased risk for melanoma.
The albinism of the feral Asinara white donkeys (Equus asinus) is determined by a missense mutation in a highly conserved position of the tyrosinase (TYR) gene deduced protein.
The ocular albinism type 1 (OA1) gene controls melanosome maturation and size.
The R402Q tyrosinase variant does not cause autosomal recessive ocular albinism.
The tyrosinase gene in gorillas and the albinism of 'Snowflake'.
Translation rate of human tyrosinase determines its N-linked glycosylation level.
Tyrosinase and Albinism.
Tyrosinase expression during neuroblast divisions affects later pathfinding by retinal ganglion cells.
Tyrosinase inhibition: its role in suntanning and in albinism.
Tyrosinase positive albinism with familial 46,XY,t(2;4) (q31.2;q31.22) balanced translocation.
Tyrosinase processing and intracellular trafficking is disrupted in mouse primary melanocytes carrying the underwhite (uw) mutation. A model for oculocutaneous albinism (OCA) type 4.
Tyrosinases of murine melanocytes with mutations at the albino locus.
Visualization of Intracellular Tyrosinase Activity in vitro.
Vitiligo.
White mutants in mice shedding light on humans.
Yellow mutant albinism: cytochemical, ultrastructural, and genetic characterization suggesting multiple allelism.
[Cellular and molecular features of mammalian pigmentation--tyrosinase and TRP]
[The relationship among human, gorilla, chimpanzee and orangutan]
Albinism, Ocular
Albinism, or the NOACH syndrome (the book of Enoch c.v. 1-20).
Autosomal recessive ocular albinism associated with a functionally significant tyrosinase gene polymorphism.
Interaction between G Protein-Coupled Receptor 143 and Tyrosinase: Implications for Understanding Ocular Albinism Type 1.
Molecular basis of albinism: mutations and polymorphisms of pigmentation genes associated with albinism.
Mutations of the P gene in oculocutaneous albinism, ocular albinism, and Prader-Willi syndrome plus albinism.
Ocular manifestations of metabolic disorders.
Periodic alternating nystagmus in humans with albinism.
Sequence analysis of tyrosinase gene in ocular and oculocutaneous albinism patients: introducing three novel mutations.
The ocular albinism type 1 (OA1) gene controls melanosome maturation and size.
The R402Q tyrosinase variant does not cause autosomal recessive ocular albinism.
Albinism, Oculocutaneous
A common temperature-sensitive allelic form of human tyrosinase is retained in the endoplasmic reticulum at the nonpermissive temperature.
A dinucleotide deletion (-delta GA115) in the tyrosinase gene responsible for type I-A (tyrosinase negative) oculocutaneous albinism in a Pakistani individual.
A frequent tyrosinase gene mutation associated with type I-A (tyrosinase-negative) oculocutaneous albinism in Puerto Rico.
A frequent tyrosinase gene mutation in classic, tyrosinase-negative (type IA) oculocutaneous albinism.
A genome-wide scan study identifies a single nucleotide substitution in the tyrosinase gene associated with white coat colour in a red deer (Cervus elaphus) population.
A nonsense mutation in the tyrosinase gene of Afghan patients with tyrosinase negative (type IA) oculocutaneous albinism.
A novel missense mutation of the TYR gene in a pedigree with oculocutaneous albinism type 1 from China.
A novel mutation (delAACT) in the tyrosinase gene in a Cameroonian black with type 1A oculocutaneous albinism.
A novel mutation of the tyrosinase gene causing oculocutaneous albinism type 1 (OCA1).
A single base insertion in the putative transmembrane domain of the tyrosinase gene as a cause for tyrosinase-negative oculocutaneous albinism.
A splicing mutation of the tyrosinase gene causes yellow oculocutaneous albinism in a Japanese patient with a pigmented phenotype.
A transgenic mouse model with inducible Tyrosinase gene expression using the tetracycline (Tet-on) system allows regulated rescue of abnormal chiasmatic projections found in albinism.
A tyrosinase gene missense mutation in temperature-sensitive type I oculocutaneous albinism. A human homologue to the Siamese cat and the Himalayan mouse.
African origin of an intragenic deletion of the human P gene in tyrosinase positive oculocutaneous albinism.
Albinism, or the NOACH syndrome (the book of Enoch c.v. 1-20).
Albinism-causing mutations in recombinant human tyrosinase alter intrinsic enzymatic activity.
Analysis of mutations in the copper B binding region associated with type I (tyrosinase-related) oculocutaneous albinism.
Analysis of tyrosinase mutations associated with tyrosinase-related oculocutaneous albinism (OCA1).
Biallelic genome modification in F(0) Xenopus tropicalis embryos using the CRISPR/Cas system.
C-terminus glycans with critical functional role in the maturation of secretory glycoproteins.
Characterization of a bystander effect induced by the endocrine-disrupting chemical 6-propyl-2-thiouracil in zebrafish embryos.
Characterization of Temperature-Dependent Kinetics of Oculocutaneous Albinism-Causing Mutants of Tyrosinase.
Cloning and sequence analysis of the tyrosinase gene from a patient with tyrosinase-positive oculocutaneous albinism.
Coexpression of wild-type tyrosinase enhances maturation of temperature-sensitive tyrosinase mutants.
Comment on homozygosity mapping of a consanguineous Pakistani family affected with oculocutaneous albinism to Tyrosinase gene.
Comparative genetics of albinism.
Detection of 53 novel DNA variations within the tyrosinase gene and accumulation of mutations in 17 patients with albinism.
Detection of heterozygotes for tyrosinase-negative oculocutaneous albinism by hairbulb tyrosinase assay.
Detection of mutations in the tyrosinase gene in a patient with type IA oculocutaneous albinism.
Determination of variants in the 3'-region of the Tyrosinase gene requires locus specific amplification.
Diagnosis of oculocutaneous albinism with molecular analysis.
DNA-based prenatal diagnosis of a Korean family with tyrosinase-related oculocutaneous albinism (OCA1).
Dynamic analysis of human tyrosinase intra-melanosomal domain and mutant variants to further understand oculocutaneous albinism type 1.
Endoplasmic reticulum retention is a common defect associated with tyrosinase-negative albinism.
Establishment of tyrosinase sequence database in normally pigmented Indians and Japanese for rapid determination of novel mutations.
Five novel mutations in tyrosinase gene of Japanese and Indian patients with oculocutaneous albinism type I (OCA1).
Functional assessment of tyrosinase variants identified in individuals with albinism is essential for unequivocal determination of genotype to phenotype correlation.
Functional in silico analysis of human tyrosinase and OCA1 associated mutations.
Functional validation of the albinism-associated tyrosinase T373K SNP by CRISPR/Cas9-mediated homology-directed repair (HDR) in rabbits.
Genetic mapping of the dominant albino locus in rainbow trout (Oncorhynchus mykiss).
Genetics of pigmentation in skin cancer--a review.
Hairbulb tyrosinase activity in oculocutaneous albinism.
Hairbulb tyrosinase activity in oculocutaneous albinism: suggestions for pathway control and block location.
Heterologous expression of tyrosinase recapitulates the misprocessing and mistrafficking in oculocutaneous albinism type 2: Effects of altering intracellular pH and pink-eyed dilution gene expression.
Homozygosity mapping of a consanguineous Pakistani family affected with oculocutaneous albinism to Tyrosinase gene.
Homozygous tyrosinase gene mutation in an American black with tyrosinase-negative (type IA) oculocutaneous albinism.
Human oculocutaneous albinism caused by single base insertion in the tyrosinase gene.
Human tyrosinase gene, mapped to chromosome 11 (q14----q21), defines second region of homology with mouse chromosome 7.
Human Tyrosinase: Temperature-Dependent Kinetics of Oxidase Activity.
Identification and characterization of a DNase hypersensitive region of the human tyrosinase gene.
Identification of a functionally significant tri-allelic genotype in the Tyrosinase gene (TYR) causing hypomorphic oculocutaneous albinism (OCA1B).
Identification of a missense mutation in the tyrosinase gene in a Chinese family with oculocutaneous albinism type 1.
Identification of genes from a schizophrenia-linked translocation breakpoint region.
Initiation codon mutation of the tyrosinase gene as a cause of human albinism.
Insertion/deletion mutations of type I oculocutaneous albinism in chinese patients from Taiwan.
Interactions between SNP alleles at multiple loci contribute to skin color differences between caucasoid and mongoloid subjects.
Loss of Oca2 disrupts the unfolded protein response and increases resistance to endoplasmic reticulum stress in melanocytes.
Minimal Efficacy of Nitisinone Treatment in a Novel Mouse Model of Oculocutaneous Albinism, Type 3.
Misrouting of tyrosinase with a truncated cytoplasmic tail as a result of the murine platinum (cp) mutation.
Molecular analyses of a tyrosinase-negative albino family.
Molecular analysis of the DNA segments cross-hybridizable to the tyrosinase gene in patients affected with oculocutaneous albinism.
Molecular analysis of type I-A (tyrosinase negative) oculocutaneous albinism.
Molecular and Functional Studies of Tyrosinase Variants Among Indian Oculocutaneous Albinism Type 1 Patients.
Molecular bases of congenital hypopigmentary disorders in humans and oculocutaneous albinism 1 in Japan.
Molecular bases of tyrosinase-negative oculocutaneous albinism: a single base insertion or a missense point mutation in the tyrosinase gene.
Molecular basis of albinism in the rhesus monkey.
Molecular basis of oculocutaneous albinism type 1 in Lebanese patients.
Molecular basis of type I (tyrosinase-related) oculocutaneous albinism: mutations and polymorphisms of the human tyrosinase gene.
Molecular basis of type IA (tyrosinase negative) oculocutaneous albinism.
Molecular basis of tyrosinase-negative oculocutaneous albinism. A single base mutation in the tyrosinase gene causing arginine to glutamine substitution at position 59.
Mutation analysis of the tyrosinase gene in oculocutaneous albinism.
Mutation in and lack of expression of tyrosinase-related protein-1 (TRP-1) in melanocytes from an individual with brown oculocutaneous albinism: a new subtype of albinism classified as "OCA3".
Mutational analysis of copper binding by human tyrosinase.
Mutational mapping of the catalytic activities of human tyrosinase.
Mutational spectrum of the TYR and SLC45A2 genes in Pakistani families with oculocutaneous albinism, and potential founder effect of missense substitution (p.Arg77Gln) of tyrosinase.
Mutations at critical N-glycosylation sites reduce tyrosinase activity by altering folding and quality control.
Mutations of the human tyrosinase gene associated with tyrosinase related oculocutaneous albinism (OCA1). Mutations in brief no. 204. Online.
Mutations of the P gene in oculocutaneous albinism, ocular albinism, and Prader-Willi syndrome plus albinism.
Mutations of the tyrosinase gene in Indo-Pakistani patients with type I (tyrosinase-deficient) oculocutaneous albinism (OCA).
Mutations of the tyrosinase gene in oculocutaneous albinism.
Mutations of the tyrosinase gene in patients with oculocutaneous albinism from various ethnic groups in Israel.
Mutations of the tyrosinase gene in three Korean patients with type I oculocutaneous albinism.
New animal models to study the role of tyrosinase in normal retinal development.
Nitisinone improves eye and skin pigmentation defects in a mouse model of oculocutaneous albinism.
Non-random distribution of missense mutations within the human tyrosinase gene in type I (tyrosinase-related) oculocutaneous albinism.
Novel Hypomorphic Alleles of the Mouse Tyrosinase Gene Induced by CRISPR-Cas9 Nucleases Cause Non-Albino Pigmentation Phenotypes.
Novel mutations of the tyrosinase (TYR) gene in type I oculocutaneous albinism (OCA1).
Nucleotide sequence of the putative human tyrosinase pseudogene.
OCA1 in different ethnic groups of india is primarily due to founder mutations in the tyrosinase gene.
Ocular albinism with absent foveal pits but without nystagmus, photophobia, or severely reduced vision.
Ocular findings in patients with oculocutaneous albinism type ia with G47D tyrosinase gene mutation in Puerto Rico: a case report.
Ocular motor behaviour of monozygotic twins with tyrosinase negative oculocutaneous albinism.
Oculocutaneous albinism and analysis of tyrosinase gene in Japanese patients.
Oculocutaneous albinism in Suncus murinus: establishment of a strain and identification of its responsible gene.
Oculocutaneous albinism in the i6 mutant of the medaka fish is associated with a deletion in the tyrosinase gene.
Oculocutaneous albinism type 1: link between mutations, tyrosinase conformational stability, and enzymatic activity.
Oculocutaneous albinism type 1: the last 100 years.
Oculocutaneous albinism type 1B associated with a functionally significant tyrosinase gene polymorphism detected with Whole Exome Sequencing.
Oculocutaneous albinism types 1 and 3 are ER retention diseases: mutation of tyrosinase or Tyrp1 can affect the processing of both mutant and wild-type proteins.
One-allele system in the Korean for MboI-RFLP in exon 1 of the human tyrosinase (TYR) gene.
Ophthalmic features of minimal pigment oculocutaneous albinism.
Pathogenesis of the platinum (cp) mutation, a model for oculocutaneous albinism.
Periodic alternating nystagmus in humans with albinism.
Polymorphic sequences of the tyrosinase gene: allele analysis on 16 OCA1 patients in Japan indicate that three polymorphic sequences in the tyrosinase gene promoter could be powerful markers for indirect gene diagnosis.
Prenatal diagnosis of oculocutaneous albinism by analysis of the fetal tyrosinase gene.
Prenatal diagnosis of oculocutaneous albinism type I: review and personal experience.
Prevalent and novel mutations of the tyrosinase gene in Korean patients with tyrosinase-deficient oculocutaneous albinism.
Progressive retinal degeneration in a girl with Knobloch syndrome who presented with signs of ocular albinism.
Purification of Recombinant Human Tyrosinase from Insect Larvae Infected with the Baculovirus Vector.
R278TER and P431L mutations of the tyrosinase gene exist in Japanese patients with tyrosinase-negative oculocutaneous albinism.
Reduced glutathione disrupts the intracellular trafficking of tyrosinase and tyrosinase-related protein-1 but not dopachrome tautomerase and Pmel17 to melanosomes, which results in the attenuation of melanization.
Role of the ubiquitin proteasome system in regulating skin pigmentation.
Sequence analysis of the human tyrosinase promoter from a patient with tyrosinase-negative oculocutaneous albinism.
Sequence analysis of tyrosinase gene in ocular and oculocutaneous albinism patients: introducing three novel mutations.
Sequence-based diagnosis of tyrosinase-related oculocutaneous albinism: successful sequence analysis of the tyrosinase gene from blood spots dried on filter paper.
Soluble tyrosinase is an endoplasmic reticulum (ER)-associated degradation substrate retained in the ER by calreticulin and BiP/GRP78 and not calnexin.
Targeted Base Editing via RNA-Guided Cytidine Deaminases in Xenopus laevis Embryos.
Technical advances in prenatal diagnosis of tyrosinase-negative oculocutaneous albinism.
Temperature sensitive oculocutaneous albinism associated with missense changes in the tyrosinase gene.
Temperature-sensitive tyrosinase associated with peripheral pigmentation in oculocutaneous albinism.
The etiology of oculocutaneous albinism (OCA) type II: the pink protein modulates the processing and transport of tyrosinase.
The molecular basis of oculocutaneous albinism type 1 (OCA1): sorting failure and degradation of mutant tyrosinases results in a lack of pigmentation.
The R402Q tyrosinase variant does not cause autosomal recessive ocular albinism.
The tyrosinase gene and oculocutaneous albinism type 1 (OCA1): A model for understanding the molecular biology of melanin formation.
Three different frameshift mutations of the tyrosinase gene in type IA oculocutaneous albinism.
Two novel tyrosinase (TYR) gene mutations with pathogenic impact on oculocutaneous albinism type 1 (OCA1).
Type I oculocutaneous albinism associated with a full-length deletion of the tyrosinase gene.
Tyrosinase (TYR) gene sequencing and literature review reveals recurrent mutations and multiple population founder gene mutations as causative of oculocutaneous albinism (OCA) in Pakistani families.
Tyrosinase and ocular diseases: some novel thoughts on the molecular basis of oculocutaneous albinism type 1.
Tyrosinase gene (TYR) mutations in Chinese patients with oculocutaneous albinism type 1.
Tyrosinase gene analysis in Japanese patients with oculocutaneous albinism.
Tyrosinase gene mutations associated with type IB ("yellow") oculocutaneous albinism.
Tyrosinase gene mutations causing oculocutaneous albinisms.
Tyrosinase gene mutations in oculocutaneous albinism 1 (OCA1): definition of the phenotype.
Tyrosinase gene mutations in type I (tyrosinase-deficient) oculocutaneous albinism define two clusters of missense substitutions.
Tyrosinase positive albinism with familial 46,XY,t(2;4) (q31.2;q31.22) balanced translocation.
Tyrosinase positive oculocutaneous albinism among the Zuni and the Brandywine triracial isolate: biochemical and clinical characteristics and fertility.
Tyrosinase processing and intracellular trafficking is disrupted in mouse primary melanocytes carrying the underwhite (uw) mutation. A model for oculocutaneous albinism (OCA) type 4.
Visual acuity development in tyrosinase negative oculocutaneous albinism.
Visual evoked potentials in Negro carriers of the gene for tyrosinase positive oculocutaneous albinism.
White mutants in mice shedding light on humans.
Yellow mutant albinism: cytochemical, ultrastructural, and genetic characterization suggesting multiple allelism.
[Early prenatal genetic diagnosis of oculocutaneous albinism type I in seven families].
[Mouse model of tyrosinase positive type oculocutaneous albinism (chinchilla mouse, Cch/Cch) : tyrosinase activity and ultrastructure of hair bulb melanocyte (author's transl)]
[Mutation screening of the TYR and P gene in three patients with oculocutaneous albinism]
[New nonsense mutation (p.E250X) in the tyrosinase gene of a patient with oculocutaneous albinism type 1A]
[Oculocutaneous albinism in French overseas territories (Reunion, French Guyana, Martinique) and Mayotte. Study of 21 cases in 16 families]
[Prenatal diagnosis of cutaneous genetic diseases by the study of fetal DNA]
[Prenatal gene diagnosis of oculocutaneous albinism type I]
[Study of tyrosinase gene mutation in oculocutaneous albinism type 1 patients].
Alkaptonuria
Tyrosinase, could it be a missing link in ochronosis in alkaptonuria?
Alopecia
The role of tyrosinase in autoimmune vitiligo.
Alopecia Areata
Altered T cell subpopulations and serum anti-TYRP2 and tyrosinase antibodies in the acute and chronic phase of alopecia areata in the C3H/HeJ mouse model.
Recent advances in the pathogenesis of autoimmune hair loss disease alopecia areata.
Alzheimer Disease
Assessment of cholinesterase and tyrosinase inhibitory and antioxidant effects of Hypericum perforatum L. (St. John's wort)
Biophenols: Enzymes (?-secretase, Cholinesterases, histone deacetylase and tyrosinase) inhibitors from olive (Olea europaea L.).
Exploring the halophyte Cistanche phelypaea (L.) Cout as a source of health promoting products: In vitro antioxidant and enzyme inhibitory properties, metabolomic profile and computational studies.
Jasonia glutinosa (L.) DC., a Traditional Herbal Tea, Exerts Antioxidant and Neuroprotective Properties in Different In Vitro and In Vivo Systems.
Metabolite Profiling by Hyphenated Liquid Chromatographic Mass Spectrometric Technique (HPLC-DAD-ESI-Q-TOF-MS/MS) and Neurobiological Potential of Haplophyllum sahinii and H. vulcanicum Extracts.
Phenolic compounds and biological effects of edible Rumex scutatus and Pseudosempervivum sempervivum: potential sources of natural agents with health benefits.
Regulation of tyrosinase trafficking and processing by presenilins: partial loss of function by familial Alzheimer's disease mutation.
[Inhibitory effects of Rhodiola plants and their oligomeric proanthocyanidins on tyrosinase and Abeta42 aggregation].
Anemia
Testing in mice the hypothesis that melanin is protective in malaria infections.
Angiomyolipoma
Expression of KIT (CD117) in angiomyolipoma.
Immunohistochemical and reverse transcription-polymerase chain reaction expression analysis of tyrosinase and microphthalmia-associated transcription factor in angiomyolipomas.
Immunohistochemical study of microphthalmia transcription factor and tyrosinase in angiomyolipoma of the kidney, renal cell carcinoma, and renal and retroperitoneal sarcomas: comparative evaluation with traditional diagnostic markers.
Melanoma markers in angiomyolipoma of the liver and kidney: a comparative study.
Renal angiomyolipoma: further immunophenotypic characterization of an expanding morphologic spectrum.
Anthrax
Identifying chelators for metalloprotein inhibitors using a fragment-based approach.
Arthritis
Oxindole and its derivatives: A review on recent progress in biological activities.
Asthma
Microbial biotransformation of bioactive and clinically useful steroids and some salient features of steroids and biotransformation.
Ataxia
An oculocerebral hypopigmentation syndrome: a case report with clinical, histochemical, and ultrastructural findings.
Ataxia Telangiectasia
Tyrosinase overexpression promotes ATM-dependent p53 phosphorylation by quercetin and sensitizes melanoma cells to dacarbazine.
Autoimmune Diseases
Recent advances in the pathogenesis of autoimmune hair loss disease alopecia areata.
Tyrosinase epitope recognized by an HLA-DR-restricted T-cell line from a Vogt-Koyanagi-Harada disease patient.
Tyrosinase family proteins are antigens specific to Vogt-Koyanagi-Harada disease.
Avian Leukosis
Expression of virally transduced mouse tyrosinase in tyrosinase-negative chick embryo melanocytes in culture.
Expression of virally-transduced mouse tyrosinase in cultured chick embryo cells.
Tissue-specific expression of mouse tyrosinase gene in cultured chicken cells.
Bacterial Infections
Relationship of Agaricus bisporus mannose-binding protein to lectins with ?-trefoil fold.
Blindness
Albinism-causing mutations in recombinant human tyrosinase alter intrinsic enzymatic activity.
Bone Resorption
Bidirectional regulation of osteoclast function by nitric oxide synthase isoforms.
Bradycardia
Fixed patterns of bradycardia during late embryonic development in domestic fowl with C locus mutations.
Brain Neoplasms
An oncolytic adenoviral vector carrying the tyrosinase promoter for glioma gene therapy.
Breast Neoplasms
Aryl butenes active against K562 cells and lacking tyrosinase inhibitory activity as new leads in the treatment of leukemia.
Chemical profile, antiproliferative, antioxidant, and enzyme inhibition activities and docking studies of Cymbopogon schoenanthus (L.) Spreng. and Cymbopogon nervatus (Hochst.) Chiov. from Sudan.
Detection of tyrosinase mRNA in melanoma by reverse transcription-PCR and electrochemiluminescence.
Does melanin affect the low LET radiation response of Cloudman S91 mouse melanoma cell lines?
Orf239342 from the mushroom Agaricus bisporus is a mannose binding protein.
Primary neuroendocrine carcinoma of the skin expresses tyrosinase mRNA: detection by a specific nested PCR technique.
Serum tyrosinase in malignant disease, its activity, and the electrophoretic patterns of the enzyme as carried by immunoglobulins'.
The challenging estrogen receptor-negative/ progesterone receptor-negative/HER-2-negative patient: a promising candidate for epidermal growth factor receptor-targeted therapy?
Tyrosinase activity in the sera of patients with malignant melanoma: method and specificity.
Tyrosinase gene expression in human tissues.
Carcinogenesis
3D QSAR pharmacophore-based virtual screening for the identification of potential inhibitors of tyrosinase.
Conjugation with Phospholipids as a Modification Increasing Anticancer Activity of Phenolic Acids in Metastatic Melanoma-In Vitro and In Silico Studies.
Exploiting Tyrosinase Expression and Activity in Melanocytic Tumors: Quercetin and the Central Role of p53.
Naturally occurring and synthetic peptides: Efficient tyrosinase inhibitors.
Quercetin as an Emerging Anti-Melanoma Agent: A Four-Focus Area Therapeutic Development Strategy.
Carcinoma
A comprehensive LC-MS/MS method validation for the quantitative investigation of 37 fingerprint phytochemicals in Achillea species: A detailed examination of A. coarctata and A. monocephala.
Augmentation of melanoma-specific gene expression using a tandem melanocyte-specific enhancer results in increased cytotoxicity of the purine nucleoside phosphorylase gene in melanoma.
Evaluation of melanocytic neoplasms: application of a pan-melanoma antibody cocktail.
Heterogeneous expression of the tumor-associated antigens RAGE-1, PRAME, and glycoprotein 75 in human renal cell carcinoma: candidates for T-cell-based immunotherapies?
Immunohistochemical study of microphthalmia transcription factor and tyrosinase in angiomyolipoma of the kidney, renal cell carcinoma, and renal and retroperitoneal sarcomas: comparative evaluation with traditional diagnostic markers.
Loss of tyrosinase activity confers increased skin tumor susceptibility in mice.
Renal angiomyolipoma: further immunophenotypic characterization of an expanding morphologic spectrum.
Serum thyrosinase in human lung carcinoma.
The possible role of tyrosinase in malignant growth.
Tyrosinase activity in the sera of patients with malignant melanoma: method and specificity.
Carcinoma, Basal Cell
Evaluation of melanocytic neoplasms: application of a pan-melanoma antibody cocktail.
Carcinoma, Hepatocellular
Antiproliferative activity of Humulus lupulus extracts on human hepatoma (Hep3B), colon (HT-29) cancer cells and proteases, tyrosinase, ?-lactamase enzyme inhibition studies.
Transplantation of melanocytes obtained from the skin ameliorates apomorphine-induced abnormal behavior in rodent hemi-parkinsonian models.
Carcinoma, Neuroendocrine
Primary neuroendocrine carcinoma of the skin expresses tyrosinase mRNA: detection by a specific nested PCR technique.
Carcinoma, Renal Cell
Heterogeneous expression of the tumor-associated antigens RAGE-1, PRAME, and glycoprotein 75 in human renal cell carcinoma: candidates for T-cell-based immunotherapies?
Immunohistochemical study of microphthalmia transcription factor and tyrosinase in angiomyolipoma of the kidney, renal cell carcinoma, and renal and retroperitoneal sarcomas: comparative evaluation with traditional diagnostic markers.
Renal angiomyolipoma: further immunophenotypic characterization of an expanding morphologic spectrum.
Carcinoma, Squamous Cell
Evaluation of melanocytic neoplasms: application of a pan-melanoma antibody cocktail.
Loss of tyrosinase activity confers increased skin tumor susceptibility in mice.
Cataract
Cataract produced by tyrosinase and tyrosine systems in rabbitens in vitro.
Metabolic alteratios in experimental cataract. I. Inhibition of lactate dehydrogenase and appearance of O-diphenol oxidase in cataractous lens of naphthalene fed rabbits.
[Experimental study on the relationship between experimental naphthalene cataract and iris color in the animal eye. III. Histochemical observation of o-diphenol oxidase activity in the iris and ciliary body in albino and pigmented rats]
Central Nervous System Neoplasms
Central nervous system tumor immunity generated by a recombinant listeria monocytogenes vaccine targeting tyrosinase related protein-2 and real-time imaging of intracranial tumor burden.
Chediak-Higashi Syndrome
Distinguishing between the catalytic potential and apparent expression of tyrosinase activities.
Molecular basis of albinism: mutations and polymorphisms of pigmentation genes associated with albinism.
Cholera
Analysis of the UV-induced melanogenesis and growth arrest of human melanocytes.
Comparative studies on the correlation between pyrimidine dimer formation and tyrosinase activity in cloudman S91 melanoma cells after ultraviolet-irradiation.
Eumelanin biosynthesis is regulated by coordinate expression of tyrosinase and tyrosinase-related protein-1 genes.
Melanogenesis in murine B16 cells exposed to Aeromonas hydrophila cytotoxic enterotoxin.
Mitogenic, melanogenic, and cAMP responses of cultured neonatal human melanocytes to commonly used mitogens.
On the analysis of the pathophysiology of Chediak-Higashi syndrome. Defects expressed by cultured melanocytes.
Phenotypic heterogeneity of melanoma. Relation to the differentiation program of melanoma cells.
Regulation of melanin synthesis of B16 mouse melanoma cells by 1 alpha, 25-dihydroxyvitamin D3 and retinoic acid.
Regulation of melanogenesis by human uveal melanocytes in vitro.
Retinoic acid is a potent inhibitor of inducible pigmentation in murine and hamster melanoma cell lines.
Signaling and transcriptional regulation in the neural crest-derived melanocyte lineage: interactions between KIT and MITF.
Stimulation of tyrosinase in human melanocytes by pro-opiomelanocortin-derived peptides.
Coinfection
Tyrosinase and tyrosinase-related protein 1 require Rab7 for their intracellular transport.
Colonic Neoplasms
Chemical profile, antiproliferative, antioxidant, and enzyme inhibition activities and docking studies of Cymbopogon schoenanthus (L.) Spreng. and Cymbopogon nervatus (Hochst.) Chiov. from Sudan.
Isolated organ perfusion does not result in systemic microembolization of tumor cells.
Congenital Abnormalities
A transgenic mouse model with inducible Tyrosinase gene expression using the tetracycline (Tet-on) system allows regulated rescue of abnormal chiasmatic projections found in albinism.
Cutis Laxa
Genetic diseases of copper metabolism.
cystathionine beta-synthase deficiency
Tyrosinase inhibition due to interaction of homocyst(e)ine with copper: the mechanism for reversible hypopigmentation in homocystinuria due to cystathionine beta-synthase deficiency.
Cystic Fibrosis
A trinucleotide deletion together with a base duplication event at codon 439 in the human tyrosinase gene identifies a mutational hotspot.
Different p97/VCP complexes function in retrotranslocation step of mammalian Er-associated degradation (ERAD).
PDZK1 Upregulation in Estrogen-Related Hyperpigmentation in Melasma.
pSURF-2, a modified BAC vector for selective YAC cloning and functional analysis.
Deafness
Human olfactory marker protein maps close to tyrosinase and is a candidate gene for Usher syndrome type I.
Dehydration
Phytochemicals and Enzyme Inhibitory Capacities of the Methanolic Extracts from the Italian Apple Cultivar Mela Rosa dei Monti Sibillini.
Suppression of polyphenol oxidases increases stress tolerance in tomato.
Dermatitis
3D QSAR pharmacophore-based virtual screening for the identification of potential inhibitors of tyrosinase.
Effect of p-aminophenols on tyrosinase activity.
Inhibition of melanin content by Punicalagins in the super fruit pomegranate (Punica granatum).
Dermatitis, Exfoliative
[Prenatal diagnosis of cutaneous genetic diseases by the study of fetal DNA]
Dermatofibrosarcoma
Tyrosinase expression in malignant melanoma, desmoplastic melanoma, and peripheral nerve tumors.
Diabetes Mellitus
LC-MS/MS Profiles and In Vitro Biological Activities of Extracts of an Endemic Species from Turkey: Stachys cretica ssp. anatolica.
Phenolic compounds and biological effects of edible Rumex scutatus and Pseudosempervivum sempervivum: potential sources of natural agents with health benefits.
Diabetes Mellitus, Type 2
Cytotoxic, Antioxidant, and Enzyme Inhibitory Properties of the Traditional Medicinal Plant Matthiola incana (L.) R. Br.
Phytochemical Analysis, Network Pharmacology and in Silico Investigations on Anacamptis pyramidalis Tuber Extracts.
Diphtheria
Precise toxigenic ablation of intermediate cells abolishes the "battery" of the cochlear duct.
Down Syndrome
Genetic diseases of copper metabolism.
Ehlers-Danlos Syndrome
Genetic diseases of copper metabolism.
Endocrine System Diseases
The role of tyrosinase in autoimmune vitiligo.
Eosinophilic Granuloma
[An etiological study of eosinophilic granuloma]
Erythema
Endothelin-1 as a new melanogen: coordinated expression of its gene and the tyrosinase gene in UVB-exposed human epidermis.
Esotropia
Investigation of albinism genes in congenital esotropia.
Exanthema
Effect of p-aminophenols on tyrosinase activity.
Eye Diseases
Purification of Recombinant Human Tyrosinase from Insect Larvae Infected with the Baculovirus Vector.
Fibrous Dysplasia, Polyostotic
Activating mutation of GS alpha in McCune-Albright syndrome causes skin pigmentation by tyrosinase gene activation on affected melanocytes.
Fowlpox
Evaluation of prime/boost regimens using recombinant poxvirus/tyrosinase vaccines for the treatment of patients with metastatic melanoma.
Fusariosis
[Conjugation resistance to Fusarium graminearum Schwabe with multiple molecular forms of some enzymes in winter wheat]
Genetic Diseases, Inborn
A novel missense mutation of the TYR gene in a pedigree with oculocutaneous albinism type 1 from China.
Fibroin particle-supported cationic lipid layers for highly efficient intracellular protein delivery.
Glaucoma
alpha-Methyl-p-tyrosine inhibits latanoprost-induced melanogenesis in vitro.
Modification of ocular defects in mouse developmental glaucoma models by tyrosinase.
Of mice and men: tyrosinase modification of congenital glaucoma in mice but not in humans.
Glioblastoma
Expression of nine tumour antigens in a series of human glioblastoma multiforme: interest of EGFRvIII, IL-13Ralpha2, gp100 and TRP-2 for immunotherapy.
Human glioblastoma ADF cells express tyrosinase, L-tyrosine hydroxylase and melanosomes and are sensitive to L-tyrosine and phenylthiourea.
Role of neurofibromin in modulation of expression of the tyrosinase-related protein 2 gene.
Glioma
An oncolytic adenoviral vector carrying the tyrosinase promoter for glioma gene therapy.
Tyrosinase transfection produces melanin synthesis and growth retardation in glioma cells.
Gout
Xanthine oxidase inhibitory activity of northeastern North American plant remedies used for gout.
Graves Disease
Detection of tyrosinase autoantibodies in patients with vitiligo using 35S-labeled recombinant human tyrosinase in a radioimmunoassay.
Hamartoma
Pigmented hamartoma of the eyelid with apocrine, follicular and sebaceous differentiation.
Heart Failure
'Mysterious' moose disease in Sweden. Similarities to copper deficiency and/or molybdenosis in cattle and sheep. Biochemical background of clinical signs and organ lesions.
Electrochemically reduced graphene and iridium oxide nanoparticles for inhibition-based angiotensin-converting enzyme inhibitor detection.
Hemangiosarcoma
Index report of cutaneous angiosarcomas with strong positivity for tyrosinase mimicking melanoma with further evaluation of melanocytic markers in a large angiosarcoma series.
Hepatic Encephalopathy
The effects of hemoperfusion using coated charcoal or tyrosinase artificial cells on middle molecules and tyrosine in brain and serum of hepatic coma rats.
Hepatitis C
In Vitro Antiviral Activity of Tyrosinase from Mushroom Agaricus bisporus against Hepatitis C Virus.
Hepatolenticular Degeneration
Inhibition kinetics of mushroom tyrosinase by copper-chelating ammonium tetrathiomolybdate.
Hereditary Sensory and Autonomic Neuropathies
[Congenital insensitivity to pain with anhidrosis. Clinical diagnosis, evolution and complications: case report].
Hermanski-Pudlak Syndrome
Abnormal translocation of tyrosinase and tyrosinase-related protein 1 in cutaneous melanocytes of Hermansky-Pudlak Syndrome and in melanoma cells transfected with anti-sense HPS1 cDNA.
Electrophoretic pattern of human hairbulb tyrosinase.
Iron upregulates melanogenesis in cultured retinal pigment epithelial cells.
Molecular basis of albinism: mutations and polymorphisms of pigmentation genes associated with albinism.
Role of the ubiquitin proteasome system in regulating skin pigmentation.
Herpes Simplex
A comparison of the properties of different retroviral vectors containing the murine tyrosinase promoter to achieve transcriptionally targeted expression of the HSVtk or IL-2 genes.
Herpes simplex virus type-1 infection upregulates cellular promoters and telomerase activity in both tumor and nontumor human cells.
Use of tissue-specific expression of the herpes simplex virus thymidine kinase gene to inhibit growth of established murine melanomas following direct intratumoral injection of DNA.
[In vitro studies of the antiviral activity of enzymatically oxidized o-diphenolic compounds against herpes simplex virus type 1 and 2 (author's transl)]
Histiocytoma
Immunohistochemical distinction of epithelioid histiocytic proliferations from epithelioid melanocytic nevi.
Histiocytoma, Benign Fibrous
The mechanism of epidermal hyperpigmentation in dermatofibroma is associated with stem cell factor and hepatocyte growth factor expression.
Tyrosinase expression in malignant melanoma, desmoplastic melanoma, and peripheral nerve tumors.
Homocystinuria
Tyrosinase inhibition due to interaction of homocyst(e)ine with copper: the mechanism for reversible hypopigmentation in homocystinuria due to cystathionine beta-synthase deficiency.
Hutchinson's Melanotic Freckle
A possible mechanism of action for azelaic acid in the human epidermis.
Activity of azelaic acid on cultures of lymphoma- and leukemia-derived cell lines, normal resting and stimulated lymphocytes and 3T3 fibroblasts.
Analytical, ultrastructural, autoradiographic and biochemical studies on [3H]dicarboxylic acid added to cultures of melanoma cells.
Effect of dicarboxylic acids on lentigo maligna.
Effect of dicarboxylic acids on normal human melanocytes in dispersed tissue culture.
Tyrosinase activity in three types of the malignant melanoma: superficial spreading melanoma, lentigo maligna melanoma and nodular melanoma.
Hyperpigmentation
(E)-2-Cyano-3-(substituted phenyl)acrylamide analogs as potent inhibitors of tyrosinase: A linear ?-phenyl-?,?-unsaturated carbonyl scaffold.
2-(3, 4-dihydroxybenzylidene)malononitrile as a novel anti-melanogenic compound.
2-(4-Fluorophenyl)-quinazolin-4(3H)-one as a novel tyrosinase inhibitor: Synthesis, inhibitory activity, and mechanism.
3-hydroxycoumarin loaded vesicles for recombinant human tyrosinase inhibition in topical applications.
4-n-butylresorcinol, a highly effective tyrosinase inhibitor for the topical treatment of hyperpigmentation.
A double-blind, placebo-controlled randomized trial of skin-lightening cream containing lycopene and wheat bran extract on melasma.
A new type of tyrosinase inhibitors from natural products as potential treatments for hyperpigmentation.
A new tyrosinase inhibitor from Crinum yemense as potential treatment for hyperpigmentation.
A novel adamantyl benzylbenzamide derivative, AP736, suppresses melanogenesis through the inhibition of cAMP-PKA-CREB-activated microphthalmia-associated transcription factor and tyrosinase expression.
A novel method for explaining the product inhibition mechanisms via molecular docking: inhibition studies for tyrosinase from Agaricus bisporus.
A possible mechanism of action for azelaic acid in the human epidermis.
A potential anti-inflammation activity and depigmentation effect of Lespedeza bicolor extract and its fractions.
Acetylcholinesterase, butyrylcholinesterase, and tyrosinase inhibition studies and antioxidant activities of 33 Scutellaria L. taxa from Turkey.
Advances in fluorescent probes for detection and imaging of endogenous tyrosinase activity.
Aloesin inhibits hyperpigmentation induced by UV radiation.
Aloin, cinnamic acid and sophorcarpidine are potent inhibitors of tyrosinase.
Aminoluciferin 4-hydroxyphenyl amide enables bioluminescence detection of endogenous tyrosinase.
An Improved Nanoemulsion Formulation Containing Kojic Monooleate: Optimization, Characterization and In Vitro Studies.
Analogs of 5-(substituted benzylidene)hydantoin as inhibitors of tyrosinase and melanin formation.
Anti-aging and tyrosinase inhibition effects of Cassia fistula flower butanolic extract.
Anti-Melanogenic Effects of Flavonoid Glycosides from Limonium tetragonum (Thunb.) Bullock via Inhibition of Tyrosinase and Tyrosinase-Related Proteins.
Anti-Melanogenic Properties of Greek Plants. A Novel Depigmenting Agent from Morus alba Wood.
Anti-tyrosinase activity of South African Aloe species and isolated compounds plicataloside and aloesin.
Bioactive oligopeptides in dermatology: Part I.
Bioactive polyphenols from muscadine grape and blackcurrant stably concentrated onto protein-rich matrices for topical applications.
Biochemical Properties of Tyrosinase from Aspergillus terreus and Penicillium copticola; Undecanoic Acid from Aspergillus flavus, an Endophyte of Moringa oleifera, Is a Novel Potent Tyrosinase Inhibitor.
Biological activity and molecular docking studies of curcumin-related ?,?-unsaturated carbonyl-based synthetic compounds as anticancer agents and mushroom tyrosinase inhibitors.
Biological evaluation of Keggin-type polyoxometalates on tyrosinase: Kinetics and molecular modeling.
Caffeic Acid Phenethyl Ester Inhibits Alpha-Melanocyte Stimulating Hormone-Induced Melanin Synthesis through Suppressing Transactivation Activity of Microphthalmia-Associated Transcription Factor.
Carbazole and hydrazone derivatives as new competitive inhibitors of tyrosinase: Experimental clues to binuclear copper active site binding.
Chalcones as potent tyrosinase inhibitors: the effect of hydroxyl positions and numbers.
Characterization of Caffeoylquinic Acids from Lepisorus thunbergianus and Their Melanogenesis Inhibitory Activity.
Characterization of inhibitory effects of the potential therapeutic inhibitors, benzoic acid and pyridine derivatives, on the monophenolase and diphenolase activities of tyrosinase.
Chicken Egg White-Advancing from Food to Skin Health Therapy: Optimization of Hydrolysis Condition and Identification of Tyrosinase Inhibitor Peptides.
Comparative Study of Glyceryl Behenate or Polyoxyethylene 40 Stearate-Based Lipid Carriers for Trans-Resveratrol Delivery: Development, Characterization and Evaluation of the In Vitro Tyrosinase Inhibition.
Computational strategies towards developing novel antimelanogenic agents.
Conjugation with Dihydrolipoic Acid Imparts Caffeic Acid Ester Potent Inhibitory Effect on Dopa Oxidase Activity of Human Tyrosinase.
Design, Synthesis and Biological Evaluation of Oxindole-Based Chalcones as Small-Molecule Inhibitors of Melanogenic Tyrosinase.
Design, synthesis of Cinnamyl-paeonol derivatives with 1, 3-Dioxypropyl as link arm and screening of tyrosinase inhibition activity in vitro.
Design, synthesis, and anti-melanogenic effects of (E)-2-benzoyl-3-(substituted phenyl)acrylonitriles.
Development of a kojic monooleate-enriched oil-in-water nanoemulsion as a potential carrier for hyperpigmentation treatment.
Differential diagnosis and management of hyperpigmentation.
Discovery of benzylidenebenzofuran-3(2H)-one (aurones) as inhibitors of tyrosinase derived from human melanocytes.
Discovery of highly potent tyrosinase inhibitor, T1, with significant anti-melanogenesis ability by zebrafish in vivo assay and computational molecular modeling.
Downregulation of melanin synthesis by haginin a and its application to in vivo lightening model.
Effect of chrysin omega-3 and 6 fatty acid esters on mushroom tyrosinase activity, stability, and structure.
Effect of hesperetin on tyrosinase: inhibition kinetics integrated computational simulation study.
Effect of saucerneol D on melanin production in cAMP-elevated melanocytes.
Effect of Sucrier Banana Peel Extracts on Inhibition of Melanogenesis through the ERK Signaling Pathway.
Effective reduction of post-inflammatory hyperpigmentation with the tyrosinase inhibitor isobutylamido-thiazolyl-resorcinol (Thiamidol).
Essential oils composition of Periploca laevigata Aiton subsp. angustifolia (Labill.) Markgraf (Apocynaceae - Periplocoideae).
Eupafolin, a skin whitening flavonoid isolated from Phyla nodiflora, downregulated melanogenesis: Role of MAPK and Akt pathways.
Evaluation of 4-(4-Fluorobenzyl)piperazin-1-yl]-Based Compounds as Competitive Tyrosinase Inhibitors Endowed with Antimelanogenic Effects.
Evaluation of Antimelanogenic Activity and Mechanism of Galangin in Silico and in Vivo.
Evaluation of the Novel Synthetic Tyrosinase Inhibitor (Z)-3-(3-bromo-4-hydroxybenzylidene)thiochroman-4-one (MHY1498) In Vitro and In Silico.
Exploring the halophyte Cistanche phelypaea (L.) Cout as a source of health promoting products: In vitro antioxidant and enzyme inhibitory properties, metabolomic profile and computational studies.
Exposure of human melanocytes to UVB twice and subsequent incubation leads to cellular senescence and senescence-associated pigmentation through the prolonged p53 expression.
Flower extracts from Paeonia decomposita and Paeonia ostii inhibit melanin synthesis via cAMP-CREB-associated melanogenesis signaling pathways in murine B16 melanoma cells.
Glucosamine: an ingredient with skin and other benefits.
Hemocyanin-derived phenoloxidase activity: a contributing factor to hyperpigmentation in Nephrops norvegicus.
Highly potent tyrosinase inhibitor, neorauflavane from Campylotropis hirtella and inhibitory mechanism with molecular docking.
Hydroquinone Therapy for Post-inflammatory Hyperpigmentation Secondary to Acne: Not Just Prescribable by Dermatologists.
Hydroxyl substituted benzoic acid/cinnamic acid derivatives: Tyrosinase inhibitory kinetics, anti-melanogenic activity and molecular docking studies.
Hyperpigmentation and melanocytic hyperplasia in transgenic mice expressing the human T24 Ha-ras gene regulated by a mouse tyrosinase promoter.
Hyperpigmentation mechanism of methyl 3,5-di-caffeoylquinate through activation of p38 and MITF induction of tyrosinase.
Identification of tyrosinase inhibitors from traditional Chinese medicines for the management of hyperpigmentation.
Identifying melanogenesis inhibitors from Cinnamomum subavenium with in vitro and in vivo screening systems by targeting the human tyrosinase.
In silico prediction of the cosmetic whitening effects of naturally occurring lead compounds.
In vitro anti-melanogenic effects of chimeric compounds, 2-(substituted benzylidene)-1,3-indanedione derivatives with a ?-phenyl-?, ? -unsaturated dicarbonyl scaffold.
Increase of tyrosinase activity at the wound site in zebrafish imaged by a new fluorescent probe.
Increased therapeutic efficacy of a newly synthesized tyrosinase inhibitor by solid lipid nanoparticles in the topical treatment of hyperpigmentation.
Inhibition of Human Tyrosinase Requires Molecular Motifs Distinctively Different from Mushroom Tyrosinase.
Inhibition of melanogensis by a novel origanoside from Origanum vulgare.
Inhibition of skin pigmentation by an extract of Lepidium apetalum and its possible implication in IL-6 mediated signaling.
Inhibitory effect of Cinnamomum osmophloeum Kanehira ethanol extracts on melanin synthesis via repression of tyrosinase expression.
Inhibitory effect of dalbergioidin isolated from the trunk of Lespedeza cyrtobotrya on melanin biosynthesis.
Inhibitory effect of phthalic Acid on tyrosinase: the mixed-type inhibition and docking simulations.
Inhibitory effect of piperlonguminine on melanin production in melanoma B16 cell line by downregulation of tyrosinase expression.
Inhibitory effects of calycosin isolated from the root of Astragalus membranaceus on melanin biosynthesis.
Inhibitory Effects of Physalis alkekengi L., Alcea rosea L., Bunium persicum B. Fedtsch. and Marrubium vulgare L. on Mushroom Tyrosinase.
Inhibitory effects of resveratrol analogs on mushroom tyrosinase activity.
Inhibitory effects of salidroside and paeonol on tyrosinase activity and melanin synthesis in mouse B16F10 melanoma cells and ultraviolet B-induced pigmentation in guinea pig skin.
Inhibitory kinetics of paeonol on the activity of mushroom tyrosinase oxidizing L-dopa.
Integrated kinetic studies and computational analysis on naphthyl chalcones as mushroom tyrosinase inhibitors.
Invitro effect of pine bark extract on melanin synthesis, tyrosinase activity, production of endothelin-1, and PPAR in cultured melanocytes exposed to Ultraviolet, Infrared, and Visible light radiation.
Kinetics of Tyrosinase Inhibitory Activity Using Vitis vinifera Leaf Extracts.
Kojic acid applications in cosmetic and pharmaceutical preparations.
Melanocytes sense blue light and regulate pigmentation through the Opsin3.
Melanogenesis Inhibitor(s) from Phyla nodiflora Extract.
Melanogenesis-Promoting Effects of Rhynchosia nulubilis and Rhynchosia volubilis Ethanol Extracts in Melan-a Cells.
Minireview: Peptide analogs and short sequence oligopeptides as modulators of skin pigmentation.
Mir-434-5p mediates skin whitening and lightening.
Modifying effects of carboxyl group on the interaction of recombinant S100A8/A9 complex with tyrosinase.
New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triazole-5(4H)-thiones, and substituted hydrazides to the dicopper active site.
Novel amide derivatives as potent tyrosinase inhibitors; in-vitro, in-vivo antimelanogenic activity and computational studies.
Novel Chemically Modified Curcumin (CMC) Derivatives Inhibit Tyrosinase Activity and Melanin Synthesis in B16F10 Mouse Melanoma Cells.
Novel vitamin E derivative with 4-substituted resorcinol moiety has both antioxidant and tyrosinase inhibitory properties.
Oleoylethanolamide inhibits ?-melanocyte stimulating hormone-stimulated melanogenesis via ERK, Akt and CREB signaling pathways in B16 melanoma cells.
Origanum essential oils reduce the level of melanin in B16-F1 melanocytes.
Overexpression of thioredoxin in Fanconi anemia fibroblasts prevents the cytotoxic and DNA damaging effect of mitomycin C and diepoxybutane.
p-Coumaric Acid as An Active Ingredient in Cosmetics: A Review Focusing on its Antimelanogenic Effects.
Phage display-mediated discovery of novel tyrosinase-targeting tetrapeptide inhibitors reveals the significance of N-terminal preference of cysteine residues and their functional sulfur atom.
Phenolic Compounds and Biological Activity of Selected Mentha Species.
Phenolic-rich Pomegranate Peel Extract: In Vitro, Cellular, and In Vivo Activities for Skin Hyperpigmentation Treatment.
Phlorotannins with Potential Anti-tyrosinase and Antioxidant Activity Isolated from the Marine Seaweed Ecklonia stolonifera.
Phytochemical Investigations and In Vitro Bioactivity Screening on Melia azedarach L. Leaves Extract from Nepal.
Plants from Brazilian Cerrado with potent tyrosinase inhibitory activity.
Postinflammatory hyperpigmentation: a review of the epidemiology, clinical features, and treatment options in skin of color.
Preparative isolation and identification of tyrosinase inhibitors from the seeds of Garcinia kola by high-speed counter-current chromatography.
Rifampicin as a novel tyrosinase inhibitor: Inhibitory activity and mechanism.
Royal jelly reduces melanin synthesis through down-regulation of tyrosinase expression.
Screening of Chinese herbal medicines for antityrosinase activity in a cell free system and B16 cells.
Screening of Nepalese crude drugs traditionally used to treat hyperpigmentation: in vitro tyrosinase inhibition.
Screening the dermatological potential of plectranthus species components: antioxidant and inhibitory capacities over elastase, collagenase and tyrosinase.
Serendipitous discovery of short peptides from natural products as tyrosinase inhibitors.
Short-Sequence Oligopeptides with Inhibitory Activity against Mushroom and Human Tyrosinase.
Skin targeting of curcumin solid lipid nanoparticles-engrossed topical gel for the treatment of pigmentation and irritant contact dermatitis.
Supravenous hyperpigmentation, transverse leuconychia and transverse melanonychia after chemotherapy for Hodgkin's disease.
Synthesis and biological activity of hydroxy substituted phenyl-benzo[d]thiazole analogues for antityrosinase activity in B16 cells.
Synthesis of methyl ether analogues of sildenafil (Viagra) possessing tyrosinase inhibitory potential.
Targeting Tyrosinase: Development and Structural Insights of Novel Inhibitors Bearing Arylpiperidine and Arylpiperazine Fragments.
The degrees of UVB-induced erythema and pigmentation correlate linearly and are reduced in a parallel manner by topical anti-inflammatory agents.
The unravelling of the complex pattern of tyrosinase inhibition.
Topical retinoic acid for photoaging: clinical response and underlying mechanisms.
Torilin from Torilis japonica Inhibits Melanin Production in alpha-Melanocyte Stimulating Hormone-Activated B16 Melanoma Cells.
Triazine-based tyrosinase inhibitors identified by chemical genetic screening.
Tyrosinase enzyme: 1. An overview on a pharmacological target.
Tyrosinase inhibition studies of cycloartane and cucurbitane glycosides and their structure-activity relationships.
Tyrosinase inhibitor-loaded microsponge drug delivery system: new approach for hyperpigmentation disorders.
Tyrosinase inhibitors from Rhododendron collettianum and their structure-activity relationship (SAR) studies.
Tyrosinase inhibitors from terrestrial and marine resources.
Tyrosinase inhibitory activity of flavonoids from Artocarpus heterophyllous.
Tyrosinase inhibitory components of immature calamondin peel.
UP256 Inhibits Hyperpigmentation by Tyrosinase Expression/Dendrite Formation via Rho-Dependent Signaling and by Primary Cilium Formation in Melanocytes.
[Factors affecting melanogenesis and methods used for identification of pigmentation disorders]
Hypersensitivity
Effect of urea-extracted sericin on melanogenesis: potential applications in post-inflammatory hyperpigmentation.
Hypertension
THE EFFECT OF TYROSINASE ON ARTERIAL HYPERTENSION.
THE EFFECT OF TYROSINASE ON EXPERIMENTAL HYPERTENSION.
Hypohidrosis
[Congenital insensitivity to pain with anhidrosis. Clinical diagnosis, evolution and complications: case report].
Hypopigmentation
A potent tyrosinase activator from Radix Polygoni multiflori and its melanogenesis stimulatory effect in B16 melanoma cells.
A splicing mutation of the tyrosinase gene causes yellow oculocutaneous albinism in a Japanese patient with a pigmented phenotype.
A tyrosinase gene missense mutation in temperature-sensitive type I oculocutaneous albinism. A human homologue to the Siamese cat and the Himalayan mouse.
AAV-mediated Tyrosinase Gene Transfer Restores Melanogenesis and Retinal Function in a Model of Oculo-cutaneous Albinism Type I (OCA1).
An oculocerebral hypopigmentation syndrome: a case report with clinical, histochemical, and ultrastructural findings.
Clinical and cellular characterization of Hermansky-Pudlak Syndrome Type-6.
Comparative Depigmentation Effects of Resveratrol and Its Two Methyl Analogues in ?-Melanocyte Stimulating Hormone-Triggered B16/F10 Murine Melanoma Cells.
Decreased CD117 expression in hypopigmented mycosis fungoides correlates with hypomelanosis: lessons learned from vitiligo.
Degradation of tyrosinase induced by phenylthiourea occurs following Golgi maturation.
Direct interaction of tyrosinase with Tyrp1 to form heterodimeric complexes in vivo.
Effects of a non-cyclodextrin cyclic carbohydrate on mouse melanoma cells: Characterization of a new type of hypopigmenting sugar.
Effects of the isoflavone puerarin and its glycosides on melanogenesis in B16 melanocytes
Evaluation of hypopigmentation in embryonic zebrafish induced by emerging disinfection byproduct, 3, 5-di-I-tyrosylalanine.
Homozygosity Mapping and Whole-Exome Sequencing to Detect SLC45A2 and G6PC3 Mutations in a Single Patient with Oculocutaneous Albinism and Neutropenia.
Hypopigmentation in Angelman syndrome.
Hypopigmentation in the Prader-Willi syndrome.
Hypopigmenting agents: an updated review on biological, chemical and clinical aspects.
Inhibition of melanogenesis by piceid isolated from Polygonum cuspidatum.
Inhibitory effects of 16-hydroxy-9-oxo-10E,12E,14E-octadecatrienoic acid (Corchorifatty acid B) isolated from Melissa officinalis Linné on melanogenesis.
Lupenone from Erica multiflora Leaf Extract Stimulates Melanogenesis in B16 Murine Melanoma Cells through the Inhibition of ERK1/2 Activation.
Melanogenic effect of purified mushroom tyrosinase on B16F10 Melanocytes: A Phase Contrast and Immunofluorescence Microscopic Study.
Melanoma-associated hypopigmentation: where are the antibodies?
Nobiletin, a Polymethoxy Flavonoid, Reduced Endothelin-1 Plus SCF-Induced Pigmentation in Human Melanocytes.
Oculocutaneous albinism type 1B associated with a functionally significant tyrosinase gene polymorphism detected with Whole Exome Sequencing.
p-Coumaric acid inhibition of CREB phosphorylation reduces cellular melanogenesis
Partially purified components of Nardostachys chinensis suppress melanin synthesis through ERK and Akt signaling pathway with cAMP down-regulation in B16F10 cells.
Pink-eyed dilution protein controls the processing of tyrosinase.
Potential adverse effect of tyrosinase inhibitors on teleosts:A review.
Prenatal diagnosis of oculocutaneous albinism type I: review and personal experience.
Quantification of Hypopigmentation Activity In Vitro.
Quercetin-3-O-?-d-glucopyranosyl-(1 ? 6)-?-d-glucopyranoside suppresses melanin synthesis by augmenting p38 MAPK and CREB signaling pathways and subsequent cAMP down-regulation in murine melanoma cells.
Recent Updates On Melanocyte Biology And The Use Of Promising Bioactive Compounds For The Treatment Of Hypopigmentary Disorders: A Review.
The BLOC-3 subunit HPS4 is required for activation of Rab32/38 GTPases in melanogenesis, but its Rab9 activity is dispensable for melanogenesis.
The lactoferricin B-derived peptide, LfB17-34, induces melanogenesis in B16F10 cells.
Tyrosinase inhibition due to interaction of homocyst(e)ine with copper: the mechanism for reversible hypopigmentation in homocystinuria due to cystathionine beta-synthase deficiency.
[Menkes syndrome. An unusual pigmentation anomaly in a mother and three sisters]
Infections
Activation of tyrosinase in Agaricus bisporus strains following infection by Pseudomonas tolaasii or treatment with a tolaasin-containing preparation.
Cross-reaction between tyrosinase peptides and cytomegalovirus antigen by T cells from patients with Vogt-Koyanagi-Harada disease.
Herpes simplex virus type-1 infection upregulates cellular promoters and telomerase activity in both tumor and nontumor human cells.
In Vitro Effects of Streptomyces tyrosinase on the Egg and Adult Worm of Toxocara vitulorum.
Isolation of tyrosinase-specific CD8+ and CD4+ T cell clones from the peripheral blood of melanoma patients following in vitro stimulation with recombinant vaccinia virus.
Microphthalmia-associated transcription factor (MITF) is required but is not sufficient to induce the expression of melanogenic genes.
Retroviral infection with human tyrosinase-related protein-1 (TRP-1) cDNA upregulates tyrosinase activity and melanin synthesis in a TRP-1-deficient melanoma cell line.
Systemic acquired resistance in Cavendish banana induced by infection with an incompatible strain of Fusarium oxysporum f. sp. cubense.
Testing in mice the hypothesis that melanin is protective in malaria infections.
Transporter (TAP)- and proteasome-independent presentation of a melanoma-associated tyrosinase epitope.
Tyrosinase and tyrosinase-related protein 1 require Rab7 for their intracellular transport.
[Ocular infiltrating CD 4+ T cells from patients with Vogt-Koyanagi-Harada disease recognize human melanocyte antigens]
Influenza, Human
Analysis of the T cell response to tumor and viral peptide antigens by an IFNgamma-ELISPOT assay.
Characterization and pharmacological potential of Lactobacillus sakei 1I1 isolated from fresh water fish Zacco koreanus.
Characterization of antigen-specific CD8+ T lymphocyte responses in skin and peripheral blood following intradermal peptide vaccination.
Evaluation of the modified ELISPOT assay for gamma interferon production in cancer patients receiving antitumor vaccines.
Function but not phenotype of melanoma peptide-specific CD8(+) T cells correlate with survival in a multiepitope peptide vaccine trial (ECOG 1696).
Generation of cytotoxic T-cell responses with synthetic melanoma-associated peptides in vivo: implications for tumor vaccines with melanoma-associated antigens.
Immune and clinical outcomes in patients with stage IV melanoma vaccinated with peptide-pulsed dendritic cells derived from CD34+ progenitors and activated with type I interferon.
Immune and clinical responses in patients with metastatic melanoma to CD34(+) progenitor-derived dendritic cell vaccine.
In vitro expansion of Ag-specific T cells by HLA-A*0201-transfected K562 cells for immune monitoring.
Long-term outcomes in patients with metastatic melanoma vaccinated with melanoma peptide-pulsed CD34(+) progenitor-derived dendritic cells.
Scalable expansion of potent genetically modified human langerhans cells in a closed system for clinical applications.
Single injection of CD34+ progenitor-derived dendritic cell vaccine can lead to induction of T-cell immunity in patients with stage IV melanoma.
The impact of imiquimod, a Toll-like receptor-7 ligand (TLR7L), on the immunogenicity of melanoma peptide vaccination with adjuvant Flt3 ligand.
The use of computer-assisted video image analysis for the quantification of CD8+ T lymphocytes producing tumor necrosis factor alpha spots in response to peptide antigens.
Intellectual Disability
An oculocerebral hypopigmentation syndrome: a case report with clinical, histochemical, and ultrastructural findings.
Iris Diseases
Genetic context determines susceptibility to intraocular pressure elevation in a mouse pigmentary glaucoma.
Keratosis, Actinic
Melan-A: not a helpful marker in distinction between melanoma in situ on sun-damaged skin and pigmented actinic keratosis.
Minireview: Peptide analogs and short sequence oligopeptides as modulators of skin pigmentation.
Lentigo
Hypopigmenting Activity of Bisabolangelone Isolated from Angelica koreana Maxim. in alpha-Melanocyte Stimulating Hormone-Activated B16 or Melan-a Cells.
Integrated kinetic studies and computational analysis on naphthyl chalcones as mushroom tyrosinase inhibitors.
Next Time, Save Mushrooms for the Pizza!
The Anti-melanogenesis Activities of Some Selected Red Macroalgae from Northern Coasts of the Persian Gulf.
The role of the epidermal endothelin cascade in the hyperpigmentation mechanism of lentigo senilis.
Topical retinoic acid for photoaging: clinical response and underlying mechanisms.
Leukemia
Aryl butenes active against K562 cells and lacking tyrosinase inhibitory activity as new leads in the treatment of leukemia.
Exchange of viral promoter/enhancer elements with heterologous regulatory sequences generates targeted hybrid long terminal repeat vectors for gene therapy of melanoma.
gamma-L-Glutaminyl-4-hydroxybenzene, an inducer of cryptobiosis in Agaricus bisporus and a source of specific metabolic inhibitors for melanogenic cells.
In vitro studies of 2,4-dihydroxyphenylalanine, a prodrug targeted against malignant melanoma cells.
Overexpression of thioredoxin in Fanconi anemia fibroblasts prevents the cytotoxic and DNA damaging effect of mitomycin C and diepoxybutane.
[Intraocular inflammation and homeostasis of the eye]
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Lichenoid drug eruption due to imatinib mesylate.
Leukemia, Myeloid
Antioxidant, Anti-tyrosinase, Anti-?-amylase, and Cytotoxic Potentials of the Invasive Weed Andropogon virginicus.
Leukemia, T-Cell
Overexpression of thioredoxin in Fanconi anemia fibroblasts prevents the cytotoxic and DNA damaging effect of mitomycin C and diepoxybutane.
[Intraocular inflammation and homeostasis of the eye]
Liposarcoma
Primary neuroendocrine carcinoma of the skin expresses tyrosinase mRNA: detection by a specific nested PCR technique.
Tyrosinase gene expression in human tissues.
Liver Failure
Tyrosinase immobilized within artificial cells for detoxification in liver failure: I. preparation and in vitro studies.
Tyrosinase immobilized within artificial cells for detoxification in liver failure: II. In vivo studies in fulminant hepatic failure rats.
Liver Failure, Acute
Tyrosinase immobilized within artificial cells for detoxification in liver failure: II. In vivo studies in fulminant hepatic failure rats.
Liver Neoplasms, Experimental
Alkylating benzamides with melanoma cytotoxicity: role of melanin, tyrosinase, intracellular pH and DNA interaction.
Lung Diseases
Detection of xanthine oxidase activity products by EPR and HPLC in bronchoalveolar lavage fluid from patients with chronic obstructive pulmonary disease.
Lupus Erythematosus, Systemic
The role of tyrosinase in autoimmune vitiligo.
Lymphatic Metastasis
Detection of melanoma cells in peripheral blood and sentinel lymph nodes by RT-PCR analysis: a comparative study with immunohistochemistry.
Expression of gp100, MART-1, tyrosinase, and S100 in paraffin-embedded primary melanomas and locoregional, lymph node, and visceral metastases: implications for diagnosis and immunotherapy. A study conducted by the EORTC Melanoma Cooperative Group.
Facts and pitfalls in the detection of tyrosinase mRNA in the blood of melanoma patients by RT-PCR.
Favorable overall survival in stage III melanoma patients after adjuvant dendritic cell vaccination.
Micro-anatomy related antigen expression in melanocytic lesions.
Role of RT-PCR tyrosinase detection in the monitoring of patients with advanced metastatic melanoma.
The analysis of tyrosinase-specific mRNA in blood samples of melanoma patients by RT-PCR is not a useful test for metastatic tumor progression.
[Detection of tyrosinase mRNA using reverse transcription/polymerase chain reaction with fine needle punctures of melanoma metastases]
Lymphoma
A comparative immunohistochemical analysis of small round cell tumors of childhood: utility of peripherin and alpha-internexin as markers for neuroblastomas.
Reliability of PCR-based detection of occult tumour cells: lessons from real-time RT-PCR.
Tyrosinase gene expression in human tissues.
Macular Edema
Autoantibody profiling in intraocular fluid of patients with uveitis.
Malaria, Cerebral
Testing in mice the hypothesis that melanin is protective in malaria infections.
Melanoma
(2E,5E)-2,5-Bis(3-hydroxy-4-methoxybenzylidene) cyclopentanone Exerts Anti-Melanogenesis and Anti-Wrinkle Activities in B16F10 Melanoma and Hs27 Fibroblast Cells.
(Z)-2-(Benzo[d]thiazol-2-ylamino)-5-(substituted benzylidene)thiazol-4(5H)-one Derivatives as Novel Tyrosinase Inhibitors.
3,3',5-L-triiodothyronine but not L-thyroxine can block the induction of tyrosinase by imidazole in cultured B16 melanoma cells.
3,4-dihydroxy-L-phenylalanine as the tyrosinase cofactor. Occurrence in melanoma and binding constant.
4,4'-Dihydroxybiphenyl as a new potent tyrosinase inhibitor.
4-n-butylresorcinol enhances proteolytic degradation of tyrosinase in B16F10 melanoma cells.
4-Norleucine, 7-D-phenylalanine-alpha-melanocyte-stimulating hormone: a highly potent alpha-melanotropin with ultralong biological activity.
4-S-Cysteaminylphenol-loaded magnetite cationic liposomes for combination therapy of hyperthermia with chemotherapy against malignant melanoma.
7,8-Dimethoxycoumarin stimulates melanogenesis via MAPKs mediated MITF upregulation.
A Bioluminogenic Probe for Monitoring Tyrosinase Activity.
A cDNA encoding tyrosinase-related protein maps to the brown locus in mouse.
A cell-specific enhancer far upstream of the mouse tyrosinase gene confers high level and copy number-related expression in transgenic mice.
A chelating derivative of alpha-melanocyte stimulating hormone as a potential imaging agent for malignant melanoma.
A chemical compound from fruit extract of Juglans mandshurica inhibits melanogenesis through p-ERK-associated MITF degradation.
A cis-acting element involved in mouse tyrosinase gene expression and partial purification of its binding protein.
A colorimetric and near -infrared ratiometric fluorescent probe for the determination of endogenous tyrosinase activity based on cyanine aggregation.
A comparison of the properties of different retroviral vectors containing the murine tyrosinase promoter to achieve transcriptionally targeted expression of the HSVtk or IL-2 genes.
A Coreceptor-Independent Transgenic Human TCR Mediates Anti-Tumor and Anti-Self Immunity in Mice.
A dual mechanism of 4-hydroxy-5-methyl-3[2H]-furanone inhibiting cellular melanogenesis.
A Fluorescent Probe for Early Detection of Melanoma and Its Metastasis by Specifically Imaging Tyrosinase Activity in a Mouse Model.
A fluorometric biosensor based on functional Au/Ag nanoclusters for real-time monitoring of tyrosinase activity.
A histochemical autoradiographic method for demonstration of tyrosinase in human melanocytes, nevi and malignant melanoma.
A melanoma multiepitope polypeptide induces specific CD8+ T-cell response.
A meta-analysis of reverse transcriptase-polymerase chain reaction for tyrosinase mRNA as a marker for circulating tumor cells in cutaneous melanoma.
A metastatic melanoma with an unusual immunophenotypic profile.
A natural compound harmine decreases melanin synthesis through regulation of the DYRK1A/NFATC3 pathway.
A new colloidal lipidic system for gene therapy.
A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas.
A new standardized absolute quantitative RT-PCR method for detection of tyrosinase mRNAs in melanoma patients: technical and operative instructions.
A new tyrosinase epitope recognized in the HLA-B*4002 context by CTL from melanoma patients.
A New Tyrosinase Inhibitor from the Red Alga Symphyocladia latiuscula (Harvey) Yamada (Rhodomelaceae).
A novel attenuated replication-competent adenovirus for melanoma therapy.
A novel bioactive chalcone of Morus australis inhibits tyrosinase activity and melanin biosynthesis in B16 melanoma cells.
A novel cancer vaccine strategy based on HLA-A*0201 matched allogeneic plasmacytoid dendritic cells.
A novel form of melanoma apoptosis resistance: melanogenesis up-regulation in apoptotic B16-F0 cells delays ursolic acid-triggered cell death.
A novel psoralen derivative-MPFC enhances melanogenesis via activation of p38 MAPK and PKA signaling pathways in B16 cells.
A novel radiopharmaceutical for detection of malignant melanoma, based on melanin formation: 3-iodo-4-hydroxyphenyl-L-cysteine.
A panel immunoblot using co-incubated monoclonal antibodies for identification of melanoma cells.
A phase I vaccination study with tyrosinase in patients with stage II melanoma using recombinant modified vaccinia virus Ankara (MVA-hTyr).
A polymerase chain reaction-based semiquantitative assessment of malignant melanoma cells in peripheral blood.
A polymethoxyflavone mixture extracted from orange peels, mainly containing nobiletin, 3,3',4',5,6,7,8-heptamethoxyflavone and tangeretin, suppresses melanogenesis through the acidification of cell organelles, including melanosomes.
A Potent Tyrosinase Inhibitor, (E)-3-(2,4-Dihydroxyphenyl)-1-(thiophen-2-yl)prop-2-en-1-one, with Anti-Melanogenesis Properties in ?-MSH and IBMX-Induced B16F10 Melanoma Cells.
A promising redox cycle-based strategy for designing a catechol-type diphenylbutadiene as a potent prooxidative anti-melanoma agent.
A safe, effective in vivo gene therapy for melanoma using tyrosinase promoter-driven cytosine deaminase gene.
A sensitive tyrosinase method for human skin.
A Strategy Based on the Enzyme-Catalyzed Polymerization Reaction of Asp-Phe-Tyr Tripeptide for Cancer Immunotherapy.
A survey of the humoral immune response of cancer patients to a panel of human tumor antigens.
A transcriptional feedback loop for tissue-specific expression of highly cytotoxic genes which incorporates an immunostimulatory component.
A two-photon fluorescent probe for intracellular detection of tyrosinase activity.
A tyrosinase nonapeptide presented by HLA-B44 is recognized on a human melanoma by autologous cytolytic T lymphocytes.
A tyrosinase peptide presented by HLA-B35 is recognized on a human melanoma by autologous cytotoxic T lymphocytes.
Aberrant retention of tyrosinase in the endoplasmic reticulum mediates accelerated degradation of the enzyme and contributes to the dedifferentiated phenotype of amelanotic melanoma cells.
Abnormal acidification of melanoma cells induces tyrosinase retention in the early secretory pathway.
Abnormal translocation of tyrosinase and tyrosinase-related protein 1 in cutaneous melanocytes of Hermansky-Pudlak Syndrome and in melanoma cells transfected with anti-sense HPS1 cDNA.
Accumulation of chlorpromazine and thiouracil by human melanoma cells in culture.
Accurate molecular detection of melanoma nodal metastases: an assessment of multimarker assay specificity, sensitivity, and detection rate.
Acteoside inhibits melanogenesis in B16F10 cells through ERK activation and tyrosinase down-regulation.
ACTH1-4 potentiates alpha-MSH-induced melanophore dispersion and excessive grooming.
Action of endogenous proteases on the distribution of tyrosinase isozymes in Harding-Passey mouse melanoma.
Action of trypsin and detergents on tyrosinase of normal and malignant melanocytes.
Actions of melanotropins on mouse melanoma cell growth in vitro.
Activation of mammalian tyrosinase by ferrous ions.
Activation of melanogenesis by vacuolar type H(+)-ATPase inhibitors in amelanotic, tyrosinase positive human and mouse melanoma cells.
Activation of melanoma tyrosinase by a cyclic AMP-dependent protein kinase in a cell-free system.
Activation of MITF by Argan Oil Leads to the Inhibition of the Tyrosinase and Dopachrome Tautomerase Expressions in B16 Murine Melanoma Cells.
Activation of neurokinin-1 receptor by substance P inhibits melanogenesis in B16-F10 melanoma cells.
Activation of the tyrosinase gene promoter by neurofibromin.
Activation of tyrosinase in microsomes and melanosomes from B16 and Harding-Passey melanomas.
Activation of tyrosinase in mouse melanoma cell cultures.
Activation of tyrosinase reduces the cytotoxic effects of the superoxide anion in B16 mouse melanoma cells.
Activity of azelaic acid on cultures of lymphoma- and leukemia-derived cell lines, normal resting and stimulated lymphocytes and 3T3 fibroblasts.
Acute effects of two melanocytolytic agents, hydroquinone and beta-mercaptoethanolamine, upon tyrosinase activity and cyclic nucleotide levels in murine melanomas.
Additive Effect of a Combination of Artocarpus lakoocha and Glycyrrhiza glabra Extracts on Tyrosinase Inhibition in Melanoma B16 Cells.
Adenoviral vectors with E1A regulated by tumor-specific promoters are selectively cytolytic for breast cancer and melanoma.
Adenovirus MART-1-engineered Autologous Dendritic Cell Vaccine for Metastatic Melanoma.
Adjuvant dendritic cell vaccination induces tumor-specific immune responses in the majority of stage III melanoma patients.
Advances in fluorescent probes for detection and imaging of endogenous tyrosinase activity.
Agents with potential specificity against melanotic melanoma.
Aggregation equilibria of tyrosinase of Harding-Passey mouse melanoma.
Agouti protein inhibits growth of B16 melanoma cells in vitro by acting through melanocortin receptors.
Alkylating benzamides with melanoma cytotoxicity: role of melanin, tyrosinase, intracellular pH and DNA interaction.
Allo-restricted CTLs generated by coculturing of PBLs and autologous monocytes loaded with allogeneic peptide/HLA/IgG1-Fc fusion protein.
Alpha melanocyte stimulating hormone (alpha MSH) stimulates normal human melanocyte growth by binding to high-affinity receptors.
Alpha-melanocyte stimulating hormone-induced pigmentation is blocked by depletion of protein kinase C.
alpha-Melanocyte-stimulating hormone binding and biological activity in a human melanoma cell line.
Alpha-melanocyte-stimulating hormone regulation of tyrosinase in Cloudman S-91 mouse melanoma cell cultures.
Alpha-MSH and other melanogenic activators mediate opposite effects on tyrosinase and dopachrome tautomerase in B16/F10 mouse melanoma cells.
Alphavirus replicon particles expressing TRP-2 provide potent therapeutic effect on melanoma through activation of humoral and cellular immunity.
Alteration of the Cloudman melanoma cell cycle by prostaglandins E1 and E2 determined by using a 5-bromo-2'-deoxyuridine method of DNA analysis.
Alteration of tyrosinase activity in human melanocytes and melanoma cells by histamine H2 and H3 ligands.
Altered N-glycosylation in macrophage x melanoma fusion hybrids.
Alternative splicing of the tyrosinase gene transcript in normal human melanocytes and lymphocytes.
Alteronol induces differentiation of melanoma b16-f0 cells.
Aminoluciferin 4-hydroxyphenyl amide enables bioluminescence detection of endogenous tyrosinase.
Amplification of MelanA messenger RNA in addition to tyrosinase increases sensitivity of melanoma cell detection in peripheral blood and is associated with the clinical stage and prognosis of malignant melanoma.
An animal model for the survival of tyrosinase isozymes in serum.
An antigenic peptide produced by reverse splicing and double asparagine deamidation.
An aqueous extract of Limoniastrum guyonianum gall induces anti-tumor effects in melanoma-injected mice via modulation of the immune response.
An ester extract of Cochinchina momordica seeds induces differentiation of melanoma B16 F1 cells via MAPKs signaling.
An HLA-A2-restricted tyrosinase antigen on melanoma cells results from posttranslational modification and suggests a novel pathway for processing of membrane proteins.
An improved and combined reverse transcription-polymerase chain reaction assay for reliable detection of metastatic melanoma cells in peripheral blood.
An N-glycosylated tyrosinase epitope associates with newly synthesized MHC class I molecules in melanoma cells.
Analysis of carbohydrate properties essential for melanogenesis in tyrosinases of cultured malignant melanoma cells by differential carbohydrate processing inhibition.
Analysis of HLA class I expression in different metastases from two melanoma patients undergoing peptide immunotherapy.
Analysis of melanoma cells in peripheral blood by reverse transcription-polymerase chain reaction for tyrosinase and MART-1 after mononuclear cell collection with cell preparation tubes: a comparison with the whole blood guanidinium isothiocyanate RNA isolation method.
Analysis of microphthalmia transcription factor expression in normal tissues and tumors, and comparison of its expression with S-100 protein, gp100, and tyrosinase in desmoplastic malignant melanoma.
Analysis of T-cell responses in metastatic melanoma patients vaccinated with dendritic cells pulsed with tumor lysates.
Analysis of the cytolytic T lymphocyte response of melanoma patients to the naturally HLA-A*0201-associated tyrosinase peptide 368-376.
Analysis of the T cell response to tumor and viral peptide antigens by an IFNgamma-ELISPOT assay.
Analytical, ultrastructural, autoradiographic and biochemical studies on [3H]dicarboxylic acid added to cultures of melanoma cells.
Anionic polysaccharide production and tyrosinase activation in cultured human melanoma cells.
Anisaldehyde, a melanogenesis potentiator.
Antagonist and agonist activities of the mouse agouti protein fragment (91-131) at the melanocortin-1 receptor.
Anti melanogenic effect of Croton roxburghii and Croton sublyratus leaves in ?-MSH stimulated B16F10?cells.
Anti-inflammatory and anti-melanogenesis activities of sulfated polysaccharides isolated from Hizikia fusiforme: Short communication.
Anti-melanization effects and inhibitory kinetics of tyrosinase of bird's nest fern (Asplenium australasicum) frond extracts on melanoma and human skin.
Anti-Melanogenesis Effects of Lotus Seedpod In Vitro and In Vivo.
Anti-melanogenesis potential of a new series of Morita-Baylis-Hillman adducts in B16F10 melanoma cell line.
Anti-melanogenesis properties of condensed tannins from Vigna angularis seeds with potent antioxidant and DNA damage protection activities.
Anti-Melanogenic Activity and Cytotoxicity of Pistacia vera Hull on Human Melanoma SKMEL-3 Cells.
Anti-melanogenic activity of Viola odorata different extracts on B16F10 murine melanoma cells.
Anti-melanogenic and anti-oxidant activities of ethanol extract of Kummerowia striata: Kummerowia striata regulate anti-melanogenic activity through down-regulation of TRP-1, TRP-2 and MITF expression.
Anti-melanogenic effect of (Z)-5-(2,4-dihydroxybenzylidene) thiazolidine-2,4-dione, a novel tyrosinase inhibitor.
Anti-melanogenic effects of Aster spathulifolius extract in UVB-exposed C57BL/6J mice and B16F10 melanoma cells through the regulation of MAPK/ERK and AKT/GSK3? signalling.
Anti-melanogenic effects of extracellular vesicles derived from plant leaves and stems in mouse melanoma cells and human healthy skin.
Anti-Melanogenic Effects of Flavonoid Glycosides from Limonium tetragonum (Thunb.) Bullock via Inhibition of Tyrosinase and Tyrosinase-Related Proteins.
Anti-Melanogenic Mechanism of Tetrahydrocurcumin and Enhancing Its Topical Delivery Efficacy Using a Lecithin-Based Nanoemulsion.
Anti-Melanogenic Properties of Greek Plants. A Novel Depigmenting Agent from Morus alba Wood.
Anti-melanoma cytotoxic T lymphocytes (CTL) recognize numerous antigenic peptides having 'self' sequences: autoimmune nature of the anti-melanoma CTL response.
Anti-melanoma vaccines engineered to simultaneously modulate cytokine priming and silence PD-L1 characterized using ex vivo myeloid-derived suppressor cells as a readout of therapeutic efficacy.
Anti-Oxidant, Anti-Aging, and Anti-Melanogenic Properties of the Essential Oils from Two Varieties of Alpinia zerumbet.
Anti-oxidative, anti-inflammatory and whitening effects of phenolic compounds from Bambusae Caulis in Liquamen.
Anti-pigmentary activity of fucoxanthin and its influence on skin mRNA expression of melanogenic molecules.
Antibacterial, Antioxidant and Melanogenesis Inhibitory Activity of Auraptene, a Coumarin from Ferula szowitsiana Root.
Anticancer therapeutic potential of soy isoflavone, genistein.
Antimelanogenesis and Anti-Inflammatory Activity of Selected Culinary-Medicinal Mushrooms.
Antimelanogenesis Effects of Fungal Exopolysaccharides Prepared from Submerged Culture of Fomitopsis castanea Mycelia.
Antimelanoma activity of perphenazine and prochlorperazine in human COLO829 and C32 cell lines.
Antimelanoma effect of 4-S-cysteaminylcatechol, an activated form of 4-S-cysteaminylphenol.
Antioxidant, Anti-Melanogenic and Anti-Wrinkle Effects of Phellinus vaninii.
Antioxidant, anti-tyrosinase and anti-melanogenic effects of (E)-2,3-diphenylacrylic acid derivatives.
Antioxidative and Antimelanogenesis Effect of Momordica charantia Methanol Extract.
Antioxidative properties and inhibitory effect of Bifidobacterium adolescentis on melanogenesis
Antioxidative properties and inhibitory effect of Bifidobacterium adolescentis on melanogenesis.
Antiproliferative and depigmenting effects of the histamine (H2) agonist dimaprit and its derivatives on human melanoma cells.
Antiserum against tyrosinase from mouse melanoma.
Antitumoral, antioxidant, and antimelanogenesis potencies of Hawthorn, a potential natural agent in the treatment of melanoma.
Antityrosinase activity of Euphorbia characias extracts.
Application of paclitaxel in low non-cytotoxic doses supports vaccination with melanoma antigens in normal mice.
Aqueous fraction from Cuscuta japonica seed suppresses melanin synthesis through inhibition of the p38 mitogen-activated protein kinase signaling pathway in B16F10 cells.
Are Human Tyrosinase and Related Proteins Suitable Targets for Melanoma Therapy?
Aromatic-turmerone inhibits ?-MSH and IBMX-induced melanogenesis by inactivating CREB and MITF signaling pathways.
Ascorbic acid increases the activity and synthesis of tyrosinase in B16F10 cells through activation of p38 mitogen-activated protein kinase.
Assay of melanotropic peptides in an in vitro mammalian system.
Assays for mammalian tyrosinase: a comparative study.
Augmentation of melanoma-specific gene expression using a tandem melanocyte-specific enhancer results in increased cytotoxicity of the purine nucleoside phosphorylase gene in melanoma.
Autoantibodies to tyrosinase: the bridge between melanoma and vitiligo.
Autoimmunity in a phase I trial of a fully human anti-cytotoxic T-lymphocyte antigen-4 monoclonal antibody with multiple melanoma peptides and Montanide ISA 51 for patients with resected stages III and IV melanoma.
Autologous human dendriphages pulsed with synthetic or natural tumor peptides elicit tumor-specific CTLs in vitro.
Autologous monocyte-derived DC vaccination combined with cisplatin in stage III and IV melanoma patients: a prospective, randomized phase 2 trial.
Baicalein inhibits melanogenesis through activation of the ERK signaling pathway.
Beclin 1 controls pigmentation by changing the nuclear localization of melanogenic factor MITF.
Benzodiazepines have high-affinity binding sites and induce melanogenesis in B16/C3 melanoma cells.
Beta-carboline alkaloids harmaline and harmalol induce melanogenesis through p38 mitogen-activated protein kinase in B16F10 mouse melanoma cells.
BETA-GALACTOSYLCERAMIDASE PROMOTES MELANOMA GROWTH VIA MODULATION OF CERAMIDE METABOLISM.
Bioactivation of luteolin by tyrosinase selectively inhibits glutathione S-transferase.
Bioactivities of alcohol based extracts of Phyllanthus emblica branches: antioxidation, antimelanogenesis and anti-inflammation.
Biochemical characterization of a new melanoma model--the minipig MeLiM strain.
Biochemical characterization of the melanogenic system in the eye of adult rodents.
Biochemical characterization of three hamster melanoma variants--I. Tyrosinase activity and melanin content.
Biochemical characterization of tyrosinase inhibitors using tyrosinase binding affinity chromatography.
Biochemical markers of malignant melanoma.
Biochemical mechanism of acetaminophen (APAP) induced toxicity in melanoma cell lines.
Biochemical mechanism of acetylsalicylic acid (Aspirin) selective toxicity toward melanoma cell lines.
Biochemical mechanism of caffeic acid phenylethyl ester (CAPE) selective toxicity towards melanoma cell lines.
Biochemistry of malignant melanoma.
Biological actions of melanocyte-stimulating hormone.
Biological activities of melanotropic peptide fatty acid conjugates.
Biological activity and binding of estradiol to SK-Mel 23 human melanoma cells.
Biological assays of BF2-naphthyridine compounds: Tyrosinase and acetylcholinesterase activity, CT-DNA and HSA binding property evaluations.
Bleomycin enhances the tyrosinase activity of human malignant melanoma cells in culture.
Blocking TCR restimulation induced necroptosis in adoptively transferred T cells improves tumor control.
Bone marrow contains melanoma-reactive CD8+ effector T cells and, compared with peripheral blood, enriched numbers of melanoma-reactive CD8+ memory T cells.
Bone marrow-derived factors support growth of N-type, but not of melanocytic neuroblastoma cells.
Boosting T cell-mediated immunity to tyrosinase by vaccinia virus-transduced, CD34(+)-derived dendritic cell vaccination: a phase I trial in metastatic melanoma.
Both CD4 and CD8 T Cells Mediate Equally Effective In Vivo Tumor Treatment When Engineered with a Highly Avid TCR Targeting Tyrosinase.
BRAF activation initiates but does not maintain invasive prostate adenocarcinoma.
Broadening the repertoire of melanoma-associated T-cell epitopes.
Bromodeoxyuridine- and cyclic AMP-mediated regulation of tyrosinase in Syrian hamster melanoma cells.
Bystander killing of melanoma cells using the human tyrosinase promoter to express the Escherichia coli purine nucleoside phosphorylase gene.
Caffeic Acid Phenethyl Ester Assisted by Reversible Electroporation-In Vitro Study on Human Melanoma Cells.
Cancer vaccines: Harnessing the potential of anti-tumor immunity.
Canine malignant melanoma alpha-3 integrin binding peptides.
Capsaicin reverses the inhibitory effect of licochalcone A/?-Arbutin on tyrosinase expression in b16 mouse melanoma cells.
Carcinogen treatment in mouse selectively expressing activated N-Ras(Q61K) in melanocytes recapitulates metastatic cutaneous melanoma development.
Catalysis-based specific detection and inhibition of tyrosinase and their application.
Catecholamine effects on human melanoma cells evoked by alpha1-adrenoceptors.
CD4+ T cells from peripheral blood of a melanoma patient recognize peptides derived from nonmutated tyrosinase.
CD40 ligand and lipopolysaccharide enhance the in vitro generation of melanoma-reactive T-cells.
CD40-stimulated B lymphocytes pulsed with tumor antigens are effective antigen-presenting cells that can generate specific T cells.
CD8-independent tumor cell recognition is a property of the T cell receptor and not the T cell.
Cell adhesion regulates melanoma specific differentiation and interactions with the 3' region of the tyrosinase gene.
Cellular localization of tyrosinase in human malignant melanoma cell lines.
Cellular sialic acid level and phenotypic expression in B16 melanoma cells: comparison of spontaneous variations and bromodeoxyuridine- and theophylline-induced changes.
Changes in expression of putative antigens encoded by pigment genes in mouse melanomas at different stages of malignant progression.
Changes in the presence of multiple markers of circulating melanoma cells correlate with clinical outcome in patients with melanoma.
Characteristics of tyrosinase in B16 melanoma.
Characterization of a novel tyrosinase inhibitor, (2RS,4R)-2-(2,4-dihydroxyphenyl)thiazolidine-4-carboxylic acid (MHY384).
Characterization of Caffeoylquinic Acids from Lepisorus thunbergianus and Their Melanogenesis Inhibitory Activity.
Characterization of chemical constituents with their antioxidant and anti-melanogenesis activities from the roots of Ampelopsis japonica.
Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients.
Characterization of gene regulatory elements for selective gene expression in human melanoma cells.
Characterization of inhibitory effects of the potential therapeutic inhibitors, benzoic acid and pyridine derivatives, on the monophenolase and diphenolase activities of tyrosinase.
Characterization of Melanogenesis Inhibitory Constituents of Morus alba Leaves and Optimization of Extraction Conditions Using Response Surface Methodology.
Characterization of seven human melanoma cell lines: melanogenesis and secretion of plasminogen activators.
Characterization of structural properties for morphological differentiation of melanosomes: I. Purification of tyrosinase by tyrosine affinity chromatography and its characterization in B16 and Harding Passey melanomas.
Characterization of sulfuretin as a depigmenting agent.
Characterization of the effects of different retinoids on the growth and differentiation of a human melanoma cell line and selected subclones.
Chemical and histochemical analyses of tyrosinase activity in melanoma and related lesions.
Chemical Composition of Miscanthus sinensis var. purpurascens Flower Absolute and Its Beneficial Effects on Skin Wound Healing and Melanogenesis-Related Cell Activities.
Chemical constituents derived from Artocarpus xanthocarpus as inhibitors of melanin biosynthesis.
Chloroform extract from Moricandia arvensis inhibits growth of B16-F0 melanoma cells and promotes differentiation in vitro.
Cholinesterase and tyrosinase activity in malignant melanoma.
Chromosome and growth factor abnormalities in melanoma.
Chronic stress induces fur color change from dark to brown by decreasing follicle melanocytes and tyrosinase activity in female C57BL/6 mice.
Chymotrypsin activation of melanosome tyrosinase in hamster melanotic melanoma.
Circulating benign nevus cells detected by ISET technique: warning for melanoma molecular diagnosis.
Circulating melanoma cells and distant metastasis-free survival in stage III melanoma patients with or without adjuvant interferon treatment (EORTC 18991 side study).
Circulating tumor cells as prognostic factor for distant metastases and survival in patients with primary uveal melanoma.
Circulating tyrosinase and MART-1 mRNA does not independently predict relapse or survival in patients with AJCC stage I-II melanoma.
Citrate activates tyrosinase from B-16 murine melanoma and human skin.
Citrus flavanone naringenin enhances melanogenesis through the activation of Wnt/?-catenin signalling in mouse melanoma cells.
Clinical and immunologic results of a randomized phase II trial of vaccination using four melanoma peptides either administered in granulocyte-macrophage colony-stimulating factor in adjuvant or pulsed on dendritic cells.
Clinical and Pathological Analysis of Two Cases of Cutaneous Malignant Melanoma.
Clinical protocol. Immunization of patients with malignant melanoma with autologous CD34(+) cell-derived dendritic cells transduced ex vivo with a recombinant replication-deficient vaccinia vector encoding the human tyrosinase gene: a phase I trial.
Clinical significance of sequential tyrosinase expression in the peripheral blood of disease-free melanoma patients: a review of literature data.
Clinical significance of the molecular detection of melanoma cells circulating in the peripheral blood in melanoma patients.
Clinical value of combined determination of plasma L-DOPA/tyrosine ratio, S100B, MIA and LDH in melanoma.
Clonal coat color variation due to a transforming gene expressed in melanocytes of transgenic mice.
Clonal expansion of Melan A-specific cytotoxic T lymphocytes in a melanoma patient responding to continued immunization with melanoma-associated peptides.
Cloning of a new gene encoding an antigen recognized by melanoma-specific HLA-A24-restricted tumor-infiltrating lymphocytes.
Co-regulation of melanin precursors and tyrosinase in human pigment cells: roles of cysteine and glutathione.
Combination and efficiency: preparation of dissolving microneedles array loaded with two active ingredients and its anti-pigmentation effects on guinea pigs.
Combination of amino acids reduces pigmentation in B16F0 melanoma cells.
Combining adenoviral oncolysis with temozolomide improves cell killing of melanoma cells.
Common origins of MDA-MB-435 cells from various sources with those shown to have melanoma properties.
Comparative analysis of the in vivo expression of tyrosinase, MART-1/Melan-A, and gp100 in metastatic melanoma lesions: implications for immunotherapy.
Comparative biological activities of alpha-MSH antagonists in vertebrate pigment cells.
Comparative cytotoxicity of phenols in vitro.
Comparative decreases in tyrosinase, TRP-1, TRP-2, and Pmel 17/silver antigenic proteins from melanotic to amelanotic stages of syngeneic mouse cutaneous melanomas and metastases.
Comparative genomic hybridization in a case of melanoma that loses expression of S100, HMB45, Melan A and tyrosinase in metastasis.
Comparative studies on the correlation between pyrimidine dimer formation and tyrosinase activity in cloudman S91 melanoma cells after ultraviolet-irradiation.
Comparative study of tyrosinases from different sources: relationship between halide inhibition and the enzyme active site.
Comparison between three molecular methods for detection of blood melanoma tyrosinase mRNA. Correlation with melanoma stages and S100B, LDH, NSE biochemical markers.
Comparison of antiaging, anti-melanogenesis effects, and active components of Raspberry (Rubus occidentalis L.) extracts according to maturity.
Comparison of antimelanoma effects of 4-S-cysteaminylphenol and its homologues.
Comparison of five antibodies as markers in the diagnosis of melanoma in cytologic preparations.
Comparison of immunohistochemical labelling of melanocyte differentiation antibodies melan-A, tyrosinase and HMB 45 with NKIC3 and S100 protein in the evaluation of benign naevi and malignant melanoma.
Comparison of in vitro cytotoxicity of N-acetyl and N-propionyl derivatives of phenolic thioether amines in melanoma and neuroblastoma cells and the relationship to tyrosinase and tyrosine hydroxylase enzyme activity.
Comparison of the inhibitory effects of vitamin E analogues on melanogenesis in mouse B16 melanoma cells.
Comparison of TRPs from murine and human malignant melanocytes.
Comparison of two cancer vaccines targeting tyrosinase: plasmid DNA and recombinant alphavirus replicon particles.
Comparison of tyrosinase levels in amelanotic and melanotic melanoma cell cultures by a competitive enzyme-linked immunoadsorbent assay and by immunotitration analysis.
Concordant loss of melanoma differentiation antigens in synchronous and asynchronous melanoma metastases: implications for immunotherapy.
Conditionally replication-competent adenoviral vectors with enhanced infectivity for use in gene therapy of melanoma.
Conjugation with Dihydrolipoic Acid Imparts Caffeic Acid Ester Potent Inhibitory Effect on Dopa Oxidase Activity of Human Tyrosinase.
Conjugation with Phospholipids as a Modification Increasing Anticancer Activity of Phenolic Acids in Metastatic Melanoma-In Vitro and In Silico Studies.
Context-dependent miR-204 and miR-211 affect the biological properties of amelanotic and melanotic melanoma cells.
Control of melanogenesis in mouse melanoma cells of varying metastatic potential.
Conversion of particulate tyrosinase to soluble form and to desialylated tyrosinase in human malignant melanoma.
Coordinated mRNA and protein expression of human LAMP-1 in induction of melanogenesis after UV-B exposure and co-transfection of human tyrosinase and TRP-1 cDNAs.
Correlation between the number of melanosomes, tyrosinase mRNA levels, and tyrosinase activity in cultured murine melanoma cells in response to various melanogenesis regulatory agents.
Correlation of positive RT-PCR for tyrosinase in peripheral blood of malignant melanoma patients with clinical stage, survival and other risk factors.
Cosmetic applications of glucitol-core containing gallotannins from a proprietary phenolic-enriched red maple (Acer rubrum) leaves extract: inhibition of melanogenesis via down-regulation of tyrosinase and melanogenic gene expression in B16F10 melanoma cells.
Cross-priming of naive CD8 T cells against melanoma antigens using dendritic cells loaded with killed allogeneic melanoma cells.
Cross-talk between DopaChromeTautomerase and Caveolin-1 is melanoma cell phenotype specific and potentially involved in tumor progression.
CTL specific for the tyrosinase autoantigen can be induced from healthy donor blood to lyse melanoma cells.
Cucurbitacins from Trichosanthes kirilowii as the inhibitory components on tyrosinase activity and melanin synthesis of B16/F10 melanoma cells.
Cutaneous malignant melanomas in 57 cats: identification of (amelanotic) signet-ring and balloon cell types and verification of their origin by immunohistochemistry, electron microscopy, and in situ hybridization.
Cutting edge: rapid cloning of tumor-specific CTL suitable for adoptive immunotherapy of melanoma.
Cyclin-dependent kinase 5 regulates proliferation, migration, tyrosinase activity, and melanin production in B16-F10 melanoma cells via the essential regulator p-CREB.
Cycloartane triterpenoid (23R, 24E)-23-acetoxymangiferonic acid inhibited proliferation and migration in B16-F10 melanoma via MITF downregulation caused by inhibition of both ?-catenin and c-Raf-MEK1-ERK signaling axis.
Cytolytic T cell reactivity against melanoma-associated differentiation antigens in peripheral blood of melanoma patients and healthy individuals.
Cytotoxicity of a selected series of substituted phenols towards cultured melanoma cells.
D-tyrosine adds an anti-melanogenic effect to cosmetic peptides.
Decay of hormone responsiveness in mouse melanoma cells in culture as a function of cell density.
Decrease in circulating tumor cells as an early marker of therapy effectiveness.
Decreased CD117 expression in hypopigmented mycosis fungoides correlates with hypomelanosis: lessons learned from vitiligo.
Dedifferentiation of human epidermal melanocytes in vitro by long-term trypsinization.
Definition of anti-tyrosinase MAb T311 linear determinant by proteome-based similarity analysis.
Demonstration of carbohydrate structures in malignant melanoma tyrosinase.
Demonstration of cytoplasmic tyrosinase mRNA in tissue-cultured cells by reverse transcription (RT) in situ polymerase chain reaction (PCR) and RT PCR in situ hybridization.
Dendritic cell-based genetic immunization in mice with a recombinant adenovirus encoding murine TRP2 induces effective anti-melanoma immunity.
Depigmentation efficacy of galacturonic acid through tyrosinase regulation in B16 murine melanoma cells and a three-dimensional human skin equivalent.
Depigmentation of ?-melanocyte-stimulating hormone-treated melanoma cells by ?-mangostin is mediated by selective autophagy.
Depigmenting effect of Kojic acid esters in hyperpigmented B16F1 melanoma cells.
Depigmenting Effect of Winter Medicinal Mushroom Flammulna velutipes (Higher Basidiomycetes) on Melanoma Cells.
Dermatological applications of the flavonoid phloretin.
Dermoscopy, reflectance confocal microscopy and histopathology of an amelanotic melanoma from an individual heterozygous for MC1R and tyrosinase variant alleles.
Design, synthesis and anti-melanogenic effect of cinnamamide derivatives.
Design, synthesis and biological evaluation of hydroxy substituted amino chalcone compounds for antityrosinase activity in B16 cells.
Design, synthesis, and anti-melanogenic effects of (E)-2-benzoyl-3-(substituted phenyl)acrylonitriles.
Design, synthesis, and antimelanogenic effects of (2-substituted phenyl-1,3-dithiolan-4-yl)methanol derivatives.
Design, synthesis, and evaluation of (E)-N-substituted benzylidene-aniline derivatives as tyrosinase inhibitors.
Desmoplastic melanoma: comparison of expression of differentiation antigens and cancer testis antigens.
Detecting human melanoma cell re-differentiation following BRAF or heat shock protein 90 inhibition using photoacoustic and magnetic resonance imaging.
Detection and quantification of blood-derived CD8+ T lymphocytes secreting tumor necrosis factor alpha in response to HLA-A2.1-binding melanoma and viral peptide antigens.
Detection and quantitation of melanoma cells in the circulation of patients.
Detection of beta-human chorionic gonadotropin mRNA as a marker for cutaneous malignant melanoma.
Detection of circulating malignant cells by RT-PCR in long-term clinically disease-free I stage melanoma patients.
Detection of circulating melanoma cells by RT-PCR amplification of three different melanocyte-specific mRNAs in a mouse model.
Detection of circulating melanoma cells by specific amplification of tyrosinase complementary DNA is not a reliable tumor marker in melanoma patients: a clinical two-center study.
Detection of circulating neoplastic cells by reverse-transcriptase polymerase chain reaction in malignant melanoma: association with clinical stage and prognosis.
Detection of disseminated melanoma cells by reverse-transcription - polymerase chain reaction.
Detection of early micrometastases in subcutaneous fat of primary malignant melanoma patients by identification of tyrosinase-mRNA.
Detection of melanocytes from uveal melanoma in peripheral blood using the polymerase chain reaction.
Detection of melanoma cells in peripheral blood and sentinel lymph nodes by RT-PCR analysis: a comparative study with immunohistochemistry.
Detection of melanoma cells in peripheral blood stem cell harvests of patients with progressive metastatic malignant melanoma.
Detection of melanoma cells in peripheral blood using reverse transcription polymerase chain reaction assay for tyrosinase mRNA.
Detection of melanoma cells in sentinel lymph nodes by reverse transcriptase-polymerase chain reaction: prognostic significance.
Detection of melanoma cells in sentinel lymph nodes, bone marrow and peripheral blood by a reverse transcription-polymerase chain reaction assay in patients with primary cutaneous melanoma: association with Breslow's tumour thickness.
Detection of melanoma micrometastases in the sentinel lymph node and in nonsentinel nodes by tyrosinase polymerase chain reaction.
Detection of melanoma micrometastasis in sentinel nodes by reverse transcription-polymerase chain reaction correlates with tumor thickness and is predictive of micrometastatic disease in the lymph node basin.
Detection of micrometastasis in sentinel lymph nodes of patients with primary cutaneous melanoma.
Detection of Misdistribution of Tyrosinase from Melanosomes to Lysosomes and Its Upregulation under Psoralen/Ultraviolet A with a Melanosome-Targeting Tyrosinase Fluorescent Probe.
Detection of mouse tyrosinase with a monoclonal antibody MAT-1 against human tyrosinase.
Detection of regional melanoma metastases by ultrasound B-scan, cytology or tyrosinase RT-PCR of fine-needle aspirates.
Detection of residual tumor cells in patients with malignant melanoma responding to immunotherapy.
Detection of submicroscopic lymph node metastases with polymerase chain reaction in patients with malignant melanoma.
Detection of tumor messenger RNA in the serum of patients with malignant melanoma.
Detection of tumor-associated circulating mRNA in serum, plasma and blood cells from patients with disseminated malignant melanoma.
Detection of tumour cells in the bloodstream of patients with uveal melanoma: influence of surgical manipulation on the dissemination of tumour cells in the bloodstream.
Detection of tyrosinase and tyrosinase-related protein 1 sequences from peripheral blood of melanoma patients using reverse transcription-polymerase chain reaction.
Detection of tyrosinase in living cells using an Enteromorpha Prolifera based fluorescent probe.
Detection of tyrosinase mRNA by an optimised nested RT-PCR in the peripheral blood of patients with advanced malignant melanoma.
Detection of tyrosinase mRNA by reverse transcription-polymerase chain reaction in melanoma sentinel nodes.
Detection of tyrosinase mRNA by RT-PCR in the peripheral blood of patients with advanced metastatic melanoma.
Detection of tyrosinase mRNA from the blood of melanoma patients.
Detection of tyrosinase mRNA in formalin-fixed, paraffin-embedded archival sections of melanoma, using the reverse transcriptase in situ polymerase chain reaction.
Detection of tyrosinase mRNA in melanoma by reverse transcription-PCR and electrochemiluminescence.
Detection of tyrosinase mRNA in the sentinel lymph nodes of melanoma patients is not a predictor of short-term disease recurrence.
Development of a multiple-marker polymerase chain reaction assay for detection of metastatic melanoma in lymph node aspirates of dogs.
Development of highly potent melanogenesis inhibitor by in vitro, in vivo and computational studies.
Development of Immunologic Assays to Measure Response in Horses Vaccinated with Xenogeneic Plasmid DNA Encoding Human Tyrosinase
Development of radioiodine-labeled 4-hydroxyphenylcysteamine for specific diagnosis of malignant melanoma.
Development of radioiodine-labeled acetaminophen for specific, high-contrast imaging of malignant melanoma.
Development of Tyrosinase Promoter-Based Fluorescent Assay for Screening of Anti-melanogenic Agents.
Differences in subcellular distribution of catechol-O-methyltransferase and tyrosinase in malignant melanoma.
Different cis-acting elements are involved in the regulation of TRP1 and TRP2 promoter activities by cyclic AMP: pivotal role of M boxes (GTCATGTGCT) and of microphthalmia.
Differential expression of MART-1, tyrosinase, and SM5-1 in primary and metastatic melanoma.
Differential regulation of tyrosinase activity in skin of white and black individuals in vivo by topical retinoic acid.
Differentiation apparently repressed by the nucleus. Rapidly-induced pigmentation of enucleated melanoma cells.
Differentiation-inducing and anti-proliferative activities of lupeol on canine melanoma cells.
Dihydro-1,4-benzothiazine-6,7-dione, the ultimate toxic metabolite of 4-S-cysteaminylphenol and 4-S-cysteaminylcatechol.
Dihydromyricetin from Ampelopsis grossedentata inhibits melanogenesis through down-regulation of MAPK, PKA and PKC signaling pathways.
Dimeric cinnamoylamide analogues for regulation of tyrosinase activity in melanoma cells: A role of diamide-link chain length.
Direct injection of protamine-protected mRNA: results of a phase 1/2 vaccination trial in metastatic melanoma patients.
Discovery, affinity maturation and multimerization of small molecule ligands against human tyrosinase and tyrosinase-related protein 1.
Diverse expansion potential and heterogeneous avidity in tumor-associated antigen-specific T lymphocytes from primary melanoma patients.
DNA damage enhances melanogenesis.
DNp73-induced degradation of tyrosinase links depigmentation with EMT-driven melanoma progression.
Docosahexaenoic acid inhibits melanin synthesis in murine melanoma cells in vitro through increasing tyrosinase degradation.
Does intensive histopathological workup by serial sectioning increase the detection of lymph node micrometastasis in patients with primary cutaneous melanoma?
Does tyrosinase exist in neuromelanin-pigmented neurons in the human substantia nigra?
Dopa oxidation and tyrosine oxygenation by human melanoma tyrosinase.
Dopachrome oxidoreductase: a new enzyme in the pigment pathway.
Dopamine-, L-DOPA-, adrenaline-, and noradrenaline-induced growth of Au nanoparticles: assays for the detection of neurotransmitters and of tyrosinase activity.
Dormant tumor cells interact with memory CD8+ T cells in RET transgenic mouse melanoma model.
Down-regulation of tyrosinase mRNA levels in melanoma cells by tumor promoters and by insulin.
Down-regulation of tyrosinase, TRP-1, TRP-2 and MITF expressions by citrus press-cakes in murine B16 F10 melanoma.
Drying methods influence the physicochemical and functional properties of seed-used pumpkin.
Early detection of melanoma progression by quantitative real-time RT-PCR analysis for multiple melanoma markers.
Ectopic expression of tyrosinase increases melanin synthesis and cell death following UVB irradiation in fibroblasts from familial atypical multiple mole and melanoma (FAMMM) patients.
Effect of ACTH and corticosterone on melanogenesis and cyclic nucleotide levels in the B-16 melanoma.
Effect of alpha-MSH on the tyrosinase activity and the rate of melanin accumulation of melanoma cells in vitro.
Effect of apigenin-7-glucoside, genkwanin and naringenin on tyrosinase activity and melanin synthesis in B16F10 melanoma cells.
Effect of chlorogenic acid on melanogenesis of B16 melanoma cells.
Effect of combination of taurine and azelaic acid on antimelanogenesis in murine melanoma cells.
Effect of dopa-loading on glutathione metabolising enzymes and tyrosinase in relation to 5-S-cysteinyl-dopa genesis in cultured B-16 melanoma cells.
Effect of melanin concentrating hormone on pigment and adrenal cells in vitro.
Effect of melanocyte stimulating hormone on human cultured choroidal melanocytes, uveal melanoma cells, and retinal epithelial cells.
Effect of Okinawa Propolis on PAK1 Activity, Caenorhabditis elegans Longevity, Melanogenesis, and Growth of Cancer Cells.
Effect of phenothiazines on melanoma tyrosinase activity.
Effect of polysaccharide FMP-1 from Morchella esculenta on melanogenesis in B16F10 cells and zebrafish.
Effect of testosterone on imidazole-induced tyrosinase expression in B16 melanoma cell culture.
Effect of the tyrosinase inhibitor (S)-N-trans-feruloyloctopamine from garlic skin on tyrosinase gene expression and melanine accumulation in melanoma cells.
Effect of theophyllin and isoproterenol on cAMP level in melanotic and amelanotic hamster melanomas.
Effect of thymidine analogs on tyrosinase activity and mRNA accumulation in mouse melanoma cells.
Effect of tissue selection on melanization of MI hamster melanoma.
Effect of triamcinolone acetonide on tyrosinase activity in a human melanoma cell line.
Effect of Vetiveria zizanioides essential oil on melanogenesis in melanoma cells: downregulation of tyrosinase expression and suppression of oxidative stress.
Effect on growth and structure of transplantable malignant melanomas of the Syrian golden hamster (Mesocricetus auratus) by depletion of phenylalanine and tyrosine in the diet and by inhibition of tyrosinase. Brief report.
Effective Clinical Responses in Metastatic Melanoma Patients after Vaccination with Primary Myeloid Dendritic Cells.
Effects of actinomycin D and cycloheximide on the increase in tyrosinase activity of hamster amelanotic melanoma cells in vitro.
Effects of alpha- and beta-arbutin on activity of tyrosinases from mushroom and mouse melanoma.
Effects of alpha-MSH on melanogenesis and tyrosinase of B-16 melanoma.
Effects of ascorbic acid on gingival melanin pigmentation in vitro and in vivo.
Effects of certain resorcinol derivatives on the tyrosinase activity and the growth of melanoma cells.
Effects of dicarboxylic acids on normal and malignant melanocytes in culture.
Effects of estradiol on estrogen receptor, progesterone receptor, and tyrosinase in hamster melanoma transplanted into athymic mice.
Effects of granulocyte-macrophage colony-stimulating factor and foreign helper protein as immunologic adjuvants on the T-cell response to vaccination with tyrosinase peptides.
Effects of L-glutamine on tyrosinase and gamma-glutamyl transpeptidase of B-16 melanoma cells in culture.
Effects of latanoprost on tyrosinase activity and mitotic index of cultured melanoma lines.
Effects of matsutake mushroom scent compounds on tyrosinase and murine B16-F10 melanoma cells.
Effects of pH and type of sugar in the medium on tyrosinase activity in cultured melanoma cells.
Effects of protein hydrolysate from chicken feather meal on tyrosinase activity and melanin formation in B16F10 murine melanoma cells.
Effects of radix polygoni multiflori components on tyrosinase activity and melanogenesis.
Effects of treatments with alpha-difluoromethylornithine and hyperthermia on the growth and polyamine metabolism of Harding-Passey murine melanoma.
Effects of tyrosinase activity on the cytotoxicity of 3,4-dihydroxybenzylamine and buthionine sulfoximine in human melanoma cells.
Effects of tyrosinase activity on the cytotoxicity of 4-S-cysteaminylphenol and N-acetyl-4-S-cysteaminylphenol in melanoma cells.
Effects of wine phenolics and sorghum tannins on tyrosinase activity and growth of melanoma cells.
Effects on proliferation and melanogenesis by inhibition of mutant BRAF and expression of wild-type INK4A in melanoma cells.
Efficacy of acetaminophen in skin B16-F0 melanoma tumor-bearing C57BL/6 mice.
Efficient and selective tumor cell lysis and induction of apoptosis in melanoma cells by a conditional replication-competent CD95L adenovirus.
Efficient melanoma cell killing and reduced melanoma growth in mice by a selective replicating adenovirus armed with TNF-related apoptosis inducing ligand.
Electro-gene-transfer as a new tool for cancer immunotherapy in animals.
Electrochemical, photoelectrochemical, and piezoelectric analysis of tyrosinase activity by functionalized nanoparticles.
Electrochemistry-Regulated Recyclable SERS Sensor for Sensitive and Selective Detection of Tyrosinase Activity.
Electrophoretic characterization of tyrosinase in the coated vesicles of malignant melanoma.
Electrophoretic profile of tyrosinase treated with neuraminidase in various subcellular fractions from mouse melanoma.
Elucidating the immunological effects of 5-azacytidine treatment in patients with myelodysplastic syndrome and identifying new conditional ligands and T-cell epitopes of relevance in melanoma.
Emergent Nanotechnological Strategies for Systemic Chemotherapy against Melanoma.
Enhanced melanogenesis of murine melanoma cells cultured on or in collagen gel.
Enhancement of gene expression and melanin production of human tyrosinase gene loaded in elastic cationic niosomes.
Enhancement of pulmonary metastasis formation and gamma-glutamyltranspeptidase activity in B16 melanoma induced by differentiation in vitro.
Enhancement of the depigmenting effect of hydroquinone by cystamine and buthionine sulfoximine.
Enzymatic and non-enzymatic oxygenation of tyrosine.
Enzyme release from cultured human melanoma cells.
Epithelioid angiomyolipoma of the kidney.
Epitope located N-glycans impair the MHC-I epitope generation and presentation.
Establishment of a melanogenesis regulation assay system using a fluorescent protein reporter combined with the promoters for the melanogenesis-related genes in human melanoma cells.
Ethyl acetate extract from Panax ginseng C.A. Meyer and its main constituents inhibit ?-melanocyte-stimulating hormone-induced melanogenesis by suppressing oxidative stress in B16 mouse melanoma cells.
Eumelanin biosynthesis is regulated by coordinate expression of tyrosinase and tyrosinase-related protein-1 genes.
Evaluation of CD8(+) T-cell frequencies by the Elispot assay in healthy individuals and in patients with metastatic melanoma immunized with tyrosinase peptide.
Evaluation of melanocytic neoplasms: application of a pan-melanoma antibody cocktail.
Evaluation of melanogenesis in A-375 cells in the presence of DMSO and analysis of pyrolytic profile of isolated melanin.
Evaluation of Novel Chalcone Oximes as Inhibitors of Tyrosinase and Melanin Formation in B16 Cells.
Evaluation of peptide vaccine immunogenicity in draining lymph nodes and peripheral blood of melanoma patients.
Evaluation of prime/boost regimens using recombinant poxvirus/tyrosinase vaccines for the treatment of patients with metastatic melanoma.
Evaluation of standard tyrosinase RT-PCR in melanoma patients by the use of the LightCycler system.
Evaluation of the inhibition of mushroom tyrosinase and cellular tyrosinase activities of oxyresveratrol: comparison with mulberroside A.
Evaluation of the modified ELISPOT assay for gamma interferon production in cancer patients receiving antitumor vaccines.
Evaluation of the Novel Synthetic Tyrosinase Inhibitor (Z)-3-(3-bromo-4-hydroxybenzylidene)thiochroman-4-one (MHY1498) In Vitro and In Silico.
Evaluation of the serum L-dopa/L-tyrosine ratio as a melanoma marker.
Evaluation of the use of tyrosinase-specific and melanA/MART-1-specific reverse transcriptase-coupled--polymerase chain reaction to detect melanoma cells in peripheral blood samples from 299 patients with malignant melanoma.
Evaluation of tyrosinase mRNA as a tumor marker in the blood of melanoma patients.
Evaluation of variants of melanoma-associated antigen genes and mRNA transcripts in melanomas of dogs.
Evidence consistent with the requirement of cresolase activity for suicide inactivation of tyrosinase.
Evidence that dopachrome tautomerase is a ferrous iron-binding glycoprotein.
Ex vivo derived primary melanoma cells: implications for immunotherapeutic vaccines.
Examination of regional lymph nodes by sentinel node biopsy and molecular analysis provides new staging facilities in primary cutaneous melanoma.
Exploitation of pigment biosynthesis pathway as a selective chemotherapeutic approach for malignant melanoma.
Exploiting Tyrosinase Expression and Activity in Melanocytic Tumors: Quercetin and the Central Role of p53.
Expression of cancer-testis antigens (MAGE-A1, MAGE-A3/6, MAGE-A4, MAGE-C1 and NY-ESO-1) in primary human uveal and conjunctival melanoma.
Expression of differentiation melanoma-associated antigen genes is associated with favorable disease outcome in advanced-stage melanomas.
Expression of gp100, MART-1, tyrosinase, and S100 in paraffin-embedded primary melanomas and locoregional, lymph node, and visceral metastases: implications for diagnosis and immunotherapy. A study conducted by the EORTC Melanoma Cooperative Group.
Expression of MAGE, gp100 and tyrosinase genes in uveal melanoma cell lines.
Expression of Melan-A/MART-1 in primary melanoma cell cultures has prognostic implication in metastatic melanoma patients.
Expression of melanin-related genes in cultured adult human retinal pigment epithelium and uveal melanoma cells.
Expression of melanocyte differentiation antigens and ki-67 in nodal nevi and comparison of ki-67 expression with metastatic melanoma.
Expression of melanocytic differentiation markers in malignant melanomas of the oral and sinonasal mucosa.
Expression of melanoma inhibitory activity in melanoma and nonmelanoma tissue specimens.
Expression of melanoma-associated antigens in melanoma cell cultures.
Expression of transporter associated with antigen processing 1 and 2 (TAP1/2) in malignant melanoma cell lines.
Expression of tyrosinase, MIA and MART-1 in sentinel lymph nodes of patients with malignant melanoma.
Expression of tyrosinase, TRP-1 and TRP-2 in ultraviolet-irradiated human melanomas and melanocytes: TRP-2 protects melanoma cells from ultraviolet B induced apoptosis.
Expression of tyrosinase-related protein 2/DOPAchrome tautomerase in the retinoblastoma.
Expression studies of pigmentation and POU-domain genes in human melanoma cells.
Extracellular matrix modulates the function of human melanocytes but not melanoma cells.
Extracts of Morus nigra L. Leaves Standardized in Chlorogenic Acid, Rutin and Isoquercitrin: Tyrosinase Inhibition and Cytotoxicity.
Facts and pitfalls in the detection of tyrosinase mRNA in the blood of melanoma patients by RT-PCR.
Fate of L-(3,5- 3H) tyrosine in cell-free extracts and tissue cultures of melanoma cells: a new assay method for tyrosinase in living cells.
Fatty acids regulate pigmentation via proteasomal degradation of tyrosinase: a new aspect of ubiquitin-proteasome function.
Favorable overall survival in stage III melanoma patients after adjuvant dendritic cell vaccination.
Fenofibrate suppresses melanogenesis in B16-F10 melanoma cells via activation of the p38 mitogen-activated protein kinase pathway.
Ferritin light chain down-modulation generates depigmentation in human metastatic melanoma cells by influencing tyrosinase maturation.
Fibroblasts expressing mouse c locus tyrosinase produce an authentic enzyme and synthesize phaeomelanin.
Ficus deltoidea (Mas cotek) extract exerted anti-melanogenic activity by preventing tyrosinase activity in vitro and by suppressing tyrosinase gene expression in B16F1 melanoma cells.
Five-year results of prognostic value of tyrosinase in peripheral blood of uveal melanoma patients.
Fixation and Permeabilization Approaches for Scanning Electrochemical Microscopy of Living Cells.
Flavonoids increase melanin production and reduce proliferation, migration and invasion of melanoma cells by blocking endolysosomal/melanosomal TPC2.
Flow cytometry assessment of residual melanoma cells in tumor-infiltrating lymphocyte cultures.
Fluorescence copolymer-based dual-signal monitoring tyrosinase activity and its inhibitor screening via blue-green emission transformation.
Fluvastatin increases tyrosinase synthesis induced by alpha-melanocyte-stimulating hormone in B16F10 melanoma cells.
Fluvastatin increases tyrosinase synthesis induced by UVB irradiation of B16F10 melanoma cells.
Fluvastatin influences hair color in C57BL/6 mice.
Formation of melanin-tyrosinase complex and its possible significance as a model for control of melanin synthesis.
Four new ginsenosides from red ginseng with inhibitory activity on melanogenesis in melanoma cells.
Frequency and relative fraction of tumor antigen-specific T cells among lymphocytes from melanoma-invaded lymph nodes.
Frequency of human leukocyte antigen-A 24 alleles in patients with melanoma determined by human leukocyte antigen-A sequence-based typing.
Friends or Foes: IL-10 and TGF-? in melanoma.
Function but not phenotype of melanoma peptide-specific CD8(+) T cells correlate with survival in a multiepitope peptide vaccine trial (ECOG 1696).
Functional analysis of the tyrosinase gene and brown-locus protein gene promoters.
Functional analysis of tyrosinase isozymes of cultured malignant melanoma cells during the recovery period following interrupted melanogenesis induced by glycosylation inhibitors.
Functional T Cell Reactivity to Melanocyte Antigens Is Lost during the Progression of Malignant Melanoma, but Is Restored by Immunization.
Functionality study of santalin as tyrosinase inhibitor: A potential depigmentation agent.
Functionalized carbon quantum dots with dopamine for tyrosinase activity analysis.
Functionalized Carbon Quantum Dots with Dopamine for Tyrosinase Activity Monitoring and Inhibitor Screening: In Vitro and Intracellular Investigation.
Furan inhibitory activity against tyrosinase and impact on B16F10 cell toxicity.
Gadolinium-based MRI contrast agent for the detection of tyrosinase.
Galvanic zinc-copper microparticles inhibit melanogenesis via multiple pigmentary pathways.
gamma-Glutamyl transpeptidase, tyrosinase, and 5-S-cysteinyldopa production in melanoma cells.
Gamma-Irradiated Luteolin Inhibits 3-Isobutyl-1-Methylxanthine-Induced Melanogenesis Through the Regulation of CREB/MITF, PI3K/Akt, and ERK Pathways in B16BL6 Melanoma Cells.
Generalized melanosis secondary to malignant melanoma. Report of a case with serum and tissue tyrosinase studies.
Generation of cytotoxic T-cell responses with synthetic melanoma-associated peptides in vivo: implications for tumor vaccines with melanoma-associated antigens.
Generation of polyclonal rabbit antisera to mouse melanoma associated antigens using gene gun immunization.
Genetic aspects of uveal melanoma: a brief review.
Genistein as an inducer of tumor cell differentiation: possible mechanisms of action.
Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells.
Giant congenital nodular melanoma in a newborn: a case report and literature review.
Glucocorticoid modulation of adrenocorticotropin-induced melanogenesis in the Cloudman S-91 melanoma in vitro.
Glucocorticoid stimulates melanogenesis and tyrosinase gene expression in B16 melanoma cells.
Glutathione depletion increases tyrosinase activity in human melanoma cells.
Glyceollins, a novel class of soybean phytoalexins, inhibit SCF-induced melanogenesis through attenuation of SCF/c-kit downstream signaling pathways.
Glycine inhibits melanogenesis in vitro and causes hypopigmentation in vivo.
Glycoproteins as differentiation markers in human malignant melanoma and melanocytes.
Glycosylation of tyrosinase is a determinant of melanin production in cultured melanoma cells.
GM-CSF plus antigenic peptide vaccination in locally advanced melanoma patients.
gp100 mRNA is more sensitive than tyrosinase mRNA for RT-PCR amplification to detect circulating melanoma cells in peripheral blood of melanoma patients.
Granule-bound tyrosinase: solubilization and its relation to the soluble form of tyrosinase.
Granulocyte-macrophage-colony-stimulating factor enhances immune responses to melanoma-associated peptides in vivo.
Growth inhibition of murine melanoma by butyric acid and dimethylsulfoxide.
Guggulsterone inhibits melanogenesis in B16 murine melanoma cells by downregulating tyrosinase expression.
Hair dyes resorcinol and lawsone reduce production of melanin in melanoma cells by tyrosinase activity inhibition and decreasing tyrosinase and microphthalmia-associated transcription factor (MITF) expression.
Hairpin DNA coated gold nanoparticles as intracellular mRNA probes for the detection of tyrosinase gene expression in melanoma cells.
Half-lives of tyrosinase isozymes from Harding-Passey mouse melanoma.
Heat shock protein 70: role in antigen presentation and immune stimulation.
Hematogenous spread of malignant melanoma cells in different stages of disease.
HER-2/neu oncogenic protein: issues in vaccine development.
Hesperidin Suppresses Melanosome Transport by Blocking the Interaction of Rab27A-Melanophilin.
Heteroclitic immunization induces tumor immunity.
Heterogeneous expression of immunotherapy candidate proteins gp100, MART-1, and tyrosinase in human melanoma cell lines and in human melanocytic lesions.
High expression of immunotherapy candidate proteins gp100, MART-1, tyrosinase and TRP-1 in uveal melanoma.
High frequency of melanoma-associated antigen or HLA class I loss does not correlate with survival in primary melanoma.
High homogeneity of MAGE, BAGE, GAGE, tyrosinase and Melan-A/MART-1 gene expression in clusters of multiple simultaneous metastases of human melanoma: implications for protocol design of therapeutic antigen-specific vaccination strategies.
High-molecular-weight forms of tyrosinase and the tyrosinase-related proteins: evidence for a melanogenic complex.
Higher frequency of selective losses of HLA-A and -B allospecificities in metastasis than in primary melanoma lesions.
Highly Selective Fluorescent Probe Based on Hydroxylation of Phenylboronic Acid Pinacol Ester for Detection of Tyrosinase in Cells.
Highly selective suppression of melanoma cells by inducible DNA cross-linking agents: bis(catechol) derivatives.
Hinokitiol-induced decreases of tyrosinase and microphthalmia-associated transcription factor are mediated by the endoplasmic reticulum-associated degradation pathway in human melanoma cells.
Hispidin and related herbal compounds from Alpinia zerumbet inhibit both PAK1-dependent melanogenesis in melanocytes and reactive oxygen species (ROS) production in adipocytes.
Hispolon decreases melanin production and induces apoptosis in melanoma cells through the downregulation of tyrosinase and microphthalmia-associated transcription factor (MITF) expressions and the activation of caspase-3, -8 and -9.
Histological localization of 4-S-cysteinylphenol in melanoma-bearing mice.
HLA-A(*)0201(+) Plasmacytoid Dendritic Cells Provide a Cell-Based Immunotherapy for Melanoma Patients.
HLA-independent heterogeneity of CD8+ T cell responses to MAGE-3, Melan-A/MART-1, gp100, tyrosinase, MC1R, and TRP-2 in vaccine-treated melanoma patients.
Human antigen-specific regulatory T cells generated by T cell receptor gene transfer.
Human CD4+ T cells specifically recognize a shared melanoma-associated antigen encoded by the tyrosinase gene.
Human melanogenesis; the tyrosinase reaction in pigment cell neoplasms, with particular reference to the malignant melanoma; preliminary report.
Human melanoma patients recognize an HLA-A1-restricted CTL epitope from tyrosinase containing two cysteine residues: implications for tumor vaccine development.
Human placental lipid induces melanogenesis through p38 MAPK in B16F10 mouse melanoma.
Human placental protein/peptides stimulate melanin synthesis by enhancing tyrosinase gene expression.
Hybrid polymeric microspheres for enhancing the encapsulation of phenylethyl resorcinol.
Hybrids of dendritic cells and tumor cells generated by electrofusion simultaneously present immunodominant epitopes from multiple human tumor-associated antigens in the context of MHC class I and class II molecules.
Hydroalcoholic extract of Rhodiola rosea L. (Crassulaceae) and its hydrolysate inhibit melanogenesis in B16F0 cells by regulating the CREB/MITF/tyrosinase pathway.
Hydrogen peroxide as a mediator of dopac-induced effects on melanoma cells.
Hydrogen peroxide as an inducer of elevated tyrosinase level in melanoma cells.
Hydrogen peroxide increases a 55-kDa tyrosinase concomitantly with induction of p53-dependent p21 waf1 expression and a greater Bax/Bcl-2 ratio in pigmented melanoma.
Identification and characterization of mouse Rab32 by mRNA and protein expression analysis.
Identification and Characterization of the Tyrosinase Inhibitory Activity of Caffeine from Camellia Pollen.
Identification by shape-based virtual screening and evaluation of new tyrosinase inhibitors.
Identification of 3,4-dihydroxyphenylalanine as tyrosinase cofactor in melanoma.
Identification of a cis-acting element that enhances the pigment cell-specific expression of the human tyrosinase gene.
Identification of a new shared HLA-A2.1 restricted epitope from the melanoma antigen tyrosinase.
Identification of a New Shared HLA-A2.1 Restricted Epitope From the Melanoma Antigen Tyrosinase.
Identification of a tyrosinase epitope recognized by HLA-A24-restricted, tumor-infiltrating lymphocytes.
Identification of five new HLA-B*3501-restricted epitopes derived from common melanoma-associated antigens, spontaneously recognized by tumor-infiltrating lymphocytes.
Identification of HLA-A*03, A*11 and B*07-restricted melanoma-associated peptides that are immunogenic in vivo by vaccine-induced immune response (VIIR) analysis.
Identification of known and novel immunogenic T-cell epitopes from tumor antigens recognized by peripheral blood T cells from patients responding to IL-2-based treatment.
Identification of L-Cysteinamide as a Potent Inhibitor of Tyrosinase-Mediated Dopachrome Formation and Eumelanin Synthesis.
Identification of multiple antigens recognized by tumor-infiltrating lymphocytes from a single patient: tumor escape by antigen loss and loss of MHC expression.
Identification of Mushroom and Murine Tyrosinase Inhibitors from Achillea biebersteinii Afan. Extract.
Identification of new melanoma epitopes on melanosomal proteins recognized by tumor infiltrating T lymphocytes restricted by HLA-A1, -A2, and -A3 alleles.
Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2-restricted tumor infiltrating lymphocytes.
Identification of the immunodominant regions of the melanoma antigen tyrosinase by anti-tyrosinase monoclonal antibodies.
Immune and clinical outcomes in patients with stage IV melanoma vaccinated with peptide-pulsed dendritic cells derived from CD34+ progenitors and activated with type I interferon.
Immune and clinical responses in patients with metastatic melanoma to CD34(+) progenitor-derived dendritic cell vaccine.
Immune responses to the HLA-A*0201-restricted epitopes of tyrosinase and glycoprotein 100 enable control of melanoma outgrowth in HLA-A*0201-transgenic mice.
Immune-related Adverse Events of Dendritic Cell Vaccination Correlate With Immunologic and Clinical Outcome in Stage III and IV Melanoma Patients.
Immunity to melanin and to tyrosinase in melanoma patients, and in people with vitiligo.
Immunity to melanoma antigens: from self-tolerance to immunotherapy.
Immunobead-based detection and characterization of circulating tumor cells in melanoma patients.
Immunochemical detection of tyrosinase in serum of patients with metastatic malignant melanomas. and from Hardy-Passey mouse melanomas.
Immunoelectron microscopic demonstration of human melanosome associated antigens (HMSA) on melanoma cells: comparison with tyrosinase distribution.
Immunogenicity, including vitiligo, and feasibility of vaccination with autologous GM-CSF-transduced tumor cells in metastatic melanoma patients.
Immunohistochemical evaluation of necrotic malignant melanomas.
Immunohistochemical expression of melan-A and tyrosinase in uveal melanoma.
Immunohistochemical Identification of Canine Melanocytic Neoplasms With Antibodies to Melanocytic Antigen PNL2 and Tyrosinase: Comparison With Melan A.
Immunohistochemical Study of Melanocyte-Melanocyte Stem Cell lineage in Vitiligo; A Clue to Interfollicular Melanocyte Stem Cell Reservoir.
Immunohistochemistry and sentinel node biopsy in melanoma: the use of tyrosinase and Melan-A.
Immunologic cross-reaction between human and mouse tyrosinases.
Immunologic responses to xenogeneic tyrosinase DNA vaccine administered by electroporation in patients with malignant melanoma.
Immunomagnetic enrichment, genomic characterization, and prognostic impact of circulating melanoma cells.
Immunophenotype and possible origin of nevi with phenotypical heterogeneity.
Immunophenotype of conjunctival melanomas: comparisons with uveal and cutaneous melanomas.
Immunophenotypic differences between uveal and cutaneous melanomas.
Immunophenotyping of melanomas for tyrosinase: implications for vaccine development.
Immunoprofile of MITF, tyrosinase, melan-A, and MAGE-1 in HMB45-negative melanomas.
Immunoselection in vivo: independent loss of MHC class I and melanocyte differentiation antigen expression in metastatic melanoma.
Immunosuppressive cytokines in the regional lymph node of a dog suffering from oral malignant melanoma.
Impact of molecular staging methods in primary melanoma: reverse-transcriptase polymerase chain reaction (RT-PCR) of ultrasound-guided aspirate of the sentinel node does not improve diagnostic accuracy, but RT-PCR of peripheral blood does predict survival.
Impairment of the melanogenic pathway in B16 melanoma cells transfected with class I H-2 genes.
Improved antimelanogenesis and antioxidant effects of polysaccharide from Cuscuta chinensis Lam seeds after enzymatic hydrolysis.
Improved immunohistochemical evaluation of micrometastases in sentinel lymph nodes of cutaneous melanoma with 'MCW melanoma cocktail'--a mixture of monoclonal antibodies to MART-1, Melan-A, and tyrosinase.
In situ expression of tumor antigens by messenger RNA-electroporated dendritic cells in lymph nodes of melanoma patients.
In vitro and cellular activities of the selected fruits residues for skin aging treatment.
In vitro and in vivo targeting of gene expression to melanoma cells.
In vitro effects of hormonal stimuli upon tyrosinase and peroxidase activities in murine melanomas.
In vitro effects of melanocytolytic agents and other compounds upon dominant human melanoma tyrosinase activity.
In vitro growth inhibition of S-91 mouse melanomas by tyrosinase substrate analogs with and without L-cysteine.
In vitro studies of 2,4-dihydroxyphenylalanine, a prodrug targeted against malignant melanoma cells.
In vivo inhibition of the tyrosinase of hamster melanoma with sodium diethyldithiocarbamate.
Inactivation mechanism of tyrosinase in mouse melanoma.
Inactivation of human tyrosinase by cysteine. Protection by dopa and tyrosine.
Inactivation of tyrosinase by dopa.
Incomplete expression of the tyrosinase gene family (tyrosinase, TRP-1, and TRP-2) in human malignant melanoma cells in vitro.
Incorporation of [125I]-5-iodo-2-thiouracil in cultured hamster, rabbit, and human melanoma cells.
Increased detection of metastatic melanoma in pediatric sentinel lymph node biopsies using RT-PCR on paraffin-embedded tissue.
Increased level of p27 subunit of proteasomes and its co-localization with tyrosinase in amelanotic melanoma cells indicate its direct role in the regulation of melanin biosynthesis.
Increased sensitivity for the detection of malignant melanoma cells in peripheral blood using an improved protocol for reverse transcription-polymerase chain reaction.
Index report of cutaneous angiosarcomas with strong positivity for tyrosinase mimicking melanoma with further evaluation of melanocytic markers in a large angiosarcoma series.
Individualized synthetic peptide vaccines with GM-CSF in locally advanced melanoma patients.
Induction of melanogenesis during the various melanoma growth phases and the role of tyrosinase, lysosome-associated membrane proteins, and p90 calnexin in the melanogenesis cascade.
Induction of melanoma in murine macrophage inflammatory protein 2 transgenic mice heterozygous for inhibitor of kinase/alternate reading frame.
Induction of pigmentation by a small molecule tyrosine kinase inhibitor nilotinib.
Induction of pigmentation in mouse fibroblasts by expression of human tyrosinase cDNA.
Induction of tyrosinase in human melanoma cells by L-tyrosine phosphate and cytochalasin D.
Induction of tyrosinase-reactive T cells by treatment with dacarbazine, cisplatin, interferon-alpha +/- interleukin-2 in patients with metastatic melanoma.
Influence of N-glycan processing disruption on tyrosinase and melanin synthesis in HM3KO melanoma cells.
Inhibition effect of phenyl compounds from the Oryza sativa roots on melanin production in murine B16-F10 melanoma cells.
Inhibition of imidazole-induced tyrosinase activity by estradiol and estriol in cultured B16/C3 melanoma cells.
Inhibition of induced melanogenesis in Cloudman melanoma cells by four phenotypic modifiers.
Inhibition of L-tyrosine-induced micronuclei production by phenylthiourea in human melanoma cells.
Inhibition of Mek 1/2 kinase activity and stimulation of melanogenesis by 5,7-dimethoxycoumarin treatment of melanoma cells.
Inhibition of melanogenesis as a radiation sensitizer for melanoma therapy.
Inhibition of Melanogenesis in Murine B16/F10 Melanoma Cells by Ligusticum sinensis Oliv.
Inhibition of melanogenesis in response to oxidative stress: transient downregulation of melanocyte differentiation markers and possible involvement of microphthalmia transcription factor.
Inhibition of melanoma tyrosinase by fusaric acid.
Inhibition of NAT10 Suppresses Melanogenesis and Melanoma Growth by Attenuating Microphthalmia-Associated Transcription Factor (MITF) Expression.
Inhibition of tyrosinase activity and melanin production by the chalcone derivative 1-(2-cyclohexylmethoxy-6-hydroxy-phenyl)-3-(4-hydroxymethyl-phenyl)-propenone.
Inhibition of tyrosinase activity and protein synthesis in melanoma cells by calcium ionophore A23187.
Inhibition of tyrosinase activity by 4-tert-butylcatechol and other depigmenting agents.
Inhibitors of melanogenesis increase toxicity of cyclophosphamide and lymphocytes against melanoma cells.
Inhibitory effect of apocarotenoids on the activity of tyrosinase: Multi-spectroscopic and docking studies.
Inhibitory Effect of Arctigenin from Fructus Arctii Extract on Melanin Synthesis via Repression of Tyrosinase Expression.
Inhibitory effect of brazilein on tyrosinase and melanin synthesis: Kinetics and in silico approach.
Inhibitory effect of Cucumis sativus on melanin production in melanoma B16 cells by downregulation of tyrosinase expression.
Inhibitory Effect of Elaeagnus umbellata Fractions on Melanogenesis in ?-MSH-Stimulated B16-F10 Melanoma Cells.
Inhibitory effect of Gastrodia elata Blume extract on alpha-melanocyte stimulating hormone-induced melanogenesis in murine B16F10 melanoma.
Inhibitory effect of Gastrodia elata extract on melanogenesis in HM3KO melanoma cells.
Inhibitory effect of hydroxyindoles and their analogues on human melanoma tyrosinase.
Inhibitory effect of magnesium L-ascorbyl-2-phosphate (VC-PMG) on melanogenesis in vitro and in vivo.
Inhibitory effect of piperlonguminine on melanin production in melanoma B16 cell line by downregulation of tyrosinase expression.
Inhibitory effect of quercetin isolated from rose hip (Rosa canina L.) against melanogenesis by mouse melanoma cells.
Inhibitory effect of RNA pool complexity on stimulatory capacity of RNA-pulsed dendritic cells.
Inhibitory Effect of Rose Hip (Rosa canina L.) on Melanogenesis in Mouse Melanoma Cells and on Pigmentation in Brown Guinea Pigs.
Inhibitory Effect of Sesamolin on Melanogenesis in B16F10 Cells Determined by In Vitro and Molecular Docking Analyses.
Inhibitory effect of sodium 5,6-benzylidene ascorbate (SBA) on the elevation of melanin biosynthesis induced by ultraviolet-A (UV-A) light in cultured B-16 melanoma cells.
Inhibitory effect of [6]-gingerol on melanogenesis in B16F10 melanoma cells and a possible mechanism of action.
Inhibitory effects of 1-O-methyl-fructofuranose from Schisandra chinensis fruit on melanogenesis in B16F0 melanoma cells.
Inhibitory effects of a novel ascorbic derivative, disodium isostearyl 2-O-L-ascorbyl phosphate on melanogenesis.
Inhibitory effects of autolysate of Leuconostoc mesenteroides isolated from kimoto on melanogenesis.
Inhibitory effects of N-(acryloyl)benzamide derivatives on tyrosinase and melanogenesis.
Inhibitory effects of plant extracts on tyrosinase, L-DOPA oxidation, and melanin synthesis.
Inhibitory effects of Ramulus mori extracts on melanogenesis.
Inhibitory effects of resveratrol on melanin synthesis in ultraviolet B-induced pigmentation in Guinea pig skin.
Inhibitory effects of salidroside and paeonol on tyrosinase activity and melanin synthesis in mouse B16F10 melanoma cells and ultraviolet B-induced pigmentation in guinea pig skin.
Inhibitory effects of Sargassum polycystum on tyrosinase activity and melanin formation in B16F10 murine melanoma cells.
Injection of DNA encoding granulocyte-macrophage colony-stimulating factor recruits dendritic cells for immune adjuvant effects.
Insect cells as HLA-restricted antigen-presenting cells for the IFN-gamma elispot assay.
Insight into Mechanistic Action of Thymoquinone Induced Melanogenesis in Cultured Melanocytes.
Insulin inhibits tyrosinase activity and 5-S-cysteinyldopa formation in human melanoma cells.
Insulin-like-growth-factor-binding-protein-3 (IGFBP-3) contrasts melanoma progression in vitro and in vivo.
Insulin-mediated inhibition of tyrosinase activity and protein synthesis in melanoma cell cultures.
Integrin A6 Cleavage in Mouse Skin Tumors.
Interaction of ACTH, corticosterone and cyclic nucleotides in Harding-Passey melanoma melanogenesis.
Interaction of human heat shock protein 70 with tumor-associated peptides.
Interactions between ultraviolet light and interleukin-1 on MSH binding in both mouse melanoma and human squamous carcinoma cells.
Interferons modulate the expression of hormone receptors on the surface of murine melanoma cells.
Interlaboratory evaluation of a new reverse transcriptase polymerase chain reaction-based enzyme-linked immunosorbent assay for the detection of circulating melanoma cells: a multicenter study of the Dermatologic Cooperative Oncology Group.
Interleukin-2: developing additional cytokine gene therapies using fibroblasts or dendritic cells to enhance tumor immunity.
Interleukins 1alpha and 1beta secreted by some melanoma cell lines strongly reduce expression of MITF-M and melanocyte differentiation antigens.
Internal binding sites for MSH: analyses in wild-type and variant Cloudman melanoma cells.
Intra-Lymph Node Prime-Boost Vaccination Against Melan A and Tyrosinase for the Treatment of Metastatic Melanoma: Results of a Phase 1 Clinical Trial.
Intracellular localization of tyrosinase inhibitor in amelanotic and melanotic malignant melanoma.
Intranodal vaccination with mRNA-optimized dendritic cells in metastatic melanoma patients.
Intratumoral T-cell infiltrates and MHC class I expression in patients with stage IV melanoma.
Intravenous and intradermal TriMix-dendritic cell therapy results in a broad T-cell response and durable tumor response in a chemorefractory stage IV-M1c melanoma patient.
Inverse relationship of melanocyte differentiation antigen expression in melanoma tissues and CD8+ cytotoxic-T-cell responses: evidence for immunoselection of antigen-loss variants in vivo.
Investigation of the Anti-Melanogenic and Antioxidant Characteristics of Eucalyptus camaldulensis Flower Essential Oil and Determination of Its Chemical Composition.
Investigation of the pro-apoptotic effects of arbutin and its acetylated derivative on murine melanoma cells.
Involvement of extracellular signal-regulated kinase in nobiletin-induced melanogenesis in murine B16/F10 melanoma cells.
Involvement of microphthalmia in the inhibition of melanocyte lineage differentiation and of melanogenesis by agouti signal protein.
Involvement of the p38 MAPK and ERK signaling pathway in the anti-melanogenic effect of methyl 3,5-dicaffeoyl quinate in B16F10 mouse melanoma cells.
Involvement of tyrosinase in melanin formation in murine melanoma.
Iodination of beta-melanotropin. Time course analysis of reaction mixtures by high pressure liquid chromatography and characterization of biologically active mono- and diiodo-beta-melanotropin.
Is MAGE-1 expression in metastatic malignant melanomas really helpful?
Isolated organ perfusion does not result in systemic microembolization of tumor cells.
Isolation and biochemical characterization of tyrosinase-rich GERL and coated vesicle in melanin synthesizing cells.
Isolation and characterization of a Golgi-rich fraction from the Harding-Passey mouse melanoma.
Isolation and characterization of tyrosinase inhibitors and their differential action on melanogenic subcellular compartments in amelanotic and melanomas.
Isolation of a unique melanogenic inhibitor from human skin xenografts: initial in vitro and in vivo characterization.
Isolation of human tyrosinase from cultured melanoma cells.
Isolation of soluble tyrosinase from human melanoma cells.
Isolation of tyrosinase and melanogenesis inhibitory flavonoids from Juniperus chinensis fruits.
Isolation of tyrosinase from bovine eyes.
Isolation of tyrosinase-specific CD8+ and CD4+ T cell clones from the peripheral blood of melanoma patients following in vitro stimulation with recombinant vaccinia virus.
Isolation, chromosomal mapping, and expression of the mouse tyrosinase gene.
KBA62 and PNL2: 2 new melanoma markers-immunohistochemical analysis of 1563 tumors including metastatic, desmoplastic, and mucosal melanomas and their mimics.
Kinetic and sensitive analysis of tyrosinase activity using electron transfer complexes: in vitro and intracellular study.
Kinetic study of the oxidation of 4-hydroxyanisole catalyzed by tyrosinase.
Kojic Acid Peptide: A New Compound with Anti-Tyrosinase Potential.
L-tyrosine induces synthesis of melanogenesis related proteins.
L-tyrosine induces tyrosinase expression via a posttranscriptional mechanism.
L-tyrosine stimulates induction of tyrosinase activity by MSH and reduces cooperative interactions between MSH receptors in hamster melanoma cells.
L-tyrosine, L-dopa, and tyrosinase as positive regulators of the subcellular apparatus of melanogenesis in Bomirski Ab amelanotic melanoma cells.
Lack of prognostic importance of reverse-transcriptase polymerase chain reaction detection of circulating messenger RNA in patients with melanoma.
Lacrimal Sac Malignant Melanoma in 15 Japanese Patients: Case Report and Literature Review.
Late onset ipilimumab-induced pericarditis and pericardial effusion: a rare but life threatening complication.
Lentivirus vector-mediated expression of tumor-associated epitopes by human antigen presenting cells.
Levels of dopachrome tautomerase in human melanocytes cultured in vitro.
Limitations of the nested reverse transcriptase polymerase chain reaction on tyrosinase for the detection of malignant melanoma micrometastases in lymph nodes.
Linear and cyclic alpha-melanotropin [4-10]-fragment analogues that exhibit superpotency and residual activity.
Lipoteichoic Acid Isolated from Lactobacillus plantarum Inhibits Melanogenesis in B16F10 Mouse Melanoma Cells.
Lipoteichoic acid isolated from Lactobacillus plantarum inhibits melanogenesis in B16F10 mouse melanoma cells.
Long-term and residual melanotropin-stimulated tyrosinase activity in S91 melanoma cells is density dependent.
Long-term freedom from recurrence in 2 stage IV melanoma patients following vaccination with tyrosinase peptides.
Long-term outcomes in patients with metastatic melanoma vaccinated with melanoma peptide-pulsed CD34(+) progenitor-derived dendritic cells.
Long-term survival of dogs with advanced malignant melanoma after DNA vaccination with xenogeneic human tyrosinase: a phase I trial.
Loss of melanogenic properties in tyrosinases induced by glucosylation inhibitors within malignant melanoma cells.
Lunasin is a novel therapeutic agent for targeting melanoma cancer stem cells.
Lyoniresinol inhibits melanogenic activity through the induction of microphthalmia-associated transcription factor and extracellular receptor kinase activation.
Magnetic bead RT-PCR: establishment of a new method for detecting circulating melanoma cells.
Malignant melanoma and fibrothecoma--an ovarian mixed tumor.
Malignant melanoma in transgenic mice.
Malignant melanoma with melanosis and melanuria, and with pigmented monocytes and tumour cells in the blood. Autoradiographic demonstration of tyrosinase in malignant cells from peritoneal fluid.
Malignant melanoma with neuroendocrine differentiation: clinical, histological, immunohistochemical and ultrastructural features of three cases.
Mammalian tyrosinase catalyzes three reactions in the biosynthesis of melanin.
Mammalian tyrosinase: biosynthesis, processing, and modulation by melanocyte-stimulating hormone.
Mangosteen leaf extract increases melanogenesis in B16F1 melanoma cells by stimulating tyrosinase activity in vitro and by up-regulating tyrosinase gene expression.
Mannosylerythritol lipid is a potent inducer of apoptosis and differentiation of mouse melanoma cells in culture.
Markers of melanogenesis in malignant melanoma.
MART-1 is expressed less frequently on circulating melanoma cells in patients who develop distant compared with locoregional metastases.
MART-1/Melan-A and tyrosinase transcripts in peripheral blood of melanoma patients: PCR analyses and follow-up testing in relation to clinical stage and disease progression.
MCW melanoma cocktail for the evaluation of micrometastases in sentinel lymph nodes of cutaneous melanoma.
Mechanism and inhibitory effect of galangin and its flavonoid mixture from Alpinia officinarum on mushroom tyrosinase and B16 murine melanoma cells.
Mechanism of antitumoral activity of catechols in culture.
Mechanism of putative neo-antigen formation from N-propionyl-4-S-cysteaminylphenol, a tyrosinase substrate, in melanoma models.
Mechanism(s) regulating inhibition of thymidylate synthase and growth by gamma-L-glutaminyl-4-hydroxy-3-iodobenzene, a novel melanin precursor, in melanogenic melanoma cells.
Melanin accelerates the tyrosinase-catalyzed oxygenation of p-hydroxyanisole (MMEH)
Melanin formation in the inner ear is catalyzed by a new tyrosine hydroxylase kinetically and structurally different from tyrosinase.
Melanin-related biochemistry of IGR 1 human melanoma cells.
Melanocyte antigen-specific antibodies cannot be used as markers for recent disease activity in patients with vitiligo.
Melanocyte culture lines from Tyr-SV40E transgenic mice: models for the molecular genetic evolution of malignant melanoma.
Melanocyte destruction after antigen-specific immunotherapy of melanoma: direct evidence of t cell-mediated vitiligo.
Melanocyte differentiation marker gp75, the brown locus protein, can be regulated independently of tyrosinase and pigmentation.
Melanocyte stimulating hormone activation of tyrosinase in B16 mouse melanoma cells. Evidence for a differential induction of two distinct isoenzymes.
Melanocyte-directed enzyme prodrug therapy (MDEPT): development of a targeted treatment for malignant melanoma.
Melanocyte-stimulating hormone (alpha-MSH) inhibits the growth of human malignant melanoma cells with the induction of phosphatidyl inositol and myo-inositol phosphate levels.
Melanocyte-stimulating hormone promotes activation of pre-existing tyrosinase molecules in Cloudman S91 melanoma cells.
Melanocytotoxicity and antimelanoma effects of phenolic amine compounds in mice in vivo.
Melanogenesis effect of Cordyceps militaris culture broth on the melanin formation of B16F0 melanoma cells.
Melanogenesis in genetically determined pigment cell tumors of platyfish and platyfish-swordtail hybrids: correlation between tyrosine activity and degree of malignancy.
Melanogenesis in human melanomas.
Melanogenesis in uveal melanoma cells: Effect of argan oil.
Melanogenesis inhibitory activities of diarylheptanoids from Alnus hirsuta Turcz in B16 mouse melanoma cell.
Melanogenesis-inducing effect of cirsimaritin through increases in microphthalmia-associated transcription factor and tyrosinase expression.
Melanogenic response of the Kupffer cells of Rana esculenta L to melanocyte stimulating hormone.
Melanogenuria as consequence of elevated tyrosinase activity in melanoma.
Melanoma cells present high levels of HLA-A2-tyrosinase in association with instability and aberrant intracellular processing of tyrosinase.
Melanoma genomics reveals signatures of sensitivity to bio- and targeted therapies.
Melanoma Masquerading as Xanthogranuloma: A Diagnostic Pitfall.
Melanoma x macrophage fusion hybrids acquire increased melanogenesis and metastatic potential: altered N-glycosylation as an underlying mechanism.
Melanoma-associated antigen tyrosinase but not Melan-A/MART-1 expression and presentation dissociate during the heat shock response.
Melanoma-associated antigens as messenger RNA detection markers for melanoma.
Melanoma-associated hypopigmentation: where are the antibodies?
Melanoma-inhibiting activity (MIA) mRNA is not exclusively transcribed in melanoma cells: low levels of MIA mRNA are present in various cell types and in peripheral blood.
Melanoma-specific cytotoxicity induced by a tyrosinase promoter-enhancer/herpes simplex virus thymidine kinase adenovirus.
Melanoma-specific expression in first-generation adenoviral vectors in vitro and in vivo -- use of the human tyrosinase promoter with human enhancers.
Melanoma-Targeted Chemothermotherapy and In Situ Peptide Immunotherapy through HSP Production by Using Melanogenesis Substrate, NPrCAP, and Magnetite Nanoparticles.
Melanoma. A multidisciplinary approach for the general surgeon.
Melanomas with concordant loss of multiple melanocytic differentiation proteins: immune escape that may be overcome by targeting unique or undefined antigens.
Melanosomal pH controls rate of melanogenesis, eumelanin/phaeomelanin ratio and melanosome maturation in melanocytes and melanoma cells.
Melanosome-Targeting Near-Infrared Fluorescent Probe with Large Stokes Shift for in Situ Quantification of Tyrosinase Activity and Assessing Drug Effects on Differently Invasive Melanoma Cells.
Melanotropic activity of gamma MSH peptides in melanoma cells.
Melanotropic peptide receptors: membrane markers of human melanoma cells.
Melatonin antagonizes alpha-melanocyte-stimulating hormone enhancement of melanogenesis in mouse melanoma cells by blocking the hormone-induced accumulation of the c locus tyrosinase.
Melatonin biological activity and binding sites in human melanoma cells.
Melatonin Induces Melanogenesis in Human SK-MEL-1 Melanoma Cells Involving Glycogen Synthase Kinase-3 and Reactive Oxygen Species.
Metabolic activation of 4-hydroxyanisole by isolated rat hepatocytes.
Metabolic bioactivation and toxicity of ethyl 4-hydroxybenzoate in human SK-MEL-28 melanoma cells.
Metabolism of 1-naphthol by tyrosinase.
Metastatic potential of human melanoma cells in nude mice--characterisation of phenotype, cytokine secretion and tumour-associated antigens.
Methoxy-Substituted Tyramine Derivatives Synthesis, Computational Studies and Tyrosinase Inhibitory Kinetics.
MHY884, a newly synthesized tyrosinase inhibitor, suppresses UVB-induced activation of NF-?B signaling pathway through the downregulation of oxidative stress.
MIA (melanoma inhibitory activity) promoter mediated tissue-specific suicide gene therapy of malignant melanoma.
Mice with DNA repair gene Ercc1 deficiency in a neural crest lineage are a model for late-onset Hirschsprung disease.
Micro-anatomy related antigen expression in melanocytic lesions.
Microheterogeneity of melanosome-bound tyrosinase from the Harding-Passey murine melanoma.
Microphthalmia-associated transcription factor and tyrosinase as markers of melanoma cells in blood of patients with melanoma.
Microphthalmia-associated transcription factor as a regulator for melanocyte-specific transcription of the human tyrosinase gene.
Microphthalmia-associated transcription factor up-regulates acetylcholinesterase expression during melanogenesis of murine melanoma cells.
Micropthalmia transcription factor (MITF) as a diagnostic marker for metastatic melanomas negative for other melanoma markers.
MicroRNA-203 Regulates Melanosome Transport and Tyrosinase Expression in Melanoma Cells by Targeting Kinesin Superfamily Protein 5b.
microRNA-374 inhibits proliferation and promotes apoptosis of mouse melanoma cells by inactivating the Wnt signalling pathway through its effect on tyrosinase.
Mimosine Dipeptide Enantiomsers: Improved Inhibitors against Melanogenesis and Cyclooxygenase.
Minimal residual disease in melanoma.
Minimally invasive staging of patients with melanoma: sentinel lymphadenectomy and detection of the melanoma-specific proteins MART-1 and tyrosinase by reverse transcriptase polymerase chain reaction.
MiR-330-5p regulates tyrosinase and PDIA3 expression and suppresses cell proliferation and invasion in cutaneous malignant melanoma.
MITF-M plays an essential role in transcriptional activation and signal transduction in Xiphophorus melanoma.
Modification of dopa toxicity in human tumour cells.
Modified vaccinia virus Ankara for delivery of human tyrosinase as melanoma-associated antigen: induction of tyrosinase- and melanoma-specific human leukocyte antigen A*0201-restricted cytotoxic T cells in vitro and in vivo.
Modifying effects of carboxyl group on the interaction of recombinant S100A8/A9 complex with tyrosinase.
Modulation of 5-S-cysteinyldopa formation by tyrosinase activity and intracellular thiols in human melanoma cells.
Modulation of antioxidant defense by Alpinia galanga and Curcuma aromatica extracts correlates with their inhibition of UVA-induced melanogenesis.
Modulation of antioxidant enzymes p21WAF1 and p53 expression during proliferation and differentiation of human melanoma cell lines.
Modulation of tyrosinase activity and viral information by 5-iodo-deoxyuridine and L-dopa in a human melanoma cell line [proceedings]
Molecular analyses of sentinel lymph nodes: an open question.
Molecular and biochemical testing in stage III melanoma: multimarker reverse transcriptase-polymerase chain reaction assay of lymph fluid after lymph node dissection and preoperative serum lactate dehydrogenase level.
Molecular and prognostic classification of advanced melanoma: a multi-marker microcontamination assay of peripheral blood stem cells.
Molecular bases of tyrosinase-negative oculocutaneous albinism: a single base insertion or a missense point mutation in the tyrosinase gene.
Molecular basis for the heterogeneity of human tyrosinase.
Molecular characterization of novel melanoma cell lines.
Molecular control of melanogenesis in malignant melanoma: functional assessment of tyrosinase and lamp gene families by UV exposure and gene co-transfection, and cloning of a cDNA encoding calnexin, a possible melanogenesis "chaperone".
Molecular detection of circulating tyrosinase mRNA: optimization in a preclinical xenograft mouse melanoma model and further evaluation in samples from advanced melanoma patients.
Molecular detection of MART-1, tyrosinase and MIA in peripheral blood, lymph nodes and metastatic sites of stage III/IV melanoma patients.
Molecular detection of tumor-associated antigens shared by human cutaneous melanomas and gliomas.
Molecular detection of tyrosinase transcripts in peripheral blood from patients with malignant melanoma: correlation of PCR sensitivity threshold with clinical and pathologic disease characteristics.
Molecular docking studies of a phlorotannin, dieckol isolated from Ecklonia cava with tyrosinase inhibitory activity.
Molecular interactions within the melanogenic complex: formation of heterodimers of tyrosinase and TRP1 from B16 mouse melanoma.
Molecular mechanism of tyrosinase regulation by L-dopa in hamster melanoma cells.
Molecular mechanisms governing melanogenesis in hamster melanomas: relative abundance of tyrosinase and catalase-B (gp 75).
Molecular staging by multimarker reverse transcriptase-polymerase chain reaction assay of lymphatic drainage and blood from melanoma patients after lymph node dissection.
Molecular staging for patients with malignant melanoma.
Molecular staging in stage II and III melanoma patients and its effect on long-term survival.
Molecular staging of malignant melanoma: correlation with clinical outcome.
Molecular staging of the sentinel lymph node in melanoma patients: correlation with clinical outcome.
Molecular test for the detection of tumor cells in blood and sentinel nodes of melanoma patients.
Molecular tumor markers in the blood: early prediction of disease outcome in melanoma patients treated with a melanoma vaccine.
Monitoring Tyrosinase Expression in Non-metastatic and Metastatic Melanoma Tissues by Scanning Electrochemical Microscopy.
Monoclonal antibodies targeted against melanoma and ovarian tumors enhance dendritic cell-mediated cross-presentation of tumor-associated antigens and efficiently cross-prime CD8+ T cells.
Monoclonal antibody against a melanosomal protein in melanotic and amelanotic human melanoma cells.
Monoclonal antibody against human tyrosinase and reactive with melanotic and amelanotic melanoma cells.
Monoclonal antibody MAT-1 against human tyrosinase can detect melanogenic cells on formalin-fixed paraffin-embedded sections.
Morin Induces Melanogenesis via Activation of MAPK Signaling Pathways in B16F10 Mouse Melanoma Cells.
Morphological and immunophenotypic variations in malignant melanoma.
MSH inhibits growth in a line of amelanotic hamster melanoma cells and induces increases in cyclic AMP levels and tyrosinase activity without inducing melanogenesis.
MSH stimulates adenylate cyclase and tyrosinase in cultivated melanoma cells in the presence of cytochalasin B.
Multi-hormonal regulation of tyrosinase expression in B16/C3 melanoma cells in culture.
Multimarker real-time reverse transcription-PCR for quantitative detection of melanoma-associated antigens: a novel possible staging method.
Multiple forms of tyrosinase from human melanoma.
Multiple RT-PCR tyrosinase testing reveals that melanoma cells circulate in the blood of melanoma patients at the frequency more than 10 times below the detection threshold.
Murine tyrosinase expressed by a T7 vector in bone marrow-derived dendritic progenitors effectively prevents and eradicates melanoma tumors in mice.
Murine tyrosinase Inhibitors from Cynanchum bungei and evaluation of in vitro and in vivo depigmenting activity.
Mutations of the tyrosinase gene in oculocutaneous albinism.
N-(3,5-Dihydroxybenzoyl)-6-hydroxytryptamine as a Novel Human Tyrosinase Inhibitor That Inactivates the Enzyme in Cooperation with L-3,4-Dihydroxyphenylalanine.
N-linked carbohydrates in tyrosinase are required for its recognition by human MHC class II-restricted CD4(+) T cells.
N-Nicotinoyl dopamine inhibits skin pigmentation by suppressing of melanosome transfer.
N-Nicotinoyl dopamine, a novel niacinamide derivative, retains high antioxidant activity and inhibits skin pigmentation.
N-[(Dihydroxyphenyl)acyl]serotonins as potent inhibitors of tyrosinase from mouse and human melanoma cells.
Nanobiotechnological Nanocapsules Containing Polyhemoglobin-Tyrosinase: Effects on Murine B16F10 Melanoma Cell Proliferation and Attachment.
Nanoemulsified adlay bran oil reduces tyrosinase activity and melanin synthesis in B16F10 cells and zebrafish.
Nanoliposomes encapsulation of enriched phenolic fraction from pistachio hulls and its antioxidant, anti-inflammatory, and anti-melanogenic activities.
Natural T cell autoreactivity to melanoma antigens: clonally expanded melanoma-antigen specific CD8?+?memory T cells can be detected in healthy humans.
Nature and biosynthesis of structural matrix protein in melanosomes: melanosomal structural protein as differentiation antigen for neoplastic melanocytes.
Nature of tyrosinase inactivation in melanosomes.
Nested quantitative real time PCR for detection of occult tumor cells.
New diterpenes leojaponins G-L from Leonurus japonicus.
New insight into the role of metabolic reprogramming in melanoma cells harboring BRAF mutations.
New Methodological Approach for the Rapid and Sensitive Detection of Melanocytes and Melanocytic Tumours. The DOPA-GA Method.
New nitrosoureas and their spin-labeled derivatives influence dopa-oxidase activity of tyrosinase.
New regulators of melanogenesis are associated with purified tyrosinase isozymes.
New thioureas and related substances intended for melanoma targeting.
NFATc2 is an intrinsic regulator of melanoma dedifferentiation.
Nicotinic acid hydroxamate downregulated the melanin synthesis and tyrosinase activity through activating the MEK/ERK and AKT/GSK3? signaling pathways.
Nitroprusside induces melanoma ferroptosis with serum supplementation and prolongs survival under serum depletion or hypoxia.
No correlation of tyrosinase mRNA in bone marrow with prognosis of metastatic melanoma.
Non-premelanosomal and premelanosomal tyrosinase activity in Greene's amelanotic and melanotic malignant melanoma.
Noninvasive dynamic fluorescence imaging of human melanomas reveals that targeted inhibition of bFGF or FGFR-1 in melanoma cells blocks tumor growth by apoptosis.
Novel amide derivatives as potent tyrosinase inhibitors; in-vitro, in-vivo antimelanogenic activity and computational studies.
Novel approach to the characterization of melanoma associated-peptide-specific CTL lines from Japanese metastatic melanoma patients.
Novel C5a agonist-based dendritic cell vaccine in a murine model of melanoma.
Novel Chemically Modified Curcumin (CMC) Derivatives Inhibit Tyrosinase Activity and Melanin Synthesis in B16F10 Mouse Melanoma Cells.
Novel delivery system for T-oligo using a nanocomplex formed with an alpha helical peptide for melanoma therapy.
Novel genes associated with malignant melanoma but not benign melanocytic lesions.
Novel oncolytic adenoviruses targeted to melanoma: specific viral replication and cytolysis by expression of E1A mutants from the tyrosinase enhancer/promoter.
Novel Quercetin Derivative of 3,7-Dioleylquercetin Shows Less Toxicity and Highly Potent Tyrosinase Inhibition Activity.
Novel tyramide-based tyrosinase assay for the detection of melanoma cells in cytological preparations.
NY-ESO-1 and CTp11 expression may correlate with stage of progression in melanoma.
Occurrence of tyrosinase in horse and fish melanomas.
Octaphlorethol A isolated from Ishige foliacea inhibits ?-MSH-stimulated induced melanogenesis via ERK pathway in B16F10 melanoma cells.
Ocular infiltrating CD4+ T cells from patients with Vogt-Koyanagi-Harada disease recognize human melanocyte antigens.
Oenothera laciniata Hill Extracts Exhibits Antioxidant Effects and Attenuates Melanogenesis in B16-F10 Cells via Downregulating CREB/MITF/Tyrosinase and Upregulating p-ERK and p-JNK.
Oligoesculin fraction induces anti-tumor effects and promotes immune responses on B16-F10 mice melanoma.
Opposite regulation of tyrosinase and glutathione peroxidase by intracellular thiols in human melanoma cells.
Optimal detection of sentinel lymph node metastases by intraoperative radioactive threshold and molecular analysis in patients with melanoma.
Optimization of Phenolics Extracted from Idesia polycarpa Defatted Fruit Residue and Its Antioxidant and Depigmenting Activity In Vitro and In Vivo.
Optimization of the tyrosinase mRNA probe to detect circulating melanocytes with reverse transcription and polymerase chain reaction.
Optimization of Ultrasonic Flavonoid Extraction from Saussurea involucrate, and the Ability of Flavonoids to Block Melanin Deposition in Human Melanocytes.
Over-production of a glycoside hydrolase family 50 beta-agarase from Agarivorans sp. JA-1 in Bacillus subtilis and the whitening effect of its product.
Oxidation of carbidopa by tyrosinase and its effect on murine melanoma.
Oxyresveratrol and hydroxystilbene compounds. Inhibitory effect on tyrosinase and mechanism of action.
Oxyresveratrol extracted from Artocarpus heterophyllus Lam. inhibits tyrosinase and age pigments in vitro and in vivo.
p-Alkoxyphenols, a new class of inhibitors of mammalian R2 ribonucleotide reductase: possible candidates for antimelanotic drugs.
p-Coumaric Acid as An Active Ingredient in Cosmetics: A Review Focusing on its Antimelanogenic Effects.
p-Coumaric acid, a constituent of Sasa quelpaertensis Nakai, inhibits cellular melanogenesis stimulated by alpha-melanocyte stimulating hormone.
p53 regulation by TRP2 is not pervasive in melanoma.
Partial characterization of IR-alpha-MSH peptides found in melanoma tumors.
Partial tyrosinase-specific self tolerance by HLA-A*0201-restricted cytotoxic T lymphocytes in mice and man.
Partially purified components of Nardostachys chinensis suppress melanin synthesis through ERK and Akt signaling pathway with cAMP down-regulation in B16F10 cells.
Particulate tyrosinase of human malignant melanoma. Solubilization, purification following trypsin treatment, and characterization.
Pathologic assessment of melanoma sentinel nodes: a role for molecular analysis using quantitative real-time reverse transcription-PCR for MART-1 and tyrosinase messenger RNA.
Pathology and ultrastructural characteristics of a hypomelanotic variant of transplantable hamster melanoma with elevated tyrosinase activity.
Paucity of functional T-cell memory to melanoma antigens in healthy donors and melanoma patients.
Peptide-specific CTL in tumor infiltrating lymphocytes from metastatic melanomas expressing MART-1/Melan-A, gp100 and Tyrosinase genes: a study in an unselected group of HLA-A2.1-positive patients.
Peripheral blood tyrosinase messenger RNA detection and survival in malignant melanoma.
pH-dependent interconvertible allosteric forms of murine melanoma tyrosinase. Physiological implications.
pH-dependent interconvertible forms of mushroom tyrosinase with different kinetic properties.
pH-sensitive liposomes are efficient carriers for endoplasmic reticulum-targeted drugs in mouse melanoma cells.
Phase 2 trial of vaccination with tyrosinase peptides and granulocyte-macrophage colony-stimulating factor in patients with metastatic melanoma.
Phase I evaluation of interleukin-2-transfected irradiated allogeneic melanoma for the treatment of metastatic melanoma: appendix 1: protocol.
Phase I study of intranodal delivery of a plasmid DNA vaccine for patients with Stage IV melanoma.
Phase I/II study of treatment with dendritic cell vaccines in patients with disseminated melanoma.
Phase I/II study of treatment with matured dendritic cells with or without low dose IL-2 in patients with disseminated melanoma.
Phase I/II trial of a long peptide vaccine (LPV7) plus toll-like receptor (TLR) agonists with or without incomplete Freund's adjuvant (IFA) for resected high-risk melanoma.
Phenolic-rich Pomegranate Peel Extract: In Vitro, Cellular, and In Vivo Activities for Skin Hyperpigmentation Treatment.
Phenotypic heterogeneity of melanoma. Relation to the differentiation program of melanoma cells.
Phlorotannins with Potential Anti-tyrosinase and Antioxidant Activity Isolated from the Marine Seaweed Ecklonia stolonifera.
Photoaffinity labelling of melanoma cell MSH receptors.
PHrmonal specificity of the melanotropin-sensitive adenylate cyclase of mouse melanoma and effect of cyclic AMP on the tyrosinase activity of mouse melanoma cells, in vitro.
Phytochemical capacity of Nitraria retusa leaves extracts inhibiting growth of melanoma cells and enhancing melanogenesis of B16F10 melanoma.
Phytochemical potential of Daphne gnidium in inhibiting growth of melanoma cells and enhancing melanogenesis of B16-F0 melanoma.
Piceatannol inhibits melanogenesis by its antioxidative actions.
Pigment content of cultured human melanocytes does not correlate with tyrosinase message level.
Pigment production in murine melanoma cells is regulated by tyrosinase, tyrosinase-related protein 1 (TRP1), DOPAchrome tautomerase (TRP2), and a melanogenic inhibitor.
Pigment-cell-specific genes from fibroblasts are transactivated after chromosomal transfer into melanoma cells.
Pigment-lightening effect of N,N'-dilinoleylcystamine on human melanoma cells.
Pigmentation Levels Affect Melanoma Responses to Coriolus versicolor Extract and Play a Crucial Role in Melanoma-Mononuclear Cell Crosstalk.
Pigmentation-associated glycoprotein of human melanomas and melanocytes: definition with a mouse monoclonal antibody.
Pigmented hamartoma of the eyelid with apocrine, follicular and sebaceous differentiation.
Pilot study of safety and feasibility of DNA microseeding for treatment of spontaneous canine melanoma.
Plumbagin Suppresses ?-MSH-Induced Melanogenesis in B16F10 Mouse Melanoma Cells by Inhibiting Tyrosinase Activity.
Polyhydroxylated phenylacrylic acid derivatives as new anti-tumor agents.
Polymerase chain reaction detection of melanoma cells in the circulation: relation to clinical stage, surgical treatment, and recurrence from melanoma.
Polymerase chain reaction in the detection of circulating tumour cells in peripheral blood of melanoma patients.
Polymerization of 5,6-dihydroxyindole-2-carboxylic acid to melanin by the pmel 17/silver locus protein.
Possible involvement of proteolytic degradation of tyrosinase in the regulatory effect of fatty acids on melanogenesis.
Possible relationship between abnormal melanosome structure and cytotoxic phenomena in malignant melanoma.
Potent and prolonged melanotropic activities of the alpha-MSH fragment analog, Ac-[Nle4,D-Phe7]-alpha-MSH4-9-NH2.
Potent melanin production enhancement of human tyrosinase gene by Tat and an entrapment in elastic cationic niosomes: Potential application in vitiligo gene therapy.
PPAR gamma regulates MITF and beta-catenin expression and promotes a differentiated phenotype in mouse melanoma S91.
Pre-existing immunity to tyrosinase-related protein (TRP)-2, a new TRP-2 isoform, and the NY-ESO-1 melanoma antigen in a patient with a dramatic response to immunotherapy.
Prediction of disease outcome in melanoma patients by molecular analysis of paraffin-embedded sentinel lymph nodes.
Prediction of metastases in melanoma patients with positive sentinel node: histological and molecular approach.
Preparation of purified tyrosinase devoid of dopachrome tautomerase from mammalian malignant melanocytes.
Presence and regulation of tyrosinase activity in human neuroblastoma cell variants in vitro.
Prevention of an additional surgery for regional lymphadenectomy in melanoma: Rapid intraoperative immunostaining of sentinel lymph node imprint smears.
Primary melanoma cells of the vertical growth phase: similarities to metastatic cells.
Prioritization and comprehensive analysis of genes associated with melanoma.
Proanthocyanidins isolated from the leaves of Photinia × fraseri block the cell cycle and induce apoptosis by inhibiting tyrosinase activity in melanoma cells.
Proanthocyanidins purified from fruit pericarp of Clausena lansium (Lour.) Skeels as efficient tyrosinase inhibitors: structure evaluation, inhibitory activity and molecular mechanism.
Production of 6-hydroxydopa by human tyrosinase.
Prognosis of metastatic melanoma: no correlation of tyrosinase mRNA in bone marrow and survival time.
Prognostic relevance of baseline and sequential peripheral blood tyrosinase expression in 200 consecutive advanced metastatic melanoma patients.
Prognostic role of circulating melanoma cells detected by reverse transcriptase-polymerase chain reaction for tyrosinase mRNA in patients with melanoma.
Prognostic significance and diagnostic value of protein S-100 and tyrosinase in patients with malignant melanoma.
Prognostic significance of detecting micrometastases by tyrosinase RT/PCR in sentinel lymph node biopsies: lessons from 322 consecutive melanoma patients.
Prognostic Significance of Molecular Staging Study of Sentinel Lymph Nodes by Reverse Transcriptase-Polymerase Chain Reaction for Tyrosinase in Melanoma Patients.
Prognostic significance of molecular staging study of sentinel lymph nodes by reverse transcriptase-polymerase chain reaction for tyrosinase in melanoma patients.
Prognostic significance of occult metastases detected by sentinel lymphadenectomy and reverse transcriptase-polymerase chain reaction in early-stage melanoma patients.
Prognostic significance of peripheral blood and bone marrow tyrosinase messenger RNA in malignant melanoma.
Prognostic significance of the detection of circulating malignant cells by reverse transcriptase-polymerase chain reaction in long-term clinically disease-free melanoma patients.
Prognostic significance of the sequential detection of circulating melanoma cells by RT-PCR in high-risk melanoma patients receiving adjuvant interferon.
Prognostic significance of tyrosinase expression in sentinel lymph node biopsy for ultra-thin, thin, and thick melanomas.
Prognostic significance of tyrosinase mRNA detected by nested RT-PCR in patients with malignant melanoma.
Prognostic value of microphthalmia-associated transcription factor and tyrosinase as markers for circulating tumor cells detection in patients with melanoma.
Prognostic value of multiple reverse transcription-PCR tyrosinase testing for circulating neoplastic cells in malignant melanoma.
Prognostic value of RT-PCR tyrosinase detection in peripheral blood of melanoma patients.
Prognostic value of tyrosinase reverse transcriptase PCR analysis in melanoma sentinel lymph nodes: long-term follow-up analysis.
Prognostic value of tyrosinase reverse-transcriptase polymerase chain reaction in metastatic melanoma.
Progressive appearance of pigmentation in amelanotic melanoma lesions.
Prolonged stimulation of S91 melanoma tyrosinase by [Nle4, D-Phe7]-substituted alpha-melanotropins.
Proper folding and endoplasmic reticulum to golgi transport of tyrosinase are induced by its substrates, DOPA and tyrosine.
Prophylactic vaccines are potent activators of monocyte-derived dendritic cells and drive effective anti-tumor responses in melanoma patients at the cost of toxicity.
Protein and non-protein biomarkers in melanoma: a critical update.
Protein kinase C-beta activates tyrosinase by phosphorylating serine residues in its cytoplasmic domain.
Protein kinase Calpha plays a critical role in mannosylerythritol lipid-induced differentiation of melanoma B16 cells.
Protein specific N-glycosylation of tyrosinase and tyrosinase-related protein-1 in B16 mouse melanoma cells.
Proteolysis with trypsin of mammalian tyrosinase isoforms from B16 mouse melanoma.
Proteomic scan for tyrosinase peptide antigenic pattern in vitiligo and melanoma: role of sequence similarity and HLA-DR1 affinity.
Protocatechuic Acid from Pear Inhibits Melanogenesis in Melanoma Cells.
Psoralens stimulate mouse melanocyte and melanoma tyrosinase activity in the absence of ultraviolet light.
Purification and characterization of neoagarotetraose from hydrolyzed agar.
Purification and properties of tyrosinase isoenzymes from hamster melanoma.
Purification of hamster melanoma tyrosinases and structural studies of their asparagine-linked sugar chains.
Purification of tyrosinase to homogeneity based on its resistance to sodium dodecyl sulfate-proteinase K digestion.
Pyrroloquinoline quinone (PQQ) inhibits the expression of tyrosinase mRNA by alpha-melanocyte stimulating hormone in murine B16 melanoma cells.
Qualitative and quantitative catalog of tyrosinase alternative transcripts in normal murine skin melanocytes as a basis for detecting melanoma-specific changes.
Quantification of melanoma micrometastases in sentinel lymph nodes using real-time RT-PCR.
Quantitative analysis of mouse tyrosinase by enzyme-linked immunosorbent assay.
Quantitative analysis of tyrosinase and tyrosinase-related protein-2 mRNA from melanoma cells in blood by real-time polymerase chain reaction.
Quantitative analysis of tyrosinase transcripts in blood.
Quantitative detection of melanoma-associated antigens by multimarker real-time RT-PCR for molecular staging: results of a 5 years study.
Quantitative nested real-time RT-PCR specific for tyrosinase transcripts to quantitate minimal residual disease.
Quantitative real-time RT-PCR as a method for monitoring T lymphocyte reactivity to full-length tyrosinase protein in vaccinated melanoma patients.
Quantitative real-time RT-PCR in sentinel lymph nodes from melanoma patients. Detection of melanocytic mRNA predicts disease-free survival.
Quantitative RT-PCR assessment of melanoma cells in peripheral blood during immunotherapy for metastatic melanoma.
Quercetin as an Emerging Anti-Melanoma Agent: A Four-Focus Area Therapeutic Development Strategy.
Quercetin enhances melanogenesis by increasing the activity and synthesis of tyrosinase in human melanoma cells and in normal human melanocytes.
Quercetin Inhibits ?-MSH-stimulated Melanogenesis in B16F10 Melanoma Cells.
Quercetin selectively inhibits bioreduction and enhances apoptosis in melanoma cells that overexpress tyrosinase.
Quercetin-3-O-?-d-glucopyranosyl-(1 ? 6)-?-d-glucopyranoside suppresses melanin synthesis by augmenting p38 MAPK and CREB signaling pathways and subsequent cAMP down-regulation in murine melanoma cells.
Rapid and reversible inhibition of tyrosinase activity by glucosidase inhibitors in human melanoma cells.
Rapid nested-PCR for tyrosinase gene detection on chip.
Rare Occurrence of an Intraocular Choroidal Solitary Fibrous Tumor/Hemangiopericytoma.
Reactivity of dinuclear copper(II) complexes towards melanoma cells: Correlation with its stability, tyrosinase mimicking and nuclease activity.
Reactivity of orthoquinones involved in tyrosinase-dependent cytotoxicity: differences between alkylthio- and alkoxy-substituents.
Reactivity to tyrosinase: expression in cancer (melanoma) and autoimmunity (vitiligo).
Receptor binding affinities and biological activities of linear and cyclic melanocortins in B16 murine melanoma cells expressing the native MC1 receptor.
Reduced glutathione disrupts the intracellular trafficking of tyrosinase and tyrosinase-related protein-1 but not dopachrome tautomerase and Pmel17 to melanosomes, which results in the attenuation of melanization.
Reduction of DNA synthesis, pigment synthesis, pigmentation gene mRNA and resistance to UVB in human melanoma cells treated with analogues of a histamine (H2) agonist.
Regulated folding of tyrosinase in the endoplasmic reticulum demonstrates that misfolded full-length proteins are efficient substrates for class I processing and presentation.
Regulation of cell division and of tyrosinase in B16 melanoma cells by imidazole: a possible role for the concept of metabolite gene regulation in mammalian cells.
Regulation of mammalian melanogenesis by tyrosinase inhibition.
Regulation of mammalian melanogenesis. I: Partial purification and characterization of a dopachrome converting factor: dopachrome tautomerase.
Regulation of melanogenesis induced by 5-methoxypsoralen without ultraviolet light in murine melanoma cells.
Regulation of melanogenesis through phosphatidylinositol 3-kinase-Akt pathway in human G361 melanoma cells.
Regulation of ornithine decarboxylase in B16 mouse melanoma cells: synergistic activation of melanogenesis by alphaMSH and ornithine decarboxylase inhibition.
Regulation of the cytosolic and melanosome-bound tyrosinase activities in Harding-Passey mouse melanoma.
Regulation of tyrosinase activity in mouse melanoma and skin by changes in melanosomal membrane permeability.
Regulation of tyrosinase expression and activity in human melanoma cells via histamine receptors.
Regulation of tyrosinase gene expression by cAMP in B16 melanoma cells involves two CATGTG motifs surrounding the TATA box: implication of the microphthalmia gene product.
Regulation of tyrosinase mRNA in mouse melanoma cells by alpha-melanocyte-stimulating hormone.
Regulation of tyrosinase mRNA levels in mouse melanoma cell clones by melanocyte-stimulating hormone and cyclic AMP.
Reliability of reverse transcription-polymerase chain reaction (RT-PCR)-based assays for the detection of circulating tumour cells: a quality-assurance initiative of the EORTC Melanoma Cooperative Group.
Repeated UVB irradiations do not have the same potential to promote stimulation of melanogenesis in cultured normal human melanocytes.
Reproducibility of detection of tyrosinase and MART-1 transcripts in the peripheral blood of melanoma patients: a quality control study using real-time quantitative RT-PCR.
Responsive Mn(II) complexes for potential applications in diagnostic Magnetic Resonance Imaging.
Results of the determination of serum markers in patients with malignant melanoma.
Retinoic acid blockade of imidazole-induced tyrosinase expression in B16 melanoma cultures: similar effects of the active retinoid and triiodothyronine.
Retinoic acid is a potent inhibitor of inducible pigmentation in murine and hamster melanoma cell lines.
Retinoic acid metabolites exhibit biological activity in human keratinocytes, mouse melanoma cells and hairless mouse skin in vivo.
Retroviral infection with human tyrosinase-related protein-1 (TRP-1) cDNA upregulates tyrosinase activity and melanin synthesis in a TRP-1-deficient melanoma cell line.
Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of nonsentinel nodes following completion lymphadenectomy for melanoma.
Reverse transcriptase-polymerase chain reaction detection of circulating tumor cells in patients with melanoma: correlation with clinical stage, tumor thickness and histological type.
Reverse transcriptase-polymerase chain reaction for expression of tyrosinase to identify malignant melanoma cells in peripheral blood.
Rhapontigenin converted from rhapontin purified from Rheum undulatum enhances the inhibition of melanin synthesis.
Role of estradiol and 2-hydroxyestradiol in melanin formation in vitro.
Role of gene expression and protein synthesis of tyrosinase, TRP-1, lamp-1, and CD63 in UVB-induced melanogenesis in human melanomas.
Role of microphthalmia transcription factor in regulation of melanocyte differentiation marker TRP-1.
Role of RT-PCR tyrosinase detection in the monitoring of patients with advanced metastatic melanoma.
Role of the mitogen-activated protein kinase signaling pathway in the regulation of human melanocytic antigen expression.
Rose Petal Extract (Rosa gallica) Exerts Skin Whitening and Anti-Skin Wrinkle Effects.
Route of administration modulates the induction of dendritic cell vaccine-induced antigen-specific T cells in advanced melanoma patients.
RT-PCR detection of tyrosinase, gp100, MART1/Melan-A, and TRP-2 gene transcripts in peripheral blood of melanoma patients.
RT-PCR for tyrosinase expression as a molecular marker in malignant melanoma.
RT-PCR tyrosinase expression in the peripheral blood of melanoma patients.
S100, HMB-45, and Melan-A negative primary melanoma.
Safety and efficacy of a xenogeneic DNA vaccine encoding for human tyrosinase as adjunctive treatment for oral malignant melanoma in dogs following surgical excision of the primary tumor.
Safety and efficacy of tyrosinase inhibition of Paeonia suffruticosa Andrews extracts on human melanoma cells.
Safety and immunogenicity of tyrosinase DNA vaccines in patients with melanoma.
Safety and immunogenicity of vaccination with MART-1 (26-35, 27L), gp100 (209-217, 210M), and tyrosinase (368-376, 370D) in adjuvant with PF-3512676 and GM-CSF in metastatic melanoma.
Safety assessment, biological effects, and mechanisms of Myrica rubra fruit extract for anti-melanogenesis, anti-oxidation, and free radical scavenging abilities on melanoma cells.
Safety of administering the canine melanoma DNA vaccine (Oncept) to cats with malignant melanoma - a retrospective study.
Salicylic acid in ginseng root alleviates skin hyperpigmentation disorders by inhibiting melanogenesis and melanosome transport.
SCD5 restored expression favors differentiation and epithelial-mesenchymal reversion in advanced melanoma.
Selective cytotoxicity of hydroquinone for melanocyte-derived cells is mediated by tyrosinase activity but independent of melanin content.
Selective in vivo accumulation of N-acetyl-4-S-cysteaminylphenol in B16F10 murine melanoma and enhancement of its in vitro and in vivo antimelanoma effect by combination of buthionine sulfoximine.
Selective increase in specific alternative splice variants of tyrosinase in murine melanomas: a projected basis for immunotherapy.
Selective induction of apoptosis in melanoma cells by tyrosinase promoter-controlled CD95 ligand overexpression.
Selective inhibition of growth and respiration of melanomas by tyrosinase inhibitors.
Selective uptake of 2-thiouracil into melanin-producing systems depends on chemical binding to enzymically generated dopaquinone.
SELECTIVITY AND EFFICIENCY OF LATE TRANSGENE EXPRESSION BY TRANSCRIPTIONALLY TARGETED ONCOLYTIC ADENOVIRUSES ARE DEPENDENT ON THE TRANSGENE INSERTION STRATEGY.
Self-tolerance to the murine homologue of a tyrosinase-derived melanoma antigen: implications for tumor immunotherapy.
Sentinel node biopsies in melanoma patients: a protocol for accurate, efficient, and cost-effective analysis by preselection for immunohistochemistry on the basis of Tyr-PCR.
Separation and characterization of multiple forms of tyrosinase from mouse melanoma.
Sequence analysis of mouse tyrosinase cDNA and the effect of melanotropin on its gene expression.
Serial follow-up and the prognostic significance of reverse transcriptase-polymerase chain reaction--staged sentinel lymph nodes from melanoma patients.
Serum and substratum-dependent coupled loss of differentiated and tumorigenic phenotypes in B16-conv melanoma cells.
Serum protein s-100 predicts clinical outcome in patients with melanoma treated with adjuvant interferon--comparison with tyrosinase rt-PCR.
Serum tyrosinase in malignant disease, its activity, and the electrophoretic patterns of the enzyme as carried by immunoglobulins'.
Serum tyrosine hydroxylase activity is increased in melanoma patients. An ROC curve analysis.
Sesamol Inhibited Melanogenesis by Regulating Melanin-Related Signal Transduction in B16F10 Cells.
Sex steroid receptor analysis in human melanoma.
Signalling pathways evoked by alpha(1)-adrenoceptors in human melanoma cells.
Simultaneous analysis of tyrosinase mRNA and markers of tyrosinase activity in the blood of patients with metastatic melanoma.
Simultaneous generation of CD8+ and CD4+ melanoma-reactive T cells by retroviral-mediated transfer of a single T-cell receptor.
Simultaneous transduction of B7-1 and IL-2 genes into human melanoma cells to be used as vaccine: enhancement of stimulatory activity for autologous and allogeneic lymphocytes.
Single injection of CD34+ progenitor-derived dendritic cell vaccine can lead to induction of T-cell immunity in patients with stage IV melanoma.
Single-Step Antigen Loading and Activation of Dendritic Cells by mRNA Electroporation for the Purpose of Therapeutic Vaccination in Melanoma Patients.
Sinonasal tract and nasopharyngeal melanomas: a clinicopathologic study of 115 cases with a proposed staging system.
Skin delivery of resveratrol encapsulated lipidic formulation for melanoma chemoprevention.
Skin resistance to UVB-induced oxidative stress and hyperpigmentation by the topical use of Lactobacillus helveticus NS8-fermented milk supernatant.
Skin whitening and anti-corrugation activities of glycoprotein fractions from liquid extracts of boiled sea cucumber.
Skin-Depigmenting Agent Monobenzone Induces Potent T-Cell Autoimmunity toward Pigmented Cells by Tyrosinase Haptenation and Melanosome Autophagy.
Skin-whitening mechanism of cumin (Cuminum cyminum L.) extract.
SLC45A2: A Melanoma Antigen with High Tumor Selectivity and Reduced Potential for Autoimmune Toxicity.
Solubilization and activation of mammalian melanoma particulate tyrosinase by lipase digestion.
Solubilizing effect of Trition X-100 on melanosome tyrosinase in hamster pigmented melanoma.
Sorafenib induces pigmentation via the regulation of ?-catenin signalling pathway in melanoma cells.
Specific Central Memory T Cells in the Bone Marrow of Patients Immunized Against Tyrosinase Peptides.
Specific Imaging of Tyrosinase in Vivo with 3-Hydroxybenzyl Caged D-Luciferins.
Specific inhibition by antityrosinase antibodies of tyrosinase-mediated melanogenesis.
Specific tyrosinases associated with melanoma replicative senescence and melanogenesis.
Specificity of growth inhibition of melanoma by 4-hydroxyanisole.
Specificity of tyrosinase and HMB45 PCR in the detection of melanoma metastases in sentinel lymph node biopsies.
Spontaneous T cell responses to melanoma differentiation antigens from melanoma patients and healthy subjects.
STAP-2 Protein Expression in B16F10 Melanoma Cells Positively Regulates Protein Levels of Tyrosinase, Which Determines Organs to Infiltrate in the Body.
State of particulate tyrosinase in melanoma.
State of tyrosinase in melanoma melanosomes.
Stellettin A induces endoplasmic reticulum stress in murine B16 melanoma cells.
Stem cell marker nestin expression in peripheral blood of patients with melanoma.
Stimulation by ionophores of tyrosinase activity of mouse melanoma cells in culture.
Stimulation of Cloudman melanoma tyrosinase activity occurs predominantly in G2 phase of the cell cycle.
Stimulation of melanogenesis by nordihydroguaiaretic Acid in human melanoma cells.
Stimulation of S91 melanoma tyrosinase activity by superpotent alpha-melanotropins.
Stimulation of the receptor for melanocyte-stimulating hormone by retinoic acid.
Stimulation of tyrosinase activity and melanin formation of cultured melanoma cells by serum deprivation alone or in combination with dibutyryl cyclic AMP and theophylline.
Stimulation of tyrosinase activity of cultured melanoma cells by lysosomotropic agents.
Stimulation of tyrosinase by dihydroxy phenyl derivatives.
Structural heterogeneity of a human melanoma-associated antigen.
Structural insight with mutational impact on tyrosinase and PKC-? interaction from Homo sapiens: Molecular modeling and docking studies for melanogenesis, albinism and increased risk for melanoma.
Structural organization of the human tyrosinase gene and sequence analysis and characterization of its promoter region.
Structural requirement of phenylthiourea analogs for their inhibitory activity of melanogenesis and tyrosinase.
Structural toxicity relationship of 4-alkoxyphenols' cytotoxicity towards murine B16-F0 melanoma cell line.
Structural/functional relationships between internal and external MSH receptors: modulation of expression in Cloudman melanoma cells by UVB radiation.
Structure-activity relationship of T-cell receptors based on alanine scanning.
Structure-toxicity relationship of phenolic analogs as anti-melanoma agents: an enzyme directed prodrug approach.
Studies on the kinetics of oxidation of 4-hydroxyanisole by tyrosinase.
Studies on the reactions between human tyrosinase, superoxide anion, hydrogen peroxide and thiols.
Subcellular distribution of tyrosinase and tyrosinase-related protein-1: implications for melanosomal biogenesis.
Subcellular tyrosinase activity in Fortner's malignant melanoma.
Substrate-Photocaged Enzymatic Fluorogenic Probe Enabling Sequential Activation for Light-Controllable Monitoring of Intracellular Tyrosinase Activity.
Sulforaphane inhibited melanin synthesis by regulating tyrosinase gene expression in B16 mouse melanoma cells.
Sulfur containing tyrosine analogs can cause selective melanocytotoxicity involving tyrosinase-mediated apoptosis.
Supermelanotic hybrids derived from mouse melanomas and normal mouse cells.
Suppression of C8161 melanoma metastatic ability by chromosome 6 induces differentiation-associated tyrosinase and decreases proliferation on adhesion-restrictive substrates mediated by overexpression of p21WAF1 and down-regulation of bcl-2 and cyclin D3.
Suppression of melanoma cell tyrosinase activity and tumorigenicity after incorporation of bromouracil for one or two cell divisions.
Suppression of pigmentation in mouse melanoma cells by 5-bromodeoxyuridine: effects on tyrosinase activity and melanosome formation.
Suppression of Pigmentation in Mouse Melanoma Cells by 5-Bromodeoxyuridine: Effects on Tyrosinase Activity.
Suppression of tyrosinase gene expression by bromodeoxyuridine in Syrian hamster melanoma cells is not due to its incorporation into upstream or coding sequences of the tyrosinase gene.
Syntheses of arbutin-alpha-glycosides and a comparison of their inhibitory effects with those of alpha-arbutin and arbutin on human tyrosinase.
Synthesis and actions of a melanotropin conjugate, Ac-[Nle4, Glu(gamma-4'-hydroxyanilide)5, D-Phe7]alpha-MSH4-10-NH2, on melanocytes and melanoma cells in vitro.
Synthesis and anti-melanogenic effects of lipoic acid-polyethylene glycol ester.
Synthesis and antityrosinase mechanism of benzaldehyde thiosemicarbazones: novel tyrosinase inhibitors.
Synthesis and biological actions of highly potent and prolonged acting biotin-labeled melanotropins.
Synthesis and biological activities of fatty acid conjugates of a cyclic lactam alpha-melanotropin.
Synthesis and biological evaluation of N-aryl-2-phenyl-hydrazinecarbothioamides: Experimental and theoretical analysis on tyrosinase inhibition and interaction with HSA.
Synthesis and Biological Evaluation of the Anti-Melanogenesis Effect of Coumaric and Caffeic Acid-Conjugated Peptides in Human Melanocytes.
Synthesis and degradation of tyrosinase in cultured melanoma cells.
Synthesis and evaluation of N-acylamino acids derivatives of triazenes. Activation by tyrosinase in human melanoma cell lines.
Synthesis of cinnamic amide derivatives and their anti-melanogenic effect in ?-MSH-stimulated B16F10 melanoma cells.
Synthesized quercetin derivatives stimulate melanogenesis in B16 melanoma cells by influencing the expression of melanin biosynthesis proteins MITF and p38 MAPK.
Synthetic peptides derived from the melanocyte-stimulating hormone receptor MC1R can stimulate HLA-A2-restricted cytotoxic T lymphocytes that recognize naturally processed peptides on human melanoma cells.
Systemic gene therapy of murine melanoma using tissue specific expression of the HSVtk gene involves an immune component.
T cell immune function in tumor, skin and peripheral blood of advanced stage melanoma patients: implications for immunotherapy.
T cell immune responses against melanoma and melanocytes in cancer and autoimmunity.
T cell receptor gene transfer exclusively to human CD8+ cells enhances tumor cell killing.
T-Cell Mediated Immune Responses Induced in ret Transgenic Mouse Model of Malignant Melanoma.
T-cell responses against tyrosinase 368-376(370D) peptide in HLA*A0201+ melanoma patients: randomized trial comparing incomplete Freund's adjuvant, granulocyte macrophage colony-stimulating factor, and QS-21 as immunological adjuvants.
Tape-Stripping Electrochemical Detection of Melanoma.
Targeted therapy for malignant melanoma.
Targeting Melanoma-Initiating Cells by Caffeine: In Silico and In Vitro Approaches.
Targeting of 111In-Labeled Dendritic Cell Human Vaccines Improved by Reducing Number of Cells.
Targeting of cytokine gene expression to malignant melanoma cells using tissue specific promoter sequences.
Telomerase RNA as a detection marker in the serum of breast cancer patients.
The activation of melanogenesis by p-CREB and MITF signaling with extremely low-frequency electromagnetic fields on B16F10 melanoma.
The amphibian melanization inhibiting factor (MIF) blocks the alpha-MSH effect on mouse malignant melanocytes.
The analysis of tyrosinase-specific mRNA in blood samples of melanoma patients by RT-PCR is not a useful test for metastatic tumor progression.
The association between Parkinson's disease and melanoma.
The clinical significance of antityrosinase antibodies in melanoma and related hypopigmentary lesions.
The cytotoxicity and apoptosis induced by 4-tertiary butylphenol in human melanocytes are independent of tyrosinase activity.
The cytotoxicity of cysteinylcatechols and related compounds to human melanoma cells in vitro.
The depigmenting effect of alpha-tocopheryl ferulate on human melanoma cells.
The detection of circulating melanoma cells correlates with tumour thickness and ulceration but is not predictive of metastasis for patients with primary melanoma.
The detection of melanoma cells in peripheral blood by reverse transcription-polymerase chain reaction.
The detection of tyrosinase mRNA in peripheral blood samples is unlikely to aid in the management of patients with localised malignant melanoma.
The detection of tyrosinase mRNA in the peripheral blood of stage I melanoma patients is not of clinical relevance in predicting metastasis risk and survival.
The detection of tyrosinase-specific mRNA in bone marrow is not more sensitive than in blood for the demonstration of micrometastatic melanoma.
The development of optimal pathological assessment of sentinel lymph nodes for melanoma.
The effect of antisense tyrosinase-related protein 1 on melanocytes and malignant melanoma cells.
The effect of chemo- and chemoimmunotherapy on the presence of circulating melanoma cells in peripheral blood. Preliminary results.
The effect of polyamines on tyrosinase activity.
The effects of gp100 and tyrosinase peptide vaccinations on nevi in melanoma patients.
The effects of pro-opiomelanocortin peptides on cyclic AMP and tyrosinase in melanoma cells.
The existence of apotyrosinase in the cytosol of Harding-Passey mouse melanoma melanocytes and characteristics of enzyme reconstitution by Cu(II).
The expression of tyrosinase, tyrosinase-related proteins 1 and 2 (TRP1 and TRP2), the silver protein, and a melanogenic inhibitor in human melanoma cells of differing melanogenic activities.
The functional property of egg yolk phosvitin as a melanogenesis inhibitor.
The functional property of royal jelly 10-hydroxy-2-decenoic acid as a melanogenesis inhibitor.
The glycosylation of tyrosinase in melanoma cells and the effect on antigen presentation.
The Improvement of Skin Whitening of Phenylethyl Resorcinol by Nanostructured Lipid Carriers.
The in vitro and in vivo depigmenting activity of Coenzyme Q10 through the down-regulation of ?-MSH signaling pathways and induction of Nrf2/ARE-mediated antioxidant genes in UVA-irradiated skin keratinocytes.
The in vivo antimelanoma effect of 4-S-cysteaminylphenol and its n-acetyl derivative.
The inhibition of early N-glycan processing targets TRP-2 to degradation in B16 melanoma cells.
The inhibitory effect of a synthetic compound, (Z)-5-(2,4-dihydroxybenzylidene) thiazolidine-2,4-dione (MHY498), on nitric oxide-induced melanogenesis.
The inhibitory effect of DL-alpha-tocopheryl ferulate in lecithin on melanogenesis.
The inhibitory effect of glycolic acid and lactic acid on melanin synthesis in melanoma cells.
The Inhibitory Effect of Phytoclear-EL1 on Melanogenesis.
The inhibitory effect of silk sericin against ultraviolet-induced melanogenesis and its potential use in cosmeceutics as an anti-hyperpigmentation compound.
The involvement of histidine at the active site of Harding-Passey mouse melanoma tyrosinase.
The killing effect of 4-S-cysteaminylphenol, a newly synthesised melanin precursor, on B16 melanoma cell lines.
The melanotropic peptide, [Nle4,D-Phe7] alpha-MSH, stimulates human melanoma tyrosinase activity and inhibits cell proliferation.
The Metabolic Bioactivation of Caffeic Acid Phenethyl Ester Mediated by Tyrosinase Selectively Inhibits Glutathione S-Transferase.
The mixture of different parts of Nelumbo nucifera and two bioactive components inhibited tyrosinase activity and melanogenesis.
The natural yeast extract isolated by ethanol precipitation inhibits melanin synthesis by modulating tyrosinase activity and downregulating melanosome transfer.
The p75 neurotrophin receptor, relative to other Schwann cell and melanoma markers, is abundantly Expressed in spindled melanomas.
The pattern of cytokine gene expression in freshly excised human metastatic melanoma suggests a state of reversible anergy of tumor-infiltrating lymphocytes.
The possible role of tyrosinase in malignant growth.
The POU domain transcription factor Brn-2: elevated expression in malignant melanoma and regulation of melanocyte-specific gene expression.
The Presence of Alpha-Synuclein in Skin from Melanoma and Patients with Parkinson's Disease.
The properties of antibody against smooth endoplasmic reticulum of melanocytes.
The relationship between melanin production and lipofuscin formation in Tyrosinase gene knockout melanocytes using CRISPR/Cas9 system.
The response of autologous T cells to a human melanoma is dominated by mutated neoantigens.
The role of adenosine 3',5'-cyclic monophosphate in the density-dependent regulation of growth and tyrosinase activity of B-16 melanoma cells.
The role of molecular staging in malignant melanoma.
The role of sulfhydryl compounds in mammalian melanogenesis: the effect of cysteine and glutathione upon tyrosinase and the intermediates of the pathway.
The role of the detection of hematogenous micrometastasis in prostate adenocarcinoma and malignant melanoma by RT-PCR.
The role of the immune system in anti-tumour responses. Potential for drug therapy.
The selective cytotoxicity of new triazene compounds to human melanoma cells.
The serum/PDGF-dependent "melanogenic" role of the minute level of the oncogenic kinase PAK1 in melanoma cells proven by the highly sensitive kinase assay.
The Silver locus product Pmel17/gp100/Silv/ME20: controversial in name and in function.
The Skin-Whitening Effects of Ectoine via the Suppression of ?-MSH-Stimulated Melanogenesis and the Activation of Antioxidant Nrf2 Pathways in UVA-Irradiated Keratinocytes.
The Standardized Extract of Juniperus communis Alleviates Hyperpigmentation in Vivo HRM-2 Hairless Mice and in Vitro Murine B16 Melanoma Cells.
The tyrosinase gene codes for an antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas.
The use of cationic liposomes DC-CHOL/DOPE and DDAB/DOPE for direct transfer of Escherichia coli cytosine deaminase gene into growing melanoma tumors.
Theophylline and melanocyte-stimulating hormone: effects on uveal melanocytes of adult rhesus eyes.
Therapeutic vaccination with an autologous mRNA electroporated dendritic cell vaccine in patients with advanced melanoma.
Therapeutic vaccine generated by electrofusion of dendritic cells and tumour cells.
Thermal activation and inactivation of melanin formation in vertebrate skins and melanomas.
Thiopurine Drugs Repositioned as Tyrosinase Inhibitors.
Thioredoxin reductase induction coincides with melanin biosynthesis in brown and black guinea pigs and in murine melanoma cells.
Thiosemicarbazones as inhibitors of tyrosinase enzyme.
Threshold levels of gene expression of the melanoma antigen gp100 correlate with tumor cell recognition by cytotoxic T lymphocytes.
Thymidylate synthase as a target enzyme for the melanoma-specific toxicity of 4-S-cysteaminylphenol and N-acetyl-4-S-cysteaminylphenol.
Tissue-specific expression of an anti-ras ribozyme inhibits proliferation of human malignant melanoma cells.
Tissue-specific gene expression from Mo-MLV retroviral vectors with hybrid LTRs containing the murine tyrosinase enhancer/promoter.
Tissue-specific, cell cycle-regulated chimeric transcription factors for the targeting of gene expression to tumor cells.
TLR4 and NLRP3 inflammasome activation in monocytes by N-propionyl cysteaminylphenol-maleimide-dextran (NPCMD).
Traditional herbal prescription LASAP-C inhibits melanin synthesis in B16F10 melanoma cells and zebrafish.
Traditional urinary cytology and tyrosinase RT-PCR in metastatic melanoma patients: correlation with clinical status.
Transcriptional regulation of differentiation, selective toxicity and ATGCAAAT binding of bisbenzimidazole derivatives in human melanoma cells.
Transcriptional repression of the microphthalmia gene in melanoma cells correlates with the unresponsiveness of target genes to ectopic microphthalmia-associated transcription factor.
Transcriptional targeting of recombinant adenoviruses to human and murine melanoma cells.
Transfer of tyrosinase to melanosomes in Harding-Passey mouse melanoma.
Transforming growth factor-beta1 inhibits basal melanogenesis in B16/F10 mouse melanoma cells by increasing the rate of degradation of tyrosinase and tyrosinase-related protein-1.
Transient expression of high molecular weight, heat sensitive, trypsin-resistant form of tyrosinase in B-16 melanoma cells.
Transient T cell depletion causes regression of melanoma metastases.
Translation rate of human tyrosinase determines its N-linked glycosylation level.
Transplantable melanomas in gerbils (Meriones unguiculatus). II: melanogenesis.
Transporter (TAP)- and proteasome-independent presentation of a melanoma-associated tyrosinase epitope.
Treatment of human melanocytes and S91 melanoma cells with the DNA repair enzyme T4 endonuclease V enhances melanogenesis after ultraviolet irradiation.
Triiodothyronine repression of imidazole-induced tyrosinase expression in B16 melanoma cells.
Tuberous sclerosis complex inactivation disrupts melanogenesis via mTORC1 activation.
Tumor antigens recognized by T lymphocytes.
Tumor cell and circulating markers in melanoma: diagnosis, prognosis, and management.
Tumor escape from immune recognition: loss of HLA-A2 melanoma cell surface expression is associated with a complex rearrangement of the short arm of chromosome 6.
Tumor immunity and autoimmunity induced by immunization with homologous DNA.
Tumor markers in peripheral blood of patients with malignant melanoma: multimarker RT-PCR versus a luminoimmunometric assay for S-100.
Tumor suppressor p53 down-regulates tissue-specific expression of tyrosinase gene in human melanoma cell lines.
Tumor-derived heat shock protein 70 peptide complexes are cross-presented by human dendritic cells.
Tumour microdissemination and survival in metastatic melanoma.
Two tyrosinase nonapeptides recognized on HLA-A2 melanomas by autologous cytolytic T lymphocytes.
TXM13 human melanoma cells: a novel source for the inhibition kinetics of human tyrosinase and for screening whitening agents.
Tyrosinase activated melanoma prodrugs.
Tyrosinase activities of cell-free extracts and living cells of cultured melanoma cells.
Tyrosinase activity and abundance in Cloudman melanoma cells.
Tyrosinase activity and isoenzyme distribution corresponding to growth and regression of melanoma in Sinclair miniature swine.
Tyrosinase activity and isozymes in B-16 mouse melanomas.
Tyrosinase activity in a highly pigmented human melanoma and in negro skin.
Tyrosinase activity in human ocular malignant melanoma.
Tyrosinase activity in primary cell culture of amelanotic melanoma cells.
Tyrosinase activity in serum from patients with malignant melanoma.
Tyrosinase activity in the medium of human melanoma cell cultures.
Tyrosinase activity in the sera of patients with malignant melanoma: method and specificity.
Tyrosinase activity in the serum of patients with malignant melanoma.
Tyrosinase activity in three types of the malignant melanoma: superficial spreading melanoma, lentigo maligna melanoma and nodular melanoma.
Tyrosinase and inhibition of proliferation of melanoma cells and fibroblasts.
Tyrosinase and nestin immunohistochemical expression in melanocytic nevi as a histopathologic pattern to trace melanocyte differentiation and nevogenesis.
Tyrosinase Degradation Is Prevented when EDEM1 Lacks the Intrinsically Disordered Region.
Tyrosinase epitope recognized by an HLA-DR-restricted T-cell line from a Vogt-Koyanagi-Harada disease patient.
Tyrosinase exhibits lag at pH 6.8 under steady state concentrations of tyrosine and 3,4-dihydroxy phenyl alanine in melanoma tissue.
Tyrosinase expression and melanogenesis in melanotic and amelanotic B16 mouse melanoma cells.
Tyrosinase Expression as a Molecular Marker for Investigating the Presence of Circulating Tumor Cells in Melanoma Patients.
Tyrosinase expression in malignant melanoma, desmoplastic melanoma, and peripheral nerve tumors.
Tyrosinase expression in the peripheral blood of stage III melanoma patients is associated with a poor prognosis: a clinical follow-up study of 110 patients.
Tyrosinase gene expression is regulated by p53.
Tyrosinase immunoreactivity in fine-needle aspiration samples of metastatic malignant melanoma.
Tyrosinase immunoreactivity in formalin-fixed, paraffin-embedded primary and metastatic melanoma: frequency and distribution.
Tyrosinase inhibition and anti-melanin generation effect of cinnamamide analogues.
Tyrosinase inhibition and antioxidant properties of Asphodelus microcarpus extracts.
Tyrosinase inhibition due to interaction of homocyst(e)ine with copper: the mechanism for reversible hypopigmentation in homocystinuria due to cystathionine beta-synthase deficiency.
Tyrosinase inhibitor in Fortner's amelanotic and melanotic malignant melanoma.
Tyrosinase inhibitors in amelanotic and melanotic malignant melanoma.
Tyrosinase inhibitory effect and inhibitory mechanism of tiliroside from raspberry.
Tyrosinase inhibitory flavonoid from Juniperus communis fruits.
Tyrosinase isoenzymes in mammalian melanocytes. 1. Biochemical characterization of two melanosomal tyrosinases from B16 mouse melanoma.
Tyrosinase isoenzymes in mammalian melanocytes. 2. Differential activation by alpha-melanocyte-stimulating hormone.
Tyrosinase isoenzymes: two melanosomal tyrosinases with different kinetic properties and susceptibility to inhibition by calcium.
Tyrosinase isolated from mouse melanoma melanosome.
Tyrosinase isozyme heterogeneity in differentiating B16/C3 melanoma.
Tyrosinase messenger RNA in peripheral blood is related to poor survival in patients with metastatic melanoma following interleukin-2-based immunotherapy.
Tyrosinase mRNA in blood of patients with melanoma treated with adjuvant interferon.
Tyrosinase mRNA levels in the blood of uveal melanoma patients: correlation with the number of circulating tumor cells and tumor progression.
Tyrosinase mRNA RT-PCR analysis as an additional diagnostic tool for the identification of melanoma cells in biological fluid samples other than blood: a preliminary report.
Tyrosinase mRNA RT-PCR analysis as an additional diagnostic tool for the identification of melanoma cells in biological fluid samples other than blood: A preliminary report.
Tyrosinase mutants are capable of prodrug activation in transfected nonmelanotic cells.
Tyrosinase of hamster melanoma: its purification and estimation by radioimmunoassay.
Tyrosinase overexpression promotes ATM-dependent p53 phosphorylation by quercetin and sensitizes melanoma cells to dacarbazine.
Tyrosinase related protein 1 (TYRP1/gp75) in human cutaneous melanoma.
Tyrosinase RT-PCR as a supplement to histology for detecting melanoma and nevus cells in paraffin sections of sentinel lymph nodes.
Tyrosinase transfection produces melanin synthesis and growth retardation in glioma cells.
Tyrosinase-activated prodrug nanomedicine as oxidative stress amplifier for melanoma-specific treatment.
Tyrosinase-induced free radical formation from VP-16,213: relationship to cytotoxicity.
Tyrosinase-Loaded Multicompartment Microreactor toward Melanoma Depletion.
Tyrosinase-mediated inhibition of in vitro leucine incorporation into mouse melanoma by 4-isopropylcatechol.
Tyrosinase-mediated melanogenesis in melanoma cells: Array comparative genome hybridization integrating proteomics and bioinformatics studies.
Tyrosine release and tyrosinase activity in amelanotic and melanotic malignant melanoma.
TYRP2-mediated resistance to cis-diamminedichloroplatinum (II) in human melanoma cells is independent of tyrosinase and TYRP1 expression and melanin content.
Ultrasensitive Tyrosinase-Activated Turn-On Near-Infrared Fluorescent Probe with a Rationally Designed Urea Bond for Selective Imaging and Photodamage to Melanoma Cells.
Up-regulation of melanin synthesis by the antidepressant fluoxetine.
Up-regulation of specific tyrosinase mRNAs in mouse melanomas with the c2j gene substituted for the wild-type tyrosinase allele: utilization in design of syngeneic immunotherapy models.
Upregulation of mRNA for the melanocortin-1 receptor but not for melanogenic proteins in macrophage x melanoma fusion hybrids exhibiting increased melanogenic and metastatic potential.
Urolithin and Reduced Urolithin Derivatives as Potent Inhibitors of Tyrosinase and Melanogenesis: Importance of the 4-Substituted Resorcinol Moiety.
Use of tissue-specific expression of the herpes simplex virus thymidine kinase gene to inhibit growth of established murine melanomas following direct intratumoral injection of DNA.
Utility of tests for circulating melanoma cells in identifying patients who develop recurrent melanoma.
Vaccination with human tyrosinase DNA induces antibody responses in dogs with advanced melanoma.
Vaccination with melanoma lysate-pulsed dendritic cells, of patients with advanced colorectal carcinoma: report from a phase I study.
Vaccine-induced CD8+ T-cell responses to MAGE-3 correlate with clinical outcome in patients with melanoma.
Value of tyrosinase RNA detection by an RT-PCR method in melanoma prognosis.
Vasoactive intestinal peptide stimulates melanogenesis in B16F10 mouse melanoma cells via CREB/MITF/tyrosinase signaling.
VEGF-165 serum levels and tyrosinase expression in melanoma patients: correlation with the clinical course.
Visualization of tyrosinase activity in melanoma cells by a BODIPY-based fluorescent probe.
Vitiliginous achromia with malignant melanoma. Tyrosinase activity and ultrastructural study of achromic and normal skin.
Vitis amurensis Ruprecht root inhibited ?-melanocyte stimulating hormone-induced melanogenesis in B16F10 cells.
Wearable Wireless Tyrosinase Bandage and Microneedle Sensors: Toward Melanoma Screening.
Whitening Effect of Watersoluble Royal Jelly from South Korea.
Whole exome sequencing identifies a novel pathogenic variation [p.(Gly194valfs*7)] in SLC45A2 in the homozygous state in multiple members of a family with oculocutaneous albinism in southern India.
Why tyrosinase for treatment of melanoma.
Widespread occurrence of inhibitors of melanoma tyrosinase in plant and mammalian tissues.
Wild-type and modified gp100 peptide-pulsed dendritic cell vaccination of advanced melanoma patients can lead to long-term clinical responses independent of the peptide used.
Wnt/?-catenin signaling inhibitor ICG-001 enhances pigmentation of cultured melanoma cells.
Xenogeneic murine tyrosinase DNA vaccine for malignant melanoma of the digit of dogs.
[8]-Gingerol inhibits melanogenesis in murine melanoma cells through down-regulation of the MAPK and PKA signal pathways.
[Current biological markers of cutaneous melanoma progression]
[Cytotoxicity of cytosine deaminase and herpes simplex virus thymidine kinase genes in melanoma cells is independent on promoter strength].
[Detection of circulating malignant cells in patients with uveal melanoma]
[Detection of circulating neoplastic cells by reverse transcriptase and polymerase chain reaction in melanoma]
[Detection of tyrosinase in normal and diseased pigment cells of the skin by means of radioactive tyrosine; original slide method; its applications in diagnosis of malignant melanoma.]
[Detection of tyrosinase mRNA using reverse transcription/polymerase chain reaction with fine needle punctures of melanoma metastases]
[Development of targeted chemoradiotherapy for malignant melanoma by exploitation of metabolic pathway]
[Disseminated melanoma cells in blood and bone marrow. Significance and detection by potential tumor markers]
[Effects of Xiaoyao Powder Extract in co-culture model of melanoma cells and keratinocytes on expression of tyrosinase and its related protein].
[Estrogen and progesterone receptors in malignant melanoma, benign pigmented nevi and basocellular epithelioma]
[Heterogeneity of tyrosinases isolated from rat skin, normal human skin, and human melanoma tumors]
[Immunologic analysis of tyrosinase in malignant melanoma, nevi and clinically normal skin]
[In vitro study on decolorization effect of argon ion laser]
[Isoenzymes of melanosomal tyrosinase isolated from transplanted hamster melanomas]
[Laboratory markers of melanoma progression]
[Melanocyte-stimulating hormone induces growth of human malignant melanoma amelanotic cells with a change in cAMP, phosphatidylinositols, and inositol phosphate concentration]
[Molecular diagnostic detection of circulating tumor cells and their prognostic implications]
[Molecular diagnostics of malignant melanoma: molecular staging, minimal residual disease]
[Nle4, D-Phe7]-alpha-MSH: a superpotent melanotropin that "irreversibly" activates melanoma tyrosinase.
[Preliminary evaluation of a method for detection of individual malignant melanoma cells in peripheral blood while monitoring the course of the malignancy and its treatment]
[Serum L-DOPA oxidase activity in patients with malignant cutaneous melanoma]
[Study of the effect of progesterone on the tyrosinase activity of melanoma S 91 in mice]
[STUDY OF TYROSINASE ACTIVITY CHANGES IN EXPERIMENTAL MOUSE MELANOMA S 91 UNDER THE INFLUENCE OF TESTOSTERONE.]
[Synthesis and melanoma inhibiting properties of 4-alkylpyrocatechol-2-O-beta-D-glucopyranosiduronic acids and their esters]
[The detection of melanoma metastases in sentinel nodes by polymerase chain reaction]
[The diagnostic significance of alpha-MSH in malignant melanoma of man]
[The effect of dinitrophenylation on the tyrosinase activity of extracts from human melanomas]
[The effects of intense pulsed light and 5-aminolevulinic acid on the cultured B16 marine melanoma cells]
[The sentinel lymph node in melanoma: utilization of molecular biology (RT-PCR) to detect occult metastases]
[Utilization of melanin precursors for experimental chemotherapy of malignant melanoma]
Melanoma, Amelanotic
Aberrant retention of tyrosinase in the endoplasmic reticulum mediates accelerated degradation of the enzyme and contributes to the dedifferentiated phenotype of amelanotic melanoma cells.
Abnormal acidification of melanoma cells induces tyrosinase retention in the early secretory pathway.
Albinism and amelanotic melanoma: occurrence in a child with positive test results for tyrosinase.
Alteration of tyrosinase activity in human melanocytes and melanoma cells by histamine H2 and H3 ligands.
Amelanotic melanoma: a detailed morphologic analysis with clinicopathologic correlation of 75 cases.
Analyses of mixed melanogenesis in tyrosinase cDNA-transfected human amelanotic melanoma cells.
Antimelanoma activity of perphenazine and prochlorperazine in human COLO829 and C32 cell lines.
Comparison of tyrosinase levels in amelanotic and melanotic melanoma cell cultures by a competitive enzyme-linked immunoadsorbent assay and by immunotitration analysis.
Coordinated mRNA and protein expression of human LAMP-1 in induction of melanogenesis after UV-B exposure and co-transfection of human tyrosinase and TRP-1 cDNAs.
Dermoscopy, reflectance confocal microscopy and histopathology of an amelanotic melanoma from an individual heterozygous for MC1R and tyrosinase variant alleles.
Detection of residual tumor cells in patients with malignant melanoma responding to immunotherapy.
Development of cutaneous amelanotic melanoma in the absence of a functional tyrosinase.
Differences in subcellular distribution of catechol-O-methyltransferase and tyrosinase in malignant melanoma.
Effects of actinomycin D and cycloheximide on the increase in tyrosinase activity of hamster amelanotic melanoma cells in vitro.
Enhanced melanogenesis induced by tyrosinase gene-transfer increases boron-uptake and killing effect of boron neutron capture therapy for amelanotic melanoma.
Expression of human papilloma virus type 16 E5 protein in amelanotic melanoma cells regulates endo-cellular pH and restores tyrosinase activity.
Functional analysis of the cDNA encoding human tyrosinase precursor.
Heterologous expression of tyrosinase recapitulates the misprocessing and mistrafficking in oculocutaneous albinism type 2: Effects of altering intracellular pH and pink-eyed dilution gene expression.
Improvement of the tumor-suppressive effect of boron neutron capture therapy for amelanotic melanoma by intratumoral injection of the tyrosinase gene.
Increased level of p27 subunit of proteasomes and its co-localization with tyrosinase in amelanotic melanoma cells indicate its direct role in the regulation of melanin biosynthesis.
Inhibition of melanin synthesis by cystamine in human melanoma cells.
Isolation and characterization of tyrosinase inhibitors and their differential action on melanogenic subcellular compartments in amelanotic and melanomas.
L-tyrosine induces tyrosinase expression via a posttranscriptional mechanism.
L-tyrosine, L-dopa, and tyrosinase as positive regulators of the subcellular apparatus of melanogenesis in Bomirski Ab amelanotic melanoma cells.
Melanogenesis in human melanomas.
Molecular and biological control of melanogenesis through tyrosinase genes and intrinsic and extrinsic regulatory factors.
Molecular mechanism of tyrosinase regulation by L-dopa in hamster melanoma cells.
Monoclonal antibody against human tyrosinase and reactive with melanotic and amelanotic melanoma cells.
MSH inhibits growth in a line of amelanotic hamster melanoma cells and induces increases in cyclic AMP levels and tyrosinase activity without inducing melanogenesis.
Selective uptake of para-boronophenylalanine increases in amelanotic melanoma cells transfected by the tyrosinase gene.
Spontaneous uveal amelanotic melanoma in transgenic Tyr-RAS+ Ink4a/Arf-/- mice.
Transient expression of high molecular weight, heat sensitive, trypsin-resistant form of tyrosinase in B-16 melanoma cells.
Translation rate of human tyrosinase determines its N-linked glycosylation level.
Tyrosinase activity in primary cell culture of amelanotic melanoma cells.
Tyrosinase activity in the amelanotic melanoma in golden hamsters.
Tyrosinase and gamma-glutamyl transpeptidase in 5-s-cysteinyldopa genesis within melanotic and amelanotic melanomas.
Tyrosinase and tyrosinase-related protein 1 require Rab7 for their intracellular transport.
Tyrosinase gene expression in clear cell sarcoma indicates a melanocytic origin: insight from the first reported canine case.
Tyrosinase gene transcription and its control by melanogenic inhibitors.
Tyrosinase, melan-A, and KBA62 as markers for the immunohistochemical identification of metastatic amelanotic melanomas on paraffin sections.
[Tyrosinase and dopa oxidase in amelanotic melanoma in man]
[Ultrastructural studies of the occurrence of tyrosinase in transplantable amelanotic melanoma in Syrian hamster]
Melanoma, Experimental
3,3',5-L-triiodothyronine but not L-thyroxine can block the induction of tyrosinase by imidazole in cultured B16 melanoma cells.
A chelating derivative of alpha-melanocyte stimulating hormone as a potential imaging agent for malignant melanoma.
A dominant negative mutant of microphthalmia transcription factor (MITF) lacking two transactivation domains suppresses transcription mediated by wild type MITF and a hyperactive MITF derivative.
A new 2-imino-1,3-thiazoline derivative, KHG22394, inhibits melanin synthesis in mouse B16 melanoma cells.
A novel bioactive chalcone of Morus australis inhibits tyrosinase activity and melanin biosynthesis in B16 melanoma cells.
A novel melanin inhibitor: hydroperoxy traxastane-type triterpene from flowers of Arnica montana.
A potent tyrosinase activator from Radix Polygoni multiflori and its melanogenesis stimulatory effect in B16 melanoma cells.
A safe, effective in vivo gene therapy for melanoma using tyrosinase promoter-driven cytosine deaminase gene.
Acanthoic acid inhibits melanogenesis through tyrosinase downregulation and melanogenic gene expression in B16 melanoma cells.
Acetoside inhibits alpha-MSH-induced melanin production in B16 melanoma cells by inactivation of adenyl cyclase.
Actions of melanotropins on mouse melanoma cell growth in vitro.
Aglycone of Rh4 inhibits melanin synthesis in B16 melanoma cells: possible involvement of the protein kinase A pathway.
Alkylating benzamides with melanoma cytotoxicity: role of melanin, tyrosinase, intracellular pH and DNA interaction.
Alteration of the Cloudman melanoma cell cycle by prostaglandins E1 and E2 determined by using a 5-bromo-2'-deoxyuridine method of DNA analysis.
Anti-pigmentary activity of fucoxanthin and its influence on skin mRNA expression of melanogenic molecules.
Anti-tyrosinase antibodies participate in the immune response to vaccination with anti-idiotypic antibodies mimicking the high-molecular-weight melanoma-associated antigen.
Antimelanogenic Activity of 3,4-Dihydroxyacetophenone: Inhibition of Tyrosinase and MITF.
Antimelanogenic and antioxidant properties of gallic acid.
Antioxidant and antimelanogenic activities of polyamine conjugates from corn bran and related hydroxycinnamic acids.
Antioxidative and melanogenesis-inhibitory activities of caffeoylquinic acids and other compounds from moxa.
Antioxidative and skin-whitening effect of an aqueous extract of Salicornia herbacea.
Arthrophytum scoparium inhibits melanogenesis through the down-regulation of tyrosinase and melanogenic gene expressions in B16 melanoma cells.
Biological activity, binding, and metabolic fate of Ac-[Nle4, D-Phe7]alpha-MSH4-11NH2 with the F1 variant of B16 melanoma cells.
BMP-2 stimulates tyrosinase gene expression and melanogenesis in differentiated melanocytes.
Calcium plays a complex role in the regulation of melanogenesis in murine B16 melanoma cells.
Cell adhesion regulates melanoma specific differentiation and interactions with the 3' region of the tyrosinase gene.
Central nervous system tumor immunity generated by a recombinant listeria monocytogenes vaccine targeting tyrosinase related protein-2 and real-time imaging of intracranial tumor burden.
Characteristics of tyrosinase in B16 melanoma.
Chemical components of Hyssopus seravshanicus: antioxidant activity, activations of melanogenesis and tyrosinase, and quantitative determination by UPLC-DAD.
Cinnamomum cassia Essential Oil Inhibits ?-MSH-Induced Melanin Production and Oxidative Stress in Murine B16 Melanoma Cells.
Comparative studies on the correlation between pyrimidine dimer formation and tyrosinase activity in cloudman S91 melanoma cells after ultraviolet-irradiation.
Curcumin-like diarylpentanoid analogues as melanogenesis inhibitors.
Cyclohexanediol Bis-Ethylhexanoate Inhibits Melanogenesis of Murine B16 Melanoma and UV-Induced Pigmentation in Human Skin.
Cytotoxicity of 4-hydroxyanisole and tyrosinase activity in variant cell lines of B16 melanoma.
Depigmentation efficacy of galacturonic acid through tyrosinase regulation in B16 murine melanoma cells and a three-dimensional human skin equivalent.
Diethylstilbestrol enhances melanogenesis via cAMP-PKA-mediating up-regulation of tyrosinase and MITF in mouse B16 melanoma cells.
Different cis-acting elements are involved in the regulation of TRP1 and TRP2 promoter activities by cyclic AMP: pivotal role of M boxes (GTCATGTGCT) and of microphthalmia.
Different susceptibilities of melanoma cells to retinoic acid-induced changes in melanotic expression.
Dihydro-1,4-benzothiazine-6,7-dione, the ultimate toxic metabolite of 4-S-cysteaminylphenol and 4-S-cysteaminylcatechol.
Down-regulation of tyrosinase expression by acetylsalicylic acid in murine B16 melanoma.
Effect of chlorogenic acid on melanogenesis of B16 melanoma cells.
EFFECT OF FUCOIDAN ON B16 MURINE MELANOMA CELL MELANIN FORMATION AND APOPTOSIS.
Effect of heterocyclic pyrimidine compounds on UVB-induced cell damage in human keratinocytes and on melanogenesis in mouse B16 cells.
Effect of inhibition of polyamine biosynthesis by DL-alpha-difluoromethylornithine on the growth and melanogenesis of B16 melanoma in vitro and in vivo.
Effect of Pinus radiate bark extracts with different molecular weight distributions on cell growth of NIH/3T3 fibroblasts and dendrite retraction of B16 melanoma cells
Effect of simultaneous administration of vitamin C, L-cysteine and vitamin E on the melanogenesis.
Effect of testosterone on imidazole-induced tyrosinase expression in B16 melanoma cell culture.
Effects of Wnt-10b on proliferation and differentiation of murine melanoma cells.
Ethosomes of Phenylethyl Resorcinol as Vesicular Delivery System for Skin Lightening Applications.
Evaluation of Antioxidant and Anti-Melanogenic Activity of Different Extracts of Aerial Parts of N. Sintenisii in Murine Melanoma B16F10 Cells.
Evaluation of depigmenting activity by 8-hydroxydaidzein in mouse b16 melanoma cells and human volunteers.
Evaluation of medicinal plants from Central Kalimantan for antimelanogenesis.
False dopa reaction in studies of mammalian tyrosinase: some characteristics and precautions.
Folium nelumbinis (Lotus leaf) volatile-rich fraction and its mechanisms of action against melanogenesis in B16 cells.
Four new ginsenosides from red ginseng with inhibitory activity on melanogenesis in melanoma cells.
Glucocorticoid stimulates melanogenesis and tyrosinase gene expression in B16 melanoma cells.
Glycosidic inhibitors of melanogenesis from leaves of Momordica charantia.
Glycosidic inhibitors of melanogenesis from leaves of Passiflora edulis.
Guaianolide sesquiterpene lactones from Achillea millefolium L.
Hepatocyte growth factor/scatter factor and hepatocytes are potent downregulators of tyrosinase expression in B16 melanoma cells.
High-molecular-weight forms of tyrosinase and the tyrosinase-related proteins: evidence for a melanogenic complex.
Hot-water extracts from adzuki beans (Vigna angularis) stimulate not only melanogenesis in cultured mouse B16 melanoma cells but also pigmentation of hair color in C3H mice.
Hydrolysates of citrus plants stimulate melanogenesis protecting against UV-induced dermal damage.
In B16 melanoma cells, the inhibition of melanogenesis by TPA results from PKC activation and diminution of microphthalmia binding to the M-box of the tyrosinase promoter.
In vitro and in vivo evaluation of ellagic acid on melanogenesis inhibition.
Inhibition of induced melanogenesis in Cloudman melanoma cells by four phenotypic modifiers.
Inhibition of melanogenesis by BMY-28565, a novel compound depressing tyrosinase activity in B16 melanoma cells.
Inhibition of N-glycan processing in B16 melanoma cells results in inactivation of tyrosinase but does not prevent its transport to the melanosome.
Inhibition of tyrosinase activity and melanine pigmentation by 2-hydroxytyrosol.
Inhibitory and Acceleratory Effects of Inonotus obliquus on Tyrosinase Activity and Melanin Formation in B16 Melanoma Cells.
Inhibitory effect of 2,4,2',4'-tetrahydroxy-3-(3-methyl-2-butenyl)-chalcone on tyrosinase activity and melanin biosynthesis.
Inhibitory effect of glyceollin isolated from soybean against melanogenesis in B16 melanoma cells.
Inhibitory effect of hydroxyindoles and their analogues on human melanoma tyrosinase.
Inhibitory effect of isoprenoid-substituted flavonoids isolated from Artocarpus heterophyllus on melanin biosynthesis.
Inhibitory effects of 6-(3-hydroxyphenyl)-2-naphthol on tyrosinase activity and melanin synthesis.
Inhibitory effects of hinokitiol on tyrosinase activity and melanin biosynthesis and its antimicrobial activities.
Inhibitory effects of Korean indigenous plants on tyrosinase and melanogenesis.
Inhibitory effects of Na7PMo11CuO40 on mushroom tyrosinase and melanin formation and its antimicrobial activities.
Inhibitory effects of p-alkylaminophenol on melanogenesis.
Inulavosin, a melanogenesis inhibitor, leads to mistargeting of tyrosinase to lysosomes and accelerates its degradation.
Investigation of the regulation of pigmentation in alpha-melanocyte-stimulating hormone responsive and unresponsive cultured B16 melanoma cells.
Involvement of calpain in melanogenesis of mouse B16 melanoma cells.
Involvement of phospholipase D1 in melanogenesis of mouse B16 melanoma cells.
Iodination of beta-melanotropin. Time course analysis of reaction mixtures by high pressure liquid chromatography and characterization of biologically active mono- and diiodo-beta-melanotropin.
Isolation and characterization of variant cDNAs encoding mouse tyrosinase.
Kaliziri extract upregulates tyrosinase, TRP-1, TRP-2 and MITF expression in murine B16 melanoma cells.
Limonoids from Azadirachta indica var. siamensis Extracts and Their Cytotoxic and Melanogenesis-Inhibitory Activities.
Lucidone, a novel melanin inhibitor from the fruit of Lindera erythrocarpa Makino.
Mechanism of pigmentation by minocycline in murine B16 melanoma cells.
Mechanisms of melanogenesis inhibition by 2,5-dimethyl-4-hydroxy-3(2H)-furanone.
Melaleuca quinquenervia essential oil inhibits ?-melanocyte-stimulating hormone-induced melanin production and oxidative stress in B16 melanoma cells.
Melanocyte-stimulating hormone promotes activation of pre-existing tyrosinase molecules in Cloudman S91 melanoma cells.
Melanogenesis Inhibition by Homoisoflavavone Sappanone A from Caesalpinia sappan.
Melanogenesis inhibitory activities of diarylheptanoids from Alnus hirsuta Turcz in B16 mouse melanoma cell.
Melanogenesis inhibitory activity of components from Salam leaf (Syzygium polyanthum) extract.
Melanogenesis Inhibitory Activity of Sesquiterpenes from Canarium ovatum Resin in Mouse B16 Melanoma Cells.
Melanogenesis-inhibitory activities of limonoids and tricyclic diterpenoids from Azadirachta indica.
Melanogenesis-inhibitory activity of aromatic glycosides from the stem bark of Acer buergerianum.
Melanogenesis-Inhibitory and Cytotoxic Activities of Limonoids, Alkaloids, and Phenolic Compounds from Phellodendron amurense Bark.
Melanoma-associated hypopigmentation: where are the antibodies?
Multiple transcripts of the mouse tyrosinase gene are generated by alternative splicing.
N-Alkylamides from Piper longum L. and their stimulative effects on the melanin content and tyrosinase activity in B16 melanoma cells.
N-trans-feruloyltyramine as a melanin biosynthesis inhibitor.
New cosmetic agents for skin whitening from Angelica dahurica.
New inhibitors of melanogenesis, OH-3984 K1 and K2. I. Taxonomy, fermentation, isolation and biological characteristics.
Nitroprusside induces melanoma ferroptosis with serum supplementation and prolongs survival under serum depletion or hypoxia.
Non-selective action of 4-hydroxyanisole on melanoma cells in vivo.
Novel and enhanced anti-melanoma DNA vaccine targeting the tyrosinase protein inhibits myeloid-derived suppressor cells and tumor growth in a syngeneic prophylactic and therapeutic murine model.
Novel screening method for potential skin-whitening compounds by a luciferase reporter assay.
Over-expression of MSG1 transcriptional co-activator increases melanin in B16 melanoma cells: a possible role for MSG1 in melanogenesis.
p21-Activated Kinase 4 Critically Regulates Melanogenesis via Activation of the CREB/MITF and ?-Catenin/MITF Pathways.
Partial characterization of IR-alpha-MSH peptides found in melanoma tumors.
Phenolic Compounds from the Leaves of Stewartia pseudocamellia Maxim. and their Whitening Activities.
Phloridzin-induced melanogenesis is mediated by the cAMP signaling pathway.
Poly-?-glutamate from Bacillus subtilis inhibits tyrosinase activity and melanogenesis.
Potentiation by alpha-difluoromethylornithine of the activity of 3,4-dihydroxybenzylamine, a tyrosinase-dependent melanolytic agent, against B16 melanoma.
Proteomic analyses for profiling regulated proteins/enzymes by Fucus vesiculosus fucoidan in B16 melanoma cells: A combination of enzyme kinetics functional study.
Pyrroloquinoline quinone (PQQ) inhibits the expression of tyrosinase mRNA by alpha-melanocyte stimulating hormone in murine B16 melanoma cells.
Quantitative proteomic analysis uncovers inhibition of melanin synthesis by silk fibroin via MITF/tyrosinase axis in B16 melanoma cells.
Regulation of cell division and of tyrosinase in B16 melanoma cells by imidazole: a possible role for the concept of metabolite gene regulation in mammalian cells.
Regulation of melanin synthesis of B16 mouse melanoma cells by 1 alpha, 25-dihydroxyvitamin D3 and retinoic acid.
Regulation of tyrosinase gene expression by cAMP in B16 melanoma cells involves two CATGTG motifs surrounding the TATA box: implication of the microphthalmia gene product.
Retinoic acid blockade of imidazole-induced tyrosinase expression in B16 melanoma cultures: similar effects of the active retinoid and triiodothyronine.
Saikosaponin b2 induces differentiation without growth inhibition in cultured B16 melanoma cells.
Sesamin induces melanogenesis by microphthalmia-associated transcription factor and tyrosinase up-regulation via cAMP signaling pathway.
Soluble Pearl Extract provides effective skin lightening by antagonizing endothelin.
Stimulation of the receptor for melanocyte-stimulating hormone by retinoic acid.
Stimulation of tyrosinase activity of cultured melanoma cells by lysosomotropic agents.
Structure-activity relationship of prenyl-substituted polyphenols from Artocarpus heterophyllus as inhibitors of melanin biosynthesis in cultured melanoma cells.
Structure-activity relationships of dimeric Catharanthus alkaloids. 2. Experimental antitumor activities of N-substituted deacetylvinblastine amide (vindesine) sulfates.
Synthesis and anti-tyrosinase mechanism of the substituted vanillyl cinnamate analogues.
Targeting of cytokine gene expression to malignant melanoma cells using tissue specific promoter sequences.
The anti-melanogenic effect of pycnogenol by its anti-oxidative actions.
The effects of Caffeoylserotonin on inhibition of melanogenesis through the downregulation of MITF via the reduction of intracellular cAMP and acceleration of ERK activation in B16 murine melanoma cells.
The effects of Salacia reticulata on anti-cellular oxidants and melanogenesis inhibition in alpha-MSH-stimulated and UV irradiated B16 melanoma cells.
The inhibitory effects of representative chalcones contained in Angelica keiskei on melanin biosynthesis in B16 melanoma cells.
The tyrosinase activity of melanosomes from the Harding-Passey melanoma: the absence of a peroxidase component in vitro.
Topical Application of gamma-Tocopherol Derivative Prevents UV-Induced Skin Pigmentation.
Transforming growth factor beta1 mediates hypopigmentation of B16 mouse melanoma cells by inhibition of melanin formation and melanosome maturation.
Triiodothyronine repression of imidazole-induced tyrosinase expression in B16 melanoma cells.
Two new lignans and melanogenesis inhibitors from Schisandra nigra.
Tyrosinase activity in the cellular fractions of Harding-Passey melanoma.
Tyrosinase maturation and pigment expression in B16 melanoma: relation to theophylline treatment and intracellular cyclic AMP.
Unequal nuclear Sp1/GC box DNA binding activity distinguishes proliferating from differentiated senescent or apoptotic cells.
Use of affinity chromatography for purification of tyrosinase.
Vesicular carriers containing phenylethyl resorcinol for topical delivery system; liposomes, transfersomes and invasomes.
Whitening activity of luteolin related to the inhibition of cAMP pathway in alpha-MSH-stimulated B16 melanoma cells.
Zinc alpha-2-glycoprotein regulates melanin production by normal and malignant melanocytes.
[Inhibitory effect of arbutin on melanogenesis--biochemical study using cultured B16 melanoma cells]
[Investigation of tyrosinase activity and phospholipid composition in Harding-Passey melanoma microsomal fraction]
[Study on tyrosinase activity in experimental melanoma S 91 in mice and its variations on the effect of estradiol]
[The effects of intense pulsed light and 5-aminolevulinic acid on the cultured B16 marine melanoma cells]
Melanosis
3-hydroxycoumarin loaded vesicles for recombinant human tyrosinase inhibition in topical applications.
A comparative study of topical 5% cysteamine versus 4% hydroquinone in the treatment of facial melasma in women.
A possible mechanism of action for azelaic acid in the human epidermis.
A split-face, double-blind, randomized and placebo-controlled pilot evaluation of a novel oligopeptide for the treatment of recalcitrant melasma.
Aminoluciferin 4-hydroxyphenyl amide enables bioluminescence detection of endogenous tyrosinase.
Anti-Melanogenic Effects of Flavonoid Glycosides from Limonium tetragonum (Thunb.) Bullock via Inhibition of Tyrosinase and Tyrosinase-Related Proteins.
Antioxidant and anti-aging carbon quantum dots using tannic acid.
Azelaic acid-loaded nanoemulsion with hyaluronic acid - a new strategy to treat hyperpigmentary skin disorders.
Combined use of two formulations containing diacetyl boldine, TGF-?1 biomimetic oligopeptide-68 with other hypopigmenting/exfoliating agents and sunscreen provides effective and convenient treatment for facial melasma. Either is equal to or is better than 4% hydroquinone on normal skin.
Effect of dicarboxylic acids on normal human melanocytes in dispersed tissue culture.
Effective Tyrosinase Inhibition by Thiamidol Results in Significant Improvement of Mild to Moderate Melasma.
Efficacy and safety of liposome-encapsulated 4-n-butylresorcinol 0.1% cream for the treatment of melasma: a randomized controlled split-face trial.
Efficacy and safety of topical isobutylamido thiazolyl resorcinol (Thiamidol) vs. 4% hydroquinone cream for facial melasma: an evaluator-blinded, randomized controlled trial.
Eupafolin, a skin whitening flavonoid isolated from Phyla nodiflora, downregulated melanogenesis: Role of MAPK and Akt pathways.
Generalized melanosis secondary to malignant melanoma. Report of a case with serum and tissue tyrosinase studies.
Histopathological study of the treatment of melasma lesions using a low-fluence Q-switched 1064-nm neodymium:yttrium-aluminium-garnet laser.
Hydroquinone-induced depigmentation: case report and review of the literature.
Hydroquinone-salicylic acid conjugates as novel anti-melasma actives show superior skin targeting compared to the parent drugs.
Hypopigmenting Activity of Bisabolangelone Isolated from Angelica koreana Maxim. in alpha-Melanocyte Stimulating Hormone-Activated B16 or Melan-a Cells.
In silico prediction of the cosmetic whitening effects of naturally occurring lead compounds.
Inhibition of Melanosis in Whiteleg Shrimp (Litopenaeus vannamei) during Refrigerated Storage Using Extracts of Different Avocado (Persea americana Mill.) By-Products.
Integrated kinetic studies and computational analysis on naphthyl chalcones as mushroom tyrosinase inhibitors.
Kojic Acid vis-a-vis its Combinations with Hydroquinone and Betamethasone Valerate in Melasma: A Randomized, Single Blind, Comparative Study of Efficacy and Safety.
Malignant melanoma with melanosis and melanuria, and with pigmented monocytes and tumour cells in the blood. Autoradiographic demonstration of tyrosinase in malignant cells from peritoneal fluid.
Melanogenesis Inhibitor(s) from Phyla nodiflora Extract.
Melanosis and associated tumors in transgenic mice.
Melasma: a review.
Momilactones A, B, and Tricin in Rice Grain and By-Products are Potential Skin Aging Inhibitors.
NF-?B/AP-1-targeted inhibition of macrophage-mediated inflammatory responses by depigmenting compound AP736 derived from natural 1,3-diphenylpropane skeleton.
Purification and determination of the chemical structure of the tyrosinase inhibitor produced by Trichoderma viride strain H1-7 from a marine environment.
Recovery of pigmentation following selective photothermolysis in adult zebrafish skin: clinical implications for laser toning treatment of melasma.
Synbiotics supplement is effective for Melasma improvement.
The Anti-melanogenesis Activities of Some Selected Red Macroalgae from Northern Coasts of the Persian Gulf.
Treatment of mild to moderate facial melasma with the Lumixyl topical brightening system.
Memory Disorders
Effects of probiotic fermentation on the enhancement of biological and pharmacological activities of Codonopsis lanceolata extracted by high pressure treatment.
Menkes Kinky Hair Syndrome
[Prenatal diagnosis of cutaneous genetic diseases by the study of fetal DNA]
Metrorrhagia
Conditional Deletion of Kit in Melanocytes: White Spotting Phenotype is Cell-Autonomous.
Microphthalmos
A distinctive translocation carcinoma of the kidney; "rosette forming," t(6;11), HMB45-positive renal tumor: a histomorphologic, immunohistochemical, ultrastructural, and molecular genetic study of 4 cases.
A small molecule inhibitor of Mitf-E-box DNA binding and its depigmenting effect in melan-a cells.
Agouti signal protein regulation in human melanoma cells.
alpha-Melanocyte-stimulating hormone signaling regulates expression of microphthalmia, a gene deficient in Waardenburg syndrome.
Analysis of microphthalmia transcription factor expression in normal tissues and tumors, and comparison of its expression with S-100 protein, gp100, and tyrosinase in desmoplastic malignant melanoma.
Antimelanogenic Activity of 3,4-Dihydroxyacetophenone: Inhibition of Tyrosinase and MITF.
Beclin 1 controls pigmentation by changing the nuclear localization of melanogenic factor MITF.
Brachyury-related transcription factor Tbx2 and repression of the melanocyte-specific TRP-1 promoter.
Celecoxib as a Valuable Adjuvant in Cutaneous Melanoma Treated with Trametinib.
Characterization and expression of soluble guanylate cyclase in skins and melanocytes of sheep.
Coordinate extinction of melanocyte-specific gene expression in hybrid cells.
Cutaneous desmoplastic melanoma.
Diethylstilbestrol enhances melanogenesis via cAMP-PKA-mediating up-regulation of tyrosinase and MITF in mouse B16 melanoma cells.
Differentiation of zebrafish melanophores depends on transcription factors AP2 alpha and AP2 epsilon.
Effect of sulfur mustard on melanogenesis in vitro.
Epithelioid angiomyolipoma of the kidney.
Expression of KIT (CD117) in angiomyolipoma.
Expression of tyrosinase and the tyrosinase related proteins in the Mitfvit (vitiligo) mouse eye: implications for the function of the microphthalmia transcription factor.
Flavonoid Glycosides from Ziziphus jujuba var. inermis (Bunge) Rehder Seeds Inhibit ?-Melanocyte-Stimulating Hormone-Mediated Melanogenesis.
Growth regulatory proteins that repress differentiation markers in melanocytes also downregulate the transcription factor microphthalmia.
HMB-45 negative clear cell perivascular epithelioid cell tumor of the skin.
Identification of a melanocyte-type promoter of the microphthalmia-associated transcription factor gene.
Identification of a novel microRNA important for melanogenesis in alpaca (Vicugna pacos).
Immunohistochemical analysis of BRAF(V600E) expression of primary and metastatic melanoma and comparison with mutation status and melanocyte differentiation antigens of metastatic lesions.
Immunohistochemical and reverse transcription-polymerase chain reaction expression analysis of tyrosinase and microphthalmia-associated transcription factor in angiomyolipomas.
Immunohistochemical diagnosis of canine oral amelanotic melanocytic neoplasms.
Immunohistochemical evaluation of necrotic malignant melanomas.
Immunohistochemical study of microphthalmia transcription factor and tyrosinase in angiomyolipoma of the kidney, renal cell carcinoma, and renal and retroperitoneal sarcomas: comparative evaluation with traditional diagnostic markers.
Immunophenotype of conjunctival melanomas: comparisons with uveal and cutaneous melanomas.
Immunoprofile of MITF, tyrosinase, melan-A, and MAGE-1 in HMB45-negative melanomas.
In B16 melanoma cells, the inhibition of melanogenesis by TPA results from PKC activation and diminution of microphthalmia binding to the M-box of the tyrosinase promoter.
Induction of "antigen silencing" in melanomas by oncostatin M: down-modulation of melanocyte antigen expression.
Inhibition of melanin production by a combination of Siberian larch and pomegranate fruit extracts.
Inhibition of melanogenic activity by 4,4'-dihydroxybiphenyl in melanoma cells.
Inhibitory effect of mulberroside A and its derivatives on melanogenesis induced by ultraviolet B irradiation.
Melanocyte-specific expression of the human tyrosinase promoter: activation by the microphthalmia gene product and role of the initiator.
Melanoma genomics reveals signatures of sensitivity to bio- and targeted therapies.
Microphthalmia associated transcription factor is a target of the phosphatidylinositol-3-kinase pathway.
Microphthalmia gene product as a signal transducer in cAMP-induced differentiation of melanocytes.
MicroRNA-21a-5p Functions on the Regulation of Melanogenesis by Targeting Sox5 in Mouse Skin Melanocytes.
Microtubule-associated protein light chain 3 is involved in melanogenesis via regulation of MITF expression in melanocytes.
MUM-1 Expression Differentiates Tumors in the PEComa Family From Clear Cell Sarcoma and Melanoma.
Neprilysin, a novel target for ultraviolet B regulation of melanogenesis via melanocortins.
Primary oral melanoma: A clinicopathologic review and case presentation.
Proanthocyanidins isolated from the leaves of Photinia × fraseri block the cell cycle and induce apoptosis by inhibiting tyrosinase activity in melanoma cells.
Regulation of melanocyte pivotal transcription factor MITF by some other transcription factors.
Regulation of tyrosinase gene expression by cAMP in B16 melanoma cells involves two CATGTG motifs surrounding the TATA box: implication of the microphthalmia gene product.
Role of microphthalmia transcription factor in regulation of melanocyte differentiation marker TRP-1.
Sinonasal tract and nasopharyngeal melanomas: a clinicopathologic study of 115 cases with a proposed staging system.
TFE3, a transcription factor homologous to microphthalmia, is a potential transcriptional activator of tyrosinase and TyrpI genes.
The mouse tyrosinase gene. Promoter modulation by positive and negative regulatory elements.
The POU domain transcription factor Brn-2: elevated expression in malignant melanoma and regulation of melanocyte-specific gene expression.
The role of sex-determining region Y-box 6 in melanogenesis in alpaca melanocytes.
trans-Caffeic acid stearyl ester from Paeonia suffruticosa inhibits melanin synthesis by cAMP-mediating down-regulation of ?-melanocyte-stimulating hormone-stimulated melanogenesis signaling pathway in B16 cells.
Transcriptional repression of the microphthalmia gene in melanoma cells correlates with the unresponsiveness of target genes to ectopic microphthalmia-associated transcription factor.
Tyrosine levels regulate the melanogenic response to alpha-melanocyte-stimulating hormone in human melanocytes: implications for pigmentation and proliferation.
Vaginal melanoma: a clinicopathologic and immunohistochemical study of 26 cases.
Whitening and anti-wrinkle activities of ferulic acid isolated from Tetragonia tetragonioides in B16F10 melanoma and CCD-986sk fibroblast cells.
Mitochondrial Myopathies
Genetic diseases of copper metabolism.
Multiple Endocrine Neoplasia
[Clinical manifestations, therapeutic response to tyrosinase inhibitor and RET gene activating mutation in a patient with multiple endocrine neoplasia 2B].
Myasthenia Gravis
New Insights into the Exploitation of Vitis vinifera L. cv. Aglianico Leaf Extracts for Nutraceutical Purposes.
Mycoses
The Drosophila PRR GNBP3 assembles effector complexes involved in antifungal defenses independently of its Toll-pathway activation function.
Mycosis Fungoides
Decreased CD117 expression in hypopigmented mycosis fungoides correlates with hypomelanosis: lessons learned from vitiligo.
Myocardial Infarction
Using tyrosinase as a tri-modality reporter gene to monitor transplanted stem cells in acute myocardial infarction.
Myopia
An oculocerebral hypopigmentation syndrome: a case report with clinical, histochemical, and ultrastructural findings.
Effects of the Tyrosinase-Dependent Dopaminergic System on Refractive Error Development in Guinea Pigs.
Neoplasm Metastasis
A colorimetric and near -infrared ratiometric fluorescent probe for the determination of endogenous tyrosinase activity based on cyanine aggregation.
A Fluorescent Probe for Early Detection of Melanoma and Its Metastasis by Specifically Imaging Tyrosinase Activity in a Mouse Model.
A spontaneous murine melanoma lung metastasis comprised of host x tumor hybrids.
Analysis of HLA class I expression in different metastases from two melanoma patients undergoing peptide immunotherapy.
Autoantibodies to tyrosinase: the bridge between melanoma and vitiligo.
Circulating melanoma cells and distant metastasis-free survival in stage III melanoma patients with or without adjuvant interferon treatment (EORTC 18991 side study).
Circulating tumor cells as prognostic factor for distant metastases and survival in patients with primary uveal melanoma.
Comparative decreases in tyrosinase, TRP-1, TRP-2, and Pmel 17/silver antigenic proteins from melanotic to amelanotic stages of syngeneic mouse cutaneous melanomas and metastases.
Comparative genomic hybridization in a case of melanoma that loses expression of S100, HMB45, Melan A and tyrosinase in metastasis.
Cutting edge: rapid cloning of tumor-specific CTL suitable for adoptive immunotherapy of melanoma.
Detection and quantification of blood-derived CD8+ T lymphocytes secreting tumor necrosis factor alpha in response to HLA-A2.1-binding melanoma and viral peptide antigens.
Detection of disseminated melanoma cells by reverse-transcription - polymerase chain reaction.
Detection of melanoma cells in peripheral blood and sentinel lymph nodes by RT-PCR analysis: a comparative study with immunohistochemistry.
Detection of melanoma micrometastases in the sentinel lymph node and in nonsentinel nodes by tyrosinase polymerase chain reaction.
Detection of regional melanoma metastases by ultrasound B-scan, cytology or tyrosinase RT-PCR of fine-needle aspirates.
Detection of tyrosinase mRNA by reverse transcription-polymerase chain reaction in melanoma sentinel nodes.
Development of radioiodine-labeled acetaminophen for specific, high-contrast imaging of malignant melanoma.
Ex vivo derived primary melanoma cells: implications for immunotherapeutic vaccines.
Examination of regional lymph nodes by sentinel node biopsy and molecular analysis provides new staging facilities in primary cutaneous melanoma.
Expression of gp100, MART-1, tyrosinase, and S100 in paraffin-embedded primary melanomas and locoregional, lymph node, and visceral metastases: implications for diagnosis and immunotherapy. A study conducted by the EORTC Melanoma Cooperative Group.
Expression of Melan-A/MART-1 in primary melanoma cell cultures has prognostic implication in metastatic melanoma patients.
Expression of melanocyte differentiation antigens and ki-67 in nodal nevi and comparison of ki-67 expression with metastatic melanoma.
Facts and pitfalls in the detection of tyrosinase mRNA in the blood of melanoma patients by RT-PCR.
Favorable overall survival in stage III melanoma patients after adjuvant dendritic cell vaccination.
Hematogenous spread of malignant melanoma cells in different stages of disease.
Heterogeneous expression of immunotherapy candidate proteins gp100, MART-1, and tyrosinase in human melanoma cell lines and in human melanocytic lesions.
Heterogeneous expression of the tumor-associated antigens RAGE-1, PRAME, and glycoprotein 75 in human renal cell carcinoma: candidates for T-cell-based immunotherapies?
High expression of immunotherapy candidate proteins gp100, MART-1, tyrosinase and TRP-1 in uveal melanoma.
High homogeneity of MAGE, BAGE, GAGE, tyrosinase and Melan-A/MART-1 gene expression in clusters of multiple simultaneous metastases of human melanoma: implications for protocol design of therapeutic antigen-specific vaccination strategies.
Inverse relationship of melanocyte differentiation antigen expression in melanoma tissues and CD8+ cytotoxic-T-cell responses: evidence for immunoselection of antigen-loss variants in vivo.
Lack of prognostic importance of reverse-transcriptase polymerase chain reaction detection of circulating messenger RNA in patients with melanoma.
MART-1 is expressed less frequently on circulating melanoma cells in patients who develop distant compared with locoregional metastases.
Metastatic malignant melanoma mimicking a salivary gland basaloid neoplasm after treatment with nivolumab.
Micro-anatomy related antigen expression in melanocytic lesions.
Molecular detection of MART-1, tyrosinase and MIA in peripheral blood, lymph nodes and metastatic sites of stage III/IV melanoma patients.
Molecular staging of malignant melanoma: correlation with clinical outcome.
Multimarker Reverse Transcriptase-Polymerase Chain Reaction Assay in Lymphatic Drainage and Sentinel Node Tumor Burden.
No correlation of tyrosinase mRNA in bone marrow with prognosis of metastatic melanoma.
Partial characterization of IR-alpha-MSH peptides found in melanoma tumors.
Pathologic assessment of melanoma sentinel nodes: a role for molecular analysis using quantitative real-time reverse transcription-PCR for MART-1 and tyrosinase messenger RNA.
Polymerase chain reaction detection of melanoma cells in the circulation: relation to clinical stage, surgical treatment, and recurrence from melanoma.
Prediction of metastases in melanoma patients with positive sentinel node: histological and molecular approach.
Prevention of an additional surgery for regional lymphadenectomy in melanoma: Rapid intraoperative immunostaining of sentinel lymph node imprint smears.
Prognosis of metastatic melanoma: no correlation of tyrosinase mRNA in bone marrow and survival time.
Prognostic significance of occult metastases detected by sentinel lymphadenectomy and reverse transcriptase-polymerase chain reaction in early-stage melanoma patients.
Prognostic significance of tyrosinase mRNA detected by nested RT-PCR in patients with malignant melanoma.
Quantitative analysis of tyrosinase transcripts in blood.
Reactivity to tyrosinase: expression in cancer (melanoma) and autoimmunity (vitiligo).
Role of RT-PCR tyrosinase detection in the monitoring of patients with advanced metastatic melanoma.
Selective increase in specific alternative splice variants of tyrosinase in murine melanomas: a projected basis for immunotherapy.
Serial follow-up and the prognostic significance of reverse transcriptase-polymerase chain reaction--staged sentinel lymph nodes from melanoma patients.
Simultaneous analysis of tyrosinase mRNA and markers of tyrosinase activity in the blood of patients with metastatic melanoma.
Specificity of tyrosinase and HMB45 PCR in the detection of melanoma metastases in sentinel lymph node biopsies.
Studies on the reactions between human tyrosinase, superoxide anion, hydrogen peroxide and thiols.
The analysis of tyrosinase-specific mRNA in blood samples of melanoma patients by RT-PCR is not a useful test for metastatic tumor progression.
The detection of tyrosinase mRNA in the peripheral blood of stage I melanoma patients is not of clinical relevance in predicting metastasis risk and survival.
The detection of tyrosinase-specific mRNA in bone marrow is not more sensitive than in blood for the demonstration of micrometastatic melanoma.
The pattern of cytokine gene expression in freshly excised human metastatic melanoma suggests a state of reversible anergy of tumor-infiltrating lymphocytes.
Tobacco smoke tumor promoters, catechol and hydroquinone, induce oxidative regulation of protein kinase C and influence invasion and metastasis of lung carcinoma cells.
Tyrosinase activity in serum from patients with malignant melanoma.
[Detection of tyrosinase mRNA using reverse transcription/polymerase chain reaction with fine needle punctures of melanoma metastases]
Neoplasm Micrometastasis
Amplification of MelanA messenger RNA in addition to tyrosinase increases sensitivity of melanoma cell detection in peripheral blood and is associated with the clinical stage and prognosis of malignant melanoma.
Assessment of melanoma-initiating cell markers and conventional parameters in sentinel lymph nodes of malignant melanoma.
Detection of melanoma micrometastases in the sentinel lymph node and in nonsentinel nodes by tyrosinase polymerase chain reaction.
Detection of melanoma micrometastasis in sentinel nodes by reverse transcription-polymerase chain reaction correlates with tumor thickness and is predictive of micrometastatic disease in the lymph node basin.
Detection of micrometastases in sentinel lymph nodes from melanoma patients: direct comparison of multimarker molecular and immunopathological methods.
Detection of submicroscopic lymph node metastases with polymerase chain reaction in patients with malignant melanoma.
Expression of tyrosinase, MIA and MART-1 in sentinel lymph nodes of patients with malignant melanoma.
Highly sensitive multivariable assay detection of melanocytic differentiation antigens and angiogenesis biomarkers in sentinel lymph nodes with melanoma micrometastases.
Improved immunohistochemical evaluation of micrometastases in sentinel lymph nodes of cutaneous melanoma with 'MCW melanoma cocktail'--a mixture of monoclonal antibodies to MART-1, Melan-A, and tyrosinase.
Increased sensitivity for the detection of malignant melanoma cells in peripheral blood using an improved protocol for reverse transcription-polymerase chain reaction.
Limitations of the nested reverse transcriptase polymerase chain reaction on tyrosinase for the detection of malignant melanoma micrometastases in lymph nodes.
Lymph node micrometastases of cutaneous melanoma: increased sensitivity of molecular diagnosis in comparison to immunohistochemistry.
Mapping of occult melanoma micrometastases in the inguinal lymph node basin by immunohistochemistry and RT-PCR.
Molecular analyses of sentinel lymph nodes: an open question.
Molecular test for the detection of tumor cells in blood and sentinel nodes of melanoma patients.
Polymerase chain reaction and immunohistochemistry frequently detect occult melanoma cells in regional lymph nodes of melanoma patients.
Prediction of metastases in melanoma patients with positive sentinel node: histological and molecular approach.
Prognostic significance of detecting micrometastases by tyrosinase RT/PCR in sentinel lymph node biopsies: lessons from 322 consecutive melanoma patients.
Sentinel lymph node: detection of micrometastases of melanoma in a molecular study.
Neoplasm, Residual
Quantitative nested real-time RT-PCR specific for tyrosinase transcripts to quantitate minimal residual disease.
Neoplasms
A colorimetric and near -infrared ratiometric fluorescent probe for the determination of endogenous tyrosinase activity based on cyanine aggregation.
A fluorometric biosensor based on functional Au/Ag nanoclusters for real-time monitoring of tyrosinase activity.
A germline mutation of CDKN2A and a novel RPLP1-C19MC fusion detected in a rare melanotic neuroectodermal tumor of infancy: a case report.
A meta-analysis of reverse transcriptase-polymerase chain reaction for tyrosinase mRNA as a marker for circulating tumor cells in cutaneous melanoma.
A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas.
A novel cancer vaccine strategy based on HLA-A*0201 matched allogeneic plasmacytoid dendritic cells.
A polymerase chain reaction-based semiquantitative assessment of malignant melanoma cells in peripheral blood.
A promising redox cycle-based strategy for designing a catechol-type diphenylbutadiene as a potent prooxidative anti-melanoma agent.
A simple phenolic antioxidant protocatechuic acid enhances tumor promotion and oxidative stress in female ICR mouse skin: dose-and timing-dependent enhancement and involvement of bioactivation by tyrosinase.
A survey of the humoral immune response of cancer patients to a panel of human tumor antigens.
A tyrosinase nonapeptide presented by HLA-B44 is recognized on a human melanoma by autologous cytolytic T lymphocytes.
Aberrant retention of tyrosinase in the endoplasmic reticulum mediates accelerated degradation of the enzyme and contributes to the dedifferentiated phenotype of amelanotic melanoma cells.
Aberrant tyrosinase expression in an atypical fibroxanthoma: A case report.
Acute effects of two melanocytolytic agents, hydroquinone and beta-mercaptoethanolamine, upon tyrosinase activity and cyclic nucleotide levels in murine melanomas.
Advances in fluorescent probes for detection and imaging of endogenous tyrosinase activity.
Altered Morphology and Immunohistochemical Characteristics in Metastatic Malignant Melanoma After Therapy With Vemurafenib.
Alteronol induces differentiation of melanoma b16-f0 cells.
Amelanotic melanoma: a detailed morphologic analysis with clinicopathologic correlation of 75 cases.
Aminoluciferin 4-hydroxyphenyl amide enables bioluminescence detection of endogenous tyrosinase.
Amplification of MelanA messenger RNA in addition to tyrosinase increases sensitivity of melanoma cell detection in peripheral blood and is associated with the clinical stage and prognosis of malignant melanoma.
An animal model for the survival of tyrosinase isozymes in serum.
An oncolytic adenoviral vector carrying the tyrosinase promoter for glioma gene therapy.
Analysis of HLA class I expression in different metastases from two melanoma patients undergoing peptide immunotherapy.
Analysis of microphthalmia transcription factor expression in normal tissues and tumors, and comparison of its expression with S-100 protein, gp100, and tyrosinase in desmoplastic malignant melanoma.
Analysis of T-cell responses in metastatic melanoma patients vaccinated with dendritic cells pulsed with tumor lysates.
Antimelanoma activity of perphenazine and prochlorperazine in human COLO829 and C32 cell lines.
Antiproliferative activity of Humulus lupulus extracts on human hepatoma (Hep3B), colon (HT-29) cancer cells and proteases, tyrosinase, ?-lactamase enzyme inhibition studies.
Application of the pMHC Array to Characterise Tumour Antigen Specific T Cell Populations in Leukaemia Patients at Disease Diagnosis.
Autoimmunity in a phase I trial of a fully human anti-cytotoxic T-lymphocyte antigen-4 monoclonal antibody with multiple melanoma peptides and Montanide ISA 51 for patients with resected stages III and IV melanoma.
Autoreactive T cells in healthy individuals.
Bioactive Constituents of Glycyrrhiza uralensis (Licorice): Discovery of the Effective Components of a Traditional Herbal Medicine.
Biochemical characterization of a new melanoma model--the minipig MeLiM strain.
Biochemical mechanism of acetaminophen (APAP) induced toxicity in melanoma cell lines.
Biochemical mechanism of acetylsalicylic acid (Aspirin) selective toxicity toward melanoma cell lines.
Boosting T cell-mediated immunity to tyrosinase by vaccinia virus-transduced, CD34(+)-derived dendritic cell vaccination: a phase I trial in metastatic melanoma.
Both CD4 and CD8 T Cells Mediate Equally Effective In Vivo Tumor Treatment When Engineered with a Highly Avid TCR Targeting Tyrosinase.
Brightly colored pigmentation in lower vertebrates: wonder searching its mechanisms and significance in the context of phylogeny.
Broad spectrum of leukoderma acquisitum centrifugum.
Canine malignant melanoma alpha-3 integrin binding peptides.
CD4+ T cells from peripheral blood of a melanoma patient recognize peptides derived from nonmutated tyrosinase.
CD40-stimulated B lymphocytes pulsed with tumor antigens are effective antigen-presenting cells that can generate specific T cells.
CD45/CD8 Myeloid Histioid Antigen and Plasma Cell Antibody Immune Response in a Case of Malignant Melanoma.
Cellular and humoral immune responses to a human pancreatic cancer antigen, coactosin-like protein, originally defined by the SEREX method.
Central nervous system tumor immunity generated by a recombinant listeria monocytogenes vaccine targeting tyrosinase related protein-2 and real-time imaging of intracranial tumor burden.
Characterization of inhibitory effects of the potential therapeutic inhibitors, benzoic acid and pyridine derivatives, on the monophenolase and diphenolase activities of tyrosinase.
Characterization of intraocular tumors arising in transgenic mice.
Chemical transformations of oxyresveratrol (trans-2,4,3',5'-tetrahydroxystilbene) into a potent tyrosinase inhibitor and a strong cytotoxic agent.
Circulating melanoma cells and distant metastasis-free survival in stage III melanoma patients with or without adjuvant interferon treatment (EORTC 18991 side study).
Circulating tyrosinase and MART-1 mRNA does not independently predict relapse or survival in patients with AJCC stage I-II melanoma.
Clinical and Pathological Analysis of Two Cases of Cutaneous Malignant Melanoma.
Clinical value of combined determination of plasma L-DOPA/tyrosine ratio, S100B, MIA and LDH in melanoma.
Cloning of a new gene encoding an antigen recognized by melanoma-specific HLA-A24-restricted tumor-infiltrating lymphocytes.
Comparative decreases in tyrosinase, TRP-1, TRP-2, and Pmel 17/silver antigenic proteins from melanotic to amelanotic stages of syngeneic mouse cutaneous melanomas and metastases.
Comparison of five antibodies as markers in the diagnosis of melanoma in cytologic preparations.
Comparison of the Sec and Tat secretion pathways for heterologous protein production by Streptomyces lividans.
Comparison of two cancer vaccines targeting tyrosinase: plasmid DNA and recombinant alphavirus replicon particles.
Comprehensive mutagenesis identifies the peptide repertoire of a p53 T-cell receptor mimic antibody that displays no toxicity in mice transgenic for human HLA-A*0201.
Consistent allelic loss on mouse chromosome 7 distal to tyrosinase in 4-nitroquinoline-1-oxide-induced oral cavity tumors with loss of heterozygosity at Ha-ras-1.
Contribution of melanogenic proteins to the heterogeneous pigmentation of human melanocytes.
Correlation of positive RT-PCR for tyrosinase in peripheral blood of malignant melanoma patients with clinical stage, survival and other risk factors.
Cross-talk between DopaChromeTautomerase and Caveolin-1 is melanoma cell phenotype specific and potentially involved in tumor progression.
CTLA-4 blockade increases antigen-specific CD8(+) T cells in prevaccinated patients with melanoma: three cases.
Cutaneous Angiomyolipoma of the Ear: A Case Report and Literature Review.
Demonstration of cytoplasmic tyrosinase mRNA in tissue-cultured cells by reverse transcription (RT) in situ polymerase chain reaction (PCR) and RT PCR in situ hybridization.
Dendritic cells containing apoptotic melanoma cells prime human CD8+ T cells for efficient tumor cell lysis.
Depletion of CD25+ regulatory cells results in suppression of melanoma growth and induction of autoreactivity in mice.
Desmoplastic melanoma of the head and neck: histopathologic and immunohistochemical study of 28 cases.
Detection of circulating melanoma cells by specific amplification of tyrosinase complementary DNA is not a reliable tumor marker in melanoma patients: a clinical two-center study.
Detection of early micrometastases in subcutaneous fat of primary malignant melanoma patients by identification of tyrosinase-mRNA.
Detection of melanoma cells in peripheral blood and sentinel lymph nodes by RT-PCR analysis: a comparative study with immunohistochemistry.
Detection of melanoma cells in peripheral blood by means of reverse transcriptase and polymerase chain reaction.
Detection of melanoma cells in sentinel lymph nodes, bone marrow and peripheral blood by a reverse transcription-polymerase chain reaction assay in patients with primary cutaneous melanoma: association with Breslow's tumour thickness.
Detection of Misdistribution of Tyrosinase from Melanosomes to Lysosomes and Its Upregulation under Psoralen/Ultraviolet A with a Melanosome-Targeting Tyrosinase Fluorescent Probe.
Detection of naturally processed and HLA-A1-presented melanoma T-cell epitopes defined by CD8(+) T-cells' release of granulocyte-macrophage colony-stimulating factor but not by cytolysis.
Detection of residual tumor cells in patients with malignant melanoma responding to immunotherapy.
Detection of tumor-associated circulating mRNA in serum, plasma and blood cells from patients with disseminated malignant melanoma.
Detection of tyrosinase in living cells using an Enteromorpha Prolifera based fluorescent probe.
Detection of tyrosinase mRNA from the blood of melanoma patients.
Detection of tyrosinase mRNA in tumor tissue microdissections from classic Kaposi's sarcoma.
Development of a multiple-marker polymerase chain reaction assay for detection of metastatic melanoma in lymph node aspirates of dogs.
Development of a xenogeneic DNA vaccine program for canine malignant melanoma at the Animal Medical Center.
Development of cutaneous amelanotic melanoma in the absence of a functional tyrosinase.
Development of Immunologic Assays to Measure Response in Horses Vaccinated with Xenogeneic Plasmid DNA Encoding Human Tyrosinase
Differentiation of new metastatic variants of B16 melanoma under different culture conditions.
Differentiation-inducing and anti-proliferative activities of lupeol on canine melanoma cells.
Does intensive histopathological workup by serial sectioning increase the detection of lymph node micrometastasis in patients with primary cutaneous melanoma?
Down-regulation of tyrosinase mRNA levels in melanoma cells by tumor promoters and by insulin.
Dual control of melanogenesis and melanoma growth: overview molecular to clinical level and the reverse.
EFFECT OF FUCOIDAN ON B16 MURINE MELANOMA CELL MELANIN FORMATION AND APOPTOSIS.
Effect of inhibition of polyamine biosynthesis by DL-alpha-difluoromethylornithine on the growth and melanogenesis of B16 melanoma in vitro and in vivo.
Effect of theophyllin and isoproterenol on cAMP level in melanotic and amelanotic hamster melanomas.
Effective Inhibition of Skin Cancer, Tyrosinase and Antioxidative Properties by Astaxanthin and Astaxanthin Esters from Green Alga Haematococcus pluvialis.
Effectiveness of 1alpha-hydroxyvitamin D2 in inhibiting tumor growth in a murine transgenic pigmented ocular tumor model.
Effects of gamma irradiation on the biological activity of green tea byproduct extracts and a comparison with green tea leaf extracts
Effects of various synthetic retinoids on proliferation and immunophenotype of human melanoma cells in vitro.
Efficient transduction and long-term retroviral expression of the melanoma-associated tumor antigen tyrosinase in CD34(+) cord blood-derived dendritic cells.
Electro-gene-transfer as a new tool for cancer immunotherapy in animals.
Electrochemical, photoelectrochemical, and piezoelectric analysis of tyrosinase activity by functionalized nanoparticles.
Enhanced Drug Photosafety by Interchromophoric Interaction Due to Intramolecular Charge Separation.
Enzyme release from cultured human melanoma cells.
Epitope located N-glycans impair the MHC-I epitope generation and presentation.
Evaluation of eight melanocytic and neural crest-associated markers in a well-characterised series of 124 malignant peripheral nerve sheath tumours (MPNST): useful to distinguish MPNST from melanoma?
Evaluation of the serum L-dopa/L-tyrosine ratio as a melanoma marker.
Evaluation of tyrosinase expression in canine and equine melanocytic tumors.
Evaluation of tyrosinase mRNA as a tumor marker in the blood of melanoma patients.
Evaluation of variants of melanoma-associated antigen genes and mRNA transcripts in melanomas of dogs.
Exploiting Tyrosinase Expression and Activity in Melanocytic Tumors: Quercetin and the Central Role of p53.
Expression of cancer-testis antigens (MAGE-A1, MAGE-A3/6, MAGE-A4, MAGE-C1 and NY-ESO-1) in primary human uveal and conjunctival melanoma.
Expression of gp100, MART-1, tyrosinase, and S100 in paraffin-embedded primary melanomas and locoregional, lymph node, and visceral metastases: implications for diagnosis and immunotherapy. A study conducted by the EORTC Melanoma Cooperative Group.
Expression of immunohistochemical markers in primary and metastatic malignant melanoma: a comparative study in 70 patients using a tissue microarray technique.
Expression of nine tumour antigens in a series of human glioblastoma multiforme: interest of EGFRvIII, IL-13Ralpha2, gp100 and TRP-2 for immunotherapy.
Facts and pitfalls in the detection of tyrosinase mRNA in the blood of melanoma patients by RT-PCR.
Fibroin particle-supported cationic lipid layers for highly efficient intracellular protein delivery.
Fixation and Permeabilization Approaches for Scanning Electrochemical Microscopy of Living Cells.
Flow cytometry assessment of residual melanoma cells in tumor-infiltrating lymphocyte cultures.
Fluorescence copolymer-based dual-signal monitoring tyrosinase activity and its inhibitor screening via blue-green emission transformation.
Genes and pathways downstream of telomerase in melanoma metastasis.
Genes coding for tumor antigens recognized by human cytolytic T lymphocytes.
Genetic aspects of uveal melanoma: a brief review.
Giant congenital nodular melanoma in a newborn: a case report and literature review.
Glucocorticoid stimulates melanogenesis and tyrosinase gene expression in B16 melanoma cells.
Glycybridins A-K, Bioactive Phenolic Compounds from Glycyrrhiza glabra.
GM-CSF plus antigenic peptide vaccination in locally advanced melanoma patients.
Half-lives of tyrosinase isozymes from Harding-Passey mouse melanoma.
Hematogenous spread of malignant melanoma cells in different stages of disease.
Herpes simplex virus type-1 infection upregulates cellular promoters and telomerase activity in both tumor and nontumor human cells.
Heteroclitic immunization induces tumor immunity.
Heterogeneous expression of immunotherapy candidate proteins gp100, MART-1, and tyrosinase in human melanoma cell lines and in human melanocytic lesions.
High expression of immunotherapy candidate proteins gp100, MART-1, tyrosinase and TRP-1 in uveal melanoma.
High frequency of melanoma-associated antigen or HLA class I loss does not correlate with survival in primary melanoma.
HLA-A(*)0201(+) Plasmacytoid Dendritic Cells Provide a Cell-Based Immunotherapy for Melanoma Patients.
Human antigen-specific regulatory T cells generated by T cell receptor gene transfer.
Human Heat Shock Protein 70 Enhances Tumor Antigen Presentation through Complex Formation and Intracellular Antigen Delivery without Innate Immune Signaling.
Human melanogenesis; the tyrosinase reaction in pigment cell neoplasms, with particular reference to the malignant melanoma; preliminary report.
Human melanoma antigens recognized by T lymphocytes.
Human melanoma patients recognize an HLA-A1-restricted CTL epitope from tyrosinase containing two cysteine residues: implications for tumor vaccine development.
Human neoplasms elicit multiple specific immune responses in the autologous host.
Humoral immune responses of cancer patients against "Cancer-Testis" antigen NY-ESO-1: correlation with clinical events.
Identification of a tyrosinase epitope recognized by HLA-A24-restricted, tumor-infiltrating lymphocytes.
Identification of known and novel immunogenic T-cell epitopes from tumor antigens recognized by peripheral blood T cells from patients responding to IL-2-based treatment.
Identification of multiple antigens recognized by tumor-infiltrating lymphocytes from a single patient: tumor escape by antigen loss and loss of MHC expression.
Imaging of Gastrointestinal Stromal Tumors: From Diagnosis to Evaluation of Therapeutic Response.
Imaging of VEGF receptor kinase inhibitor-induced antiangiogenic effects in drug-resistant human adenocarcinoma model.
Immune responses to the HLA-A*0201-restricted epitopes of tyrosinase and glycoprotein 100 enable control of melanoma outgrowth in HLA-A*0201-transgenic mice.
Immunodiagnosis of melanoma using chimpanzee antihuman melanoma antiserum.
Immunohistochemical analysis of BRAF(V600E) expression of primary and metastatic melanoma and comparison with mutation status and melanocyte differentiation antigens of metastatic lesions.
Immunohistochemical distinction of epithelioid histiocytic proliferations from epithelioid melanocytic nevi.
Immunohistochemical evaluation of necrotic malignant melanomas.
Immunohistochemical Identification of Canine Melanocytic Neoplasms With Antibodies to Melanocytic Antigen PNL2 and Tyrosinase: Comparison With Melan A.
Immunologic hierarchy, class II MHC promiscuity, and epitope spreading of a melanoma helper peptide vaccine.
Immunological determination of tyrosinase in sera of melanoma-bearing hamsters.
Immunophenotyping of melanomas for tyrosinase: implications for vaccine development.
Immunoselection in vivo: independent loss of MHC class I and melanocyte differentiation antigen expression in metastatic melanoma.
Improvement of the tumor-suppressive effect of boron neutron capture therapy for amelanotic melanoma by intratumoral injection of the tyrosinase gene.
In vitro studies of 2,4-dihydroxyphenylalanine, a prodrug targeted against malignant melanoma cells.
Individualized synthetic peptide vaccines with GM-CSF in locally advanced melanoma patients.
Injection of DNA encoding granulocyte-macrophage colony-stimulating factor recruits dendritic cells for immune adjuvant effects.
Interlaboratory evaluation of a new reverse transcriptase polymerase chain reaction-based enzyme-linked immunosorbent assay for the detection of circulating melanoma cells: a multicenter study of the Dermatologic Cooperative Oncology Group.
Intrathymic selection: new insight into tumor immunology.
Intratumoral injection of IFN-alpha dendritic cells after dacarbazine activates anti-tumor immunity: results from a phase I trial in advanced melanoma.
Kinetic phases of distribution and tumor targeting by T cell receptor engineered lymphocytes inducing robust antitumor responses.
Long-term survival of dogs with advanced malignant melanoma after DNA vaccination with xenogeneic human tyrosinase: a phase I trial.
Loss of tyrosinase activity confers increased skin tumor susceptibility in mice.
Malignant melanoma with a rhabdoid phenotype: histologic, immunohistochemical, and ultrastructural study of a case and review of the literature.
Malignant melanoma with melanosis and melanuria, and with pigmented monocytes and tumour cells in the blood. Autoradiographic demonstration of tyrosinase in malignant cells from peritoneal fluid.
Malignant melanotic schwannian tumor: a clinicopathologic, immunohistochemical, and gene expression profiling study of 40 cases, with a proposal for the reclassification of "melanotic schwannoma".
Malignant rhabdoid tumors originating within and outside the central nervous system are clinically and molecularly heterogeneous.
MART-1 is expressed less frequently on circulating melanoma cells in patients who develop distant compared with locoregional metastases.
Melanocyte destruction after antigen-specific immunotherapy of melanoma: direct evidence of t cell-mediated vitiligo.
Melanogenesis in genetically determined pigment cell tumors of platyfish and platyfish-swordtail hybrids: correlation between tyrosine activity and degree of malignancy.
Melanoma markers in angiomyolipoma of the liver and kidney: a comparative study.
Melanoma-associated antigen expression in lymphangioleiomyomatosis renders tumor cells susceptible to cytotoxic T cells.
Melanoma-associated antigens as messenger RNA detection markers for melanoma.
Melanotic Xp11 Translocation Renal Cancer: A Case With PSF-TFE3 Gene Fusion and Up-regulation of Melanogenetic Transcripts.
Melanotrichoblastoma: immunohistochemical study of a variant of pigmented trichoblastoma.
Metastatic malignant melanoma mimicking a salivary gland basaloid neoplasm after treatment with nivolumab.
Micropthalmia transcription factor (MITF) as a diagnostic marker for metastatic melanomas negative for other melanoma markers.
Minimal residual disease in melanoma.
Molecular and prognostic classification of advanced melanoma: a multi-marker microcontamination assay of peripheral blood stem cells.
Molecular detection of circulating tyrosinase mRNA: optimization in a preclinical xenograft mouse melanoma model and further evaluation in samples from advanced melanoma patients.
Molecular staging for patients with malignant melanoma.
Molecular staging in stage II and III melanoma patients and its effect on long-term survival.
Monoclonal antibodies targeted against melanoma and ovarian tumors enhance dendritic cell-mediated cross-presentation of tumor-associated antigens and efficiently cross-prime CD8+ T cells.
Monoclonal antibody MAT-1 against human tyrosinase can detect melanogenic cells on formalin-fixed paraffin-embedded sections.
Monophosphoryl lipid A (MPL) as an adjuvant for anti-cancer vaccines: clinical results.
Monophosphoryl Lipid A (MPL) as an Adjuvant for Anti-Cancer Vaccines: Clinical Results.
MR molecular imaging of tumors based on an optimal hTERT promoter tyrosinase expression system.
Multi-wavelength photoacoustic imaging of inducible tyrosinase reporter gene expression in xenograft tumors.
MUM-1 Expression Differentiates Tumors in the PEComa Family From Clear Cell Sarcoma and Melanoma.
Murine tyrosinase expressed by a T7 vector in bone marrow-derived dendritic progenitors effectively prevents and eradicates melanoma tumors in mice.
Naturally occurring and synthetic peptides: Efficient tyrosinase inhibitors.
Near-Infrared Fluorescent Probe with New Recognition Moiety for Specific Detection of Tyrosinase Activity: Design, Synthesis, and Application in Living Cells and Zebrafish.
New Methodological Approach for the Rapid and Sensitive Detection of Melanocytes and Melanocytic Tumours. The DOPA-GA Method.
New nitrosoureas and their spin-labeled derivatives influence dopa-oxidase activity of tyrosinase.
No correlation of tyrosinase mRNA in bone marrow with prognosis of metastatic melanoma.
Non-myelotoxic antitumour effects of L-dopa, buthionine sulphoximine and tamoxifen on neuroblastoma cells in vitro and in vivo.
Noninvasive dynamic fluorescence imaging of human melanomas reveals that targeted inhibition of bFGF or FGFR-1 in melanoma cells blocks tumor growth by apoptosis.
Novel and enhanced anti-melanoma DNA vaccine targeting the tyrosinase protein inhibits myeloid-derived suppressor cells and tumor growth in a syngeneic prophylactic and therapeutic murine model.
Novel approach to the characterization of melanoma associated-peptide-specific CTL lines from Japanese metastatic melanoma patients.
Optimization of the tyrosinase mRNA probe to detect circulating melanocytes with reverse transcription and polymerase chain reaction.
Oxidative conjugation of chlorogenic acid with glutathione. Structural characterization of addition products and a new nitrite-Promoted pathway.
Peptide-specific CTL in tumor infiltrating lymphocytes from metastatic melanomas expressing MART-1/Melan-A, gp100 and Tyrosinase genes: a study in an unselected group of HLA-A2.1-positive patients.
Peripheral blood tyrosinase messenger RNA detection and survival in malignant melanoma.
Phage display-mediated discovery of novel tyrosinase-targeting tetrapeptide inhibitors reveals the significance of N-terminal preference of cysteine residues and their functional sulfur atom.
Phase I evaluation of interleukin-2-transfected irradiated allogeneic melanoma for the treatment of metastatic melanoma: appendix 1: protocol.
Phase I trial of intravenous peptide-pulsed dendritic cells in patients with metastatic melanoma.
Phenoloxidase activity of intact and chemically modified functional unit RvH1: a from molluscan Rapana venosa hemocyanin.
Phenylthiourea alters toxicity of mercury compounds in zebrafish larvae.
Phosphonic and phosphinic acid analogues of tyrosine and 3,4-dihydroxyphenylalanine (dopa) as potential antimelanotic agents.
Pigmented (melanotic) neurofibroma: a clinicopathologic and immunohistochemical analysis of 19 lesions from 17 patients.
Pigmented hamartoma of the eyelid with apocrine, follicular and sebaceous differentiation.
Pigmented uveal tumours in a transgenic mouse model.
Potentiation by alpha-difluoromethylornithine of the activity of 3,4-dihydroxybenzylamine, a tyrosinase-dependent melanolytic agent, against B16 melanoma.
Pre-existing immunity to tyrosinase-related protein (TRP)-2, a new TRP-2 isoform, and the NY-ESO-1 melanoma antigen in a patient with a dramatic response to immunotherapy.
Prediction of metastases in melanoma patients with positive sentinel node: histological and molecular approach.
Preparing clinical-grade myeloid dendritic cells by electroporation-mediated transfection of in vitro amplified tumor-derived mRNA and safety testing in stage IV malignant melanoma.
Primary clear cell sarcoma of the ileum: an uncommon and misleading site.
Primary Cutaneous Nevoid Melanoma With Homer-Wright Rosettes: A Hitherto Unrecognized Variant with Immunohistochemical and Ultrastructural Study.
Primary Gliosarcoma of the Optic Nerve: A Unique Adult Optic Pathway Glioma.
Primary Malignant Melanoma of the Breast: A Report of Two Cases.
Primary malignant melanoma of the oesophagus: a clinical and pathological study with emphasis on the immunophenotype of the tumours for melanocyte differentiation markers and cancer/testis antigens.
Primary neuroendocrine carcinoma of the skin expresses tyrosinase mRNA: detection by a specific nested PCR technique.
Prognosis of metastatic melanoma: no correlation of tyrosinase mRNA in bone marrow and survival time.
Prognostic value of microphthalmia-associated transcription factor and tyrosinase as markers for circulating tumor cells detection in patients with melanoma.
Prognostic value of RT-PCR tyrosinase detection in peripheral blood of melanoma patients.
Prognostic value of tyrosinase reverse-transcriptase polymerase chain reaction in metastatic melanoma.
Progressive appearance of pigmentation in amelanotic melanoma lesions.
Prophylactic vaccines are potent activators of monocyte-derived dendritic cells and drive effective anti-tumor responses in melanoma patients at the cost of toxicity.
Protective effect of Daucus carota against UV-DMBA induced skin cancer in mice.
Purification of tyrosinase to homogeneity based on its resistance to sodium dodecyl sulfate-proteinase K digestion.
Quantitative nested real-time RT-PCR specific for tyrosinase transcripts to quantitate minimal residual disease.
Reactivity to tyrosinase: expression in cancer (melanoma) and autoimmunity (vitiligo).
Recognition of tyrosinase by tumor-infiltrating lymphocytes from a patient responding to immunotherapy.
Relationship between sentinel lymph node status and regression of primary malignant melanoma.
Responsive Mn(II) complexes for potential applications in diagnostic Magnetic Resonance Imaging.
Reverse transcriptase-polymerase chain reaction detection of circulating tumor cells in patients with melanoma: correlation with clinical stage, tumor thickness and histological type.
Role of RT-PCR tyrosinase detection in the monitoring of patients with advanced metastatic melanoma.
RT-PCR tyrosinase expression in the peripheral blood of melanoma patients.
Safety and efficacy of a xenogeneic DNA vaccine encoding for human tyrosinase as adjunctive treatment for oral malignant melanoma in dogs following surgical excision of the primary tumor.
Safety and immunogenicity of tyrosinase DNA vaccines in patients with melanoma.
Selective increase in specific alternative splice variants of tyrosinase in murine melanomas: a projected basis for immunotherapy.
Self-tolerance to the murine homologue of a tyrosinase-derived melanoma antigen: implications for tumor immunotherapy.
Serendipitous discovery of short peptides from natural products as tyrosinase inhibitors.
Serum protein s-100 predicts clinical outcome in patients with melanoma treated with adjuvant interferon--comparison with tyrosinase rt-PCR.
Simultaneous analysis of tyrosinase mRNA and markers of tyrosinase activity in the blood of patients with metastatic melanoma.
Simultaneous humoral and cellular immune response against cancer-testis antigen NY-ESO-1: definition of human histocompatibility leukocyte antigen (HLA)-A2-binding peptide epitopes.
Specific Imaging of Tyrosinase in Vivo with 3-Hydroxybenzyl Caged D-Luciferins.
Specific incorporation of 2-thiouracil into biological melanins.
Spontaneous uveal amelanotic melanoma in transgenic Tyr-RAS+ Ink4a/Arf-/- mice.
STAP-2 Protein Expression in B16F10 Melanoma Cells Positively Regulates Protein Levels of Tyrosinase, Which Determines Organs to Infiltrate in the Body.
Stem cell marker nestin expression in peripheral blood of patients with melanoma.
Supermelanotic hybrids derived from mouse melanomas and normal mouse cells.
Suppression of C8161 melanoma metastatic ability by chromosome 6 induces differentiation-associated tyrosinase and decreases proliferation on adhesion-restrictive substrates mediated by overexpression of p21WAF1 and down-regulation of bcl-2 and cyclin D3.
Surface display of glycosylated Tyrosinase related protein-2 (TRP-2) tumour antigen on Lactococcus lactis.
Synthesis and bioassay of a new class of furanyl-1,3,4-oxadiazole derivatives.
Synthesis of interleukin-1 alpha and beta by normal human melanocytes.
Systemic gene therapy of murine melanoma using tissue specific expression of the HSVtk gene involves an immune component.
T cell immune function in tumor, skin and peripheral blood of advanced stage melanoma patients: implications for immunotherapy.
T cell responses in early-stage melanoma patients occur frequently and are not associated with humoral response.
T-Cell Mediated Immune Responses Induced in ret Transgenic Mouse Model of Malignant Melanoma.
T-cell responses against tyrosinase 368-376(370D) peptide in HLA*A0201+ melanoma patients: randomized trial comparing incomplete Freund's adjuvant, granulocyte macrophage colony-stimulating factor, and QS-21 as immunological adjuvants.
Targeting of cytokine gene expression to malignant melanoma cells using tissue specific promoter sequences.
The analysis of tyrosinase-specific mRNA in blood samples of melanoma patients by RT-PCR is not a useful test for metastatic tumor progression.
The detection of melanoma cells in peripheral blood by reverse transcription-polymerase chain reaction.
The effects of pro-opiomelanocortin peptides on cyclic AMP and tyrosinase in melanoma cells.
The influence of normal and cancer blood on tyrosinase activity in vitro.
The majority of autologous cytolytic T-lymphocyte clones derived from peripheral blood lymphocytes of a melanoma patient recognize an antigenic peptide derived from gene Pmel17/gp100.
The reaction of mercaptans with tyrosinases and hemocyanins.
The regulation of cyclic AMP production and the role of cyclic AMP in B16 melanoma cells of differing metastatic potential.
The role of molecular staging in malignant melanoma.
The role of the immune system in anti-tumour responses. Potential for drug therapy.
The use of cationic liposomes DC-CHOL/DOPE and DDAB/DOPE for direct transfer of Escherichia coli cytosine deaminase gene into growing melanoma tumors.
Threshold levels of gene expression of the melanoma antigen gp100 correlate with tumor cell recognition by cytotoxic T lymphocytes.
Transfer of tyrosinase to melanosomes in Harding-Passey mouse melanoma.
Transgenic mice with pigmented intraocular tumors: tissue of origin and treatment.
Transglutaminase-dependent antiproliferative and differentiative properties of nimesulide on B16-F10 mouse melanoma cells.
Transient expression of high molecular weight, heat sensitive, trypsin-resistant form of tyrosinase in B-16 melanoma cells.
Tumor cell and circulating markers in melanoma: diagnosis, prognosis, and management.
Tumor suppressor p53 down-regulates tissue-specific expression of tyrosinase gene in human melanoma cell lines.
Tumor-Related Methylated Cell-Free DNA and Circulating Tumor Cells in Melanoma.
Tyrosinase activity and isoenzyme distribution corresponding to growth and regression of melanoma in Sinclair miniature swine.
Tyrosinase activity in primary cell culture of amelanotic melanoma cells.
Tyrosinase activity in serum from patients with malignant melanoma.
Tyrosinase activity in the sera of patients with malignant melanoma: method and specificity.
Tyrosinase Degradation Is Prevented when EDEM1 Lacks the Intrinsically Disordered Region.
Tyrosinase Expression as a Molecular Marker for Investigating the Presence of Circulating Tumor Cells in Melanoma Patients.
Tyrosinase expression in malignant melanoma, desmoplastic melanoma, and peripheral nerve tumors.
Tyrosinase gene expression in clear cell sarcoma indicates a melanocytic origin: insight from the first reported canine case.
Tyrosinase immunohistochemistry can be employed for the diagnosis of atypical teratoid/rhabdoid tumours of the tyrosinase subgroup (ATRT-TYR).
Tyrosinase immunoreactivity in fine-needle aspiration samples of metastatic malignant melanoma.
Tyrosinase immunoreactivity in formalin-fixed, paraffin-embedded primary and metastatic melanoma: frequency and distribution.
Tyrosinase isozyme heterogeneity in differentiating B16/C3 melanoma.
Tyrosinase messenger RNA in peripheral blood is related to poor survival in patients with metastatic melanoma following interleukin-2-based immunotherapy.
Tyrosinase mRNA levels in the blood of uveal melanoma patients: correlation with the number of circulating tumor cells and tumor progression.
Tyrosinase mRNA RT-PCR analysis as an additional diagnostic tool for the identification of melanoma cells in biological fluid samples other than blood: a preliminary report.
Tyrosinase mRNA RT-PCR analysis as an additional diagnostic tool for the identification of melanoma cells in biological fluid samples other than blood: A preliminary report.
Tyrosinase overexpression promotes ATM-dependent p53 phosphorylation by quercetin and sensitizes melanoma cells to dacarbazine.
Tyrosinase RT-PCR as a supplement to histology for detecting melanoma and nevus cells in paraffin sections of sentinel lymph nodes.
Tyrosinase-activated prodrug nanomedicine as oxidative stress amplifier for melanoma-specific treatment.
Use of tissue-specific expression of the herpes simplex virus thymidine kinase gene to inhibit growth of established murine melanomas following direct intratumoral injection of DNA.
Wearable Wireless Tyrosinase Bandage and Microneedle Sensors: Toward Melanoma Screening.
Xanthogranulomas with inconspicuous foam cells and giant cells mimicking malignant melanoma: a clinical, histologic, and immunohistochemical study of three cases.
Zinc alpha-2-glycoprotein regulates melanin production by normal and malignant melanocytes.
[A case of amelanotic anorectal malignant melanoma mimicking gastrointestinal stromal tumor].
[Clinical manifestations, therapeutic response to tyrosinase inhibitor and RET gene activating mutation in a patient with multiple endocrine neoplasia 2B].
[Detection of tumor circulating cells in patients with ocular melanoma]
[Immunohistochemical demonstration of tyrosinase 4 in normal skin and melanocytic tumors]
[Investigation of tyrosinase activity and phospholipid composition in Harding-Passey melanoma microsomal fraction]
[Laboratory markers of melanoma progression]
[Melanoma and cancer emergence in persons of 20-60 years against normal quantity of cambial cells in morphofunctional zones].
[Primary uterine cervix melanoma].
[Solitary fibrous tumor of a kidney: a case report]
[Tumor antigens presented to T helper lymphocytes--critical components of the cancer vaccine]
Neoplastic Cells, Circulating
A meta-analysis of reverse transcriptase-polymerase chain reaction for tyrosinase mRNA as a marker for circulating tumor cells in cutaneous melanoma.
A polymerase chain reaction-based semiquantitative assessment of malignant melanoma cells in peripheral blood.
Amplification of MelanA messenger RNA in addition to tyrosinase increases sensitivity of melanoma cell detection in peripheral blood and is associated with the clinical stage and prognosis of malignant melanoma.
Circulating melanoma cells and distant metastasis-free survival in stage III melanoma patients with or without adjuvant interferon treatment (EORTC 18991 side study).
Detection of circulating melanoma cells by specific amplification of tyrosinase complementary DNA is not a reliable tumor marker in melanoma patients: a clinical two-center study.
Detection of tumor-associated circulating mRNA in serum, plasma and blood cells from patients with disseminated malignant melanoma.
Facts and pitfalls in the detection of tyrosinase mRNA in the blood of melanoma patients by RT-PCR.
Interlaboratory evaluation of a new reverse transcriptase polymerase chain reaction-based enzyme-linked immunosorbent assay for the detection of circulating melanoma cells: a multicenter study of the Dermatologic Cooperative Oncology Group.
Optimization of the tyrosinase mRNA probe to detect circulating melanocytes with reverse transcription and polymerase chain reaction.
Peripheral blood tyrosinase messenger RNA detection and survival in malignant melanoma.
Prognostic value of microphthalmia-associated transcription factor and tyrosinase as markers for circulating tumor cells detection in patients with melanoma.
Prognostic value of multiple reverse transcription-PCR tyrosinase testing for circulating neoplastic cells in malignant melanoma.
Prognostic value of tyrosinase reverse-transcriptase polymerase chain reaction in metastatic melanoma.
Relationship between sentinel lymph node status and regression of primary malignant melanoma.
The analysis of tyrosinase-specific mRNA in blood samples of melanoma patients by RT-PCR is not a useful test for metastatic tumor progression.
Tyrosinase Expression as a Molecular Marker for Investigating the Presence of Circulating Tumor Cells in Melanoma Patients.
Tyrosinase mRNA levels in the blood of uveal melanoma patients: correlation with the number of circulating tumor cells and tumor progression.
[Detection of tumor circulating cells in patients with ocular melanoma]
Nerve Sheath Neoplasms
Tyrosinase expression in malignant melanoma, desmoplastic melanoma, and peripheral nerve tumors.
Nervous System Diseases
Oxyresveratrol: Sources, Productions, Biological Activities, Pharmacokinetics, and Delivery Systems.
Neurilemmoma
Immunoprofile of MITF, tyrosinase, melan-A, and MAGE-1 in HMB45-negative melanomas.
Primary neuroendocrine carcinoma of the skin expresses tyrosinase mRNA: detection by a specific nested PCR technique.
Tyrosinase expression in malignant melanoma, desmoplastic melanoma, and peripheral nerve tumors.
Tyrosinase gene expression in human tissues.
Neuroblastoma
A comparative immunohistochemical analysis of small round cell tumors of childhood: utility of peripherin and alpha-internexin as markers for neuroblastomas.
Analysis of differential DNA damage in the mitochondrial genome employing a semi-long run real-time PCR approach.
Bone marrow-derived factors support growth of N-type, but not of melanocytic neuroblastoma cells.
Comparison of in vitro cytotoxicity of N-acetyl and N-propionyl derivatives of phenolic thioether amines in melanoma and neuroblastoma cells and the relationship to tyrosinase and tyrosine hydroxylase enzyme activity.
Human glioblastoma ADF cells express tyrosinase, L-tyrosine hydroxylase and melanosomes and are sensitive to L-tyrosine and phenylthiourea.
Increased dopamine and its metabolites in SH-SY5Y neuroblastoma cells that express tyrosinase.
Neuromelanin Modulates Heterocyclic Aromatic Amine-Induced Dopaminergic Neurotoxicity.
Non-myelotoxic antitumour effects of L-dopa, buthionine sulphoximine and tamoxifen on neuroblastoma cells in vitro and in vivo.
Parkin protects against tyrosinase-mediated dopamine neurotoxicity by suppressing stress-activated protein kinase pathways.
Presence and regulation of tyrosinase activity in human neuroblastoma cell variants in vitro.
Neurodegenerative Diseases
Chemical Characterisation-Biological Evaluation of Greek Cultivar Cardoon Seeds (Cynara cardunculus). A By-product with Potential High Added Value.
Cholinesterase and Tyrosinase Inhibitory Potential and Antioxidant Capacity of Lysimachia verticillaris L. and Isolation of the Major Compounds.
Development of an Efficient Protocol for Cimifugin Isolation from Peucedanum schottii and Evaluation of Enzyme Inhibitory Activity.
Evaluation of crocin and curcumin affinity on mushroom tyrosinase using surface plasmon resonance.
Identification by shape-based virtual screening and evaluation of new tyrosinase inhibitors.
Inhibitory potential of the leaves and berries of Myrtus communis L. (myrtle) against enzymes linked to neurodegenerative diseases and their antioxidant actions.
New evidence for presence of tyrosinase in substantia nigra, forebrain and midbrain.
Olive Oil Polyphenols in Neurodegenerative Pathologies.
Phage display-mediated discovery of novel tyrosinase-targeting tetrapeptide inhibitors reveals the significance of N-terminal preference of cysteine residues and their functional sulfur atom.
Serendipitous discovery of short peptides from natural products as tyrosinase inhibitors.
Synthesis of new 1,2,4-triazole-(thio)semicarbazide hybrid molecules: Their tyrosinase inhibitor activities and molecular docking analysis.
Neurofibroma
Tyrosinase expression in malignant melanoma, desmoplastic melanoma, and peripheral nerve tumors.
Neurofibromatoses
[Prenatal diagnosis of cutaneous genetic diseases by the study of fetal DNA]
Neurofibrosarcoma
Evaluation of eight melanocytic and neural crest-associated markers in a well-characterised series of 124 malignant peripheral nerve sheath tumours (MPNST): useful to distinguish MPNST from melanoma?
Tyrosinase expression in malignant melanoma, desmoplastic melanoma, and peripheral nerve tumors.
Neuroinflammatory Diseases
Trichilia catigua and Turnera diffusa extracts: In vitro inhibition of tyrosinase, antiglycation activity and effects on enzymes and pathways engaged in the neuroinflammatory process.
Nevus
A histochemical autoradiographic method for demonstration of tyrosinase in human melanocytes, nevi and malignant melanoma.
BETA-GALACTOSYLCERAMIDASE PROMOTES MELANOMA GROWTH VIA MODULATION OF CERAMIDE METABOLISM.
Circulating benign nevus cells detected by ISET technique: warning for melanoma molecular diagnosis.
Clinical and Pathological Analysis of Two Cases of Cutaneous Malignant Melanoma.
Expression of melanocyte differentiation antigens and ki-67 in nodal nevi and comparison of ki-67 expression with metastatic melanoma.
Growth and phenotypic characteristics of human nevus cells in culture.
Heterogeneous expression of immunotherapy candidate proteins gp100, MART-1, and tyrosinase in human melanoma cell lines and in human melanocytic lesions.
Immunophenotype and possible origin of nevi with phenotypical heterogeneity.
Primary neuroendocrine carcinoma of the skin expresses tyrosinase mRNA: detection by a specific nested PCR technique.
Recurrent melanocytic nevus: a histologic and immunohistochemical evaluation.
The effects of gp100 and tyrosinase peptide vaccinations on nevi in melanoma patients.
The Presence of Alpha-Synuclein in Skin from Melanoma and Patients with Parkinson's Disease.
Tyrosinase activity in dermal nevus cells.
Tyrosinase and nestin immunohistochemical expression in melanocytic nevi as a histopathologic pattern to trace melanocyte differentiation and nevogenesis.
Tyrosinase gene expression in human tissues.
Tyrosinase RT-PCR as a supplement to histology for detecting melanoma and nevus cells in paraffin sections of sentinel lymph nodes.
[Immunologic analysis of tyrosinase in malignant melanoma, nevi and clinically normal skin]
[The sentinel lymph node in melanoma: utilization of molecular biology (RT-PCR) to detect occult metastases]
Nevus, Intradermal
Tyrosinase and nestin immunohistochemical expression in melanocytic nevi as a histopathologic pattern to trace melanocyte differentiation and nevogenesis.
Nevus, Pigmented
Immunohistochemical distinction of epithelioid histiocytic proliferations from epithelioid melanocytic nevi.
Monoclonal antibody MAT-1 against human tyrosinase can detect melanogenic cells on formalin-fixed paraffin-embedded sections.
Tyrosinase and nestin immunohistochemical expression in melanocytic nevi as a histopathologic pattern to trace melanocyte differentiation and nevogenesis.
Nystagmus, Congenital
Incremental light detection thresholds across the central visual field of human albinos.
Obesity
Cytotoxic, Antioxidant, and Enzyme Inhibitory Properties of the Traditional Medicinal Plant Matthiola incana (L.) R. Br.
Phytochemical profiling of Blumea laciniata (Roxb.) DC. and its phytopharmaceutical potential against diabetic, obesity, and Alzheimer's.
Osteoporosis
'Mysterious' moose disease in Sweden. Similarities to copper deficiency and/or molybdenosis in cattle and sheep. Biochemical background of clinical signs and organ lesions.
Ovarian Neoplasms
Adenoviral vectors with E1A regulated by tumor-specific promoters are selectively cytolytic for breast cancer and melanoma.
Corilagin from longan seed: Identification, quantification, and synergistic cytotoxicity on SKOv3ip and hey cells with ginsenoside Rh2 and 5-fluorouracil.
Monoclonal antibodies targeted against melanoma and ovarian tumors enhance dendritic cell-mediated cross-presentation of tumor-associated antigens and efficiently cross-prime CD8+ T cells.
Pain Insensitivity, Congenital
[Congenital insensitivity to pain with anhidrosis. Clinical diagnosis, evolution and complications: case report].
Papilloma
Expression of human papilloma virus type 16 E5 protein in amelanotic melanoma cells regulates endo-cellular pH and restores tyrosinase activity.
Paralysis
Jasonia glutinosa (L.) DC., a Traditional Herbal Tea, Exerts Antioxidant and Neuroprotective Properties in Different In Vitro and In Vivo Systems.
Parkinson Disease
3D QSAR pharmacophore-based virtual screening for the identification of potential inhibitors of tyrosinase.
Assessment of cholinesterase and tyrosinase inhibitory and antioxidant effects of Hypericum perforatum L. (St. John's wort)
Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson's disease pathogenesis.
Catalysis-based specific detection and inhibition of tyrosinase and their application.
Dopamine- or L-DOPA-induced neurotoxicity: the role of dopamine quinone formation and tyrosinase in a model of Parkinson's disease.
Dopamine-, L-DOPA-, adrenaline-, and noradrenaline-induced growth of Au nanoparticles: assays for the detection of neurotransmitters and of tyrosinase activity.
Fluorescence copolymer-based dual-signal monitoring tyrosinase activity and its inhibitor screening via blue-green emission transformation.
Gadolinium-based MRI contrast agent for the detection of tyrosinase.
Highly potent tyrosinase inhibitor, neorauflavane from Campylotropis hirtella and inhibitory mechanism with molecular docking.
In silico approach to inhibition of tyrosinase by ascorbic acid using molecular docking simulations.
Kinetic and sensitive analysis of tyrosinase activity using electron transfer complexes: in vitro and intracellular study.
Laccase- and peroxidase-free tyrosinase production by isolated microbial strain.
Melanosome-Targeting Near-Infrared Fluorescent Probe with Large Stokes Shift for in Situ Quantification of Tyrosinase Activity and Assessing Drug Effects on Differently Invasive Melanoma Cells.
Metabolite Profiling by Hyphenated Liquid Chromatographic Mass Spectrometric Technique (HPLC-DAD-ESI-Q-TOF-MS/MS) and Neurobiological Potential of Haplophyllum sahinii and H. vulcanicum Extracts.
New evidence for presence of tyrosinase in substantia nigra, forebrain and midbrain.
Olive Oil Polyphenols in Neurodegenerative Pathologies.
Pigment epithelium derived factor (PEDF) is neuroprotective in two in vitro models of Parkinson's disease.
Retinal pigment epithelial cell transplantation could provide trophic support in Parkinson's disease: results from an in vitro model system.
Synthesis and bioassay of a new class of furanyl-1,3,4-oxadiazole derivatives.
Synthesis and crystal structures of the potential tyrosinase inhibitors N-(4-acetylphenyl)-2-chloroacetamide and 2-(4-acetylanilino)-2-oxoethyl cinnamate.
Synthesis of new 1,2,4-triazole-(thio)semicarbazide hybrid molecules: Their tyrosinase inhibitor activities and molecular docking analysis.
The reaction of alpha-synuclein with tyrosinase: possible implications for Parkinson disease.
Transplantation of melanocytes obtained from the skin ameliorates apomorphine-induced abnormal behavior in rodent hemi-parkinsonian models.
Tyrosinase exacerbates dopamine toxicity but is not genetically associated with Parkinson's disease.
Periodontitis
[A method for demonstrating leukocyte enzyme activity in the oral cavity in relation to the periodontal findings. A preliminary report]
Peripheral Nervous System Neoplasms
Tyrosinase expression in malignant melanoma, desmoplastic melanoma, and peripheral nerve tumors.
Phenylketonurias
Competitive inhibition of mammalian tyrosinase by phenylalanine and its relationship to hair pigmentation in phenylketonuria.
Photosensitivity Disorders
Photoinactivation of tyrosinase sensitized by folic acid photoproducts.
Piebaldism
Functional regulation of tyrosinase and LAMP gene family of melanogenesis and cell death in immortal murine melanocytes after repeated exposure to ultraviolet B.
Tyrosinase and acid phosphatase activities in melanocytes from avian albinos.
Pigmentation Disorders
(Z)-2-(Benzo[d]thiazol-2-ylamino)-5-(substituted benzylidene)thiazol-4(5H)-one Derivatives as Novel Tyrosinase Inhibitors.
A Series of Benzylidenes Linked to Hydrazine-1-carbothioamide as Tyrosinase Inhibitors: Synthesis, Biological Evaluation and Structure-Activity Relationship.
Antioxidant, Antimicrobial, and Bioactive Potential of Two New Haloarchaeal Strains Isolated from Odiel Salterns (Southwest Spain).
Design, synthesis and anti-melanogenic effect of cinnamamide derivatives.
Inhibition of melanogenesis by 2-[4-(5-chlorobenzo[d]thiazol-2-yl)phenoxy]-2-methylpropanoic acid (MHY908).
Inhibitory activity and mechanism of trilobatin on tyrosinase: kinetics, interaction mechanism and molecular docking.
Mushroom Tyrosinase-Based Enzyme Inhibition Assays Are Not Suitable for Bioactivity-Guided Fractionation of Extracts.
Mutations at critical N-glycosylation sites reduce tyrosinase activity by altering folding and quality control.
Nanoliposomes encapsulation of enriched phenolic fraction from pistachio hulls and its antioxidant, anti-inflammatory, and anti-melanogenic activities.
Quercetin as a tyrosinase inhibitor: Inhibitory activity, conformational change and mechanism.
Recombinant Tyrosinase from Polyporus arcularius: Overproduction in Escherichia coli, Characterization, and Use in a Study of Aurones as Tyrosinase Effectors.
Regulation of tyrosinase gene expression by cAMP in B16 melanoma cells involves two CATGTG motifs surrounding the TATA box: implication of the microphthalmia gene product.
SAR and QSAR research on tyrosinase inhibitors using machine learning methods.
Sulphonamides incorporating 1,3,5-triazine structural motifs show antioxidant, acetylcholinesterase, butyrylcholinesterase, and tyrosinase inhibitory profile.
Synthesis of calix[4]azacrown substituted sulphonamides with antioxidant, acetylcholinesterase, butyrylcholinesterase, tyrosinase and carbonic anhydrase inhibitory action.
Synthesis of cinnamic amide derivatives and their anti-melanogenic effect in ?-MSH-stimulated B16F10 melanoma cells.
Vasoactive intestinal peptide stimulates melanogenesis in B16F10 mouse melanoma cells via CREB/MITF/tyrosinase signaling.
[Inhibitory effects of Rhodiola plants and their oligomeric proanthocyanidins on tyrosinase and Abeta42 aggregation].
Pleural Effusion
Tyrosinase mRNA RT-PCR analysis as an additional diagnostic tool for the identification of melanoma cells in biological fluid samples other than blood: a preliminary report.
Tyrosinase mRNA RT-PCR analysis as an additional diagnostic tool for the identification of melanoma cells in biological fluid samples other than blood: A preliminary report.
Polydactyly
A new allele of Gli3 and a new mutation, circletail (Crc), resulting from a single transgenic experiment.
Prader-Willi Syndrome
Mutations of the P gene in oculocutaneous albinism, ocular albinism, and Prader-Willi syndrome plus albinism.
Oculocutaneous albinoidism as a manifestation of reduced neural crest derivatives in the Prader-Willi syndrome.
Prostatic Neoplasms
BRAF activation initiates but does not maintain invasive prostate adenocarcinoma.
Prostate cancer risk: associations with ultraviolet radiation, tyrosinase and melanocortin-1 receptor genotypes.
Ultraviolet radiation: effects on risks of prostate cancer and other internal cancers.
Protein-Energy Malnutrition
Tyrosyluria in marasmus.
Protoporphyria, Erythropoietic
Minireview: Peptide analogs and short sequence oligopeptides as modulators of skin pigmentation.
Psoriasis
Gene Expression Analysis of the Corticotrophin-releasing Hormone-proopiomelanocortin System in Psoriasis Skin Biopsies.
Pulmonary Fibrosis
[Preliminary study of exon sequence in pneumoconiosis using high-throughput and intervention of EGFR-TKIs on silicosis rats].
Renal Insufficiency, Chronic
Novel Bacillus subtilis Spore-Displayed Tyrosinase Kit for Rapid Detection of Tyrosine in Urine: Pharmaceutical Applications for the Early Diagnosis of Kidney-Related Diseases.
Retinal Degeneration
FVB.129P2-Pde6b(+) Tyr(c-ch)/Ant, a sighted variant of the FVB/N mouse strain suitable for behavioral analysis.
Retinoblastoma
Expression of tyrosinase-related protein 2/DOPAchrome tautomerase in the retinoblastoma.
Retinoschisis
Tyrosinase is the Modifier of Retinoschisis in Mice.
Sarcoma
Expression and network analysis of genes related to melanocyte development in the Silky Fowl and White Leghorn embryos.
Immunohistochemical study of microphthalmia transcription factor and tyrosinase in angiomyolipoma of the kidney, renal cell carcinoma, and renal and retroperitoneal sarcomas: comparative evaluation with traditional diagnostic markers.
MicroRNA-5110 regulates pigmentation by cotargeting melanophilin and WNT family member 1.
Technical note: Advantages and limitations of authenticating Palmera goat dairy products by pyrosequencing the melanocortin 1 receptor (MC1R) gene.
Tissue-specific expression of mouse tyrosinase gene in cultured chicken cells.
Tyrosinase activity in the sera of patients with malignant melanoma: method and specificity.
Tyrosinase gene expression in clear cell sarcoma indicates a melanocytic origin: insight from the first reported canine case.
Sarcoma, Avian
Tumor suppressor p53 down-regulates tissue-specific expression of tyrosinase gene in human melanoma cell lines.
Sarcoma, Clear Cell
Tyrosinase gene expression in clear cell sarcoma indicates a melanocytic origin: insight from the first reported canine case.
Sarcoma, Kaposi
Detection of tyrosinase mRNA in tumor tissue microdissections from classic Kaposi's sarcoma.
Scabies
Apparent cytoplasmic inheritance of tyrosinase competence in Streptomyces scabies.
TYROSINASE INHERITANCE IN STREPTOMYCES SCABIES. I. GENETIC RECOMBINATION.
TYROSINASE INHERITANCE IN STREPTOMYCES SCABIES. II. INDUCTION OF TYROSINASE DEFICIENCY BY ACRIDINE DYES.
Skin Diseases
Activities of different types of Thai honey on pathogenic bacteria causing skin diseases, tyrosinase enzyme and generating free radicals.
Advances in fluorescent probes for detection and imaging of endogenous tyrosinase activity.
Detection of Misdistribution of Tyrosinase from Melanosomes to Lysosomes and Its Upregulation under Psoralen/Ultraviolet A with a Melanosome-Targeting Tyrosinase Fluorescent Probe.
In Situ Fluorogenic and Chromogenic Reactions for the Sensitive Dual-Readout Assay of Tyrosinase Activity.
Inhibitory mechanism of epicatechin gallate on tyrosinase: inhibitory interaction, conformational change and computational simulation.
Polymethyldopa Nanoparticles-Based Fluorescent Sensor for Detection of Tyrosinase Activity.
Specific Imaging of Tyrosinase in Vivo with 3-Hydroxybenzyl Caged D-Luciferins.
The inhibition effect of starch nanoparticles on tyrosinase activity and its mechanism.
The unravelling of the complex pattern of tyrosinase inhibition.
Tyrosinase inhibition studies of cycloartane and cucurbitane glycosides and their structure-activity relationships.
Tyrosinase Inhibitory and Anti-oxidative Effects of Lactic Acid Bacteria Isolated from Dairy Cow Feces.
Skin Neoplasms
A Series of Benzylidenes Linked to Hydrazine-1-carbothioamide as Tyrosinase Inhibitors: Synthesis, Biological Evaluation and Structure-Activity Relationship.
Analysis of Kojic Acid Derivatives as Competitive Inhibitors of Tyrosinase: A Molecular Modeling Approach.
Assessment of tyrosinase variants and skin cancer risk in a large cohort of French subjects.
Effective Inhibition of Skin Cancer, Tyrosinase and Antioxidative Properties by Astaxanthin and Astaxanthin Esters from Green Alga Haematococcus pluvialis.
Protective effect of Daucus carota against UV-DMBA induced skin cancer in mice.
Tyrosinase-related protein-2 and -1 are trafficked on distinct routes in B16 melanoma cells.
Spinal Cord Diseases
[Intraocular inflammation and homeostasis of the eye]
Starvation
Mitogen-activated protein kinase cascade required for regulation of development and secondary metabolism in Neurospora crassa.
Role of sulfhydryl compounds in the control of tyrosinase activity in Neurospora crassa.
Sunburn
Protective effects of an extract of the freshwater microalga Scenedesmus rubescens on UV-irradiated skin cells.
Tetanus
Clinical and immunologic results of a randomized phase II trial of vaccination using four melanoma peptides either administered in granulocyte-macrophage colony-stimulating factor in adjuvant or pulsed on dendritic cells.
Phase I/II trial of a long peptide vaccine (LPV7) plus toll-like receptor (TLR) agonists with or without incomplete Freund's adjuvant (IFA) for resected high-risk melanoma.
Thrombophlebitis
Supravenous hyperpigmentation, transverse leuconychia and transverse melanonychia after chemotherapy for Hodgkin's disease.
Thyroiditis
A Case of Oculocutaneous Albinism in a Patient with Hashimoto's Thyroiditis.
Tics
Nitroprusside induces melanoma ferroptosis with serum supplementation and prolongs survival under serum depletion or hypoxia.
Tinea
Pyocyanin as anti-tyrosinase and anti tinea corporis: A novel treatment study.
Tourette Syndrome
The genetic susceptibility to Gilles de la Tourette syndrome in a large multiple affected British kindred: linkage analysis excludes a role for the genes coding for dopamine D1, D2, D3, D4, D5 receptors, dopamine beta hydroxylase, tyrosinase, and tyrosine hydroxylase.
Tuberculosis, Multidrug-Resistant
Analogues of ethionamide, a drug used for multidrug-resistant tuberculosis, exhibit potent inhibition of tyrosinase.
tyrosinase deficiency
Detection of Misdistribution of Tyrosinase from Melanosomes to Lysosomes and Its Upregulation under Psoralen/Ultraviolet A with a Melanosome-Targeting Tyrosinase Fluorescent Probe.
Genetic and experimental studies on a new pigment mutant in Xenopus laevis.
Novel human pathological mutations. Gene symbol: TYR. Disease: tyrosinase deficiency.
Tyrosinase deficiency increases protein carbonyl content in substantia nigra of mice administered retinol palmitate.
TYROSINASE INHERITANCE IN STREPTOMYCES SCABIES. II. INDUCTION OF TYROSINASE DEFICIENCY BY ACRIDINE DYES.
Tyrosinemias
The Inhibitory Activity of Plants from Central Argentina on p-Hydroxyphenylpyruvate Dioxygenase. Isolation and Mechanism of Inhibition of a Flavanone from Flourensia oolepis.
Urticaria
Minireview: Peptide analogs and short sequence oligopeptides as modulators of skin pigmentation.
Usher Syndromes
Human olfactory marker protein maps close to tyrosinase and is a candidate gene for Usher syndrome type I.
Uveitis
[Intraocular inflammation and homeostasis of the eye]
Uveomeningoencephalitic Syndrome
Cross-reaction between tyrosinase peptides and cytomegalovirus antigen by T cells from patients with Vogt-Koyanagi-Harada disease.
Tyrosinase epitope recognized by an HLA-DR-restricted T-cell line from a Vogt-Koyanagi-Harada disease patient.
Tyrosinase family proteins are antigens specific to Vogt-Koyanagi-Harada disease.
Tyrosinase gene family and Vogt-Koyanagi-Harada disease in Japanese patients.
Vaccinia
A phase I vaccination study with tyrosinase in patients with stage II melanoma using recombinant modified vaccinia virus Ankara (MVA-hTyr).
Boosting T cell-mediated immunity to tyrosinase by vaccinia virus-transduced, CD34(+)-derived dendritic cell vaccination: a phase I trial in metastatic melanoma.
Clinical protocol. Immunization of patients with malignant melanoma with autologous CD34(+) cell-derived dendritic cells transduced ex vivo with a recombinant replication-deficient vaccinia vector encoding the human tyrosinase gene: a phase I trial.
Evaluation of prime/boost regimens using recombinant poxvirus/tyrosinase vaccines for the treatment of patients with metastatic melanoma.
Human melanoma patients recognize an HLA-A1-restricted CTL epitope from tyrosinase containing two cysteine residues: implications for tumor vaccine development.
Inhibition of melanin synthesis by cystamine in human melanoma cells.
Isolation of tyrosinase-specific CD8+ and CD4+ T cell clones from the peripheral blood of melanoma patients following in vitro stimulation with recombinant vaccinia virus.
Modified vaccinia virus Ankara for delivery of human tyrosinase as melanoma-associated antigen: induction of tyrosinase- and melanoma-specific human leukocyte antigen A*0201-restricted cytotoxic T cells in vitro and in vivo.
Self-tolerance to the murine homologue of a tyrosinase-derived melanoma antigen: implications for tumor immunotherapy.
Transporter (TAP)- and proteasome-independent presentation of a melanoma-associated tyrosinase epitope.
Vaccination with a recombinant vaccinia virus encoding a "self" antigen induces autoimmune vitiligo and tumor cell destruction in mice: requirement for CD4(+) T lymphocytes.
Vesicular Stomatitis
Exchange of viral promoter/enhancer elements with heterologous regulatory sequences generates targeted hybrid long terminal repeat vectors for gene therapy of melanoma.
Virus Diseases
Tissue-specific expression of mouse tyrosinase gene in cultured chicken cells.
Transcription of the tyrosinase gene family in an Atlantic salmon leukocyte cell line (SHK-1) is influenced by temperature, but not by virus infection or bacterin stimulation.
Vision, Low
Oculocutaneous albinism type 1B associated with a functionally significant tyrosinase gene polymorphism detected with Whole Exome Sequencing.
Prenatal diagnosis of oculocutaneous albinism type I: review and personal experience.
Vitiligo
A Quantitative Increase in Regulatory T Cells Controls Development of Vitiligo.
Advances in fluorescent probes for detection and imaging of endogenous tyrosinase activity.
Autoantibodies to tyrosinase: the bridge between melanoma and vitiligo.
Autoimmune response against tyrosinase induces depigmentation in C57BL/6 black mice.
Biologic characteristics of cultured human vitiligo melanocytes.
Catalysis-based specific detection and inhibition of tyrosinase and their application.
Comparison of tyrosinase antibody, tyrosinase-related protein-1 and -2 antibodies, melanin-concentrating hormone receptor antibody levels with autologous serum skin test and autologous plasma skin test results in patients with vitiligo.
Cytotoxic T lymphocyte reactivity to gp100, MelanA/MART-1, and tyrosinase, in HLA-A2-positive vitiligo patients.
Decreased CD117 expression in hypopigmented mycosis fungoides correlates with hypomelanosis: lessons learned from vitiligo.
Defective tetrahydrobiopterin and catecholamine biosynthesis in the depigmentation disorder vitiligo.
Definition of anti-tyrosinase MAb T311 linear determinant by proteome-based similarity analysis.
Demonstration of tyrosinase in the vitiligo skin of human beings by a sensitive fluorometric method as well as by 14C(U)-L-tyrosine incorporation into melanin.
Detection of Misdistribution of Tyrosinase from Melanosomes to Lysosomes and Its Upregulation under Psoralen/Ultraviolet A with a Melanosome-Targeting Tyrosinase Fluorescent Probe.
Detection of tyrosinase autoantibodies in patients with vitiligo using 35S-labeled recombinant human tyrosinase in a radioimmunoassay.
Development and in vitro assessment of psoralen and resveratrol co-loaded ultradeformable liposomes for the treatment of vitiligo.
Effect of tryptophan on tyrosinase in relation to vitiligo.
Effects of 4-tertiary butylphenol on the tyrosinase activity in human melanocytes.
Enhancement of gene expression and melanin production of human tyrosinase gene loaded in elastic cationic niosomes.
Enhancement of transdermal absorption, gene expression and stability of tyrosinase plasmid (pMEL34)-loaded elastic cationic niosomes: Potential application in vitiligo treatment.
Evaluation of the effect of narrow band-ultraviolet B on the expression of tyrosinase, TYRP-1, and TYRP-2 mRNA in vitiligo skin and their correlations with clinical improvement: A retrospective study.
Factors affecting vitiligo response to treatment: do MiRNA 196a2C/T gene polymorphism and serum tyrosinase levels have any role?
First histopathological and immunophenotypic analysis of early dynamic events in a patient with segmental vitiligo associated with halo nevi.
Fluorescence copolymer-based dual-signal monitoring tyrosinase activity and its inhibitor screening via blue-green emission transformation.
Free radical reduction in the human epidermis.
Functionalized carbon quantum dots with dopamine for tyrosinase activity analysis.
Generation of albino Xenopus tropicalis using zinc-finger nucleases.
Identification of epitopes on tyrosinase which are recognized by autoantibodies from patients with vitiligo.
Identification of Novel HLA-A*0201-Restricted CTL Epitopes in Chinese Vitiligo Patients.
Identification of the Role of Wnt/?-Catenin Pathway Through Integrated Analyses and in vivo Experiments in Vitiligo.
Identification of TYR, TYRP1, DCT and LARP7 as related biomarkers and immune infiltration characteristics of vitiligo via comprehensive strategies.
Immunity to melanin and to tyrosinase in melanoma patients, and in people with vitiligo.
Immunoprecipitation of melanogenic enzyme autoantigens with vitiligo sera: evidence for cross-reactive autoantibodies to tyrosinase and tyrosinase-related protein-2 (TRP-2).
Increased expression of Toll-like receptor 7 and 9 in vitiligo melanocytes: a pilot study.
Interferon-gamma (IFN-?)-mediated retinal ganglion cell death in human tyrosinase T cell receptor transgenic mouse.
Involvement of Different Genes Expressions during Immunological and Inflammatory Responses in Vitiligo.
Lack of functionally active Melan-A(26-35)-specific T cells in the blood of HLA-A2+ vitiligo patients.
Mechanisms underlying the dysfunction of melanocytes in vitiligo epidermis: role of SCF/KIT protein interactions and the downstream effector, MITF-M.
Melanocyte antigen-specific antibodies cannot be used as markers for recent disease activity in patients with vitiligo.
Melanogenic effect of purified mushroom tyrosinase on B16F10 Melanocytes: A Phase Contrast and Immunofluorescence Microscopic Study.
Melanoma-associated hypopigmentation: where are the antibodies?
Melanosome-Targeting Near-Infrared Fluorescent Probe with Large Stokes Shift for in Situ Quantification of Tyrosinase Activity and Assessing Drug Effects on Differently Invasive Melanoma Cells.
miR-196a-2 rs11614913 polymorphism is associated with vitiligo by affecting heterodimeric molecular complexes of Tyr and Tyrp1.
Oxidative stress level and tyrosinase activity in vitiligo patients.
Oxidized tyrosinase: A possible antigenic stimulus for non-segmental vitiligo autoantibodies.
Potent melanin production enhancement of human tyrosinase gene by Tat and an entrapment in elastic cationic niosomes: Potential application in vitiligo gene therapy.
Proteomic scan for tyrosinase peptide antigenic pattern in vitiligo and melanoma: role of sequence similarity and HLA-DR1 affinity.
Ratiometric target-triggered fluorescent silicon nanoparticles probe for quantitative visualization of tyrosinase activity.
Screening the Marker Components in Psoralea corylifolia L. with the Aids of Spectrum-Effect Relationship and Component Knock-Out by UPLC-MS².
Specific cytotoxic T lymphocyte responses against Melan-A/MART1, tyrosinase and gp100 in vitiligo by the use of major histocompatibility complex/peptide tetramers: the role of cellular immunity in the etiopathogenesis of vitiligo.
Specific Imaging of Tyrosinase in Vivo with 3-Hydroxybenzyl Caged D-Luciferins.
Synthesis and bioactivity of novel isoxazole chalcone derivatives on tyrosinase and melanin synthesis in murine B16 cells for the treatment of vitiligo.
Targeted gene disruption in the Xenopus tropicalis genome using designed TALE nucleases.
The antibody response against MART-1 differs in patients with melanoma-associated leucoderma and vitiligo.
The clinical significance of antityrosinase antibodies in melanoma and related hypopigmentary lesions.
The role of tyrosinase in autoimmune vitiligo.
The role of VIT1/FBXO11 in the regulation of apoptosis and tyrosinase export from endoplasmic reticulum in cultured melanocytes.
Tyrosinase as an autoantigen in patients with vitiligo.
Update on childhood vitiligo.
Upregulation of Melanogenesis and Tyrosinase Activity: Potential Agents for Vitiligo.
Vaccine-specific local T cell reactivity in immunotherapy-associated vitiligo in melanoma patients.
Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo.
Vitiliginous achromia with malignant melanoma. Tyrosinase activity and ultrastructural study of achromic and normal skin.
Vitiligo antibodies are not directed to tyrosinase.
Vitiligo puzzle: the pieces fall in place.
Vitiligo: analysis of grafting versus curettage alone, using melanocyte morphology and reverse transcriptase polymerase chain reaction for tyrosinase mRNA.
Vogt-Koyanagi-Harada disease and vitiligo: where does the illness begin?
[Effect of zibuganshenfang on the expression and activity of tyrosinase on B16 cells].
[Expression and purification of epitope peptide of human tyrosinase and its antigenicity in vitiligo patients]
[Expression of InnVit/FBXO11 in vitiligo and its role in tyrosinase export from endoplasmic reticulum]
[Our experience in the use of tyrosinase in vitiligo]
Vitreoretinopathy, Proliferative
Dedifferentiation of the retinal pigment epithelium compared to the proliferative membranes of proliferative vitreoretinopathy.
Waardenburg Syndrome
alpha-Melanocyte-stimulating hormone signaling regulates expression of microphthalmia, a gene deficient in Waardenburg syndrome.
Wilms Tumor
Peptide-pulsed dendritic cell vaccine in combination with carboplatin and paclitaxel chemotherapy for stage IV melanoma.
Xanthogranuloma, Juvenile
Immunohistochemical distinction of epithelioid histiocytic proliferations from epithelioid melanocytic nevi.