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DL-glycerol 3-phosphate + oxidized 2,6-dichlorophenolindophenol
dihydroxyacetone phosphate + reduced 2,6-dichlorophenolindophenol
glyceraldehyde-3-phosphate + NAD(P)+
?
crystal structure with complexed substrate analogue is determined
-
-
?
glyceric acid 2-phosphate + NAD(P)+
?
crystal structure with complexed substrate analogue is determined
-
-
?
glycerol 3-phosphate + a quinone
dihydroxyacetone phosphate + a quinol
-
-
-
?
phosphoenolpyruvate + NAD(P)+
?
crystal structure with complexed substrate analogue is determined
-
-
?
sn-glycerol 3-phosphate + 1-methyl-2-decyl-3,4-dimethoxybenzoquinone
glycerone phosphate + ?
-
-
-
-
?
sn-glycerol 3-phosphate + 2,6-dichlorophenolindophenol
?
sn-glycerol 3-phosphate + 2,6-dichlorophenolindophenol
glycerone phosphate + reduced 2,6-dichlorophenolindophenol
-
-
-
-
r
sn-glycerol 3-phosphate + 2,6-dichlorophenolindophenol
glycerone phosphate + reduced 2,6-dichlorophenylindophenol
sn-glycerol 3-phosphate + a quinone
glycerone phosphate + a quinol
sn-glycerol 3-phosphate + acceptor
glycerone phosphate + reduced acceptor
sn-glycerol 3-phosphate + coenzyme Q0
dihydroxyacetone phosphate + reduced coenzyme Q0
-
-
-
?
sn-glycerol 3-phosphate + coenzyme Q0
glycerone phosphate + reduced coenzyme Q0
-
-
-
-
?
sn-glycerol 3-phosphate + coenzyme Q1
dihydroxyacetone phosphate + reduced coenzyme Q1
-
-
-
?
sn-glycerol 3-phosphate + coenzyme Q1
glycerone phosphate + reduced coenzyme Q1
sn-glycerol 3-phosphate + coenzyme Q10
glycerone phosphate + reduced coenzyme Q10
sn-glycerol 3-phosphate + coenzyme Q2
glycerone phosphate + reduced coenzyme Q2
sn-glycerol 3-phosphate + coenzyme Q5
glycerone phosphate + reduced coenzyme Q5
-
-
-
-
?
sn-glycerol 3-phosphate + coenzyme Q6
glycerone phosphate + reduced coenzyme Q6
-
-
-
-
?
sn-glycerol 3-phosphate + decylubiquinone
glycerone phosphate + decylubiquinol
sn-glycerol 3-phosphate + duroquinone
glycerone phosphate + duroquinol
sn-glycerol 3-phosphate + ferricyanide
glycerone phosphate + ferrocyanide
sn-glycerol 3-phosphate + menadione
glycerone phosphate + reduced menadione
sn-glycerol 3-phosphate + methylene blue
glycerone phosphate + reduced methylene blue
-
-
-
-
?
sn-glycerol 3-phosphate + NAD(P)+
glycerone phosphate + NAD(P)H + H+
-
-
-
?
sn-glycerol 3-phosphate + oxidized coenzyme Q
glycerone phosphate + reduced coenzyme Q
sn-glycerol 3-phosphate + phenazine methosulfate
?
sn-glycerol 3-phosphate + phenazine methosulfate
glycerone phosphate + reduced phenazine methosulfat
-
-
-
-
r
sn-glycerol 3-phosphate + phenazine methosulfate
glycerone phosphate + reduced phenazine methosulfate
sn-glycerol 3-phosphate + quinone
glycerone phosphate + quinol
-
-
-
-
?
sn-glycerol 3-phosphate + ubiquinone
glycerone phosphate + ubiquinol
sn-glycerol 3-phosphate + vitamin K3
glycerone phosphate + reduced vitamin K3
-
-
-
-
?
additional information
?
-
DL-glycerol 3-phosphate + oxidized 2,6-dichlorophenolindophenol
dihydroxyacetone phosphate + reduced 2,6-dichlorophenolindophenol
-
-
-
-
?
DL-glycerol 3-phosphate + oxidized 2,6-dichlorophenolindophenol
dihydroxyacetone phosphate + reduced 2,6-dichlorophenolindophenol
-
-
-
-
?
sn-glycerol 3-phosphate + 2,6-dichlorophenolindophenol
?
-
-
-
?
sn-glycerol 3-phosphate + 2,6-dichlorophenolindophenol
?
-
-
-
?
sn-glycerol 3-phosphate + 2,6-dichlorophenolindophenol
?
-
-
-
?
sn-glycerol 3-phosphate + 2,6-dichlorophenolindophenol
?
-
-
-
?
sn-glycerol 3-phosphate + 2,6-dichlorophenolindophenol
glycerone phosphate + reduced 2,6-dichlorophenylindophenol
-
-
-
-
?
sn-glycerol 3-phosphate + 2,6-dichlorophenolindophenol
glycerone phosphate + reduced 2,6-dichlorophenylindophenol
-
-
-
-
?
sn-glycerol 3-phosphate + 2,6-dichlorophenolindophenol
glycerone phosphate + reduced 2,6-dichlorophenylindophenol
-
-
-
-
?
sn-glycerol 3-phosphate + 2,6-dichlorophenolindophenol
glycerone phosphate + reduced 2,6-dichlorophenylindophenol
-
-
-
-
?
sn-glycerol 3-phosphate + a quinone
glycerone phosphate + a quinol
-
-
-
-
?
sn-glycerol 3-phosphate + a quinone
glycerone phosphate + a quinol
-
-
-
-
?
sn-glycerol 3-phosphate + a quinone
glycerone phosphate + a quinol
-
-
-
?
sn-glycerol 3-phosphate + a quinone
glycerone phosphate + a quinol
the enzyme plays a central role in glycerolipid metabolism and stress response. It increases salt and osmotic stress resistance by modulating redox state and respiration
-
-
?
sn-glycerol 3-phosphate + a quinone
glycerone phosphate + a quinol
-
-
-
-
?
sn-glycerol 3-phosphate + a quinone
glycerone phosphate + a quinol
-
-
-
-
?
sn-glycerol 3-phosphate + a quinone
glycerone phosphate + a quinol
-
-
-
-
?
sn-glycerol 3-phosphate + a quinone
glycerone phosphate + a quinol
-
-
-
?
sn-glycerol 3-phosphate + a quinone
glycerone phosphate + a quinol
the enzyme converts cytosolic glycerol-3-phosphate to dihydroxyacetone phosphate, feeding electrons directly from the cytosolic side of the mitochondrial inner membrane to the CoQ-pool within the inner membrane
-
-
?
sn-glycerol 3-phosphate + a quinone
glycerone phosphate + a quinol
-
-
-
-
?
sn-glycerol 3-phosphate + a quinone
glycerone phosphate + a quinol
-
-
-
-
?
sn-glycerol 3-phosphate + acceptor
glycerone phosphate + reduced acceptor
-
key enzyme of the glycerol phosphate shuttle
-
-
?
sn-glycerol 3-phosphate + acceptor
glycerone phosphate + reduced acceptor
-
enzyme is linked to the respiratory chain
-
-
?
sn-glycerol 3-phosphate + coenzyme Q1
glycerone phosphate + reduced coenzyme Q1
-
63% of the activity with 2,6-dichloroindophenol
-
-
?
sn-glycerol 3-phosphate + coenzyme Q1
glycerone phosphate + reduced coenzyme Q1
-
-
-
-
?
sn-glycerol 3-phosphate + coenzyme Q1
glycerone phosphate + reduced coenzyme Q1
-
-
-
-
?
sn-glycerol 3-phosphate + coenzyme Q1
glycerone phosphate + reduced coenzyme Q1
-
-
-
-
?
sn-glycerol 3-phosphate + coenzyme Q10
glycerone phosphate + reduced coenzyme Q10
-
coenzyme Q10 is the only natural electron acceptor in insect flight muscles
-
-
?
sn-glycerol 3-phosphate + coenzyme Q10
glycerone phosphate + reduced coenzyme Q10
-
coenzyme Q10 is the only natural electron acceptor in insect flight muscles
-
-
?
sn-glycerol 3-phosphate + coenzyme Q10
glycerone phosphate + reduced coenzyme Q10
-
-
-
-
?
sn-glycerol 3-phosphate + coenzyme Q2
glycerone phosphate + reduced coenzyme Q2
-
-
-
-
?
sn-glycerol 3-phosphate + coenzyme Q2
glycerone phosphate + reduced coenzyme Q2
-
-
-
-
?
sn-glycerol 3-phosphate + coenzyme Q2
glycerone phosphate + reduced coenzyme Q2
-
-
-
-
?
sn-glycerol 3-phosphate + decylubiquinone
glycerone phosphate + decylubiquinol
-
-
-
-
?
sn-glycerol 3-phosphate + decylubiquinone
glycerone phosphate + decylubiquinol
-
-
-
-
?
sn-glycerol 3-phosphate + duroquinone
glycerone phosphate + duroquinol
-
-
-
-
?
sn-glycerol 3-phosphate + duroquinone
glycerone phosphate + duroquinol
-
-
-
-
?
sn-glycerol 3-phosphate + ferricyanide
glycerone phosphate + ferrocyanide
-
70% of the activity with 2,6-dichloroindophenol
-
-
?
sn-glycerol 3-phosphate + ferricyanide
glycerone phosphate + ferrocyanide
-
-
-
-
?
sn-glycerol 3-phosphate + ferricyanide
glycerone phosphate + ferrocyanide
-
-
-
-
?
sn-glycerol 3-phosphate + menadione
glycerone phosphate + reduced menadione
-
-
-
-
?
sn-glycerol 3-phosphate + menadione
glycerone phosphate + reduced menadione
-
-
-
?
sn-glycerol 3-phosphate + menadione
glycerone phosphate + reduced menadione
-
-
-
-
?
sn-glycerol 3-phosphate + oxidized coenzyme Q
glycerone phosphate + reduced coenzyme Q
-
-
-
-
?
sn-glycerol 3-phosphate + oxidized coenzyme Q
glycerone phosphate + reduced coenzyme Q
-
-
-
-
?
sn-glycerol 3-phosphate + phenazine methosulfate
?
-
-
-
-
?
sn-glycerol 3-phosphate + phenazine methosulfate
?
-
-
-
-
?
sn-glycerol 3-phosphate + phenazine methosulfate
glycerone phosphate + reduced phenazine methosulfate
-
-
-
-
?
sn-glycerol 3-phosphate + phenazine methosulfate
glycerone phosphate + reduced phenazine methosulfate
-
phenazine methosulfate coupled 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide reduction assay
-
-
?
sn-glycerol 3-phosphate + phenazine methosulfate
glycerone phosphate + reduced phenazine methosulfate
-
-
-
-
?
sn-glycerol 3-phosphate + phenazine methosulfate
glycerone phosphate + reduced phenazine methosulfate
-
specific for L-3-glycerophosphate
-
-
?
sn-glycerol 3-phosphate + phenazine methosulfate
glycerone phosphate + reduced phenazine methosulfate
-
phenazine methosulfate-coupled reduction of thiazolyl blue tetrazolium
-
-
?
sn-glycerol 3-phosphate + ubiquinone
glycerone phosphate + ubiquinol
-
-
-
ir
sn-glycerol 3-phosphate + ubiquinone
glycerone phosphate + ubiquinol
the ubiquinone-linked reaction catalyzed by mGPDH is irreversible
-
-
ir
sn-glycerol 3-phosphate + ubiquinone
glycerone phosphate + ubiquinol
-
-
-
ir
sn-glycerol 3-phosphate + ubiquinone
glycerone phosphate + ubiquinol
the ubiquinone-linked reaction catalyzed by mGPDH is irreversible
-
-
ir
sn-glycerol 3-phosphate + ubiquinone
glycerone phosphate + ubiquinol
-
-
-
ir
sn-glycerol 3-phosphate + ubiquinone
glycerone phosphate + ubiquinol
the ubiquinone-linked reaction catalyzed by mGPDH is irreversible
-
-
ir
sn-glycerol 3-phosphate + ubiquinone
glycerone phosphate + ubiquinol
-
-
-
ir
sn-glycerol 3-phosphate + ubiquinone
glycerone phosphate + ubiquinol
the ubiquinone-linked reaction catalyzed by mGPDH is irreversible
-
-
ir
additional information
?
-
-
enzyme forms part of a glycerol-3-phosphate shuttle and links cytosolic glycerol-3-phosphate metabolism to carbon source utilization and energy metabolism
-
-
?
additional information
?
-
-
SDP6 is essential for glycerol catabolism
-
-
?
additional information
?
-
expression of DsFAD-GPDH is enhanced at first by salt treatment, and repressed by oxygen deficiency and cold stress
-
-
?
additional information
?
-
-
expression of DsFAD-GPDH is enhanced at first by salt treatment, and repressed by oxygen deficiency and cold stress
-
-
?
additional information
?
-
-
high susceptibility to production of reactive oxygen species by mGPDH may reflect inefficient protection of its interaction with coenzyme Q and possibly also the low Fe-S content
-
-
?
additional information
?
-
usage of an assay method specific for superoxide/H2O2 production by mGPDH
-
-
?
additional information
?
-
usage of an assay method specific for superoxide/H2O2 production by mGPDH
-
-
?
additional information
?
-
-
distinct binding sites on the mitochondrial L-glycerol-3-phosphate dehydrogenase for hydrophobic and hydrophilic electron acceptors in vitro
-
-
?
additional information
?
-
usage of an assay method specific for superoxide/H2O2 production by mGPDH
-
-
?
additional information
?
-
usage of an assay method specific for superoxide/H2O2 production by mGPDH
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
sn-glycerol 3-phosphate + a quinone
glycerone phosphate + a quinol
sn-glycerol 3-phosphate + acceptor
glycerone phosphate + reduced acceptor
sn-glycerol 3-phosphate + coenzyme Q0
dihydroxyacetone phosphate + reduced coenzyme Q0
-
-
-
?
sn-glycerol 3-phosphate + coenzyme Q1
dihydroxyacetone phosphate + reduced coenzyme Q1
-
-
-
?
sn-glycerol 3-phosphate + coenzyme Q10
glycerone phosphate + reduced coenzyme Q10
sn-glycerol 3-phosphate + oxidized coenzyme Q
glycerone phosphate + reduced coenzyme Q
sn-glycerol 3-phosphate + ubiquinone
glycerone phosphate + ubiquinol
additional information
?
-
sn-glycerol 3-phosphate + a quinone
glycerone phosphate + a quinol
-
-
-
-
?
sn-glycerol 3-phosphate + a quinone
glycerone phosphate + a quinol
-
-
-
-
?
sn-glycerol 3-phosphate + a quinone
glycerone phosphate + a quinol
the enzyme plays a central role in glycerolipid metabolism and stress response. It increases salt and osmotic stress resistance by modulating redox state and respiration
-
-
?
sn-glycerol 3-phosphate + a quinone
glycerone phosphate + a quinol
-
-
-
-
?
sn-glycerol 3-phosphate + a quinone
glycerone phosphate + a quinol
-
-
-
-
?
sn-glycerol 3-phosphate + a quinone
glycerone phosphate + a quinol
-
-
-
-
?
sn-glycerol 3-phosphate + a quinone
glycerone phosphate + a quinol
the enzyme converts cytosolic glycerol-3-phosphate to dihydroxyacetone phosphate, feeding electrons directly from the cytosolic side of the mitochondrial inner membrane to the CoQ-pool within the inner membrane
-
-
?
sn-glycerol 3-phosphate + a quinone
glycerone phosphate + a quinol
-
-
-
-
?
sn-glycerol 3-phosphate + a quinone
glycerone phosphate + a quinol
-
-
-
-
?
sn-glycerol 3-phosphate + acceptor
glycerone phosphate + reduced acceptor
-
key enzyme of the glycerol phosphate shuttle
-
-
?
sn-glycerol 3-phosphate + acceptor
glycerone phosphate + reduced acceptor
-
enzyme is linked to the respiratory chain
-
-
?
sn-glycerol 3-phosphate + coenzyme Q10
glycerone phosphate + reduced coenzyme Q10
-
coenzyme Q10 is the only natural electron acceptor in insect flight muscles
-
-
?
sn-glycerol 3-phosphate + coenzyme Q10
glycerone phosphate + reduced coenzyme Q10
-
coenzyme Q10 is the only natural electron acceptor in insect flight muscles
-
-
?
sn-glycerol 3-phosphate + oxidized coenzyme Q
glycerone phosphate + reduced coenzyme Q
-
-
-
-
?
sn-glycerol 3-phosphate + oxidized coenzyme Q
glycerone phosphate + reduced coenzyme Q
-
-
-
-
?
sn-glycerol 3-phosphate + ubiquinone
glycerone phosphate + ubiquinol
-
-
-
ir
sn-glycerol 3-phosphate + ubiquinone
glycerone phosphate + ubiquinol
-
-
-
ir
sn-glycerol 3-phosphate + ubiquinone
glycerone phosphate + ubiquinol
-
-
-
ir
sn-glycerol 3-phosphate + ubiquinone
glycerone phosphate + ubiquinol
-
-
-
ir
additional information
?
-
-
enzyme forms part of a glycerol-3-phosphate shuttle and links cytosolic glycerol-3-phosphate metabolism to carbon source utilization and energy metabolism
-
-
?
additional information
?
-
-
SDP6 is essential for glycerol catabolism
-
-
?
additional information
?
-
expression of DsFAD-GPDH is enhanced at first by salt treatment, and repressed by oxygen deficiency and cold stress
-
-
?
additional information
?
-
-
expression of DsFAD-GPDH is enhanced at first by salt treatment, and repressed by oxygen deficiency and cold stress
-
-
?
additional information
?
-
-
high susceptibility to production of reactive oxygen species by mGPDH may reflect inefficient protection of its interaction with coenzyme Q and possibly also the low Fe-S content
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1,2-Dihydroxybenzene 3,5-disulfonic acid
-
-
1-(2-Thenoyl)-3,3,3-trifluoroacetone
-
-
2,2-dimethyl-5-nitro-2H-benzimidazole
-
-
2-[(7-nitro-3-oxo-2,1,3l5-benzoxadiazol-4-yl)oxy]phenol
-
-
2-[(E)-(4-hydroxyphenyl)diazenyl]-1-benzothiophene-3-ol
-
-
4-(4-chloroanilino)-4-oxobutanoic acid
4-(4-methylanilino)-4-oxobutanoic acid
4-(hexylamino)-4-oxobutanoic acid
4-[3-(1H-benzimidazol-2-yl)anilino]-4-oxobutanoic acid
4-[4-(1,3-benzothiazol-2-yl)anilino]-4-oxobutanoic acid
4-[4-(1,3-benzoxazol-2-yl)anilino]-4-oxobutanoic acid
4-[4-(1H-benzimidazol-2-yl)anilino]-4-oxobutanoic acid
4-[4-(1H-naphtho[2,3-d]imidazol-2-yl)anilino]-4-oxobutanoic acid
4-[4-(5-methyl-1H-benzimidazol-2-yl)anilino]-4-oxobutanoic acid
4-[4-[5-(3-carboxypropanamido)-1H-benzimidazol-2-yl]anilino]-4-oxobutanoic acid
4-[4-[5-(cyclohexa-2,4-diene-1-carbonyl)-1H-benzimidazol-2-yl]anilino]-4-oxobutanoic acid
5-[(E)-(3-chlorophenyl)diazenyl]-2-hydroxybenzaldehyde
-
-
6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol
-
-
adriamycin
-
significant inhibition of reaction with hydrophobic electron acceptors, coenzyme Q or vitamin K3
alpha-tocopheryl succinate
Cetylpyridinium bromide
-
-
Chloroquine
-
inhibits reaction with coenzyme Q1, no inhibition of the reaction with 2,6-dichloroindophenol
Cu2+
-
specifically inhibits phenazine methosulfate coupled 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide reduction assay
D-2-Phosphoglyceric acid
-
-
D-glyceraldehyde 3-phosphate
-
Digitonin
-
strong inhibition, the activity is recovered to 148% of control values by the addition of exogenous synthetic analog of CoQ idebenone, i.e. hydroxydecylubiquinone, and cytochrome c. The compound also strongly activates glycerol-3-phosphate oxidation inhibited by endogenous or added free fatty acids
dihydroxyacetone phosphate
-
-
ethyl 4-(3-oxo-1,2-thiazol-2(3H)-yl)benzoate
-
-
FMN
-
reaction with methylene blue
glyceraldehyde 3-phosphate
glyceraldehyde-3-phosphate
competitive inhibitor
glyceric acid 2-phosphate
competitive inhibitor
L-Glyceraldehyde 3-phosphate
-
methyl 4-(4-methylanilino)-4-oxobutanoate
N-(3,5-dibromo-4-hydroxyphenyl)-4-methylbenzene-1-sulfonamide
-
-
N-[4-(1H-naphtho[2,3-d]imidazol-2-yl)phenyl]butanamide
N-[4-(5,6-dihydro-1H-benzimidazol-2-yl)phenyl]-2-oxopropanamide
N-[4-(5,6-dihydro-1H-benzimidazol-2-yl)phenyl]-3-methylbutanamide
N-[4-(5,6-dihydro-1H-benzimidazol-2-yl)phenyl]-4-ethoxybenzamide
N-[4-(5,6-dihydro-1H-benzimidazol-2-yl)phenyl]cyclopropanecarboxamide
N-[4-(5,6-dihydro-1H-benzimidazol-2-yl)phenyl]furan-2-carboxamide
Thenoyltrifluoroacetone
-
-
1,10-phenanthroline
-
-
4-(4-chloroanilino)-4-oxobutanoic acid
-
4-(4-chloroanilino)-4-oxobutanoic acid
-
4-(4-methylanilino)-4-oxobutanoic acid
-
4-(4-methylanilino)-4-oxobutanoic acid
-
4-(hexylamino)-4-oxobutanoic acid
-
4-(hexylamino)-4-oxobutanoic acid
-
4-[3-(1H-benzimidazol-2-yl)anilino]-4-oxobutanoic acid
-
4-[3-(1H-benzimidazol-2-yl)anilino]-4-oxobutanoic acid
-
4-[4-(1,3-benzothiazol-2-yl)anilino]-4-oxobutanoic acid
-
4-[4-(1,3-benzothiazol-2-yl)anilino]-4-oxobutanoic acid
-
4-[4-(1,3-benzoxazol-2-yl)anilino]-4-oxobutanoic acid
-
4-[4-(1,3-benzoxazol-2-yl)anilino]-4-oxobutanoic acid
-
4-[4-(1H-benzimidazol-2-yl)anilino]-4-oxobutanoic acid
mixed type inhibition, potent and selective inhibitor
4-[4-(1H-benzimidazol-2-yl)anilino]-4-oxobutanoic acid
mixed type inhibition, potent and selective inhibitor
4-[4-(1H-naphtho[2,3-d]imidazol-2-yl)anilino]-4-oxobutanoic acid
mixed type inhibition
4-[4-(1H-naphtho[2,3-d]imidazol-2-yl)anilino]-4-oxobutanoic acid
mixed type inhibition
4-[4-(5-methyl-1H-benzimidazol-2-yl)anilino]-4-oxobutanoic acid
-
4-[4-(5-methyl-1H-benzimidazol-2-yl)anilino]-4-oxobutanoic acid
-
4-[4-[5-(3-carboxypropanamido)-1H-benzimidazol-2-yl]anilino]-4-oxobutanoic acid
-
4-[4-[5-(3-carboxypropanamido)-1H-benzimidazol-2-yl]anilino]-4-oxobutanoic acid
-
4-[4-[5-(cyclohexa-2,4-diene-1-carbonyl)-1H-benzimidazol-2-yl]anilino]-4-oxobutanoic acid
-
4-[4-[5-(cyclohexa-2,4-diene-1-carbonyl)-1H-benzimidazol-2-yl]anilino]-4-oxobutanoic acid
-
alpha-tocopheryl succinate
-
-
alpha-tocopheryl succinate
-
-
D-3-phosphoglyceric acid
-
-
D-3-phosphoglyceric acid
-
-
D-3-phosphoglyceric acid
-
competitive with respect to glycerophosphate
glyceraldehyde 3-phosphate
about 80% inhibition at 2.5 mM, glyceraldehyde 3-phosphate is not a specific inhibitor of mGPDH but also alters succinate oxidation
glyceraldehyde 3-phosphate
about 80% inhibition at 2.5 mM, glyceraldehyde 3-phosphate is not a specific inhibitor of mGPDH but also alters succinate oxidation
glyceraldehyde 3-phosphate
-
D-3-glyceraldehyde phosphate; L-3-glyceraldehyde phosphate
glyceraldehyde 3-phosphate
-
-
glycerone phosphate
product inhibition
glycerone phosphate
product inhibition
methyl 4-(4-methylanilino)-4-oxobutanoate
-
methyl 4-(4-methylanilino)-4-oxobutanoate
-
N-[4-(1H-naphtho[2,3-d]imidazol-2-yl)phenyl]butanamide
-
N-[4-(1H-naphtho[2,3-d]imidazol-2-yl)phenyl]butanamide
-
N-[4-(5,6-dihydro-1H-benzimidazol-2-yl)phenyl]-2-oxopropanamide
-
N-[4-(5,6-dihydro-1H-benzimidazol-2-yl)phenyl]-2-oxopropanamide
-
N-[4-(5,6-dihydro-1H-benzimidazol-2-yl)phenyl]-3-methylbutanamide
-
N-[4-(5,6-dihydro-1H-benzimidazol-2-yl)phenyl]-3-methylbutanamide
-
N-[4-(5,6-dihydro-1H-benzimidazol-2-yl)phenyl]-4-ethoxybenzamide
-
N-[4-(5,6-dihydro-1H-benzimidazol-2-yl)phenyl]-4-ethoxybenzamide
-
N-[4-(5,6-dihydro-1H-benzimidazol-2-yl)phenyl]cyclopropanecarboxamide
-
N-[4-(5,6-dihydro-1H-benzimidazol-2-yl)phenyl]cyclopropanecarboxamide
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N-[4-(5,6-dihydro-1H-benzimidazol-2-yl)phenyl]furan-2-carboxamide
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N-[4-(5,6-dihydro-1H-benzimidazol-2-yl)phenyl]furan-2-carboxamide
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PCMB
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phosphoenolpyruvate
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phosphoenolpyruvate
competitive inhibitor
Triton X100
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Triton X100
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in presence of phospholipids
Zn2+
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specifically inhibits ferricyanide reduction assay
additional information
screening and identification of cell-permeant small-molecule inhibitors of mGPDH (iGP) discovered through small-molecule screening. Structure-activity analysis identifies a core benzimidazole-phenyl-succinamide structure as being essential to inhibition of mGPDH while modifications to the benzimidazole ring system modulate both potency and off-target effects. The iGPs penetrate cellular membranes. Inhibitor selectivity, and effects of the inhibitors on kinetics of mGPDH, overview
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additional information
screening and identification of cell-permeant small-molecule inhibitors of mGPDH (iGP) discovered through small-molecule screening. Structure-activity analysis identifies a core benzimidazole-phenyl-succinamide structure as being essential to inhibition of mGPDH while modifications to the benzimidazole ring system modulate both potency and off-target effects. The iGPs penetrate cellular membranes. Inhibitor selectivity, and effects of the inhibitors on kinetics of mGPDH, overview
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