Literature summary for 1.1.5.3 extracted from

Kota, V.; Rai, P.; Weitzel, J.M.; Middendorff, R.; Bhande, S.S.; Shivaji, S.
Role of glycerol-3-phosphate dehydrogenase 2 in mouse sperm capacitation (2010), Mol. Reprod. Dev., 77, 773-783.

Search for more literature for 1.1.5.3

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	the enzyme is localized to the outer membrane of the mitochondria facing the cytoplasm	Mus musculus	5739	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
80000	-	SDS-PAGE	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q64521	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	GPD2 is tyrosine phosphorylated only in capacitated spermatozoa of wild type mice	Mus musculus

Source Tissue

Source Tissue	Comment	Organism	Textmining
spermatozoon	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
sn-glycerol 3-phosphate + menadione	-	Mus musculus	glycerone phosphate + reduced menadione	-	?

Synonyms

Synonyms	Comment	Organism
glycerol-3-phosphate dehydrogenase 2	-	Mus musculus
GPD2	-	Mus musculus

Cofactor

Cofactor	Comment	Organism	Structure
FAD	-	Mus musculus

pI Value

Organism	Comment	pI Value Maximum	pI Value
Mus musculus	isoelectric focusing	7.1	6.7

General Information

General Information	Comment	Organism
malfunction	in the absence of Gpd2, hyperactivation and acrosome reaction are significantly altered, and a few changes in protein tyrosine phosphorylation are observed during sperm capacitation. The testicular size of Gpd2-deficient animals is about 10% smaller than in wild type animals. Gpd2-null animals show a 4% reduction in tubular diameter and about 10% reduction in numbers of both spermatocytes and spermatids per seminiferous tubule	Mus musculus
physiological function	GPD2 enables tyrosine phosphorylation during sperm capacitation. GPD2 activity is required for reactive oxygen species generation in mouse spermatozoa during capacitation	Mus musculus

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Release 2023.1 (January 2023)