2.7.3.4: taurocyamine kinase
This is an abbreviated version!
For detailed information about taurocyamine kinase, go to the full flat file.
Word Map on EC 2.7.3.4
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2.7.3.4
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creatine
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glycocyamine
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lombricine
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annelid
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polychaete
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cdna-derived
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arenicola
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2.7.3.3
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neanthes
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paragonimus
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phosphoarginine
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westermani
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drug development
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pharmacology
- 2.7.3.4
- creatine
- glycocyamine
- lombricine
-
annelid
-
polychaete
-
cdna-derived
- arenicola
-
2.7.3.3
- neanthes
- paragonimus
- phosphoarginine
- westermani
- drug development
- pharmacology
Reaction
Synonyms
ATP:taurocyamine phosphotransferase, CsTK, guanidino kinase, hypotaurocyamine kinase, kinase (phosphorylating), taurocyamine, kinase, taurocyamine (phosphorylating), MiTK, More, phosphagen kinase, PK1, PK2, SmGK, taurocyamine kinase, taurocyamine phosphotransferase, TK, TPK
ECTree
2.7.3.4 taurocyamine kinaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.7.3.4 - taurocyamine kinase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + beta-guanidinopropionic acid
?
-
isoform PK1 shows 14% and isoform PK2 7% activity compared to tauromycine
-
-
?
ATP + guanidopropionic acid
ADP + N-phosphoguanidinopropionic acid
-
low activity
-
-
?
ATP + glycocyamine
ADP + N-phosphoglycocyamine
no activity
-
-
?
ATP + glycocyamine
ADP + N-phosphoglycocyamine
7% of taurocyamine activity
-
-
?
ATP + glycocyamine
ADP + N-phosphoglycocyamine
low activity
-
-
?
ATP + glycocyamine
ADP + N-phosphoglycocyamine
no activity
-
-
?
ATP + glycocyamine
ADP + N-phosphoglycocyamine
35% of taurocyamine activity
-
-
?
ATP + lombricine
ADP + N-phospholombricine
30% of taurocyamine activity
-
-
?
ATP + lombricine
ADP + N-phospholombricine
9% of taurocyamine activity
-
-
?
ATP + lombricine
ADP + N-phospholombricine
21% of taurocyamine activity
-
-
?
ATP + lombricine
ADP + N-phospholombricine
31% of taurocyamine activity
-
-
?
ATP + taurocyamine
ADP + N-phosphotaurocyamine
key role in the interconnection between energy production and utilization in animals
-
-
?
ATP + taurocyamine
ADP + N-phosphotaurocyamine
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key role in the interconnection between energy production and utilization in animals
-
-
?
ATP + taurocyamine
ADP + N-phosphotaurocyamine
high substrate specificity for taurocyamine
-
-
?
ATP + taurocyamine
ADP + N-phosphotaurocyamine
the enzyme has a unique substrate binding mechanism
-
-
?
ATP + taurocyamine
ADP + N-phosphotaurocyamine
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strong activity
-
-
?
ATP + taurocyamine
ADP + N-phosphotaurocyamine
key role in the interconnection between energy production and utilization in animals
-
-
?
ATP + taurocyamine
ADP + N-phosphotaurocyamine
the enzyme catalyzes the reversibleMg2-dependent transfer of a phosphoryl group between ATP and taurocyamine
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r
additional information
?
-
cytoplasmic TK shows activity only for D-lombricine and taurocyamine (the second activity being in the range of 15% to that for the main substrate), no activity for creatine
-
-
?
additional information
?
-
cytoplasmic TK shows activity only for D-lombricine and taurocyamine (the second activity being in the range of 15% to that for the main substrate), no activity for creatine
-
-
?
additional information
?
-
the mitochondrial isoform of MiTK shows high activity for glycocyamine (48%), in addition to D-lombricine (80%), the MiTK also shows weak but significant activity for L-arginine (0.2%)
-
-
?
additional information
?
-
the mitochondrial isoform of MiTK shows high activity for glycocyamine (48%), in addition to D-lombricine (80%), the MiTK also shows weak but significant activity for L-arginine (0.2%)
-
-
?
additional information
?
-
residues R58, I60 and Y84 of domain 1, and H60, I63 and Y87 of domain 2 participate in binding taurocyamine. Recombinant CsTK enzyme protein has low sensitivity and specificity toward Clonorchis sinensis and platyhelminth-infected human sera on ELISA
-
-
?
additional information
?
-
-
residues R58, I60 and Y84 of domain 1, and H60, I63 and Y87 of domain 2 participate in binding taurocyamine. Recombinant CsTK enzyme protein has low sensitivity and specificity toward Clonorchis sinensis and platyhelminth-infected human sera on ELISA
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-
?
additional information
?
-
-
no activity with L-arginine, D-arginine, creatine, glycocyamine, gamma-guanidinobutyric acid, homoarginine, methylguanidine and L-acetylguanidine
-
-
?
additional information
?
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the phosphagen kinases in the invertebrates are observed to utilize other guanidino substrates. These include arginine, glycocyamine, taurocyamine, lombricine, hypotaurocyamine, and opheline. Analysis of phosphagen formation by 31P NMR, overview
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-
?
additional information
?
-
-
the phosphagen kinases in the invertebrates are observed to utilize other guanidino substrates. These include arginine, glycocyamine, taurocyamine, lombricine, hypotaurocyamine, and opheline. Analysis of phosphagen formation by 31P NMR, overview
-
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?
additional information
?
-
no kinase activity with the more ubiquitous guanidinium substrates, creatine or arginine
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-
?
additional information
?
-
-
no kinase activity with the more ubiquitous guanidinium substrates, creatine or arginine
-
-
?
additional information
?
-
the phosphagen kinases in the invertebrates are observed to utilize other guanidino substrates. These include arginine, glycocyamine, taurocyamine, lombricine, hypotaurocyamine, and opheline. Analysis of phosphagen formation by 31P NMR, overview
-
-
?
additional information
?
-
no kinase activity with the more ubiquitous guanidinium substrates, creatine or arginine
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-
?
additional information
?
-
recombinant enzyme shows catalytic activity with several guanidylic compounds, the highest activity being measured with taurocyamine, taurocyamine may not be the physiological substrate and that Schistosoma mansoni may use another phosphagen
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?
additional information
?
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recombinant enzyme shows catalytic activity with several guanidylic compounds, the highest activity being measured with taurocyamine, taurocyamine may not be the physiological substrate and that Schistosoma mansoni may use another phosphagen
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?
