2.7.1.144: tagatose-6-phosphate kinase

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For detailed information about tagatose-6-phosphate kinase, go to the full flat file.

Reaction

Synonyms

D-tagatose 6-phosphate kinase, D-tagatose-6-phosphate kinase, Lacc, phosphotagatokinase, tagatose 6-phosphate kinase (phosphorylating)

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.1 Phosphotransferases with an alcohol group as acceptor

                2.7.1.144 tagatose-6-phosphate kinase

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Results	in table
2	Activating Compound
8648	AA Sequence
1	CAS Registry Number
5	Cloned(Commentary)
2	Cofactor
2	Crystallization (Commentary)
2	General Information
1	General Stability
6	Inhibitors
14	KM Value [mM]
11	Metals/Ions
3	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
12	Organism
10	Pathway
19	PDB ID
5	pH Optimum
1	pH Range
1	Protein Variants
4	Purification (Commentary)
2	Reaction
1	Reaction Type
12	Reference
1	Source Tissue
16	Specific Activity [micromol/min/mg]
1	Storage Stability
24	Substrates and Products (Substrate)
2	Subunits
9	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Crystallization

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Crystallization on EC 2.7.1.144 - tagatose-6-phosphate kinase

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

high resolution structures of D-tagatose-6-phosphate kinase (LacC) in two crystal forms. The structures define LacC in apoform, in binary complexes with ADP or the cofactor analogue adenosine 5'-(beta,gamma-imino)triphosphate, and in a ternary complex with adenosine 5'-(beta,gamma-imino)triphosphate and D-tagatose-6-phosphate. LacC adopts a closed structure required for phosphoryl transfer only when both substrate and co-factor are bound

Staphylococcus aureus

P0A0B9

674827

native and L124M, L125M double mutant crystallized by hanging drop vapor diffusion method in apoform, in binary complexes with ADP or the cofactor analogue AMP-PNP, and in a ternary complex with AMP-PNP and D-tagatose-6-phosphate, wild-type protein give crystals that diffracte only to low resolution, the SeMet double mutant protein produced much more ordered crystals

Staphylococcus aureus

P0A0B9

674827