2.6.1.18: beta-alanine-pyruvate transaminase
This is an abbreviated version!
For detailed information about beta-alanine-pyruvate transaminase, go to the full flat file.
Word Map on EC 2.6.1.18
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2.6.1.18
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vibrio
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fluvialis
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ketone
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synthesis
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transamination
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acetophenone
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enantiomeric
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alpha-methylbenzylamine
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enantiomerically
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thuringiensis
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uracil
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s-specific
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transaminases
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2-butanone
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r-amine
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biotechnology
- 2.6.1.18
-
vibrio
- fluvialis
- ketone
- synthesis
-
transamination
- acetophenone
-
enantiomeric
- alpha-methylbenzylamine
-
enantiomerically
- thuringiensis
- uracil
-
s-specific
- transaminases
- 2-butanone
-
r-amine
- biotechnology
Reaction
Synonyms
3FCR_4M mutant, alanine:glyoxylate aminotransferase/beta-alanine:pyruvate aminotransferase, aminotransferase, beta-alanine-pyruvate, AptA, At3g08860, ATA117 11Rd mutant, beta-A:P TAm, beta-alanine-alpha-alanine transaminase, beta-alanine-pyruvate aminotransferase, beta-alanine-pyruvate aminotransferase 3, beta-alanine:pyruvate aminotransferase, beta-alanine:pyruvate transaminase, FG99_15380, More, omega-amino acid:pyruvate transaminase, omega-TA, omega-transaminase, omega-VpTA, PAO2, S-selective omega-TA, Sthe_0848
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General Information
General Information on EC 2.6.1.18 - beta-alanine-pyruvate transaminase
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evolution
metabolism
physiological function
additional information
aminotransferase enzymes function via a bimolecular double displacement ping-pong mechanism where an amino acid usually serves as the amino donor and an alpha-keto acid serves as the amino acceptor. Aminotransferases are ubiquitous in the three domains of life and are involved in a variety of metabolic pathways including amino acid metabolism, nitrogen assimilation, gluconeogenesis, responses to a number of biotic/abiotic stresses, and among other pathways. The aminotransferase gene family in the model plant Arabidopsis thaliana consists of 44 genes, eight of which are suggested to be alanine aminotransferases. One of the putative alanine aminotransferases genes, At3g08860, is attributed the function of alanine:glyoxylate aminotransferase/beta-alanine:pyruvate aminotransferase based on the analysis of gene expression networks and homology to other beta-alanine aminotransferases in plants
evolution
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fold type I and IV of PLP-dependent omega-transaminases (omega-TAs) show (R)- and (S)-selectivity, respectively
evolution
Arabidopsis thaliana Col7
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aminotransferase enzymes function via a bimolecular double displacement ping-pong mechanism where an amino acid usually serves as the amino donor and an alpha-keto acid serves as the amino acceptor. Aminotransferases are ubiquitous in the three domains of life and are involved in a variety of metabolic pathways including amino acid metabolism, nitrogen assimilation, gluconeogenesis, responses to a number of biotic/abiotic stresses, and among other pathways. The aminotransferase gene family in the model plant Arabidopsis thaliana consists of 44 genes, eight of which are suggested to be alanine aminotransferases. One of the putative alanine aminotransferases genes, At3g08860, is attributed the function of alanine:glyoxylate aminotransferase/beta-alanine:pyruvate aminotransferase based on the analysis of gene expression networks and homology to other beta-alanine aminotransferases in plants
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the expression of At3g08860 is highly coordinated with the genes of the uracil degradation pathway leading to the non-proteinogenic amino acid beta-alanine
metabolism
Arabidopsis thaliana Col7
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the expression of At3g08860 is highly coordinated with the genes of the uracil degradation pathway leading to the non-proteinogenic amino acid beta-alanine
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the enzyme produces beta-alanine, which is an osmoprotectant in plants
physiological function
Arabidopsis thaliana Col7
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the enzyme produces beta-alanine, which is an osmoprotectant in plants
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additional information
structural analysis and homology modeling of the At3g08860-encoded enzyme
additional information
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structural analysis and homology modeling of the At3g08860-encoded enzyme
additional information
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the reaction mechanism of transaminase-catalyzed reactions consists of two half-reactions and is described as a ping-pong-bi-bi mechanism. The widespread alpha-TAs are limited to alpha-amino acids, containing the amino or keto group in the alpha position to a carboxylic function. In contrast, omega-TAs are able to transfer amino groups in different positions to the carboxylic moiety or even in the absence of carboxylic functions
additional information
Arabidopsis thaliana Col7
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structural analysis and homology modeling of the At3g08860-encoded enzyme
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