2.6.1.17: succinyldiaminopimelate transaminase

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For detailed information about succinyldiaminopimelate transaminase, go to the full flat file.

Reaction

Synonyms

aminotransferase, succinyldiaminopimelate, AspB2, DAP-AT, DapC, N-succinyl-L-diaminopimelic-glutamic transaminase, Rv0858c, SDAT-AT, succinyldiaminopimelate aminotransferase

ECTree

     2 Transferases

         2.6 Transferring nitrogenous groups

             2.6.1 Transaminases

                2.6.1.17 succinyldiaminopimelate transaminase

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Results	in table
6327	AA Sequence
1	Application
1	CAS Registry Number
1	Cloned(Commentary)
3	Cofactor
2	Crystallization (Commentary)
1	General Information
9	Inhibitors
2	Ki Value [mM]
5	KM Value [mM]
2	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
24	Organism
6	Pathway
32	PDB ID
3	pH Optimum
1	pH Range
1	Protein Variants
3	Purification (Commentary)
1	Reaction
1	Reaction Type
24	Reference
1	Specific Activity [micromol/min/mg]
31	Substrates and Products (Substrate)
6	Subunits
14	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Turnover Number [1/s]

Crystallization

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Crystallization on EC 2.6.1.17 - succinyldiaminopimelate transaminase

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

diffration to 2.0 A resolution. The orthorhombic crystals contain one functional dimer in the asymmetric unit. The homodimer displays the typical S-shape of class I pyridoxal 5'-phosphate-binding proteins. The two active sites of the dimer both feature an internal aldimine with the co-factor pyridoxal 5'-phosphate covalently bound to the Lys232, although neither substrate nor cofactor has been added during protein production, purification and crystallization. Nine water molecules are conserved in the active site and form an intricate hydrogen-bonding network with the co-factor and the surrounding amino acid residues

Mycobacterium tuberculosis

P9WPZ5

675439

sitting drop vapour diffusion method, in the presence of 20% (w/v) PEG-3350, Tris-HCl (pH 8.5) and 200 mM MgCl2

Mycobacterium tuberculosis

P9WPZ5

675439