2.3.2.17: N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N6-glycyl)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase
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Reaction
+ 2 glycyl-tRNAGly = + 2 tRNAGly
Synonyms
FemA
ECTree
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Application
Application on EC 2.3.2.17 - N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N6-glycyl)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase
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analysis
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definition of a consensus sequence of the femA gene and analysis of interspecies variations for staphylococci species-specific identification
medicine
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expression levels of femA in methicillin-sensitive, low-level methicillin-resistant and high-level methicillin-resistant Staphylococcus aureus are 0.035%-29.91%, 0.055%-310% and 13.88-5500%, respectively. EMSA detects a signal shift in 57 high-level methicillin-resistant isolates but not in four low-level methicillin-resistant and four methicillin-sensitive strains. Expression of femA in high-level methicillin-resistant non-beta-lactamase-producing strains is higher than in low-level methicilln-resistant and methicillin-sensitive strains
medicine
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in 40 methicillin-susceptible and 6 resistant clinical isolates of Staphylococcus aureus, the FemA content or its affinity to the antibodies is reduced compared to laboratory parent strains. In susceptible strains, an additional protein of higher molecular weight, present in large quantities, is also able to bind the FemA antibodies. Such a protein is also present in methicillin-resistant isolates, although it is not as pronounced as in the susceptible strains