2.3.1.243: acyl-Kdo2-lipid IVA acyltransferase
This is an abbreviated version!
For detailed information about acyl-Kdo2-lipid IVA acyltransferase, go to the full flat file.
Reaction
Synonyms
ESA01386, Jhp0255, lauroyl-Kdo2-lipid IVA myristoyltransferase, lipid A biosynthesis myristoyltransferase, LpxJ, LpxL, LpxL2, LpxM, MsbB acyltransferase, myristoyl-[acyl-carrier protein]:alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(dodecanoyl)-lipid IVA O-myristoyltransferase, tetradecanoyl-[acyl-carrier protein]:dodecanoyl-Kdo2-lipid IVA O-tetradecanoyltransferase
ECTree
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Cloned
Cloned on EC 2.3.1.243 - acyl-Kdo2-lipid IVA acyltransferase
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expression in Escherichia coli
lipid A in lipopolysaccharide (LPS) of Escherichia coli mutant strains is modified by the introduction of myristoyltransferase gene cloned from Klebsiella pneumoniae. When the lpxL2 gene is introduced into the mutant having lipid A containing only 3-hydroxymyristic acids, it produces lipid A with two additional myristic acids (C14:0). When the same gene is introduced into the mutant with pentaacylated lipid A containing one lauric acid (C12:0), C12:0 is replaced by C14:0
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