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2.1.1.300: pavine N-methyltransferase

This is an abbreviated version!
For detailed information about pavine N-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.300

Reaction

S-adenosyl-L-methionine
+
(+/-)-pavine
=
S-adenosyl-L-homocysteine
 +
N-methylpavine

Synonyms

pavine NMT, PavNMT, PfPavNMT

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.300 pavine N-methyltransferase

Substrates Products

Substrates Products on EC 2.1.1.300 - pavine N-methyltransferase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + (+/-)-N-methylpavine
S-adenosyl-L-homocysteine + (+/-)-N,N-dimethylpavine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + (+/-)-pavine
S-adenosyl-L-homocysteine + (+/-)-N-methylpavine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + (+/-)-pavine
S-adenosyl-L-homocysteine + N-methylpavine
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + (R,S)-scoulerine
S-adenosyl-L-homocysteine + N-methylscoulerine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + (R,S)-stylopine
S-adenosyl-L-homocysteine + N-methylstylopine
show the reaction diagram
S-adenosyl-L-methionine + (S)-reticuline
S-adenosyl-L-homocysteine + (S)-tetrahydropapaverine
show the reaction diagram
best substrate. (R)-reticuline is not accepted as a substrate, revealing a strong stereoselectivity for (S)-reticuline
-
-
?
S-adenosyl-L-methionine + (S)-scoulerine
S-adenosyl-L-homocysteine + N-methyl-(S)-scoulerine
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + (S)-tetrahydropapaverine
S-adenosyl-L-homocysteine + (S)-laudanosine
show the reaction diagram
additional information
?
-
analysis of substrate specificity by mass spectrometry, overview. Enzyme PavNMT exhibits a preference for (+)-pavine and the 1-benzylisoquinoline (S)-reticuline, but also accepts the protoberberines scoulerine and stylopine and, to a lesser extent, tetrahydropapaverine (THP). No activity with (R)-reticuline and papaverine, as well as cryptopine, glaucine, codeine, canadaline, noscapine, and berbamine. Structural determinants of substrate binding are derived from crystal structure analysis
-
-
-