2.1.1.17: phosphatidylethanolamine N-methyltransferase
This is an abbreviated version!
For detailed information about phosphatidylethanolamine N-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.17
-
2.1.1.17
-
phosphatidylcholine
-
choline
-
homocysteine
-
cytidylyltransferase
-
cdp-choline
-
betaine
-
s-adenosylhomocysteine
-
ctp:phosphocholine
-
cdp-diacylglycerol
-
phosphatidyl-n,n-dimethylethanolamine
-
phosphatidyl-n-monomethylethanolamine
-
choline-deficient
-
transmethylation
-
n-methyltransferases
-
kennedy
-
adomet
-
vance
-
phosphatidylmonomethylethanolamine
-
medicine
-
ptdcho
-
analysis
-
phosphatidyldimethylethanolamine
-
mthfd1
-
remethylation
-
cholinephosphotransferase
-
adohcy
-
choline-supplemented
- 2.1.1.17
- phosphatidylcholine
- choline
- homocysteine
- cytidylyltransferase
- cdp-choline
- betaine
- s-adenosylhomocysteine
-
ctp:phosphocholine
- cdp-diacylglycerol
- phosphatidyl-n,n-dimethylethanolamine
- phosphatidyl-n-monomethylethanolamine
-
choline-deficient
-
transmethylation
- n-methyltransferases
-
kennedy
- adomet
-
vance
- phosphatidylmonomethylethanolamine
- medicine
-
ptdcho
- analysis
- phosphatidyldimethylethanolamine
- mthfd1
-
remethylation
-
cholinephosphotransferase
-
adohcy
-
choline-supplemented
Reaction
Synonyms
lipid methyl transferase, LMTase, methyltransferase, phosphatidylethanolamine, PE N-MTase, PE-NMT, PEMT, PEMT shorter isoform, phosphatidylethanolamine methyltransferase, phosphatidylethanolamine N-methyltransferase, phosphatidylethanolamine-N-methylase, phosphatidylethanolamine-N-methyltransferase, phosphatidylethanolamine-S-adenosylmethionine methyltransferase, phospholipid N-methyltransferase, PmtA, PmtX1, PmtX3
ECTree
Advanced search results
Natural Substrates Products
Natural Substrates Products on EC 2.1.1.17 - phosphatidylethanolamine N-methyltransferase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REACTION DIAGRAM
3 S-adenosyl-L-methionine + phosphatidylethanolamine
3 S-adenosyl-L-homocysteine + phosphatidylcholine + 2 H+
betaine attenuates alcoholic steatosis by restoring phosphatidylcholine generation via the phosphatidylethanolamine methyltransferase pathway, overview
-
-
?
S-adenosyl-L-methionine + phosphatidyl-N,N-dimethylethanolamine
S-adenosyl-L-homocysteine + phosphatidylcholine
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
S-adenosyl-L-homocysteine + phosphatidylcholine
-
the enzyme catalyzes the stepwise methylation of phosphatidylethanolamine to phosphatidylcholine, in addition to the main pathway that synthesizes phosphatidylcholine directly from choline
-
?
S-adenosyl-L-methionine + phosphatidyl-N,N-dimethylethanolamine
S-adenosyl-L-homocysteine + phosphatidylcholine
-
-
-
?
S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
-
the enzyme catalyzes the stepwise methylation of phosphatidylethanolamine to phosphatidylcholine, in addition to the main pathway that synthesizes phosphatidylcholine directly from choline
-
?
S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine
-
-
-
?
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
expression of PEMT2 in CHO cells does not down-regulate, but rather enhance, the expression of CTP-phosphocholine cytidylyltransferase
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
a decrease in enzyme activity is observed in the frontal cortex of the brain affected with Alzheimers disease
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
methylation of phosphatidylethanolamine may play a role in very low density lipoprotein secretion
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
possible role of PEMT2 in the suppression of liver proliferation, and perhaps in hepatic carcinogenesis
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
activation of phosphatidylethanolamine methylation at the level of gene expression may be the mechanism by which choline-deficient rats compensate for the lack of dietary choline
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
enzyme form PEMT2 plays an important role in the regulation of hepatocyte cell division and as a liver tumor suppressor
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
the enzyme catalyzes the stepwise methylation of phosphatidylethanolamine to phosphatidylcholine, in addition to the main pathway that synthesizes phosphatidylcholine directly from choline. Loss of PEMT function may contribute to malignant transformation of hepatocytes
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
inactivation of enzyme form PEMT2 may have a role in the regulation of non-neoplastic growth of liver
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
enzyme form PEMT2 may have a role in the regulation of in vivo hepatoma and hepatocyte cell division as well as hepatocyte cell death by apoptosis
-
-
?
S-adenosyl-L-methionine + phosphatidylethanolamine
S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine
-
the first-step methylation from phosphatidylethanolamine to phosphatidylcholine is rate-limiting
-
-
?
?
-
only reaction for de novo synthesis of choline in the body via methylation of phosphatidylethanolamine to form phosphatidylcholine
-
-
?
additional information
?
-
-
enzyme-mediated secretion of homocysteine correlates with the methyltransferase activity of the enzyme, independently of subcellular localization
-
-
?
additional information
?
-
-
phosphatidylethanolamine N-methyltransferase is the key enzyme for endogenous biosynthesis of phosphatidylcholine.
-
-
?
additional information
?
-
-
a striking gender-specific conservation of choline in female mice does not occur in male mice
-
-
?
additional information
?
-
-
physiological functions of phosphatidylcholine, mutational analysis, overview
-
-
?