2.1.1.164: demethylrebeccamycin-D-glucose O-methyltransferase
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For detailed information about demethylrebeccamycin-D-glucose O-methyltransferase, go to the full flat file.
Reaction
Synonyms
rebeccamycin MT, rebeccamycin O-methyltransferase, RebM, RebM.
ECTree
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Systematic Name
Systematic Name on EC 2.1.1.164 - demethylrebeccamycin-D-glucose O-methyltransferase
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S-adenosyl-L-methionine:demethylrebeccamycin-D-glucose O-methyltransferase
Catalyses the last step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the bacterium Lechevalieria aerocolonigenes. The enzyme is able to use a wide variety substrates, tolerating variation on the imide heterocycle, deoxygenation of the sugar moiety, and even indolocarbazole glycoside anomers [1]. The enzyme is a member of the general acid/base-dependent O-methyltransferase family [2].