2.1.1.162: glycine/sarcosine/dimethylglycine N-methyltransferase

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For detailed information about glycine/sarcosine/dimethylglycine N-methyltransferase, go to the full flat file.

Reaction

3 S-adenosyl-L-methionine +

= 3 S-adenosyl-L-homocysteine +

Synonyms

GSDMT, THAPSDRAFT_20797

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.162 glycine/sarcosine/dimethylglycine N-methyltransferase

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Results	in table
6	AA Sequence
2	CAS Registry Number
1	Cloned(Commentary)
1	Expression
1	Inhibitors
9	KM Value [mM]
1	Metals/Ions
3	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
5	Organism
2	Pathway
2	pH Optimum
5	pI Value
1	Protein Variants
1	Purification (Commentary)
12	Reaction
3	Reference
3	Specific Activity [micromol/min/mg]
14	Substrates and Products (Substrate)
3	Subunits
3	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]

Engineering

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Engineering on EC 2.1.1.162 - glycine/sarcosine/dimethylglycine N-methyltransferase

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additional information

Thalassiosira pseudonana

B8BQQ3

GSDMT protein has two repeated AdoMet-binding motifs in the N-terminal and C-terminal domains. A truncation mutant carrying the N-terminal part exhibits high activity for glycine, low activity for sarcosine and no activity for dimethylglycine. A truncation mutant carrying the C-terminal part displays the highest activity to dimethylgycine, slightly lower to sarcosine and low activity to glycine

758064