2.1.1.115: (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase

This is an abbreviated version!
For detailed information about (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase, go to the full flat file.

Reaction

Synonyms

(R,S)-Tetrahydrobenzylisoquinoline-N-methyltransferase, Methyltransferase, tetrahydrobenzylisoquinoline, NMT, Norreticuline N-methyltransferase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.115 (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase

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Results	in table
1	AA Sequence
1	Application
1	CAS Registry Number
2	General Stability
12	KM Value [mM]
3	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
33	Organism
2	Pathway
8	PDB ID
2	pH Optimum
1	Purification (Commentary)
1	Reaction
1	Reaction Type
33	Reference
1	Source Tissue
1	Storage Stability
19	Substrates and Products (Substrate)
4	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
2	Temperature Stability [°C]

Substrates Products

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Substrates Products on EC 2.1.1.115 - (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

S-Adenosyl-L-methionine + (R)-6-O-methylnorlaudanosoline

?

Berberis koetineana

-

-

15190

-

-

?

S-Adenosyl-L-methionine + (R)-norcoclaurine

?

Berberis koetineana

-

-

15190

-

-

?

S-Adenosyl-L-methionine + (R)-norprotosinomenine

?

Berberis koetineana

-

isoenzyme NMT-I: 6% of maximal activity with (R)-tetrahydropapaverine

15190

-

-

?

S-Adenosyl-L-methionine + (R,S)-4'-O-methylnorlaudanosoline

?

Berberis koetineana

-

isoenzyme NMT-I: 3% of maximal activity with (R)-tetrahydropapaverine

15190

-

-

?

S-Adenosyl-L-methionine + (R,S)-7-O-methylnorlaudanosoline

?

Berberis koetineana

-

isoenzyme NMT-I: 12% of maximal activity with (R)-tetrahydropapaverine

15190

-

-

?

S-Adenosyl-L-methionine + (R,S)-isococlaurine

?

Berberis koetineana

-

-

15190

-

-

?

S-Adenosyl-L-methionine + (R,S)-norarmepavine

?

Berberis koetineana

-

-

15190

-

-

?

S-Adenosyl-L-methionine + (R,S)-norcodamine

?

Berberis koetineana

-

-

15190

-

-

?

S-Adenosyl-L-methionine + (R,S)-nororientaline

?

Berberis koetineana

-

-

15190

-

-

?

S-Adenosyl-L-methionine + (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline

?

Berberis koetineana

-

-

15190

-

-

?

S-Adenosyl-L-methionine + (S)-6-O-methylnorlaudanosoline

?

Berberis koetineana

-

-

15190

-

-

?

S-Adenosyl-L-methionine + (S)-norcoclaurine

?

Berberis koetineana

-

-

15190

-

-

?

S-Adenosyl-L-methionine + coclaurine

?

Berberis koetineana

-

-

15190

-

-

?

S-Adenosylmethionine + (R)-coclaurine

S-Adenosyl-L-homocysteine + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline

Berberis koetineana

-

isoenzyme NMT-II and NMT-III show maximal activity with (R)-coclaurine

15190

-

15190

?

S-Adenosylmethionine + (R)-norreticuline

?

Berberis koetineana

-

-

15190

-

-

?

S-Adenosylmethionine + (R)-tetrahydropapaverine

?

Berberis koetineana

-

isoenzyme NMT-I shows maximal activity with (R)-tetrahydropapaverine

15190

-

-

?

S-Adenosylmethionine + (S)-coclaurine

S-Adenosylhomocysteine + N-methylcoclaurine

Berberis koetineana

-

-

15190

-

15190

?

S-Adenosylmethionine + (S)-norreticuline

S-Adenosylhomocysteine + (S)-scoulerine

Berberis koetineana

-

-

15190

-

15190

?

S-Adenosylmethionine + (S)-tetrahydropapaverine

?

Berberis koetineana

-

-

15190

-

-

?