1.7.2.5: nitric oxide reductase (cytochrome c)

This is an abbreviated version!
For detailed information about nitric oxide reductase (cytochrome c), go to the full flat file.

Reaction

Synonyms

Anor, ba3-oxidase, c-type nitric oxide reductase, cNOR, Cnor1, Cnor2, cytochrome c dependent nitric oxide reductase, cytochrome c dependent NOR, cytochrome c type NOR, cytochrome c-dependent nitric oxide reductase, cytochrome c-dependent NO reductase, EC 1.7.99.7, flavorubredoxin, FlRd, Fnor, FprA, membrane-integrated nitric oxide reductase, nitric oxide reductase, nitric oxide reductase cytochrome, nitric oxide-reductase, nitrogen oxide reductase, NO reductase, NO-reductase, NOR, NorB, NorBC, NorC, NorCB, NorZ, P450nor, qCuANOR, respiratory nitric oxide reductase, respiratory NO reductase, S-NOR, scavenging nitric oxide reductase, Tnor

ECTree

     1 Oxidoreductases

         1.7 Acting on other nitrogenous compounds as donors

             1.7.2 With a cytochrome as acceptor

                1.7.2.5 nitric oxide reductase (cytochrome c)

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Results	in table
5	Activating Compound
1196	AA Sequence
4	Application
1	CAS Registry Number
17	Cloned(Commentary)
107	Cofactor
7	Crystallization (Commentary)
2	Expression
12	General Information
5	General Stability
32	Inhibitors
8	Ki Value [mM]
21	KM Value [mM]
45	Localization
71	Metals/Ions
30	Molecular Weight [Da]
100	Natural Substrates/ Products (Substrates)
366	Organism
7	Pathway
20	PDB ID
10	pH Optimum
4	pH Range
1	pH Stability
1	Posttranslational Modification
41	Protein Variants
28	Purification (Commentary)
3	Reaction
4	Reaction Type
180	Reference
2	Source Tissue
24	Specific Activity [micromol/min/mg]
6	Storage Stability
186	Substrates and Products (Substrate)
37	Subunits
206	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
26	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 1.7.2.5 - nitric oxide reductase (cytochrome c)

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

2-heptyl-3-hydroxy-4-quinolone

Pseudomonas aeruginosa

-

i.e. Pseudomonas quinolone signal or PQS, a cell-to-cell communication signal, PQS represses denitrification in vivo and regulates denitrification primarily through iron chelation, PQS signaling under anaerobic conditions, detailed overview

692888

Antimycin

Paracoccus denitrificans

-

100% inhibition at 0.005 mg per mg vesicle protein, no inhibition with isoascorbate plus 2,3,5,6-tetramethyl-1,4-benzendiamine as electron donors

395137

antimycin A

Paracoccus denitrificans

-

100% inhibition at 0.0075 mg per ml, no inhibition with ascorbate plus 2,3,5,6-tetramethyl-1,4-benzendiamine as electron donors

395141

CN-

Paracoccus denitrificans

-

10 mM, 50% inhibition

659327

CO

Pseudomonas aeruginosa

-

-

662315

cytochrome c

Schinkia azotoformans

-

-

658038

elaidic acid

Pseudomonas stutzeri

-

-

395132

KCN

2 entries

linoleic acid

Pseudomonas stutzeri

-

-

395132

linolenic acid

Pseudomonas stutzeri

-

-

395132

Myxothiazol

2 entries

NH2OH

Pseudomonas denitrificans (nom. rej.)

-

at 5 mM 58% inhibition

395143

NO

5 entries

NO2

Bradyrhizobium japonicum

-

1 mM, 20% inhibition of activity

671949

o-phenanthroline

Pseudomonas denitrificans (nom. rej.)

-

at 1 mM 60% inhibition

395143

oleic acid

Pseudomonas stutzeri

-

-

395132

p-chloromercuribenzoate

Pseudomonas denitrificans (nom. rej.)

-

at 1 mM 85% inhibition

395143

palmitoleic acid

Pseudomonas stutzeri

-

-

395132

Triton X-100

4 entries

additional information

2 entries

-

KCN

Paracoccus denitrificans

-

50% inhibition at 0.3 mM

395131

KCN

Pseudomonas stutzeri

-

-

395138

Myxothiazol

Bradyrhizobium japonicum

-

0.045 mM, 40% inhibition of activity

671949

Myxothiazol

Paracoccus denitrificans

-

100% inhibition at 200 ng per mg vesicle protein, no inhibition with isoascorbate plus 2,3,5,6-tetramethyl-1,4-benzendiamine as electron donors

395137

NO

Achromobacter cycloclastes

-

substrate inhibition

395120

NO

Halomonas halodenitrificans

-

substrate inhibition

395120

NO

Paracoccus denitrificans

-

substrate inhibition

395120, 395124, 395127

NO

Paracoccus denitrificans

-

reversible inhibition

395134

NO

Pseudomonas stutzeri

-

substrate inhibition

395120

Triton X-100

Achromobacter cycloclastes

-

7.5% Triton X-100 results in complete inactivation after 6 h

395139

Triton X-100

Paracoccus denitrificans

-

5% Triton X-100 results in complete inactivation after 4-5 h

395139

Triton X-100

Pseudomonas aeruginosa

-

5% Triton X-100 results in complete inactivation after 4-5 h

395139

Triton X-100

Pseudomonas stutzeri

-

5% Triton X-100 results in complete inactivation after 4-5 h

395139

additional information

Pseudomonas aeruginosa

-

the dissimilative nitrate respiration regulator DNR is involved in NO-sensing and transcription regulation of the enzyme, apo-DNR binds heme in vitro and the heme-bound form reacts with carbon monoxide and NO, thus supporting the hypothesis that NO sensing involves gas binding to the ferrous heme, mechanism and structure, overview

693636

-

additional information

Roseobacter denitrificans

-

oxidation of NADH by membranes is inhibited almost completely by antimycin A or myxothiazole, indicating that the bacterium does not have a quinol oxidase

698646

-