1.5.1.B5: DELTA1-piperideine-2-carboxylate/DELTA1-pyrroline-2-carboxylate reductase (NADH)

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For detailed information about DELTA1-piperideine-2-carboxylate/DELTA1-pyrroline-2-carboxylate reductase (NADH), go to the full flat file.

Word Map on EC 1.5.1.B5

1.5.1.B5

sulfatases

mucopolysaccharidosis

formylglycine-generating

metachromatic

sulfatase-modifying

leukodystrophy

ichthyosis

formylglycine

aav-mediated

x-linked

co-delivery

intracerebral

infantile

autosomal-recessive

ataxia

mpsiiia

adeno-associated

posttranslationally

sulfamidase

Reaction

Synonyms

DELTA-pyrroline-2-carboxylate reductase, DELTA1-pyrroline-2-carboxylate reductase, NADH-dependent Pyr2C reductase, Pyr2C reductase, TlLhpI, tlPyr2C

ECTree

1 Oxidoreductases

1.5 Acting on the CH-NH group of donors

1.5.1 With NAD⁺ or NADP⁺ as acceptor

1.5.1.B5 DELTA1-piperideine-2-carboxylate/DELTA1-pyrroline-2-carboxylate reductase (NADH)

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Results	in table
2	Cloned(Commentary)
7	Cofactor
1	Crystallization (Commentary)
14	General Information
7	kcat/KM [mM/s]
7	KM Value [mM]
2	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
15	Organism
6	pH Optimum
3	pH Range
24	Protein Variants
2	Purification (Commentary)
11	Reaction
9	Reference
2	Specific Activity [micromol/min/mg]
28	Substrates and Products (Substrate)
7	Subunits
30	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
7	Turnover Number [1/s]

Cofactor

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Cofactor on EC 1.5.1.B5 - DELTA1-piperideine-2-carboxylate/DELTA1-pyrroline-2-carboxylate reductase (NADH)

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NAD+

3 entries

NADH

3 entries

additional information

Thermococcus litoralis

the preference of tlPyr2C for NADH instead of NADPH can be rationalized by analysing the residues of tlPyr2C that bind to the 2'-hydroxyl group of NADH and comparing them with the residues of tlPyr2C orthologues that bind to the phosphate group of NADPH. Determination and analysis of the NADH binding structure and interaction network of tlPyr2C, structure comparisons, detailed overview. A role of Asn168 in the selectivity for NADH versus NADPH is suggested

763843