1.3.99.6: 3-oxo-5beta-steroid 4-dehydrogenase

This is an abbreviated version!
For detailed information about 3-oxo-5beta-steroid 4-dehydrogenase, go to the full flat file.

Reaction

Synonyms

3-keto-DELTA4-steroid-5beta-reductase, 3-oxo-5beta-steroid DELTA4-dehydrogenase, 3-oxo-DELTA4-steroid-5beta-reductase, 5beta-reductase, AKR1D1, Aldo-keto reductase family 1 member D1, Delta(4)-3-ketosteroid 5-beta-reductase, DELTA-3-ketosteroid-5beta-reductase, DELTA4-3-ketosteroid-5beta-reductase, DELTA4-3-oxosteroid 5beta-reductase, DELTA4-5beta-DH, steroid 5beta reductase, steroid 5beta-reductase, steroid DELTA-5beta-dehydrogenase, testosterone 5beta-reductase

ECTree

     1 Oxidoreductases

         1.3 Acting on the CH-CH group of donors

             1.3.99 With unknown physiological acceptors

                1.3.99.6 3-oxo-5beta-steroid 4-dehydrogenase

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Results	in table
2	Activating Compound
64	AA Sequence
1	Application
1	CAS Registry Number
2	Cloned(Commentary)
2	Cofactor
54	Disease/ Diagnostics
2	General Stability
5	Inhibitors
1	KM Value [mM]
1	Localization
3	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
9	Organism
2	Oxidation Stability
2	Pathway
4	pH Optimum
1	pH Range
3	Protein Variants
2	Purification (Commentary)
1	Reaction
3	Reaction Type
9	Reference
8	Source Tissue
2	Specific Activity [micromol/min/mg]
2	Storage Stability
25	Substrates and Products (Substrate)
1	Subunits
16	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]

Substrates Products

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of the Enzyme Summary Page.

Substrates Products on EC 1.3.99.6 - 3-oxo-5beta-steroid 4-dehydrogenase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

17beta-hydroxy-5beta-androstan-3-one + menaphthone

testosterone + reduced acceptor

2 entries

21-hydroxy-5beta-pregnan-3,20-dione + acceptor

21-hydroxy-pregn-4-en-3,20-dione + reduced acceptor

Comamonas testosteroni

-

acceptor: 1,2-naphthoquinone, 1,4-naphthoquinone, 1,4-benzoquinone, menadione or coenzyme Q10

391402

-

-

?

3,12-dioxo-5beta-cholan-24-oic acid + menaphthone

3,12-dioxo-4-cholen-24-oic acid + reduced menaphthone

Clostridium paraputrificum

-

-

391381

-

-

?

3,12-dioxo-5beta-cholan-24-oic acid + phenazine methosulfate

3,12-dioxo-4-cholen-24-oic acid + reduced phenazine methosulphate

Clostridium paraputrificum

-

-

391381

-

-

?

3,12-dioxo-5beta-cholan-24-oic acid methyl ester + menaphthone

3,12-dioxo-4-cholen-24 oic acid methyl ester + reduced menaphthone

Clostridium paraputrificum

-

-

391381

-

-

?

3,12-dioxo-5beta-cholan-24-oic acid methyl ester + phenazine methosulfate

3,12-dioxo-4-cholen-24 oic acid methyl ester + reduced phenazine methosulfate

Clostridium paraputrificum

-

-

391381

-

-

?

3-oxo-5beta-24-cholan-oic acid + phenazine methosulfate

3-oxo-4-cholen-24-oic acid + reduced phenazine methosulfate

Clostridium paraputrificum

-

-

391381

-

-

?

3-oxo-5beta-cholan-24-oic acid + menaphthone

3-oxo-4-cholen-24-oic acid + reduced menaphthone

Clostridium paraputrificum

-

-

391381

-

-

?

4-pregnen-3,20-dione + NADH

5beta-pregnan-3,20-dione + NAD+

2 entries

5beta-androst-3,17-dione + acceptor

androst-1,4-dien-3,17-dione + reduced acceptor

Comamonas testosteroni

-

acceptor: 1,2-naphthoquinone, 1,4-naphthoquinone, 1,4-benzoquinone, menadione or coenzyme Q10

391402

-

-

?

5beta-androstan-3,17-dione + acceptor

4-androsten-3,17-dione + reduced acceptor

3 entries

5beta-androstane-3,17-dione + acceptor

androst-4-en-3,17-dione + reduced acceptor

Comamonas testosteroni

-

acceptor: 1,2-naphthoquinone, 1,4-naphthoquinone, 1,4-benzoquinone, menadione or coenzyme Q10

391402

-

-

?

5beta-pregnan-3,20-dione + menaphthone

4-pregnen-3,20-dione + reduced menaphthone

Clostridium paraputrificum

-

-

391381

-

-

?

5beta-pregnan-3,20-dione + phenazine methosulfate

4-pregnen-3,20-dione + reduced menazine methosulfate

Clostridium paraputrificum

-

-

391381

-

-

?

progesterone + NADPH + H+

5beta-pregnane-3,20-dione + NADP+

Homo sapiens

-

-

676039

-

-

?

testosterone + NADH

17beta-hydroxy-5beta-androstan-3-one + NAD+

[Clostridium] innocuum

-

-

287079

-

-

?

additional information

?

-

5 entries

17beta-hydroxy-5beta-androstan-3-one + menaphthone

testosterone + reduced acceptor

Clostridium paraputrificum

-

acceptor: phenazine methosulfate

391381

-

-

?

17beta-hydroxy-5beta-androstan-3-one + menaphthone

testosterone + reduced acceptor

Comamonas testosteroni

-

acceptor: 1,2-naphthoquinone, 1,4-naphthoquinone, 1,4-benzoquinone, menadione or coenzyme Q10

391402

-

-

?

4-pregnen-3,20-dione + NADH

5beta-pregnan-3,20-dione + NAD+

Clostridium paraputrificum

-

-

287079

-

-

?

4-pregnen-3,20-dione + NADH

5beta-pregnan-3,20-dione + NAD+

[Clostridium] innocuum

-

i.e. progesterone

287079

-

-

?

5beta-androstan-3,17-dione + acceptor

4-androsten-3,17-dione + reduced acceptor

Clostridium paraputrificum

-

acceptor: phenazine methosulfate

391381

-

-

?

5beta-androstan-3,17-dione + acceptor

4-androsten-3,17-dione + reduced acceptor

Comamonas testosteroni

-

acceptor: 1,2-naphthoquinone, 1,4-naphthoquinone, 1,4-benzoquinone, menadione or coenzyme Q10

391402

-

-

?

5beta-androstan-3,17-dione + acceptor

4-androsten-3,17-dione + reduced acceptor

Pseudomonas sp.

-

acceptor: nitroblue tetrazolium

389552

-

-

?

additional information

?

-

Clostridium paraputrificum

-

no activity with: NAD+, NADP+, FMN and FAD

391381

-

-

?

additional information

?

-

Clostridium paraputrificum

-

inducible by 3-oxo-5beta-cholan-24-oic acid

391381

-

-

?

additional information

?

-

Homo sapiens

-

enzyme is essential in bile acids formation, analysis of bile acid contents in urine and plasma from healthy persons and 3 different patients with neonatal onset cholestatic liver disease, physiolgical role of the enzyme, overview

655692

-

-

?

additional information

?

-

Pseudomonas sp.

-

inducible by testosterone and progesterone

389552

-

-

?

additional information

?

-

Rattus norvegicus

-

enzyme is involved in bile acid biosynthesis

391405

-

-

?