1.3.1.78: arogenate dehydrogenase (NADP+)
This is an abbreviated version!
For detailed information about arogenate dehydrogenase (NADP+), go to the full flat file.
Word Map on EC 1.3.1.78
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1.3.1.78
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kinase-inactive
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prephenate
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gadd45
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malformation
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annexin
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ifngamma
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neurulation
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perinuclear
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calcium-dependent
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mekks
- 1.3.1.78
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kinase-inactive
- prephenate
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gadd45
-
malformation
-
annexin
-
ifngamma
-
neurulation
-
perinuclear
-
calcium-dependent
-
mekks
Reaction
Synonyms
ADH1, ADH2, arogenate dehydrogenase, arogenate dehydrogenase isoform 1, arogenate dehydrogenase isoform 2, cyclohexadienyl dehydrogenase, TyrA arogenate dehydrogenase, TyrA1, TyrA2, TyrAa, TyrAAT, TyrAAT1, TyrAsy
ECTree
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General Information
General Information on EC 1.3.1.78 - arogenate dehydrogenase (NADP+)
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evolution
prephenate dehydrogenases (TyrAps, also known as PDHs) from two legumes, Glycine max (soybean) and Medicago truncatula, are phylogenetically distinct from canonical plant ADH enzymes, prefer prephenate to arogenate substrate, localize outside of the plastids and are not inhibited by L-Tyr. Diversification of primary metabolic Tyr pathway via an alternative cytosolic PDH pathway in plants, phylogenetic and biochemical differentiation of ADHs and PDHs
malfunction
metabolism
TyrA1 suppression reduces seed yield due to impaired anther dehiscence
malfunction
TyrA2 knockout leads to slow growth with reticulate leaves. TyrA2 deficiency alters the levels of multiple amino acids but not of tyrosine
in plants, L-Tyr is synthesized in the plastids via the arogenate dehydrogenase pathway, in which prephenate is first converted to arogenate by prephenate aminotransferase, EC 2.6.1.7, and then to L-Tyr by enzyme ADH
metabolism
most plants synthesize tyrosine by TyrA arogenate dehydrogenases. TyrA1 and TyrA2 have distinct and overlapping functions in flower and leaf development, respectively. The imbalance of tyrosine, caused by altered TyrA activity and regulation, impacts growth and development of Arabidopsis